THE ASSAY OF CORTICOTROPHIN IN MICE

1963 ◽  
Vol 44 (2) ◽  
pp. 237-249 ◽  
Author(s):  
Claus Rerup ◽  
Pavo Hedner
Keyword(s):  
Subcutaneous Administration ◽  
Small Sample ◽  
Lower Body ◽  
Sample Analysis ◽  
Lower Body Weight ◽  
Increased Sensitivity ◽  
The Mean ◽  
The Difference ◽  
Response Line ◽  
Free Plasma

ABSTRACT The assay of corticotrophin was performed in mice by means of small sample analysis of free plasma corticosteroids. In this method hypophysectomy was replaced by dexamethasone pretreatment. The response was measured preferably in a single mouse weighing 20 g or more. When mice of a lower body weight were used the plasma of two randomly assigned mice was pooled. Corticosteroids (mainly corticosterone) were determined fluorometrically in 0.25 (0.20) ml samples of plasma from heparinized blood. The results show that valid corticotrophin assays can be performed in mice both by the intravenous and subcutaneous route. Compared with the adrenal ascorbic acid depletion method or the plasma corticosteroid method in the rat the assay in mice was found to be at least five times more sensitive. 40 micro-units of corticotrophin were consistently detectable. Precision was dependent on the route of administration, the mean index of precision (s/b) being 0.20 in the intravenous and 0.12 in the subcutaneous assay. The difference was due to a steeper slope of the logdose-response line after subcutaneous administration. Contrary to the findings in the rat, corticotrophin A (oxycel purified) did not differ significantly in potency estimates from subcutaneous and intravenous assays in mice, when crude corticotrophin (U. S. P. Corticotropin Reference Standard) was the basis of comparison. Accordingly results of subcutaneous assays of corticotrophin A samples in terms of the U. S. P. standard were lower in mice than in rats. The use of gelatine instead of saline as diluent in the subcutaneous assays yielded slightly but not significantly higher potency estimates (25 per cent). The interpretation of the results is that for intravenous corticotrophin assays the mouse method is comparable to the rat assay. For subcutaneous corticotrophin assays, however, the mouse method is not suitable, if crude corticotrophin (U. S. P. standard) is the basis of comparison, but if corticotrophin A (oxycel purified) is the standard of reference (e. g. the Third International Standard for Corticotrophin), the mouse method may justifiably be used. The advantages of the mouse method are increased sensitivity, precision, convenience, and economy.

QUANTITATIVE STUDIES ON THE HORMONAL INDUCTION OF OESTRUS IN SPAYED EWES

1955 ◽  
Vol 12 (3) ◽  
pp. 163-173 ◽  
Author(s):  
T. J. ROBINSON
Keyword(s):  
Hormonal Control ◽  
Behaviour Pattern ◽  
Physiological Changes ◽  
Quantitative Studies ◽  
Oestradiol Benzoate ◽  
Endogenous Oestrogen ◽  
The Mean ◽  
The Difference ◽  
Response Line ◽  
Mean Time

SUMMARY Seven trials were conducted with sixty-nine ovariectomized Suffolk cross-bred ewes to determine the requirements of oestradiol benzoate (ODB), given alone or preceded by 75 mg progesterone (6 × 12·5 mg in oil over 3 days, followed 2 days later by oestrogen), for oestrous behaviour and characteristic vaginal changes. Progesterone pretreatment resulted in a marked increase of sensitivity to oestrogen. For oestrus, the respective values of the median effective dose (ED 50) for ODB preceded by progesterone and for ODB alone were 22 and 64 μg, the difference being significant (P<0·001). The 99% fiducial limits associated with these estimates were respectively 19 and 26 μg and 52 and 81 μg. For vaginal changes the corresponding values were 10-14-17 and 20-24-28 (P<0·001). Progesterone pretreatment resulted in an apparently steeper dose-response line for oestrus, and advanced the mean time of onset by about 12 hr. The behaviour pattern following progesterone—ODB appeared to differ from that following ODB alone. Oestrus in the ewe appears to be under dual hormonal control. Endogenous oestrogen production is insufficient to induce the full psychic and physiological changes associated with normal oestrus, unless the animal has been conditioned previously by progesterone.

scholarly journals Perbedaan Kadar Malondialdehide dan Tromboksan B2 pada Remaja dengan Dismenore dan Tanpa Dismenore

