URINARY STEROIDS DURING PREGNANCY

1962 ◽  
Vol 40 (1) ◽  
pp. 123-132 ◽  
Author(s):  
A. W. Steinbeck ◽  
Helen Theile
Keyword(s):  
Urinary Excretion ◽  
Normal Pregnancy ◽  
Normal Range ◽  
Urinary Steroids ◽  
Steroid Excretion

ABSTRACT The urinary excretion of steroids, as measured by Norymberski techniques, was studied throughout normal pregnancy by repeated urine collections (i. e. serial determinations). In addition, urine collections were obtained in other subjects over several days at various stages of pregnancy which allowed one estimate of steroid excretion (i. e. isolated determinations). Some possible difficulties of the latter method were shown. Most of the actual excretion values fell within the normal range and only 17-hydroxycorticosteroid and 21-deoxyketol excretions increased consistently with advancing pregnancy. Significantly, steroidal dihydroxyacetone excretions did not increase. Increased excretions were corrected shortly after delivery, suggesting that they were not due to adrenocortical hyperfunction. The significance of the findings is suggested.

STEROID EXCRETION IN IDIOPATHIC HIRSUTISM

1962 ◽  
Vol 24 (4) ◽  
pp. 463-470 ◽  
Author(s):  
V. H. T. JAMES ◽  
W. S. PEART ◽  
S. D. ILES
Keyword(s):  
Urinary Excretion ◽  
Control Subjects ◽  
Urinary Steroids ◽  
Idiopathic Hirsutism ◽  
The Mean ◽  
Steroid Excretion

SUMMARY The excretion of urinary steroids and their response to corticotrophin has been studied in a group of patients with idiopathic hirsutism. The mean resting levels of 17-oxosteroids and 17-hydroxycorticosteroids were higher, and the response to corticotrophin was greater, in the patients as compared to control subjects. Fractionation of 17-oxosteroids in eight patients showed an elevated or abnormally high excretion of steroid metabolites which were presumably being derived from androgen. This appeared to be associated with an adequate production of cortisol, as judged from urinary excretion studies.

ON THE VALUE OF SOME PARAMETERS OF ADRENOCORTICAL GLUCOCORTICOID FUNCTION

1963 ◽  
Vol 44 (4) ◽  
pp. 499-504 ◽  
Author(s):  
M. Van Der Straeten ◽  
A. Vermeulen ◽  
N. Orie ◽  
P. Regniers
Keyword(s):  
Urinary Excretion ◽  
Adrenal Cortex ◽  
Isotope Dilution ◽  
Isotope Dilution Method ◽  
Dilution Method ◽  
Steroid Excretion ◽  
Colorimetric Methods

ABSTRACT The authors studied the correlation between cortisol production, as measured by an isotope dilution method, and the urinary excretion of total and free Porter-Silber chromogens, as well as of 17-ketogenic steroids. Although a significant correlation exists between total Porter-Silber chromogens, 17-ketogenic steroid excretion and cortisol production, discrepancies are occasionally observed. Hence, different colorimetric methods should be used to assess the glucocorticoid activity of the adrenal cortex.

CORTICOSTEROIDS AND ANTIDIURETIC SUBSTANCE IN NEPHROTIC CHILDREN

PEDIATRICS ◽  
1953 ◽  
Vol 12 (3) ◽  
pp. 233-252
Author(s):  
ENRIQUE GALÁN ◽  
MANUEL PÉREZ-STABLE ◽  
ORLANDO GARCÍA FAEZ ◽  
EMILIO UNANUE ◽  
OTTO GARCÍA ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Urinary Excretion ◽  
Ascitic Fluid ◽  
Renal Hemodynamics ◽  
Tubular Function ◽  
Urinary Flow ◽  
Adrenal Steroids ◽  
Functional Disturbance ◽  
Urinary Steroids ◽  
Nephrotic Children

