scholarly journals The MYST family histone acetyltransferase complex regulates stress resistance and longevity through transcriptional control of DAF ‐16/ FOXO transcription factors

EMBO Reports ◽  
2017 ◽  
Vol 18 (10) ◽  
pp. 1716-1726 ◽  
Author(s):  
Takako Ikeda ◽  
Masaharu Uno ◽  
Sakiko Honjoh ◽  
Eisuke Nishida
Keyword(s):  
Transcription Factors ◽  
Stress Resistance ◽  
Transcriptional Control ◽  
Histone Acetyltransferase ◽  
Foxo Transcription Factors

scholarly journals FoxO Transcription Factors Support Oxidative Stress Resistance in Human Chondrocytes

2014 ◽  
Vol 66 (12) ◽  
pp. 3349-3358 ◽  
Author(s):  
Yukio Akasaki ◽  
Oscar Alvarez-Garcia ◽  
Masahiko Saito ◽  
Beatriz Caramés ◽  
Yukihide Iwamoto ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Transcription Factors ◽  
Stress Resistance ◽  
Human Chondrocytes ◽  
Oxidative Stress Resistance ◽  
Foxo Transcription Factors

scholarly journals FOXO Transcription Factors: Regulators of Metabolism and Stress Resistance

Proceedings ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 11
Author(s):  
Klotz
Keyword(s):  
Transcription Factors ◽  
Stress Resistance ◽  
Mammalian Cells ◽  
Cellular Response ◽  
Target Genes ◽  
Model Organism ◽  
Genes Encoding ◽  
Antioxidant Proteins ◽  
Foxo Transcription Factors

FOXO (Forkhead box, class O) proteins are transcriptional regulators ubiquitously expressed in mammalian cells with roles in modulating fuel metabolism, stress resistance and cell death. FOXO transcription factors are regulated by redox processes at several levels, including enzymatic and nonenzymatic posttranslational modification. Target genes controlled by FOXO proteins include genes encoding antioxidant proteins, thus likely contributing to the key role FOXOs play in the cellular response to oxidative stress. Here, an overview is provided on (i) the modulation of FOXO proteins by thiol depleting agents, (ii) consequences of thiol depletion for stress resistance and life span of a model organism, Caenorhabditis elegans and (iii) the role of FOXO proteins therein.

scholarly journals p300/CBP proteins: HATs for transcriptional bridges and scaffolds

2001 ◽  
Vol 114 (13) ◽  
pp. 2363-2373 ◽  
Author(s):  
Ho Man Chan ◽  
Nicholas B. La Thangue
Keyword(s):  
Transcription Factors ◽  
Human Disease ◽  
Transcriptional Control ◽  
Histone Acetyltransferase ◽  
Tumour Suppressor ◽  
Research Activity ◽  
Protein Scaffold ◽  
Activator Proteins ◽  
Transcriptional Regulatory ◽  
Regulatory Complex

p300/CBP transcriptional co-activator proteins play a central role in co-ordinating and integrating multiple signal-dependent events with the transcription apparatus, allowing the appropriate level of gene activity to occur in response to diverse physiological cues that influence, for example, proliferation, differentiation and apoptosis. p300/CBP activity can be under aberrant control in human disease, particularly in cancer, which may inactivate a p300/CBP tumour-suppressor-like activity. The transcription regulating-properties of p300 and CBP appear to be exerted through multiple mechanisms. They act as protein bridges, thereby connecting different sequence-specific transcription factors to the transcription apparatus. Providing a protein scaffold upon which to build a multicomponent transcriptional regulatory complex is likely to be an important feature of p300/CBP control. Another key property is the presence of histone acetyltransferase (HAT) activity, which endows p300/CBP with the capacity to influence chromatin activity by modulating nucleosomal histones. Other proteins, including the p53 tumour suppressor, are targets for acetylation by p300/CBP. With the current intense level of research activity, p300/CBP will continue to be in the limelight and, we can be confident, yield new and important information on fundamental processes involved in transcriptional control.