2015 ◽  
Vol 4 (3) ◽  
Author(s):  
Berliana Irianti ◽  
Ermawati Ermawati ◽  
Arni Amir
Keyword(s):  
Lipid Peroxidation ◽  
Observational Study ◽  
Thiobarbituric Acid ◽  
Sample Analysis ◽  
Cross Sectional ◽  
Significant Difference ◽  
The Mean ◽  
The Difference ◽  
Cross Sectional Design ◽  
Biomedical Laboratory

Abstrak Penyebab dismenore belum semuanya diketahui, ada dugaan peningkatan proses peroksida lipid yang akan mengaktivasi mediator inflamasi pada endometrium yang menimbulkan rasa nyeri haid (dismenore). Tujuan penelitian ini adalah menentukan perbedaan kadar malondialdehide dan tromboksan B 2  pada dismenore dan tanpa dismenore. Studi observasional ini menggunakan desain potong lintang komparatif. Subjek penelitian terdiri dari dua kelompok yaitu 23 remaja dismenore dan 23 remaja tanpa dismenore dengan waktu penelitian dari Juni sampai Juli 2014. Analisis sampel dilakukan di Laboratorium Biomedik dan Biokimia Universitas Andalas Padang. Pemeriksaan kadartromboksan B 2  menggunakan metode ELISA dan kadar malondialdehide menggunakan metode Asam Thiobarbiturat (TBA). Hasil penelitian diperoleh bahwa rerata kadar malondialdehid pada remaja dengan dismenore yaitu 2,60±0,63 µmol/ml, rerata remaja tanpa dismenore 1,98±0,12 µmol/ml dengan probabilitas p<0,05 (0,000), sedangkan reratakadar Tromboksan B 2  pada remaja dengan dismenore 20,043±9,56 ng/ml, rerata remaja tanpa dismenore 19,222±10,79 ng/ml, dengan probabilitas p>0,05 (0,786). Kesimpulan penelitian ini adalah terdapat perbedaan yang signifikan rerata kadar malondialdehid pada remaja dengan dismenore dan tanpa dismenore dan tidak terdapatperbedaan signifikan pada kadar tromboksan B 2 pada remaja dengan dismenore dan tanpa dismenore.Kata kunci: remaja, dismenore, malondialdehide, tromboksan B2 Abstract The precise cause of dysmenorrhea is still unclear, there may be increased lipid peroxidation process will activate the inflammatory mediators at endometrium that cause menstrual cramps (dysmenorrhea). The objective of this study was to determine the difference of malondialdehyde levels and thromboxane B 2  levels in dysmenorrhea and without dysmenorrhea. It was an observational study with comparative cross-sectional design. The subjects consisted of two groups, they are 23 adolescent with dysmenorrhea and 23 adolescents without dysmenorrhea, done in Juny -July 2014. Sample analysis was conducted in Laboratory of Biochemistry and Biomedical Laboratory of Andalas University Padang. The examination of Thromboxane B 2  levels used ELISA and the examination of malondialdehyde levels used a Thiobarbituric acid method. The results showed the mean of malondialdehyde levels in adolescents withdysmenorrhea was 2.60±0.63 µmol/ml, the mean level in adolescent without dysmenorrhea was 1.98±0.12 µmol/ml with probability p<0.05 (0.000), while the mean levels of thromboxane B 2  in adolescents with dysmenorrhea was 20.043±9.56 ng/ml, the mean level in adolescent without dysmenorrhea was 19.222±10.79 ng/ml, with probabilityp>0.05 (0.786). It can be concluded that there is a significant difference in the mean of malondialdehyde levels between adolescents with dysmenorrhea and without dysmenorrhea and there is no significant differences in thromboxane B 2 level between adolescents with dysmenorrhea and without dysmenorrheaKeywords: adolescent, dysmenorrhea, malondialdehyde, thromboxane B2

scholarly journals Clinical onset serial interval and diagnostic serial interval of SARS-CoV-2/COVID-19 in South Korea

2020 ◽  
Author(s):  
Sofia K. Mettler ◽  
Marloes H. Maathuis
Keyword(s):  
South Korea ◽  
Bootstrap Method ◽  
Sample Analysis ◽  
Bootstrap Confidence Intervals ◽  
Clinical Onset ◽  
Serial Interval ◽  
The Mean ◽  
The Difference ◽  
A Chain ◽  
Project Data

