scholarly journals Prospects for Manipulation of Mesenchymal Stem Cells in Tumor Therapy: Anti-Angiogenesis Property on the Spotlight

2021 ◽  
Author(s):  
Marzieh Ghollasi ◽  
Shahram Ghasembaglou ◽  
Dariush Rahban ◽  
Mohsen Korani ◽  
Morteza Motallebnezhad ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Tumor Therapy

scholarly journals The Dynamic Roles of Mesenchymal Stem Cells in Colon Cancer

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Shan Wang ◽  
Zhiguo Miao ◽  
Qiyuan Yang ◽  
Yimin Wang ◽  
Jinzhou Zhang
Keyword(s):  
Stem Cells ◽  
Colon Cancer ◽  
Mesenchymal Stem Cells ◽  
Tumor Growth ◽  
Tumor Therapy ◽  
Potential Functions ◽  
Cell Group ◽  
Potential Candidate ◽  
Structural Support ◽  
Metastatic Sites

Colon cancer is still one of the most common causes of cancer in human and is characterized by lymphocyte infiltrates and originates from the epithelial cells found in the lining of colon or rectum of the gastrointestinal tract. Mesenchymal stem cells (MSCs) are composed of the multipotent stem cell group of stroma and can be differentiated as various cell lineages, such as fibroblasts, osteoblasts, and adipocytes. MSCs provide mechanical and structural support and have potential functions during tumor growth and metastasis. The efficacy of MSC-based therapies is partly dependent on the migration and homing of MSCs to tumors and metastatic sites. However, their migratory and engraftment potential is poorly understood. In this review, the characteristics and mechanisms of MSC’s dynamic interaction with colon cancer were summarized, particularly the potential functions of MSCs on colon cancer, including its role in improving tumor growth and as a potential candidate for tumor therapy. Understanding MSC homing provides new insights into the manipulation of MSC and the improvement of their efficacy for colon cancer therapy.

scholarly journals ATPS-90EFFICACY OF NON-VIRAL ENGINEERED ADIPOSE MESENCHYMAL STEM CELLS FOR BRAIN TUMOR THERAPY

2015 ◽  
Vol 17 (suppl 5) ◽  
pp. v38.2-v38
Author(s):  
Antonella Mangraviti ◽  
Stephany Tzeng ◽  
David Gullotti ◽  
Kristen Kozielski ◽  
Jennifer Kim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Brain Tumor ◽  
Tumor Therapy ◽  
Adipose Mesenchymal Stem Cells ◽  
Brain Tumor Therapy

scholarly journals Tumor stroma engraftment of gene-modified mesenchymal stem cells as anti-tumor therapy against ovarian cancer

Cytotherapy ◽  
2013 ◽  
Vol 15 (1) ◽  
pp. 20-32.e2 ◽  
Author(s):  
Jennifer L. Dembinski ◽  
Shanna M. Wilson ◽  
Erika L. Spaeth ◽  
Matus Studeny ◽  
Claudia Zompetta ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Tumor Therapy ◽  
Tumor Stroma

scholarly journals IFN-γ-Secreting-Mesenchymal Stem Cells Exert an Antitumor EffectIn Vivovia the TRAIL Pathway

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Xinyuan Yang ◽  
Jingchun Du ◽  
Xia Xu ◽  
Chun Xu ◽  
Wu Song
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Tumor Cells ◽  
Caspase 3 ◽  
Lentiviral Vector ◽  
Lung Tumor ◽  
Tumor Therapy ◽  
Target Cells ◽  
Control Mscs ◽  
Induced Apoptosis

Mesenchymal stem cells (MSCs) can exhibit either prooncogenic or antitumor properties depending on the context. Based on our previous study, we hypothesized that MSCs engineered to deliver IFN-γwould kill cancer cells through persistent activation of the TRAIL pathway. Human bone-marrow (BM-) derived MSCs were isolated, amplified, and transduced with a lentiviral vector encoding the IFN-γgene under the control of the EF1αpromoter. The IFN-γ-modified MSCs effectively secreted functional IFN-γ, which led to long-term expression of TRAIL. More importantly, the IFN-γ-modified MSCs selectively induced apoptosis in lung tumor cells through caspase-3 activation within the target cells. The percentage of activated-caspase-3-positive tumor cells in IFN-γ-modified MSCs cocultures was significantly higher than in control MSCs cocultures. Treatment with anti-TRAIL antibody dramatically suppressed the caspase-3 activation observed in H460 cells. After injection into nude mice, the IFN-γ-modified MSCs inhibited the growth and progression of lung carcinoma compared with control cells. Collectively, our results provide a new strategy for tumor therapy that utilizes IFN-γ-modified MSCs.

Proliferation and multi-differentiation potentials of human mesenchymal stem cells on thermoresponsive PDMS surfaces grafted with PNIPAAm

2010 ◽  
Vol 30 (6) ◽  
pp. 455-455 ◽  
Author(s):  
Dongyan Shi ◽  
Dan Ma ◽  
Feiqing Dong ◽  
Chen Zong ◽  
Liyue Liu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells

1417: Mesenchymal Stem Cells Alone or Modified with ENOS Restore Erectile Function in the Aged Rat: Cell-Based Gene Therapy for Erectile Dysfunction

2004 ◽  
Vol 171 (4S) ◽  
pp. 373-373
Author(s):  
Trinity J. Bivalacqua ◽  
Mustafa F. Usta ◽  
Hunter C. Champion ◽  
Weiwen Deng ◽  
Philip J. Kadowitz ◽  
...  
Keyword(s):  
Stem Cells ◽  
Gene Therapy ◽  
Mesenchymal Stem Cells ◽  
Erectile Dysfunction ◽  
Erectile Function ◽  
Aged Rat
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