scholarly journals EFFECT OF SELECTED MUCOADHESIVE POLYMERS ON PHARMACEUTICAL PROPERTIES OF CHITOSAN FORMULATIONS

2021 ◽  
Vol 26 ◽  
pp. 61-70
Author(s):  
Bożena Grimling ◽  
Keyword(s):  
Physicochemical Properties ◽  
Xanthan Gum ◽  
Absorption Capacity ◽  
Polymer Complex ◽  
Natural Polymers ◽  
Technical Process ◽  
Polyelectrolyte Complexes ◽  
Mucoadhesive Polymers ◽  
Texture Parameters ◽  
Pharmaceutical Properties

The aim of this study was to develop a technical process and composition of mucoadhesive hydrogels containing benzocaine, based on different concentration ratios of the natural polymers chitosan and xanthan gum. For this purpose, lyophilisates of polymeric complexes with the quantitative ratios of 0.5:1, 1:1 and 1:0.5 chitosan to xanthan gum were prepared and subsequently used to prepare hydrogels of various concentrations. The physicochemical properties and pharmaceutical availability of benzocaine were evaluated and diffractograms and Fourier-transform infrared spectra of individual polymers and their polyelectrolyte complexes were compared. The 1:1 formulation exhibited the highest water absorption capacity and the gels showed the highest viscosity and the shortest blurring times. More chitosan increased carrier texture parameters, including hardness, cohesiveness and consistency, whereas more xanthan gum led to the longest gel blurring times and improved carrier stability. The concentration ratio of chitosan to xanthan gum in lyophilisates determined the viscosity, texture, spreadability and blurring time of the gels. Increases in lyophilisate percentage in the gels also affected the physicochemical properties of the carrier. In addition, the proportions of polymers in the mixture did not influence the availability of the drug from the prepared gel; this factor appears to depend more on the lyophilisate content in the carrier. Variations in the ratio of chitosan to xanthan gum in the polymer complex as well as lyophilisate percentage in the gel may impact the properties of the hydrogel and its efficacy as a carrier for therapeutic substances administered to the oral cavity mucosa.

An investigation on the physicochemical properties of chitosan/DNA polyelectrolyte complexes

Biomaterials ◽  
2005 ◽  
Vol 26 (15) ◽  
pp. 2705-2711 ◽  
Author(s):  
Wenguang Liu ◽  
Shujun Sun ◽  
Zhiqiang Cao ◽  
Xin Zhang ◽  
Kangde Yao ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Polyelectrolyte Complexes

The Influence of Factors of a Biological and Physical Nature on the Biodegradation and Physicochemical Properties of Composites Based on Polyvinyl Chloride and Natural Polymers

2018 ◽  
Vol 45 (6) ◽  
pp. 283-288
Author(s):  
V.F. Smirnov ◽  
A.A. Glagoleva ◽  
A.E. Mochalova ◽  
L.A. Smirnova ◽  
N.A. Anikina
Keyword(s):  
Physicochemical Properties ◽  
Polyvinyl Chloride ◽  
Polymeric Material ◽  
Starch Content ◽  
Physical Nature ◽  
Physical Factors ◽  
Microscopic Fungi ◽  
Natural Polymers ◽  
Properties Of Composites

It has been established that the degree of biodegradation of composites based on polyvinyl chloride and natural polymers by microscopic fungi changes as a function of the chitosan and starch content in the composites. Biodegradation of polymeric material is accompanied with change in its physicochemical properties. A number of physical factors result in an increase in the degree of biodegradation of the materials investigated.

Effect of hydrocolloids on physicochemical properties, stability, and digestibility of Pickering emulsions stabilized by nanofibrillated cellulose

2022 ◽  
Author(s):  
Nuttinee Tangsrianugul ◽  
Thunnalin Winuprasith ◽  
Manop Suphantharika ◽  
Jirarut Wongkongkatep
Keyword(s):  
Physicochemical Properties ◽  
Xanthan Gum ◽  
Guar Gum ◽  
Nanofibrillated Cellulose ◽  
Pickering Emulsions ◽  
Positively Charged

In this study, effect of hydrocolloids with different electrostatic characteristics, i.e. negatively charged xanthan gum (XG), positively charged chitosan (CH), and non-ionic guar gum (GG) on physicochemical properties, stability, and...

scholarly journals FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF LEVOSULPIRIDE BY USING NATURAL POLYMER

2017 ◽  
Vol 10 (5) ◽  
pp. 285
Author(s):  
S Shanmugam
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Xanthan Gum ◽  
Diffusion Mechanism ◽  
Matrix Tablets ◽  
In Vitro Dissolution ◽  
Release Kinetic ◽  
Natural Polymers ◽  
In Vitro Drug Release

