ADRENAL STEROID SYNTHESIS IN AMYLOID DEGENERATION LOCALISED EXCLUSIVELY TO THE ZONA RETICULARIS

1961 ◽  
Vol 37 (3) ◽  
pp. 321-328 ◽  
Author(s):  
J. Ofstad ◽  
J. Lamvik ◽  
K. F. Støa ◽  
R. Emberland
Keyword(s):  
Pulmonary Fibrosis ◽  
The Other ◽  
Renal Amyloidosis ◽  
Zona Fasciculata ◽  
Post Mortem ◽  
Steroid Synthesis ◽  
Zona Reticularis ◽  
Adrenal Steroid ◽  
Post Mortem Examination ◽  
Reticular Zone

ABSTRACT In a 47-year-old male suffering from bronchiectasis, pulmonary fibrosis and renal amyloidosis, post-mortem examination of the adrenals revealed amyloid degeneration of the zona reticularis, the other adrenocortical zones being apparently intact. A thorough analysis of the endocrine functions during the last period of his life showed an abnormally low production of C19-steroids, even following corticotrophin stimulation. The formation of 17-hydroxycorticosteroids was found to be normal, while, on the other hand, the aldosterone excretion was elevated. These findings may imply that the synthesis of adrenal C19-steroids takes place in the reticular zone, while the C21-steroids apparently can be formed predominantly in the zona fasciculata.

scholarly journals The Production of Rabbits free from Lesions Associated with Encephalitozoon Cuniculi

1968 ◽  
Vol 2 (2) ◽  
pp. 143-146 ◽  
Author(s):  
J. Mcc Howell ◽  
N. Edington
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Experimental Results ◽  
The Other ◽  
Post Mortem ◽  
Encephalitozoon Cuniculi ◽  
Post Mortem Examination ◽  
The Central Nervous System

Lesions produced by Encephalitozoon cuniculi are common in the central nervous system of laboratory rabbits, and may affect experimental results. Post-mortem examination often does disclosed that three manifested typical lesions, while the other seven did not. Of the fourteen young born to the three does in which lesions were discovered, four (29 per cent) were free from obvious evidence of the disease. Of the fifty young born to the seven lesion-free does, forty-seven (94 per cent) were also free from such lesions.

THE EFFECT OF BLOOD-BORNE FACTORS ON ADRENAL STEROID SYNTHESIS IN THE GOLDEN HAMSTER (MESOCRICETUS AURATUS NEHRING)

1967 ◽  
Vol 37 (2) ◽  
pp. 139-146 ◽  
Author(s):  
BARBARA J. WHITEHOUSE ◽  
G. P. VINSON ◽  
P. A. JANSSENS
Keyword(s):  
Enzyme Activity ◽  
Golden Hamster ◽  
Venous Blood ◽  
Ringer Solution ◽  
The Other ◽  
Steroid Synthesis ◽  
Adrenal Steroid ◽  
Adrenal Tissue ◽  
Rapid Conversion

SUMMARY Incubation of hamster adrenal tissue in Krebs bicarbonate Ringer solution gave rapid conversion of added [4-14C]cortisol to cortisone. Moreover, incubation in Ringer solution with [4-14C]progesterone as precursor invariably yielded cortisone in greater amounts than cortisol. On the other hand it has been confirmed that cortisol is the major free ultraviolet absorbing steroid in the adrenal venous blood of the hamster. Incubation of adrenal tissue with [4-14C]progesterone in hamster whole blood gave relatively greater amounts of cortisol which were more in keeping with the findings in vivo. This suggested that the blood contains factors which affect the cortisone-cortisol equilibrium by modifying adrenal enzyme activity. Some reduction of [3H] cortisone to cortisol was also observed during incubation with blood alone.

Memoirs: The Development of the Adrenal Gland of the Mouse

1935 ◽  
Vol s2-78 (310) ◽  
pp. 329-366
Author(s):  
H. WARING
Keyword(s):  
Zona Fasciculata ◽  
Zona Reticularis ◽  
Connective Tissue Capsule ◽  
Foetal Life ◽  
Embryonic Life ◽  
Cortical Substance ◽  
Sympathetic Nervous ◽  
Maximum Development ◽  
Reticular Zone ◽  
Tissue Capsule

1. The cortical anlage is constituted from the mesenchyme at about the 12th day of embryonic life. 2. The medullary anlage is constituted at about the 13th day of embryonic life from the anlage of the sympathetic nervous system and lies closely adpressed to the cortical anlage. 3. At about the 14th day sympatho-chromaffin elements migrate from the closely adpressed sympathetic nervous mass into the cortical anlage and form irregularly arranged ‘nests’ in its substance. 4. Between 16 and 18 days of foetal life part of the cortical substance has differentiated by becoming less eosinophil and is destined to form the adult permanent cortex. 5. By the day of birth the sympatho-chronianin elements are concentrated at the centre of the gland and are beginning to metamorphose into medullary cells. The undifferentiated eosinophil cortical tissue now forms a layer immediately outside the medulla and interlocking with the medullary tissue. The less eosinophil tissue now shows the first distinct signs of the arrangement characteristic of the adult glomerular and fasciculate zones. 6. After birth, in both sexes, the interlocking zone increases, attaining its maximum at about 21 days in the male but continuing to increase in the female, so that at about 25 days there is a distinct sex difference. The three zones of the adult cortex are distinguishable in both sexes by 25 days the glomerulosa, zona fasciculata, and zona reticularis. The reticular zone is distinctly a product of the zona fasciculata and not of the interlocking eosinophil zone. 7. At 80 days in the male degeneration of the interlocking zone has begun in the female the zone is still increasing. The male reticular zone is now very clearly developed but that of the female has remained at the 25-days condition. 8. At 35 days in the male degeneration of the interlocking zone has become well established. In the female this zone attains its maximum development at about this period. 9. By 56 days in the male the degeneration of the interlocking zone is complete, leaving a connective tissue capsule between the medulla and the well-marked zona reticularis of the permanent cortex. (The female is not discussed beyond 35 days.)10. The interlocking zone of the adrenal of the mouse (X-zone of Miller) is shown to be probably homologous with the boundary zone of man and of the cat.