The role of tubular reabsorption in the pathogenesis of nephrotic edema led the authors to study the participation of antidiuretic hormone and adrenal steroids in regard to changes in renal hemodynamics and tubular function during different clinical events that may induce an increase or a decrease of urinary flow in nephrotic children. Formaldehydogenic steroids in urine, plasma and ascitic fluid and serum antidiuretic substance were simultaneously studied with clearance tests, electrolyte excretion and plasma constituents through 10 different periods of observations. From previous and present studies on renal function it was found that changes in renal hemodynamics and tubular transport mechanisms are responsible for variations in urinary flow leading to accumulation or disappearance of edema in the nephrotic syndrome. An increase in urinary flow was seen to occur with no change in the GFR but with a marked decrease in the U/P inulin and potassium ratio. Serum antidiuretic substance appeared to correlate closely with antidiuresis. Injection of nephrotic sera into peritoneal cavity of rats was followed by an antidiuretic effect similar to that produced by pitressin and posterior pituitary hormone. Antidiuretic factor seemed to be present in the globulin fraction of plasma proteins. No such effect was seen with intraperitoneal injections of plasma albumin, protein-free filtrate and ascitic fluid. An increase in titer of antidiuretic substance was observed during initial doses of ACTH and the reverse at the onset of diuretic response. Urinary excretion of formaldehydogenic steroids depended partly on diuresis in nephrotic children; this was not so in control cases. The influence of tubular function was suggested by the relationship found between urinary excretion of steroids and the V/Cin and V/Cth ratio and between clearance of steroids and diuresis. The influence of renal functional disturbance prevented a correct evaluation of adrenal activity by estimation of urinary steroids in nephrotic children. During the edematous-oliguric stage of nephrosis and in the absence of any stimulating or depressing effect upon the elaboration of adrenal steroids their urinary excretion was not significantly different from that seen in control cases. Formaldehydogenic steroids did not seem to have a direct role in producing variations of urine flow in nephrotic children. Increase and decrease in diuresis occurred simultaneously with an increase and a decrease in urinary and plasma steroids and vice versa. Formaldehydogenic material was found in variable amounts in the ascitic fluid suggesting an appreciable retention in the increased extracellular fluid during the oliguricedematous stage of the nephrotic syndrome. This material appears to be mostly true adrenal steroids. Potassium excretion was related to urinary steroids in nephrotic children but not in control cases. Potassium clearance was related to glomerular filtration in both control and nephrotic children. At the present time it remains a matter of some speculation of the role that steroids present in extracellular fluids may play in the physiologic and morphologic changes known to occur in the course of the nephrotic syndrome and experimentally reproduced by injection of DOCA to animals.

A LONGITUDINAL STUDY OF THE URINARY EXCRETION OF INDIVIDUAL STEROIDS IN CHILDREN FROM 3 TO 7 YEARS OLD

1971 ◽  
Vol 68 (1) ◽  
pp. 141-163 ◽  
Author(s):  
D. Gupta ◽  
W. A. Marshall
Keyword(s):  
Sex Differences ◽  
Longitudinal Study ◽  
Urinary Excretion ◽  
Skeletal Maturity ◽  
Older Children ◽  
Significant Relationships ◽  
The Mean ◽  
Mean Trend ◽  
Steroid Excretion ◽  
Cortisol Metabolites

ABSTRACT A longitudinal study was made of the daily urinary excretion, on or near each birthday, of a number of C19 and C21 steroids in 9 healthy girls and 5 healthy boys aged 3 to 7 years. The amount of androsterone excreted by each individual increased slowly during the period of study but the absolute amounts varied greatly between individuals. The excretion of aetiocholanolone was greater than that of androsterone, contrary to reported findings in older children. Small amounts of DHA were found. Testosterone was found in only about 40% of samples; epitestosterone in 70 % and 11β-OH-androsterone in only 62 %. Cortisol metabolites were excreted in amounts which increased with age and all three metabolites of corticosterone were present in most specimens. 11-Deoxycortisol was found in about 50 % of the samples and THS in 63 %. The mean trend in the ratio of glucuronides to sulphates of the 11-deoxy-17-oxosteroids decreased with increasing age, but the 11-deoxy-11-oxy ratio of 17-oxosteroids increased as did the 5α/5β ratio of the C19 and C21 steroids. No sex differences were observed. The excretion of cortisol metabolites showed a positive correlation with height and weight. 11-Deoxy-17-oxosteroids were positively correlated with the weight. No significant relationships between steroid excretion and skeletal maturity were found.