BACKGROUNDThe clinical onset serial interval, or the time between the onset of symptoms in successive cases in a chain of infection, is often used as a measurable proxy for the transmission serial interval of an infectious disease. Current estimates of the mean clinical onset serial interval of COVID-19 range from 3.96 to 7.5 days. In this article, we define the diagnostic serial interval as the time between the diagnosis dates of the infector and infectee. We study and compare the clinical onset and diagnostic serial intervals of SARS-CoV-2/COVID-19 in South Korea.METHODSAnalyzing the DS4C project data which summarize information on SARS-CoV-2/COVID-19 cases reported by regional governments in South Korea, we estimate the means of the clinical onset serial interval, the diagnostic serial interval and the difference between the two. We use the balanced cluster bootstrap method to construct 95% bootstrap confidence intervals.RESULTSThe mean clinical onset serial interval and mean diagnostic serial interval were estimated to be 3.58 days (95% CI: 2.62, 4.53) and 3.68 days (95% CI: 3.14, 4.22), respectively. A matched sample analysis showed that the diagnostic serial interval was significantly shorter than the clinical onset serial interval (estimated mean difference −1.17 days, 95% CI: −2.26, −0.09).CONCLUSIONSThe short diagnostic serial interval of SARS-CoV-2/COVID-19 in South Korea may explain why South Korea was able to contain the COVID-19 outbreak and avoid high mortality. We conjecture that the mean diagnostic serial interval may serve as a predictor for the success of a country’s containment efforts.

scholarly journals Aggregation of plaque disclosing agent in a dentifrice

2004 ◽  
Vol 12 (2) ◽  
pp. 154-158 ◽  
Author(s):  
Débora Dias da Silva ◽  
Camila da Silva Gonçalo ◽  
Maria da Luz Rosário de Sousa ◽  
Ronaldo Seichi Wada
Keyword(s):  
Dental Plaque ◽  
Small Sample Size ◽  
Health Assessment ◽  
Small Sample ◽  
Control Group ◽  
Assessment Index ◽  
Plaque Removal ◽  
The Mean ◽  
The Difference ◽  
Two Stages

Dental plaque removal is an important issue in health promotion. Toothbrushing is one of the main methods employed for such purpose, since it can prevent dental caries by means of the fluoride present in the dentifrice. Dentifrices might contain plaque disclosing agents and thus allow dental plaque observation. The aim of this study was to assess whether utilization of a plaque disclosing agent interfered with plaque removal among adolescents, as well as the difference between utilization of erythrosine tablets and dentifrices containing plaque disclosing agent. The sample was composed of 62 students from Piracicaba, SP, Brazil, aged 12 to 14 years old, divided into 3 groups: G1 or control group (toothbrushing without plaque disclosure); G2 (plaque disclosing with an erythrosine tablet and toothbrushing) and G3 (toothbrushing with dentifrice containing plaque disclosing agent). After toothbrushing, disclosure of the remaining dental plaque was performed in all groups with a fuchsin tablet and measured through the Simplified Oral Health Assessment Index (OHI-S), in two stages with a 2-month interval between them. The analysis of variance (ANOVA) showed that there was no difference in the OHI-S index between the groups (p>0.05), however the G3 displayed a higher proportion of students with plaque reduction (23%) than G2 (21%), besides the smallest difference in the mean remaining dental plaque. There was no difference between groups; however, it was suggested that the dentifrice with plaque disclosing agent had positive results in relation to the erythrosine tablet, even though the small sample size may have interfered with the results, indicating the need of complementary studies.

Influence of temperature, photoperiod, and food on the speed of development, longevity, fecundity, and other qualities of the Diamond-Back moth Plutella Maculipennis (Curtis) (Lepidoptera: Tineidae).

1955 ◽  
Vol 3 (2) ◽  
pp. 185 ◽  
Author(s):  
AS Atwal
Keyword(s):  
Body Weight ◽  
Dry Matter ◽  
Egg Laying ◽  
Lower Body ◽  
Green Leaves ◽  
Lower Body Weight ◽  
Different Temperatures ◽  
Quality Of Food ◽  
The Difference

