scholarly journals Xenogeneic Humoral Immune Responses to Human Mesenchymal Stem Cells in Mice

2021 ◽  
Author(s):  
Jun-Man Hong ◽  
Jin-Hee Kim ◽  
Gwang-Hoon Kim ◽  
Hyun-Mu Shin ◽  
Young-il Hwang
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Immune Responses ◽  
Human Mesenchymal Stem Cells ◽  
Humoral Immune ◽  
Humoral Immune Responses

scholarly journals MHC-Matched Induced Pluripotent Stem Cells Can Attenuate Cellular and Humoral Immune Responses but Are Still Susceptible to Innate Immunity in Pigs

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e98319 ◽  
Author(s):  
Yoshihisa Mizukami ◽  
Tomoyuki Abe ◽  
Hiroaki Shibata ◽  
Yukitoshi Makimura ◽  
Shuh-hei Fujishiro ◽  
...  
Keyword(s):  
Stem Cells ◽  
Innate Immunity ◽  
Immune Responses ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Induced Pluripotent

scholarly journals Immunosuppressant Drugs Mitigate Immune Responses Generated by Human Mesenchymal Stem Cells Transplanted into the Mouse Parenchyma

2021 ◽  
Vol 30 ◽  
pp. 096368972110190
Author(s):  
Jung Won Hwang ◽  
Su Hyeon Myeong ◽  
Na-Hee Lee ◽  
Hyeongseop Kim ◽  
Hyo Jin Son ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Immune Responses ◽  
Immune Surveillance ◽  
Human Mesenchymal Stem Cells ◽  
Immunohistochemical Analysis ◽  
Human Mscs ◽  
Cast Doubt ◽  
Study Support ◽  
High Infiltration

It has been widely accepted that mesenchymal stem cells (MSCs) can evade the immune surveillance of the recipient. However, emerging research cast doubt on whether MSCs are intrinsically immune-privileged. Previously, we observed that the transplantation of human MSCs (hMSCs) into the mouse parenchyma attracted a high infiltration of leukocytes into the injection tract. Thus, in order to reduce the immune responses generated by hMSCs, the aim of this study was to assess which immunosuppressant condition (dexamethasone only, tacrolimus only, or dexamethasone and tacrolimus together) would not only reduce the overall immune response but also enhance the persistence of MSCs engrafted into the caudate putamen of wild-type C57BL/6 mice. According to immunohistochemical analysis, compared to the hMSC only group, the administration of immunosuppressants (for all three conditions) reduced the infiltration of CD45-positive leukocytes and neutrophils at the site of injection. The highest hMSC persistence was detected from the group that received combinatorial administrations of dexamethasone and tacrolimus. Moreover, compared to the immunocompetent WT mouse, higher MSC engraftment was observed from the immunodeficient BALB/c mice. The results of this study support the use of immunosuppressants to tackle MSC-mediated immune responses and to possibly prolong the engraftment of transplanted MSCs.

scholarly journals Cancer stem cell vaccine inhibits metastases of primary tumors and induces humoral immune responses against cancer stem cells

2015 ◽  
Vol 4 (3) ◽  
pp. e990767 ◽  
Author(s):  
Lin Lu ◽  
Huimin Tao ◽  
Alfred E Chang ◽  
Yangyang Hu ◽  
Guoshun Shu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cancer Stem Cells ◽  
Immune Responses ◽  
Cancer Stem Cell ◽  
Cell Vaccine ◽  
Primary Tumors ◽  
Humoral Immune ◽  
Humoral Immune Responses

scholarly journals Preconditioning of Human Mesenchymal Stem Cells to Enhance Their Regulation of the Immune Response

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Arman Saparov ◽  
Vyacheslav Ogay ◽  
Talgat Nurgozhin ◽  
Medet Jumabay ◽  
William C. W. Chen
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Immune Responses ◽  
Tissue Injury ◽  
Ex Vivo ◽  
Inflammatory Diseases ◽  
Human Mesenchymal Stem Cells ◽  
Regulatory Function ◽  
Harsh Environment ◽  
Human Mscs

Mesenchymal stem cells (MSCs) have attracted the attention of researchers and clinicians for their ability to differentiate into a number of cell types, participate in tissue regeneration, and repair the damaged tissues by producing various growth factors and cytokines, as well as their unique immunoprivilege in alloreactive hosts. The immunomodulatory functions of exogenous MSCs have been widely investigated in immune-mediated inflammatory diseases and transplantation research. However, a harsh environment at the site of tissue injury/inflammation with insufficient oxygen supply, abundance of reactive oxygen species, and presence of other harmful molecules that damage the adoptively transferred cells collectively lead to low survival and engraftment of the transferred cells. Preconditioning of MSCsex vivoby hypoxia, inflammatory stimulus, or other factors/conditions prior to their use in therapy is an adaptive strategy that prepares MSCs to survive in the harsh environment and to enhance their regulatory function of the local immune responses. This review focuses on a number of approaches in preconditioning human MSCs with the goal of augmenting their capacity to regulate both innate and adaptive immune responses.

Proliferation and multi-differentiation potentials of human mesenchymal stem cells on thermoresponsive PDMS surfaces grafted with PNIPAAm

2010 ◽  
Vol 30 (6) ◽  
pp. 455-455 ◽  
Author(s):  
Dongyan Shi ◽  
Dan Ma ◽  
Feiqing Dong ◽  
Chen Zong ◽  
Liyue Liu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells

Specific humoral immune responses in 12 cases of food sensitization to sesame seed

1997 ◽  
Vol 27 (11) ◽  
pp. 1285-1291 ◽  
Author(s):  
M. N. KOLOPP-SARDA ◽  
D. A. MONERET-VAUTRIN ◽  
B. GOBERT ◽  
G. KANNY ◽  
M. BRODSCHII ◽  
...  
Keyword(s):  
Immune Responses ◽  
Sesame Seed ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Food Sensitization

The Effect of Link N on the Differentiation of Human Mesenchymal Stem Cells

2012 ◽  
Vol 2 (1_suppl) ◽  
pp. s-0032-1320001-s-0032-1320001
Author(s):  
F. Mwale ◽  
H. T. Wang ◽  
L. Haglund ◽  
P. J. Roughley ◽  
J. Antoniou
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells

Generation of human mesenchymal stem cells lacking diabetoporosity-associated miRNAs using CRISPR/Cas9

2020 ◽  
Author(s):  
I Foessl ◽  
A Groselj-Strele ◽  
JC Piswanger-Sölkner ◽  
H Dobnig ◽  
A Fahrleitner-Pammer ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells
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