Steroid and catecholamine studies on pilots during prolonged experiments in a space cabin simulator

1963 ◽  
Vol 18 (6) ◽  
pp. 1257-1262 ◽  
Author(s):  
F. Ulvedal ◽  
W. R. Smith ◽  
B. E. Welch
Keyword(s):  
Urinary Excretion ◽  
Stress Hormones ◽  
Correlation Coefficients ◽  
Ground Level ◽  
Linear Increase ◽  
Significant Trend ◽  
Continuous Linear ◽  
Steroid Excretion ◽  
Medical Examinations ◽  
Level 2

Urinary excretion of 17-hydroxycorticosteroids, corticosterone-like hormones, and catecholamines (epinephrine and norepinephrine) has been investigated on pilots during prolonged experiments in a two-man space cabin simulator. The experimental profiles were: 1) two 17-day experiments at ground level; 2) two 14-day experiments at 27,000 ft; and 3) four experiments at 33,500 ft lasting 17 days. In the latter two groups the atmosphere was essentially 100% O2. The hormone parameters indicate that conditions imposed by the experimental procedures were no more stressful to the subjects than undergoing extensive medical examinations as observed from pre- and postexperimental values. The only significant trend was the continuous linear increase in the excretion of corticosterone-like hormones. There were borderline indications that the excretion of 17-hydroxycorticosteroids and norepinephrine were altitude dependent. Extraordinary occurrences in the simulator were correlated with increased catecholamine and steroid excretion. The correlation coefficients and the analyses of variance for the four hormone parameters were calculated and discussed. endocrinology; sealed environments; stress hormones Submitted on March 26, 1963

Urinary excretion of N-acetyl-β-d-glucosaminidase during normal pregnancy

1995 ◽  
Vol 235 (1) ◽  
pp. 113-115 ◽  
Author(s):  
Masami Yoshida ◽  
Kei Furiya ◽  
Yuichi Takakuwa
Keyword(s):  
Urinary Excretion ◽  
Normal Pregnancy

THE EFFECT OF EPHEDRINE ON THE EXCRETION OF REDUCING STEROIDS, 17-KETOSTEROIDS AND URIC ACID IN HEALTHY MEN

1952 ◽  
Vol 8 (1) ◽  
pp. 27-31 ◽  
Author(s):  
BARBARA M. BRAY ◽  
W. H. H. MERIVALE ◽  
D. R. C. WILLCOX
Keyword(s):  
Uric Acid ◽  
Urinary Excretion ◽  
Inverse Relationship ◽  
Control Period ◽  
Acid Excretion ◽  
Normal Range ◽  
Healthy Men ◽  
Uric Acid Excretion ◽  
Upper Limit ◽  
Consistent Change

The urinary excretion in five healthy men of 17-ketosteroids, reducing steroids, uric acid and creatinine was studied for a 3-day control period, a period of 2 days during which 6 grains (390 mg.) of ephedrine were given by mouth, and for 1 day immediately thereafter. In all five men the excretion of reducing steroids rose to levels outside the normal range on one of the days on which ephedrine was given. There was an abrupt return to normal, even in the men who showed the increased excretion, on the first day of the administration of ephedrine. In two men 17-ketosteroid excretion rose above the upper limit of normal, but in two others there was no significant alteration, while in one the 17-ketosteroid excretion bore an inverse relationship to that of the reducing steroids. No consistent change occurred in the uric acid excretion.

scholarly journals Urinary β2-Microglobulin Testing in Pediatric Uveitis: A Case Report of a 9-Year-Old Boy with Renal and Ocular Sarcoidosis

2015 ◽  
Vol 6 (1) ◽  
pp. 101-105 ◽  
Author(s):  
Kathryn L. Pepple ◽  
Deborah L. Lam ◽  
Laura S. Finn ◽  
Russell Van Gelder
Keyword(s):  
Case Report ◽  
Urinary Excretion ◽  
Renal Biopsy ◽  
Anterior Uveitis ◽  
Immune Modulation ◽  
Kidney Biopsy ◽  
Tubulointerstitial Nephritis ◽  
Normal Range ◽  
Granulomatous Interstitial Nephritis ◽  
Β2 Microglobulin

We present here a case of a 9-year-old boy with bilateral anterior uveitis and an extremely elevated urinary β2-microglobulin level (25,400 μg/l). The normal range for urinary excretion of β2-microglobulin is 0-300 μg/l. In patients with tubulointerstitial nephritis and uveitis syndrome (TINU), elevations typically range from 1,260 to 5,160 μg/l. Renal biopsy was pursued, and significant granulomatous interstitial nephritis consistent with sarcoidosis was identified. Systemic immune modulation was required for control of ocular inflammation. This case highlights the importance of urinary β2-microglobulin testing in the pediatric patient uveitis population, and additionally the need to pursue kidney biopsy in the presence of extreme elevations in urinary β2-microglobulin to differentiate between TINU and sarcoidosis.

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