Larvae of Plutella maculipennis (Curtis) were reared on food of different qualities at different temperatures and were exposed during their development to different photoperiods. The plants on which the larvae were reared were also exposed to different photoperiods during their development to see whether this influenced the quality of food for the insect. It was found that although caterpillars developed more quickly at 25�C than at l8�C, they weighed less at pupation at 25�C than at l8�C, but the ratio of dry matter to water was the same at both temperatures. Exposure of caterpillars to different photoperiods influenced their speed of development. There was an indication that the influence of light was different at different temperatures. The influence of quality of food was more evident. Larvae reared on white or young green leaves of cabbage developed more quickly than those reared on green but mature or senescing leaves; the slower speed of development was associated with a higher death-rate and a lower body weight combined with a higher water content of the pupae. Irrespective of temperature and the quality of the food, females developed more slowly than males and also had more dry matter and a higher liveweight in the pupal stage. Insects bred at a lower temperature produced more eggs than those at a higher temperature; the difference was thought to be due to a lower body weight in the latter. Photoperiod also influenced fecundity but the effect was not so clear. Caterpillars reared on plants grown in a long photoperiod were more fecund in the adult stage than those reared on plants grown in a short photoperiod, but the difference was not quite significant. Insects reared on white or young green leaves of cabbage laid significantly more eggs than those reared on green but mature leaves. Simarly when larvae were reared on the better quality food they produced more silk, the resulting moths lived longer, and a higher proportion of the males were fertile. The general conclusion is drawn that for normal activities of Plutella a balance of nutrients is required. For the normal activities of the insect body, like healthy development and reproduction, nutrients may be required in certain proportions. If owing to some cause (as probably, with change in season) that proportion is upset, certain abnormalities may appear in the metabolism or form of the insect, such as deformities in wings and shape of body, slower development, reduction or impediment in egg-laying capacity or diapause, etc. In the author's opinion this general conclusion may be a useful hypothesis on which to base further work. In the light of the above observations and observations on other insects, the seasonal activity of Plutella is discussed. It is stated that although apparently its behaviour and activity seem to be nicely adjusted to seasons, showing a beautiful picture of adaptation, yet the recurrent heavy reductions in numbers which this insect and many other species suffer in the field suggest that the adaptations are not as efficient as may at first sight appear.

scholarly journals The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial

2020 ◽  
Vol 41 (3) ◽  
pp. 332-342
Author(s):  
Gabriela Cormick ◽  
Ana Pilar Betrán ◽  
Janetta Harbron ◽  
Armando Seuc ◽  
Cintia White ◽  
...  
Keyword(s):  
Public Health ◽  
Body Weight ◽  
Body Weight Gain ◽  
Calcium Supplementation ◽  
Public Health Problem ◽  
Lower Body ◽  
Lower Body Weight ◽  
The Difference ◽  
To Receive ◽  
Elemental Calcium

Introduction: Obesity is a major and challenging public health problem. The aim of this substudy is to evaluate the effect of calcium supplementation on body weight in women recruited in the Calcium and Preeclampsia trial. Methods: Women were recruited before pregnancy and randomized to receive a calcium supplement containing 500 mg of elemental calcium or placebo until 20 weeks’ gestation; all women received 1.5 g from 20 weeks until delivery. Results: A total of 630 women conceived during the study, 322 allocated to calcium and 308 to placebo. Among these, 230 allocated to calcium and 227 allocated to placebo had information on body weight at baseline and at 8 weeks' gestation. During the study period, women allocated to calcium had a mean weight increase of 1.1 (SD ±5.5) kg, whereas those allocated to placebo had a mean increase of 1.5 (SD ±6.1) kg, a mean difference of 0.4 kg (95% −0.4 (−1.4 to 0.6); P = .408). Women classified as obese at the start of the trial had a lower body weight gain at 8 weeks’ gestation (1.0 kg; 95% CI: −3.2 to 1.2; P = .330) and at 32 weeks’ gestation (2.1 kg; 95% CI: 5.6-1.3; P = .225) if they received calcium as compared to placebo. However, none of these differences were statistically significant. Conclusion: The smaller increase in body weight found in women supplemented with 500 mg elemental calcium daily is quantitatively consistent with previous studies. However, in this study, the difference was not statistically significant.

scholarly journals Efficacy of Daptomycin in Experimental Endocarditis Due to Methicillin-Resistant Staphylococcusaureus

2003 ◽  
Vol 47 (5) ◽  
pp. 1714-1718 ◽  
Author(s):  
George Sakoulas ◽  
George M. Eliopoulos ◽  
Jeff Alder ◽  
Claudie Thauvin- Eliopoulos
Keyword(s):  
Subcutaneous Administration ◽  
Phase Iii ◽  
Methicillin Resistant ◽  
Bacterial Counts ◽  
Phase Iii Clinical Trials ◽  
Viable Bacteria ◽  
The Mean ◽  
The Difference ◽  
Lipopeptide Antibiotic

