scholarly journals From Molecules to Patients: The Clinical Applications of Translational Bioinformatics

2015 ◽  
Vol 24 (01) ◽  
pp. 164-169 ◽  
Author(s):  
K. Regan ◽  
P.R.O. Payne
Keyword(s):  
Personalized Medicine ◽  
Knowledge Engineering ◽  
Social Issues ◽  
Clinical Applications ◽  
Future Research ◽  
Translational Bioinformatics ◽  
Clinical Implementation ◽  
Clinical Support ◽  
Three Stages ◽  
User Friendly

Summary Objective: In order to realize the promise of personalized medicine, Translational Bioinformatics (TBI) research will need to continue to address implementation issues across the clinical spectrum. In this review, we aim to evaluate the expanding field of TBI towards clinical applications, and define common themes and current gaps in order to motivate future research. Methods: Here we present the state-of-the-art of clinical implementation of TBI-based tools and resources. Our thematic analyses of a targeted literature search of recent TBI-related articles ranged across topics in genomics, data management, hypothesis generation, molecular epidemiology, diagnostics, therapeutics and personalized medicine. Results: Open areas of clinically-relevant TBI research identified in this review include developing data standards and best practices, publicly available resources, integrative systems-level approaches, user-friendly tools for clinical support, cloud computing solutions, emerging technologies and means to address pressing legal, ethical and social issues. Conclusions: There is a need for further research bridging the gap from foundational TBI-based theories and methodologies to clinical implementation. We have organized the topic themes presented in this review into four conceptual foci – domain analyses, knowledge engineering, computational architectures and computation methods alongside three stages of knowledge development in order to orient future TBI efforts to accelerate the goals of personalized medicine.

scholarly journals 4th ESPT Conference: pharmacogenomics and personalized medicine – research progress and clinical implementation

2019 ◽  
Vol 20 (15) ◽  
pp. 1063-1069
Author(s):  
Csilla Sipeky ◽  
Adrián Llerena ◽  
Vangelis G Manolopoulos ◽  
Ewan Pearson ◽  
Vid Mlakar ◽  
...  
Keyword(s):  
Personalized Medicine ◽  
European Society ◽  
Healthcare Professionals ◽  
Clinical Applications ◽  
Personalized Therapy ◽  
Research Progress ◽  
Clinical Implementation ◽  
Medicine Research ◽  
Biennial Conference ◽  
And Personalized Medicine

The Fourth European Society of Pharmacogenomics and Personalized Therapy biennial conference was organized in collaboration with the Italian Society of Personalized Medicine (SIMeP) and was held at Benedictine Monastery of San Nicolò l’Arena in Catania, Sicily (Italy) on 4–7 October 2017. The congress addressed the research progress and clinical implementation in pharmacogenomics and personalized medicine. The Fourth European Society of Pharmacogenomics and Personalized Therapy congress brought together leading international scientists and healthcare professionals actively working in the fields of pharmacogenomics and personalized therapy. Altogether, 25 speakers in 15 session comprehensively covered broad spectrum of pharmacogenetics and pharmacogenomics research, clinical applications in different clinical disciplines attended by 270 delegates.

Applying personalized medicine to adult severe asthma

2021 ◽  
Vol 42 (1) ◽  
pp. e8-e16 ◽  
Author(s):  
Angelica Tiotiu
Keyword(s):  
Personalized Medicine ◽  
Severe Asthma ◽  
Negative Impact ◽  
Target Therapy ◽  
Asthma Management ◽  
Future Research ◽  
Biologic Therapies ◽  
Eosinophilic Asthma ◽  
Definition Of ◽  
Structured Approach

Background: Severe asthma is a heterogeneous disease that consists of various phenotypes driven by different pathways. Associated with significant morbidity, an important negative impact on the quality of life of patients, and increased health care costs, severe asthma represents a challenge for the clinician. With the introduction of various antibodies that target type 2 inflammation (T2) pathways, severe asthma therapy is gradually moving to a personalized medicine approach. Objective: The purpose of this review was to emphasize the important role of personalized medicine in adult severe asthma management. Methods: An extensive research was conducted in medical literature data bases by applying terms such as “severe asthma” associated with “structured approach,” “comorbidities,” “biomarkers,” “phenotypes/endotypes,” and “biologic therapies.” Results: The management of severe asthma starts with a structured approach to confirm the diagnosis, assess the adherence to medications and identify confounding factors and comorbidities. The definition of phenotypes or endotypes (phenotypes defined by mechanisms and identified through biomarkers) is an important step toward the use of personalized medicine in asthma. Severe allergic and nonallergic eosinophilic asthma are two defined T2 phenotypes for which there are efficacious targeted biologic therapies currently available. Non-T2 phenotype remains to be characterized, and less efficient target therapy exists. Conclusion: Despite important progress in applying personalized medicine to severe asthma, especially in T2 inflammatory phenotypes, future research is needed to find valid biomarkers predictive for the response to available biologic therapies to develop more effective therapies in non-T2 phenotype.

