scholarly journals Myf6/MRF4 is a myogenic niche regulator required for the maintenance of the muscle stem cell pool

EMBO Reports ◽  
2020 ◽  
Vol 21 (12) ◽  
Author(s):  
Felicia Lazure ◽  
Darren M Blackburn ◽  
Aldo H Corchado ◽  
Korin Sahinyan ◽  
Nabila Karam ◽  
...  
Keyword(s):  
Stem Cell ◽  
Muscle Stem Cell ◽  
Cell Pool ◽  
Stem Cell Pool

scholarly journals Sprouty1 Regulates Reversible Quiescence of a Self-Renewing Adult Muscle Stem Cell Pool during Regeneration

2010 ◽  
Vol 6 (2) ◽  
pp. 117-129 ◽  
Author(s):  
Kelly L. Shea ◽  
Wanyi Xiang ◽  
Vincent S. LaPorta ◽  
Jonathan D. Licht ◽  
Charles Keller ◽  
...  
Keyword(s):  
Stem Cell ◽  
Muscle Stem Cell ◽  
Adult Muscle ◽  
Cell Pool ◽  
Stem Cell Pool

scholarly journals Myf6/MRF4 is a Myogenic Niche Regulator Required for the Maintenance of the Muscle Stem Cell Pool

2019 ◽  
Author(s):  
Felicia Lazure ◽  
Darren M. Blackburn ◽  
Nabila Karam ◽  
Korin Sahinyan ◽  
Ahmad Sharanek ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Stem Cell ◽  
P38 Map Kinase ◽  
Postnatal Life ◽  
Muscle Stem Cell ◽  
Muscle Stem Cells ◽  
Cell Pool ◽  
Knockout Animals ◽  
Stem Cell Pool

AbstractIn metazoans, skeletal muscle evolved to contract and produce force. However, recent experimental evidence suggests that skeletal muscle has also acquired endocrine functions and produces a vast array of myokines. Using ChIP-Seq and gene expression analyses of myogenic factors, we show that Myf6/MRF4 transcriptionally regulates a broad spectrum of myokines and muscle-secreted proteins, including ligands for downstream activation of key signaling pathways such as EGFR, STAT3 and VEGFR. Homozygous deletion of Myf6 causes a significant reduction in the ability of muscle to produce key myokines such as EGF, VEGFA and LIF. Consequently, although Myf6 knockout mice are born with a normal muscle stem cell compartment, they undergo progressive reduction in their stem cell pool during postnatal life. Mechanistically, muscle stem cells from the Myf6 knockout animals show defects in activation of EGFR and STAT3 signaling, upregulate the p38 MAP kinase pathway and spontaneously break from quiescence. Exogenous application of recombinant EGF and LIF rescue the defects in the muscle stem cell pool of Myf6 knockout animals. Finally, skeletal muscles of mice lacking Myf6 have a significantly reduced ability to sustain donor-engrafted muscle stem cells. Taken together, our data uncovers a novel role for Myf6 in regulating the expression of niche factors and myokines to maintain the skeletal muscle stem cell pool in adult mice.

scholarly journals Three-dimensional niche stiffness synergizes with Wnt7a to modulate the extent of satellite cell symmetric self-renewal divisions

2020 ◽  
Vol 31 (16) ◽  
pp. 1703-1713
Author(s):  
Louise A. Moyle ◽  
Richard Y. Cheng ◽  
Haijiao Liu ◽  
Sadegh Davoudi ◽  
Silvia A. Ferreira ◽  
...  
Keyword(s):  
Stem Cell ◽  
Tissue Repair ◽  
Stem Cell Niche ◽  
Three Dimensional ◽  
Repair Process ◽  
Self Renewal ◽  
Muscle Stem Cell ◽  
Cell Pool ◽  
Cell Niche ◽  
Stem Cell Pool

The skeletal muscle stem cell niche transiently stiffens during the tissue repair process, which serves to increase planar-oriented divisions and, when combined with WNT7a, induces symmetric cell division to expand the stem cell pool.

scholarly journals Reduced expression of calcitonin receptor is closely associated with age-related loss of the muscle stem cell pool

2019 ◽  
Vol 2 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Madoka Ikemoto-Uezumi ◽  
Akiyoshi Uezumi ◽  
Lidan Zhang ◽  
Heying Zhou ◽  
Naohiro Hashimoto ◽  
...  
Keyword(s):  
Stem Cell ◽  
Calcitonin Receptor ◽  
Muscle Stem Cell ◽  
Cell Pool ◽  
Age Related ◽  
Stem Cell Pool

Experimental epilepsy affects Notch1 signalling and the stem cell pool in the dentate gyrus

2012 ◽  
Vol 36 (12) ◽  
pp. 3643-3652 ◽  
Author(s):  
Mirjam Sibbe ◽  
Ute Häussler ◽  
Sandra Dieni ◽  
Daniel Althof ◽  
Carola A. Haas ◽  
...  
Keyword(s):  
Stem Cell ◽  
Dentate Gyrus ◽  
Experimental Epilepsy ◽  
Cell Pool ◽  
Stem Cell Pool

Regenerating the skin: a task for the heterogeneous stem cell pool and surrounding niche

2013 ◽  
Vol 14 (11) ◽  
pp. 737-748 ◽  
Author(s):  
Guiomar Solanas ◽  
Salvador Aznar Benitah
Keyword(s):  
Stem Cell ◽  
Cell Pool ◽  
Stem Cell Pool
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