ABSTRACT Methicillin-resistant Staphylococcus aureus is becoming increasingly prevalent as both a nosocomial and a community-acquired pathogen. Daptomycin, a lipopeptide antibiotic now in phase III clinical trials, is rapidly bactericidal in vitro against a range of gram-positive organisms, including methicillin-resistant S. aureus (MRSA). In this study, we compared the efficacy of daptomycin with that of vancomycin, each with or without rifampin, in a model of experimental aortic valve endocarditis due to MRSA. The infecting strain (MRSA strain 32) was susceptible to daptomycin (MIC = 1 μg/ml), vancomycin (MIC = 0.5 μg/ml), and rifampin (MIC = 0.5 μg/ml). Daptomycin was administered at 25 or 40 mg/kg q24h (q24h) by subcutaneous injection in an attempt to simulate human doses of 4 and 6 mg/kg q24h, respectively. Vancomycin was given at 150 mg/kg q24h by continuous intravenous infusion. Rifampin was given at 25 mg/kg by intramuscular injection q24h. Treatment was started 6 h postinoculation and continued for 4.5 days. Outcome was assessed by counting the residual viable bacteria in vegetations. The mean peak daptomycin levels in serum at 2 h after subcutaneous administration of 25 and 40 mg/kg were 64 and 91 μg/ml, respectively. Daptomycin was undetectable in serum at 24 h. The total exposure was comparable to that achieved clinically in humans receiving the drug. Bacterial counts (mean log10 number of CFU per gram ± the standard deviation) in untreated controls reached 10.6 ± 0.8. In treated rats, bacterial counts were as follows: vancomycin, 7.1 ± 2.5; daptomycin at 25 mg/kg, 5.5 ± 1.7; daptomycin at 40 mg/kg, 4.2 ± 1.5. The difference between daptomycin at 40 mg/kg and vancomycin at 150 mg/kg was statistically significant (P = 0.004). In the study of combination therapy, vegetation bacterial counts were as follows: daptomycin at 40 mg/kg, 4.6 ± 1.6; rifampin, 3.6 ± 1.3; vancomycin plus rifampin, 3.3 ± 1.1; daptomycin plus rifampin, 2.9 ± 0.8. The difference between daptomycin and daptomycin plus rifampin was statistically significant (P = 0.006). These results support the continued evaluation of daptomycin for serious MRSA infections, including infective endocarditis.

Pc.6 Acupressure for Dental Nausea: A Prospective Randomised Double Blind Clinical Trial with Crossover, Part 2

1998 ◽  
Vol 16 (2) ◽  
pp. 69-72 ◽  
Author(s):  
RAC Chate
Keyword(s):  
Clinical Trial ◽  
Selection Criterion ◽  
Initial Point ◽  
First Trimester ◽  
Small Sample ◽  
Double Blind ◽  
Double Blind Clinical Trial ◽  
The Mean ◽  
The Difference ◽  
Prior Application

This reports the second part of a single-centre, prospective, randomised, double-blind clinical trial with crossover. It has aimed to assess whether PC.6 acupressure could reduce nausea related to maxillary dental impression taking. The selection criterion was a self registration of nausea greater than 33% of a 100mm visual analogue scale (VAS) following an initial maxillary impression (control) in patients referred for treatment. Exclusion criteria were: current medication with a secondary emetic or anti-emetic effect, prior knowledge of PC.6 acupressure, a recent history of nausea, and the first trimester of pregnancy. Twenty three entered the trial and 18 completed. The test involved a second and third impression with prior application of finger pressure on either PC.6 or a dummy point on the forearm The initial point was chosen by the patient, leaving the other point to be pressed subsequent to crossover. The mean level of nausea was recorded by patients after PC.6 acupressure and also after pressure at a dummy point. These recordings were then compared. The sample consisted of 6 males and 12 females, and the mean age was 14.74 years. The mean difference in nausea between PC.6 acupressure and pressure at the dummy point was −0.39mm % of the VAS (SD 40.48mm %). The 95% Confidence Interval was −20.52 and 19.74mm %, and the difference was not significant. Three and a half minutes of PC.6 acupressure did not significantly reduce nausea experienced with a maxillary impression, compared with pressure at the dummy point, in this small sample: both showed a mean reduction of 50% on the control figure.

The Effect of Vocabulary Intervention on Text Comprehension: Who Benefits?

