AN EXTRA-ADRENAL DIABETOGENIC RESPONSE TO CORTICOTROPHIN IN THE RAT

1962 ◽  
Vol 41 (2) ◽  
pp. 227-233 ◽  
Author(s):  
Norman B. Marshall ◽  
F. Lee Richardson ◽  
Frank L. Engel
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Treatment ◽  
Tube Feeding ◽  
Hormone Treatment ◽  
High Carbohydrate Diet ◽  
Carbohydrate Diet ◽  
Glucose Levels ◽  
High Carbohydrate ◽  
Blood Glucose Levels ◽  
Adrenalectomized Rats

ABSTRACT Sham-operated and adrenalectomized rats primed by tube-feeding a high carbohydrate diet and the daily administration of 5 mg of cortisone acetate were challenged at intervals with corticotrophin (ACTH) or growth hormone and suitable inert proteins as controls. Blood glucose levels, measured 1, 2, 3 and 4 hours after the ACTH, which was administered 3½ hours after the morning meal, showed a marked hyperglycaemic response in both intact and adrenalectomized rats tested up to the fifty-fifth day of forced-feeding and cortisone treatment. Oxidation of ACTH with H2O2 abolished the hyperglycaemic response, whereas reduction with cysteine restored activity. Growth hormone did not elicit hyperglycaemia in these experiments, in keeping with previous experience showing that several days of growth hormone treatment are required to elicit hyperglycaemia. Sham-operated and adrenalectomized rats receiving deoxycorticosterone responded to ACTH with hypoglycaemia, confirming earlier results. The conditions necessary to elicit the hyper- and hypoglycaemic extra-adrenal effects of ACTH are contrasted and discussed.

The Effect of Yacon Leaf Powder (Smallanthus Sonchifolius) on White Rats (Rattus norvegicus) Blood Glucose Levels with High Sugar Diet

2021 ◽  
Vol 8 (2) ◽  
pp. 217-220
Author(s):  
Thatit Nurmawati ◽  
Sandi Alfa Wiga Arsa ◽  
Nawang Wulandari ◽  
Agus Saparudin
Keyword(s):  
Blood Glucose ◽  
Treatment Group ◽  
Carbohydrate Diet ◽  
Glucose Levels ◽  
Smallanthus Sonchifolius ◽  
High Carbohydrate ◽  
White Rats ◽  
Blood Glucose Levels ◽  
Treatment Dose ◽  
Significant Difference

Maintaining a lifestyle can reduce the incidence of DM (diabetes mellitus). DM occurs due to insulin disorders so that blood glucose levels increase, which can lead to various complications. The management of blood glucose levels by activating the insulin function can be done by using natural ingredients such as the Yakon (Smallanthus sonchifolius) plant. Yakon leaves contain phenol which can reduce blood glucose. The design of this study was experimental with a pre-posttest approach with control-group design, using male and healthy white rats (Rattus norvegicus). Rats were divided into 3 groups, treatment dose 1, treatment dose 2 and control. The rats were given a high carbohydrate diet during 9 weeks to make the rats hyperglycemic. In the treatment group, dose 1 was 150 mg/kg BW, dose 2 was 300 mg kg BW, and was given for 3 days. The results showed that the rats in the treatment group dose 1 had decreased in the average blood sugar level of 114.10 mg / dl (p 0.002) and dose 2 was 105.27 mg / dl (p 0.005). This showed that there was an effect of treatments on blood sugar levels. The comparison results showed that there was a significant difference between the dose 1, the dose 2 group and the control (Sig. (2-tailed) = 0.001 (α) = 0.05). There was no significant difference in the treatment group dose 1 and treatment dose 2 (Sig. (2-tailed) = 0.693, (α) = 0.05). Yakon leaves can be used alternative to lower to control blood glucose levels in rats receiving a high-carbohydrate diet

scholarly journals Low blood glucose levels and other complications during growth hormone supplementation in sepsis

