scholarly journals Mesenchymal Stem Cells Decrease Tunnel Widening of Anterior Cruciate Ligament Reconstruction in Rabbit Model

2019 ◽  
Vol 12 (1) ◽  
pp. 162-169 ◽  
Author(s):  
Chang-Ich Hur ◽  
Hyeon-Wook Ahn ◽  
Jong-Keun Seon ◽  
Eun-Kyoo Song ◽  
Ga-Eon Kim
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Anterior Cruciate Ligament ◽  
Anterior Cruciate Ligament Reconstruction ◽  
Ligament Reconstruction ◽  
Cruciate Ligament ◽  
Rabbit Model ◽  
Tunnel Widening ◽  
Cruciate Ligament Reconstruction ◽  
Anterior Cruciate

An interference screw made by silk fibroin-based bulk material with high content of hydroxyapatite for anterior cruciate ligament reconstruction in a rabbit model

2021 ◽  
Author(s):  
Zhuo Yan ◽  
Wenbo Chen ◽  
Wenhe Jin ◽  
Yaying Sun ◽  
Kai Gu ◽  
...  
Keyword(s):  
Anterior Cruciate Ligament ◽  
Anterior Cruciate Ligament Reconstruction ◽  
Silk Fibroin ◽  
Ligament Reconstruction ◽  
Bulk Material ◽  
Cruciate Ligament ◽  
Rabbit Model ◽  
Interference Screw ◽  
Cruciate Ligament Reconstruction ◽  
Anterior Cruciate

Upgradation is still in need for the clinical-applied interference screws in anterior cruciate ligament reconstruction for more reliable fixation. Silk fibroin bulk materials offer a promising opportunity for this application...

Tunnel Widening after Anterior Cruciate Ligament Reconstruction

2009 ◽  
Vol 37 (8) ◽  
pp. 1609-1617 ◽  
Author(s):  
Alexandra Neddermann ◽  
Elmar Willbold ◽  
Frank Witte ◽  
Christof Hurschler ◽  
Stefan Hankemeier ◽  
...  
Keyword(s):  
Anterior Cruciate Ligament ◽  
Anterior Cruciate Ligament Reconstruction ◽  
Ligament Reconstruction ◽  
Cruciate Ligament ◽  
Bone Volume ◽  
Tunnel Widening ◽  
Tunnel Enlargement ◽  
Cruciate Ligament Reconstruction ◽  
Anteroposterior Translation ◽  
Anterior Cruciate

Background A common clinical concern after anterior cruciate ligament reconstruction is the expansion of the bone tunnels as seen radiographically. The etiology and clinical relevance of this phenomenon remain unclear. Hypothesis Tunnel widening results in an increased anteroposterior translation, and there are specific histologic changes due to osteoclastic bone resorption associated with this phenomenon. Study Design Controlled laboratory study. Methods Thirty sheep (age, 4 months) underwent an anterior cruciate ligament reconstruction using a soft tissue graft. Graft fixation was achieved using the EndoButton and Suture Washer. Six animals each were sacrificed at 0, 3, 6, 12, and 24 weeks after surgery. Each anterior cruciate ligament–reconstructed knee was examined by computed tomography. Anteroposterior translation was determined using a universal force-moment sensor robot. The bone surrounding the tunnel was evaluated histologically. Results The prevalence of tunnel enlargement on the femoral side was 77.3%. Animals with tunnel widening did not demonstrate increased anteroposterior translation. Widening of the femoral tunnel was significantly associated with a higher stiffness of the graft (P <. 05) and hypertrophy of the graft throughout the remodeling process. The histologic evaluation of the bone tunnel walls demonstrated an increase of bone volume in animals with tunnel enlargement. No statistically significant correlation could be found between the number of osteoclasts and the presence of tunnel widening. Conclusion In this large animal model of anterior cruciate ligament reconstruction, animals with significant tunnel widening did not suffer increased anteroposterior translation. Tunnel widening was associated with a high stiffness of the graft, graft hypertrophy, and an increase in bone volume of the tunnel wall. Clinical Relevance The present data correspond to the current opinion in humans that tunnel widening is not associated with knee instability. Further research is needed to understand the role of graft stiffness, graft hypertrophy, and the increase in bone volume in this phenomenon.

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