scholarly journals Rediscovering the Cooperative Enterprise: A Systematic Review of Current Topics and Avenues for Future Research

2021 ◽  
Author(s):  
Andres Felipe Camargo Benavides ◽  
Michel Ehrenhard
Keyword(s):  
Social Impact ◽  
Social Issues ◽  
Social Enterprises ◽  
Future Research ◽  
Generation Process ◽  
Managerial Practices ◽  
Organizational Perspective ◽  
Multilevel Studies ◽  
Cooperative Enterprise ◽  
Organizational Literature

AbstractFor decades, the cooperative enterprise (CE) produces market goods and/or provides services in the interest to its members, such as communities, customers, and suppliers. The upsurge of interest in social enterprises, and their balancing of social and economic interests, has also led to a renewed interest in CEs, often seen as a specific type of social enterprise. However, from an organizational perspective, this renewed interest has been both limited and scattered over a variety of fields. In this paper, we systematically review papers on CE in the mainstream organizational literature, defined as literature in the fields of economics, business, management and sociology. Our review integrates and synthesizes the current topics in the mainstream organizational literature and provides a number of avenues for future research. In addition, we compare our findings in the organizational literature to the social issues literature as these appeared to be quite complimentary. We found multilevel studies, determination of social impact—in particular measurable impact, managerial practices for sustainable (organisational) development, and the entrepreneurial opportunity generation process as the four key avenues for future research.

Personalized Medicine Through SNP Testing for Breast Cancer Risk: Clinical Implementation

2014 ◽  
Vol 24 (5) ◽  
pp. 744-751 ◽  
Author(s):  
Rebecca Howe ◽  
Talya Miron-Shatz ◽  
Yaniv Hanoch ◽  
Zehra B. Omer ◽  
Cristina O’Donoghue ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Personalized Medicine ◽  
Cancer Risk ◽  
Clinical Implementation ◽  
Snp Testing

Clinical implementation of personalized medicine in community pharmacies: considerations for clinicians

2017 ◽  
Vol 14 (6) ◽  
pp. 471-475 ◽  
Author(s):  
David R Bright ◽  
Angelo J Greco ◽  
Anna Langerveld ◽  
David F Kisor
Keyword(s):  
Personalized Medicine ◽  
Community Pharmacies ◽  
Clinical Implementation

CEO statements on racial inequity – (how) do they matter to shareholders?

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Pyemo Afego ◽  
Imhotep Alagidede
Keyword(s):  
Chief Executive Officers ◽  
Social Issues ◽  
Chief Executive ◽  
Future Research ◽  
Research Approach ◽  
Content Type ◽  
Racial Injustice ◽  
Communication Decisions ◽  
Executive Officers ◽  
The Impact

Purpose The purpose of this study is to explore how citizen protests against perceived acts of racial injustice impact on share prices of companies who weigh in on the protests. In particular, corporate statements that directly address the issues around the protests are identified and possible mechanisms underlying how these may impact shareholder value are discussed. Design/methodology/approach The authors first use a qualitative research approach of content and sentiment analysis to track how companies or their chief executive officers (CEOs) present their stance against racial injustice, as represented by their use of linguistic markers. Then, the authors use an event study methodology to assess the response from stock market participants. Findings The findings suggest that CEOs primarily convey their stance using language that is emotive and empathic. In addition, shareholders earn a significant abnormal return of 2.13%, on average, in the three days following the release of the statements. Research limitations/implications This study considered only US-listed companies. The sample size, also, is relatively small. Institutional and cultural differences across countries may also vary. Thus, future research could explore the extent to which the findings generalize to other contexts. Practical implications Results provide insights to top managers who communicate with various stakeholders on emotionally charged social issues. Findings also offer insights on the timing of trades for investors and arbitrageurs. Social implications Findings contribute to the understanding of corporate behaviour in times of social upheaval. Insights from the study may also be used to inform corporate communication decisions about important social issues. Originality/value This study brings into focus the role that affective appeal and moral emotion can play in evoking motivation for corporate activism, and the impact that this has on investor opinions’ formation process.