Objective: The objective of the present study was to develop sustained release matrix tablets of levosulpiride by using natural polymers.Method: The tablets were prepared with different ratios of Chitosan, Xanthan gum and Guar gum by wet granulation technique. The solubility study of the levosulpiride was conducted to select a suitable dissolution media for in vitro drug release studies.Results: Fourier transform infrared (FTIR) study revealed no considerable changes in IR peak of levosulpiride and hence no interaction between drug and the excipients. DSC thermograms showed that no drug interaction occurred during the manufacturing process. In vitro dissolution study was carried out for all the formulation and the results compared with marketed sustained release tablet. The drug release from matrix tablets was found to decrease with increase in polymer ratio of Chitosan, Xanthan gum and Guar gum.Conclusion: Formulation LF3 exhibited almost similar drug release profile in dissolution media as that of marketed tablets. From the results of dissolution data fitted to various drug release kinetic equations, it was observed that highest correlation was found for First order, Higuchi’s and Korsmeyer equation, which indicate that the drug release occurred via diffusion mechanism.  Keywords: Levosulpiride, sustained release tablets, natural polymers, in vitro drug release studies 

Natural and synthetic polymers in fabric and home care applications

2017 ◽  
Vol 2 (9) ◽  
Author(s):  
Monissa Paderes ◽  
Deepak Ahirwal ◽  
Susana Fernández Prieto
Keyword(s):  
Home Care ◽  
Xanthan Gum ◽  
Food Industry ◽  
Consumer Products ◽  
Dye Transfer ◽  
Natural Polymers ◽  
Textile Printing ◽  
Synthetic And Natural Polymers ◽  
Transfer Inhibition ◽  
Rheology Modifier

AbstractPolymers can be tailored to provide different benefits in Fabric & Home Care formulations depending on the monomers and modifications used, such as avoiding dye transfer inhibition in the wash, modifying the surface of tiles or increasing the viscosity and providing suspension properties to consumer products. Specifically, the rheology modification properties of synthetic and natural polymers are discussed in this chapter. The choice of a polymeric rheology modifier will depend on the formulation ingredients (charges, functional groups), the type and the amount of surfactants, the pH and the desired rheology modification. Natural polymeric rheology modifiers have been traditionally used in the food industry, being xanthan gum one of the most well-known ones. On the contrary, synthetic rheology modifiers are preferably used in paints & coats, textile printing and cleaning products.

scholarly journals Evaluation of an alkali-polymer flooding technique for enhanced oil recovery in Trinidad and Tobago

2020 ◽  
Vol 10 (8) ◽  
pp. 3947-3959
Author(s):  
Kyle Medica ◽  
Rean Maharaj ◽  
David Alexander ◽  
Mohammad Soroush
Keyword(s):  
Trinidad And Tobago ◽  
Enhanced Oil Recovery ◽  
Oil Recovery ◽  
Energy Demand ◽  
Xanthan Gum ◽  
Net Present Value ◽  
Flow Characteristics ◽  
Absorption Capacity ◽  
Polymer Flooding ◽  
Screening Criteria

Abstract Trinidad and Tobago (TT) is seeking to develop more economical methods of enhanced oil recovery to arrest the decline in crude oil production and to meet the current and future energy demand. The utilization of alkaline-polymer flooding to enhance oil recovery in TT requires key studies to be conducted to obtain critical information of the flooding system (soil type, additive type, pH, adsorption characteristics and rheological (flow) characteristics). Understanding the role of, interplay and optimizing of these variables will provide key input data for the required simulations to produce near realistic projections of the required EOR efficiencies. The parameters of various wells in TT were compared to the screening criteria for alkali-polymer flooding, and the EOR 4 well was found to be suitable and thus selected for evaluation. Laboratory adsorption studies showed that the 1000 ppm xanthan gum flooding solution containing 0.25% NaOH exhibited the lowest absorption capacity for the gravel packed sand and exhibited the lowest viscosity at all the tested shear rates. The lowest adsorption was 2.27 × 10−7 lbmole/ft3 which occurred with the 1000 ppm xanthan gum polymer containing 0.25% NaOH, and the evidence showed that the polymer was adsorbed on the other side of the faults, indicating that it has moved further and closer to the producing well. Implementation of an alkali polymer flooding resulted in an incremental increase in the recovery factors (~ 3%) compared to polymer flooding; however, a change in the oil recovery as a function of the alkaline concentration was not observed. The simulated economic analysis clearly shows that all the analysed EOR scenarios resulted in economically feasible outcomes of net present value (NPV), Internal Rate of Return (IRR) and payback period for oil price variations between $35 and $60 USD per barrel of oil. A comparison of the individual strategies shows that the alkali-polymer flood system utilizing 0.25% sodium hydroxide with 1000 ppm xanthan gum is the best option in terms of cumulative production, recovery factor, NPV, IRR and time to payback.

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