2019 ◽  
Vol 50 (4) ◽  
pp. 562-578 ◽  
Author(s):  
Dawna Duff
Keyword(s):  
Middle School ◽  
Reading Comprehension ◽  
Text Comprehension ◽  
Classroom Instruction ◽  
Vocabulary Instruction ◽  
Clinical Intervention ◽  
Vocabulary Knowledge ◽  
Vocabulary Intervention ◽  
The Mean ◽  
The Difference

Purpose Vocabulary intervention can improve comprehension of texts containing taught words, but it is unclear if all middle school readers get this benefit. This study tests 2 hypotheses about variables that predict response to vocabulary treatment on text comprehension: gains in vocabulary knowledge due to treatment and pretreatment reading comprehension scores. Method Students in Grade 6 ( N = 23) completed a 5-session intervention based on robust vocabulary instruction (RVI). Knowledge of the semantics of taught words was measured pre- and posttreatment. Participants then read 2 matched texts, 1 containing taught words (treated) and 1 not (untreated). Treated texts and taught word lists were counterbalanced across participants. The difference between text comprehension scores in treated and untreated conditions was taken as a measure of the effect of RVI on text comprehension. Results RVI resulted in significant gains in knowledge of taught words ( d RM = 2.26) and text comprehension ( d RM = 0.31). The extent of gains in vocabulary knowledge after vocabulary treatment did not predict the effect of RVI on comprehension of texts. However, untreated reading comprehension scores moderated the effect of the vocabulary treatment on text comprehension: Lower reading comprehension was associated with greater gains in text comprehension. Readers with comprehension scores below the mean experienced large gains in comprehension, but those with average/above average reading comprehension scores did not. Conclusion Vocabulary instruction had a larger effect on text comprehension for readers in Grade 6 who had lower untreated reading comprehension scores. In contrast, the amount that children learned about taught vocabulary did not predict the effect of vocabulary instruction on text comprehension. This has implications for the identification of 6th-grade students who would benefit from classroom instruction or clinical intervention targeting vocabulary knowledge.

Efficacy and Safety of Oral Ivermectin and Topical Permethrin in the Treatment of Scabies

2020 ◽  
Vol 33 (1) ◽  
pp. 41-47
Author(s):  
Mohsena Akhter ◽  
Ishrat Bhuiyan ◽  
Zulfiqer Hossain Khan ◽  
Mahfuza Akhter ◽  
Gulam Kazem Ali Ahmad ◽  
...  
Keyword(s):  
Skin Diseases ◽  
Close Contact ◽  
Randomized Study ◽  
Sarcoptes Scabiei ◽  
Efficacy And Safety ◽  
Common Skin ◽  
Group A ◽  
The Mean ◽  
The Difference ◽  
Group B

Background: Scabies is one of the most common skin diseases in our country. It is caused by the mite Sarcoptes scabiei var hominis, which is an ecto-parasite infesting the epidermis. Scabies is highly contagious. Prevalence is high in congested or densely populated areas. Individuals with close contact with an affected person should be treated with scabicidal which is available in both oral and topical formulations. The only oral but highly effective scabicidal known to date is Ivermectin. Amongst topical preparations, Permethrin 5 % cream is the treatment of choice. Objective: To evaluate the efficacy & safety of oral Ivermectin compared to topical Permethrin in the treatment of scabies. Methodology: This prospective, non-randomized study was conducted at the out-patient department of Dermatology and Venereology of Shaheed Suhrawardy Medical College & Hospital over a period of 6 months, from August 2016 to January 2017. The study population consisted of one hundred patients having scabies, enrolled according to inclusion criteria. They were divided into two groups. group A was subjected to oral Ivermectin and the group B to Permethrin 5% cream. Patients were followed up on day 7 and 14 for assessment of efficacy and safety. Result: The mean scoring with SD in group A (Ivermectin) and group B (Permethrin) were 8.26 ± 2.22 and 7.59 ± 2.01 respectively at the time of observation. The difference between the mean score of the two group is not significant (p=0.117) the mean scoring with SD in group A and group B were 4.54 ± 2.05 and 1.64 ± 1.84 respectively at 7thdays. The difference between the mean score of the two group is significant (p<0.001). The mean scoring with SD in group A and group B were 2.68± 2.35 and .36± 1.10 respectively at 14th day difference between the mean score of the group is significant (p<0.001). Conclusion: Topical application of permethrin 5% cream is more effective and safer than oral Ivermectin in the treatment of scabies. TAJ 2020; 33(1): 41-47

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