A national survey of telemedicine use by US emergency departments

2018 ◽  
Vol 26 (5) ◽  
pp. 278-284 ◽  
Author(s):  
Kori S Zachrison ◽  
Krislyn M Boggs ◽  
Emily M Hayden ◽  
Janice A Espinola ◽  
Carlos A Camargo
Keyword(s):  
Emergency Department ◽  
Emergency Departments ◽  
Multivariable Analysis ◽  
Clinical Applications ◽  
Future Research ◽  
Emergency Medical Care ◽  
Adults And Children ◽  
Annual Total ◽  
National Emergency ◽  
Total Visit

Objective Telemedicine has the potential to improve the delivery of emergency medical care: however, the extent of its adoption in United States (US) emergency departments is not known. Our objective was to characterise the prevalence of telemedicine use among all US emergency departments, describe clinical applications for which it is most commonly used, and identify emergency department characteristics associated with its use. Methods As part of the National Emergency Department Inventory-USA survey, we queried all 5375 US emergency departments open in 2016. Multivariable logistic regression analyses identified characteristics associated with emergency department receipt of telemedicine services. Results Overall, 4507 emergency departments (84%) responded to our survey, with 4031 responding to both telemedicine questions (75%). Although 1694 emergency departments (42%) reported no telemedicine in 2016, most did: 1923 (48%) emergency departments received telemedicine services, 149 (4%) emergency departments received telemedicine services and were in hospitals that provided telemedicine, and 265 emergency departments (7%) did not receive telemedicine but were in hospitals that provided telemedicine services. Among emergency departments receiving telemedicine, the most common applications were stroke/neurology (76%), psychiatry (38%), and paediatrics (15%). In multivariable analysis, telemedicine-receiving emergency departments had higher annual total visit volume for adults and lower annual total visit volume by children; were less likely to be academic or freestanding; and varied by region. In multivariable analysis, emergency departments in telemedicine-providing hospitals had higher annual total visit volume for adults and children, were more likely to be academic and were less likely to be freestanding. Conclusion In 2016, telemedicine was used in most US emergency departments (58%), especially for stroke/neurology and psychiatry. Future research is needed to understand the value of telemedicine for different clinical applications, and the barriers to its implementation.

The Singularity of Social Entrepreneurship: Untangling its Uniqueness and Market Function

2017 ◽  
Vol 26 (2) ◽  
pp. 137-162 ◽  
Author(s):  
Philip T. Roundy ◽  
Michaël Bonnal
Keyword(s):  
Social Entrepreneurship ◽  
Social Issues ◽  
Unique Function ◽  
Future Research ◽  
Consumer Spending ◽  
Social Entrepreneurs ◽  
Nonprofit Organisations ◽  
Positive Externalities ◽  
Self Sufficiency ◽  
Voluntary Exchange

Social entrepreneurship is an activity that is receiving intense scrutiny from scholars, practitioners and policymakers. However, research is only beginning to explore the unique function social entrepreneurs fill in the marketplace. This conceptual article examines if social entrepreneurs indeed represent a novel category of market actor. Building on prior work claiming that the unique function of social entrepreneurs is the creation of positive externalities and generation of spillover benefits for society, we compare social entrepreneurs with conventional entrepreneurs and other entities that seek to increase social welfare, including governments and traditional nonprofit organisations. Specifically, we contend that the strengths of social entrepreneurship are its reliance on voluntary exchange, promotion of dignity and self-sufficiency in beneficiaries, attunement to the signals of the marketplace and ability to tap into consumer spending. We also uncover the limitations of social entrepreneurship, which include the challenge of combining multiple institutional logics, the existence of social issues around which viable businesses cannot be built, dependence on consumer demand and competitive disadvantages relative to conventional businesses. We discuss the implications of our conceptualisation of social entrepreneurship for practitioners, policymakers and future research.

scholarly journals Visualized Analysis of Heavy Ion Radiotherapy: Development, Barriers and Future Directions

2021 ◽  
Vol 11 ◽  
Author(s):  
Yuanchang Jin ◽  
Jingwen Li ◽  
Jieyun Li ◽  
Na Zhang ◽  
Kangle Guo ◽  
...  
Keyword(s):  
Radiation Oncology ◽  
Web Of Science ◽  
Heavy Ion ◽  
Future Research ◽  
Effectiveness Research ◽  
Human Society ◽  
Future Directions ◽  
Core Collections ◽  
Three Stages ◽  
Heavy Ion Radiotherapy

BackgroundHeavy ion radiotherapy (HIRT) has great advantages as tumor radiotherapy.MethodsBased on 1,558 literatures from core collections of Web of Science from 1980 to 2020, this study visually analyzes the evolution of HIRT research, and sorts out the hotspots and trends of HIRT research using CiteSpace software.ResultsResearch on HIRT has received more extensive attention over the last 40 years. The development of HIRT is not only closely related to radiation and oncology, but also closely related to the development of human society. In terms of citation frequency, “International Journal of Radiation Oncology*Biology*Physics” was the top journal. In terms of influence, “Radiotherapy and Oncology” was the top journal. “Radiation therapy” and “carbon ion radiotherapy” were the two most frequently used keywords in this field.ConclusionThe evolution of the HIRT research has occurred in approximately three stages, including technological exploration, safety and effectiveness research and technological breakthroughs. Finally, some suggestions for future research are put forward.

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