1999 ◽  
Vol 54 (4) ◽  
pp. 135-138
Author(s):  
Joel Faintuch ◽  
Renata B. A. Leme ◽  
Maria Emilia L. F. Cruz ◽  
Angela M. B. Lima ◽  
Daniel Giannella Neto ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Blood Glucose ◽  
Heart Arrest ◽  
Tube Feeding ◽  
Normal Range ◽  
Peripheral Edema ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Clinical Series ◽  
High Calorie

Blood glucose levels in the high normal range or even moderate hyperglycemia is the expected profile in septic postoperative patients receiving high-calorie enteral alimentation. The addition of growth hormone as an anabolic agent should additionally reinforce this tendency. In a cancer patient undergoing partial gastrectomy with lymphadenectomy and suffering from postoperative subphrenic abscess and prolonged sepsis, tube feeding (38.3 kcal/kg/day) and growth hormone (0.17 IU/kg/day) were simultaneously administered for 25 days. Blood glucose levels were in the lower limits of the normal range before growth hormone introduction, and continued with a similar tendency during most of the therapeutic period. Two additional complications, namely heart arrest and peripheral edema, were documented during the same period. It is concluded that sepsis was the most likely mechanism for low glucose values, and that high-calorie enteral diet and growth hormone supplementation did not prevent that result. It is uncertain whether heart arrest was due to the drug, but its association with peripheral edema is well documented in clinical series.

THE EFFECT OF A HIGH-CARBOHYDRATE DIET ON GLUCOSE, INSULIN SENSITIVITY AND PLASMA INSULIN IN RATS

1969 ◽  
Vol 44 (1) ◽  
pp. 107-113 ◽  
Author(s):  
E. BLÁZQUEZ ◽  
CLEMENTE LOPEZ QUIJADA
Keyword(s):  
Plasma Insulin ◽  
Control Diet ◽  
High Carbohydrate Diet ◽  
Carbohydrate Diet ◽  
Plasma Insulin Concentration ◽  
Glucose Levels ◽  
High Carbohydrate ◽  
Fat Deposits ◽  
Glucose Plasma

SUMMARY When groups of rats were kept on control and high-carbohydrate diets from the end of lactation until their body weight reached 150 g. it was found that the animals fed on the high-carbohydrate diet gained weight more rapidly, with an increase in fat deposits. Glucose and plasma insulin in both groups were compared with the amounts of hormone extracted from their pancreases. When the rats on the control diet were killed the insulin and glucose plasma levels were 40 ± 3 μu./ml. and 156·69 ± 13 mg./100 ml. respectively. After 17–20 hr. fasting these values decreased significantly (P < 0·01) to 18 ± 1·5 μu./ml. and 116 ± 13 mg./ml. The amount of insulin in the pancreas was not modified by fasting. In the rats fed on the high-carbohydrate diet the plasma insulin and glucose values were higher than those in the control rats (50 ± 3·8 μu./ml. and 187 ± 19 mg./100 ml.); after 17–20 hr. starvation the glucose levels were reduced and the plasma insulin concentration remained higher (44 ± 2·9 μu./ml.); the insulin content of the pancreas was higher than in the control rats. In vitro the epididymal fat and the diaphragm of the rats on the high-carbohydrate diet were less sensitive to insulin than the same tissues in the controls.

2167-PUB: Effect of Low-Available Carbohydrate Diet Containing Okara and Konjac on Blood Glucose Levels in Spontaneous Diabetic Torii Fatty Rats

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2167-PUB
Author(s):  
KOHEI SURUGA ◽  
TSUYOSHI TOMITA ◽  
MASAKAZU KOBAYASHI ◽  
TADAHIKO MITSUI ◽  
KAZUNARI KADOKURA
Keyword(s):  
Blood Glucose ◽  
Carbohydrate Diet ◽  
Glucose Levels ◽  
Blood Glucose Levels

Effect of glucocorticoid and growth hormone treatment on proinsulin levels in humans

Diabetes ◽  
1993 ◽  
Vol 42 (7) ◽  
pp. 1082-1085 ◽  
Author(s):  
S. E. Kahn ◽  
F. F. Horber ◽  
R. L. Prigeon ◽  
M. W. Haymond ◽  
D. Porte
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Treatment ◽  
Hormone Treatment
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