scholarly journals Zonal human hepatocytes are differentially permissive to Plasmodium falciparum malaria parasites

2021 ◽  
Author(s):  
Annie S P Yang ◽  
Youri M Waardenburg ◽  
Marga Vegte‐Bolmer ◽  
Geert‐Jan A Gemert ◽  
Wouter Graumans ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Falciparum Malaria ◽  
Plasmodium Falciparum Malaria ◽  
Human Hepatocytes ◽  
Malaria Parasites

scholarly journals Invasion of erythrocytes by Plasmodium falciparum malaria parasites: evidence for receptor heterogeneity and two receptors

Blood ◽  
1986 ◽  
Vol 67 (5) ◽  
pp. 1519-1521 ◽  
Author(s):  
GH Mitchell ◽  
TJ Hadley ◽  
MH McGinniss ◽  
FW Klotz ◽  
LH Miller
Keyword(s):  
Plasmodium Falciparum ◽  
Sialic Acid ◽  
Falciparum Malaria ◽  
Plasmodium Falciparum Malaria ◽  
Malaria Parasites

Abstract Plasmodium falciparum malaria parasites with different capabilities of invading sialic acid-deficient erythrocytes were identified. Thai-2 parasites cultured in Tn erythrocytes invaded neuraminidase-treated and Tn erythrocytes twice as efficiently as Thai-2 parasites cultured in normal erythrocytes and seven to ten times more efficiently than a cloned line of Camp parasites cultured in normal erythrocytes. All three parasite lines required sialic acid for optimal invasion, but Thai-2 parasites cultured in Tn erythrocytes invaded neuraminidase- treated erythrocytes with 45% efficiency whereas Camp parasites invaded neuraminidase-treated erythrocytes with less than 10% efficiency. P falciparum malaria parasites probably possess two receptors: one that binds to a sialic acid-dependent ligand and another that binds to a sialic acid-independent ligand. Parasites may differ in the quantity or affinity of their receptors for the sialic acid-independent ligand.

scholarly journals Genomic Sequencing of Plasmodium falciparum Malaria Parasites from Senegal Reveals the Demographic History of the Population

2012 ◽  
Vol 29 (11) ◽  
pp. 3427-3439 ◽  
Author(s):  
Hsiao-Han Chang ◽  
Daniel J. Park ◽  
Kevin J. Galinsky ◽  
Stephen F. Schaffner ◽  
Daouda Ndiaye ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Falciparum Malaria ◽  
Demographic History ◽  
Plasmodium Falciparum Malaria ◽  
Genomic Sequencing ◽  
Malaria Parasites ◽  
History Of

scholarly journals Development of Chemical Entities Endowed with Potent Fast-Killing Properties against Plasmodium falciparum Malaria Parasites

2019 ◽  
Vol 62 (20) ◽  
pp. 9217-9235 ◽  
Author(s):  
Alexios N. Matralis ◽  
Adnan Malik ◽  
Maria Penzo ◽  
Inmaculada Moreno ◽  
Maria J. Almela ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Falciparum Malaria ◽  
Plasmodium Falciparum Malaria ◽  
Malaria Parasites
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