MGA2 and SPT23 Are Modifiers of Transcriptional Silencing in Yeast

Genetics ◽  
2000 ◽  
Vol 156 (3) ◽  
pp. 933-941 ◽  
Author(s):  
Mary Lou Dula ◽  
Scott G Holmes
Keyword(s):  
Transcription Factors ◽  
Chromatin Structure ◽  
Transcriptional Control ◽  
Transcriptional Silencing ◽  
Sir Proteins

Abstract Transcriptional silencing at the HM loci and telomeres in yeast depends on several trans-acting factors, including Rap1p and the Sir proteins. The SUM1-1 mutation was identified by its ability to restore silencing to strains deficient in one or more of these trans-acting factors. The mechanism by which SUM1-1 bypasses the requirement for silencing proteins is not known. We identified four loci that when reduced in dosage in diploid strains increase the ability of SUM1-1 strains to suppress silencing defects. Two of the genes responsible for this effect were found to be MGA2 and SPT23. Mga2p and Spt23p were previously identified as functionally related transcription factors that influence chromatin structure. We find that deletion of MGA2 or SPT23 also increases the efficiency of silencing in haploid SUM1-1 strains. These results suggest that Mga2p and Spt23p are antagonists of silencing. Consistent with this proposal we find that deletion of MGA2 or SPT23 also suppresses the silencing defects caused by deletion of the SIR1 gene or by mutations in the HMR silencer sequences. However, we find that Mga2p and Spt23p can positively affect silencing in other contexts; deletion of either MGA2 or SPT23 decreases mating in strains bearing mutations in the HML-E silencer. Mga2p and Spt23p appear to be a novel class of factors that influence disparate pathways of transcriptional control by chromatin.

Transcriptional Control of Parturition: Insights from Gene Regulation Studies in the Myometrium

2021 ◽  
Author(s):  
Nawrah Khader ◽  
Virlana M Shchuka ◽  
Oksana Shynlova ◽  
Jennifer A Mitchell
Keyword(s):  
Transcription Factors ◽  
Regulatory Networks ◽  
Transcriptional Control ◽  
Progesterone Receptors ◽  
Activator Protein 1 ◽  
Transcriptional Regulatory Networks ◽  
Regulatory Pathways ◽  
Transcriptional Regulatory ◽  
Mechanistic Basis ◽  
Labour Onset

Abstract The onset of labour is a culmination of a series of highly coordinated and preparatory physiological events that take place throughout the gestational period. In order to produce the associated contractions needed for fetal delivery, smooth muscle cells in the muscular layer of the uterus (i.e. myometrium) undergo a transition from quiescent to contractile phenotypes. Here, we present the current understanding of the roles transcription factors play in critical labour-associated gene expression changes as part of the molecular mechanistic basis for this transition. Consideration is given to both transcription factors that have been well-studied in a myometrial context, i.e. activator protein 1 (AP-1), progesterone receptors (PRs), estrogen receptors (ERs), and nuclear factor kappa B (NF-κB), as well as additional transcription factors whose gestational event-driving contributions have been demonstrated more recently. These transcription factors may form pregnancy- and labour- associated transcriptional regulatory networks in the myometrium to modulate the timing of labour onset. A more thorough understanding of the transcription factor-mediated, labour-promoting regulatory pathways holds promise for the development of new therapeutic treatments that can be used for the prevention of preterm labour in at-risk women.

scholarly journals Resveratrol Induces Growth Arrest and Apoptosis through Activation of FOXO Transcription Factors in Prostate Cancer Cells

PLoS ONE ◽  
2010 ◽  
Vol 5 (12) ◽  
pp. e15288 ◽  
Author(s):  
Qinghe Chen ◽  
Suthakar Ganapathy ◽  
Karan P. Singh ◽  
Sharmila Shankar ◽  
Rakesh K. Srivastava
Keyword(s):  
Prostate Cancer ◽  
Transcription Factors ◽  
Cancer Cells ◽  
Growth Arrest ◽  
Prostate Cancer Cells ◽  
Foxo Transcription Factors

scholarly journals 256 FOXO TRANSCRIPTION FACTORS IN ARTICULAR CHONDROCYTES

2009 ◽  
Vol 17 ◽  
pp. S141
Author(s):  
N. de Isla ◽  
N. Charif ◽  
C. Huselstein ◽  
D. Bensoussan ◽  
J.-F. Stoltz
Keyword(s):  
Transcription Factors ◽  
Articular Chondrocytes ◽  
Foxo Transcription Factors
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