scholarly journals The Method of Expressing the Silica Content of the Lung

1935 ◽  
Vol 35 (1) ◽  
pp. 64-68 ◽  
Author(s):  
Douglas H. Collins ◽  
J. Henry Dible
Keyword(s):  
Pulmonary Fibrosis ◽  
Pulmonary Disease ◽  
Normal Forms ◽  
Pathological Condition ◽  
Silica Content ◽  
The Other ◽  
Post Mortem ◽  
The Subject ◽  
Set Up ◽  
Corroborative Evidence

Withincreasing knowledge of the effects of inhaled dusts upon the lungs has come an increase in the number of cases of Workmen's Compensation in which pulmonary disease is attributed to exposure to this form of risk during employment. Where a post-mortem examination has been made, and the opinion of a pathologist is sought, no difficulty is encountered in those cases of silicosis in which the disease is well developed, since the lesions are characteristic and easily recognised. The position, however, is by no means so easy where lesser degrees of pulmonary fibrosis are present and, in particular, where it becomes necessary to try to assess the bearing which these may have upon the susceptibility to, and the progress of, intercurrent pulmonary disease—for example lobar pneumonia. In these difficult circumstances recourse is frequently had to the chemical estimation of the quantity of silica recoverable from samples of lung. Certain standards have been set up, and the presence of silica in quantities in excess of the “normal” forms valuable corroborative evidence that a pulmonary fibrosis is attributable to its influence, where the subject in question has been exposed to this risk in his employment, and on the other hand the absence of an excess of silica is evidence that any pathological condition in the lung is due to other causes.

scholarly journals Post-mortem Examination of Genital Organs from Sows with Reproductive Disturbances in a Sow-pool

1997 ◽  
Vol 38 (3) ◽  
pp. 253-262
Author(s):  
A.-M. Dalin ◽  
K. Gidlund ◽  
L. Eliasson-Selling
Keyword(s):  
Post Mortem ◽  
Post Mortem Examination

scholarly journals Severe Posaconazole-Induced Glucocorticoid Deficiency with Concurrent Pseudohyperaldosteronism: An Unfortunate Two-for-One Special

2021 ◽  
Vol 7 (8) ◽  
pp. 620
Author(s):  
Alejandro Villar-Prados ◽  
Julia J. Chang ◽  
David A. Stevens ◽  
Gary K. Schoolnik ◽  
Samantha X. Y. Wang
Keyword(s):  
Mechanism Of Action ◽  
Antifungal Agents ◽  
Laboratory Findings ◽  
Steroid Synthesis ◽  
Adrenal Steroid ◽  
History Of ◽  
Glucocorticoid Deficiency

A 56-year-old Hispanic man with a history of disseminated coccidioidomycosis was diagnosed with persistent glucocorticoid insufficiency and pseudohyperaldosteronism secondary to posaconazole toxicity. This case was notable for unexpected laboratory findings of both pseudohyperaldosteronism and severe glucocorticoid deficiency due to posaconazole’s mechanism of action on the adrenal steroid synthesis pathway. Transitioning to fluconazole and starting hydrocortisone resolved the hypokalemia but not his glucocorticoid deficiency. This case highlights the importance of recognizing iatrogenic glucocorticoid deficiency with azole antifungal agents and potential long term sequalae.

scholarly journals VIII. On the descending degenerations which follow lesions of the gyrus marginalis and gyrus fornicatus in monkeys

1889 ◽  
Vol 180 ◽  
pp. 331-354
Keyword(s):  
The Other ◽  
Post Mortem ◽  
Cerebral Lesions ◽  
Series Of Experiments ◽  
The Government ◽  
Government Grant

The following paper contains the record of an investigation into the degenerations which follow lesions of the gyrus marginalis and gyrus fornicatus in Monkeys. The work has been carried on under my direction by Mr. France, with the aid of a grant from the Government Grant Fund, and represents part of a long investigation into the degenerations which follow artificially produced cerebral lesions, the material for which has been furnished by cases operated upon in conjunction respectively with Professor V. Horsley and Dr. Sanger Brown. These cases and the physiological results of the operations have already been published in the ‘Philosophical Transactions.’ The experiments here dealt with, twelve in number, comprise only the lesions of the gyrus marginalis and gyrus fornicatus, and, with one exception (case 12), are taken from the series of experiments performed in conjunction with Mr. Horsley. Of the twelve cases, six were of removal, or attempted removal, of the gyrus marginalis, and six of removal, or attempted removal, of the gyrus fornicatus. But in only one or two instances was the lesion, as determined by post-mortem examination, exactly limited to the convolution which it was attempted to remove, for in most cases the adjacent gyrus was to a certain extent involved in the injury. This was especially the case when removal of the gyrus fornicatus had been attempted, on account of its deep situation, and the difficulty of getting at it without some manipulation of the superjacent gyrus. Nevertheless, the removal of one or the other gyrus was sufficiently complete in all the cases here selected to produce characteristic symptoms and characteristic descending degenerations.

Sign in / Sign up

Export Citation Format

Share Document