scholarly journals Roles of plant retinoblastoma protein: cell cycle and beyond

2020 ◽  
Vol 39 (19) ◽  
Author(s):  
Bénédicte Desvoyes ◽  
Crisanto Gutierrez
Keyword(s):  
Cell Cycle ◽  
Retinoblastoma Protein ◽  
Protein Cell

scholarly journals Cell cycle function of a Medicago sativa A2-type cyclin interacting with a PSTAIRE-type cyclin-dependent kinase and a retinoblastoma protein

2000 ◽  
Vol 23 (1) ◽  
pp. 73-83 ◽  
Author(s):  
Francois Roudier ◽  
Elena Fedorova ◽  
Janos Gyorgyey ◽  
Attila Feher ◽  
Spencer Brown ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Medicago Sativa ◽  
Retinoblastoma Protein ◽  
Cyclin Dependent Kinase

Retinoblastoma Protein, Gene Expression, and Cell Cycle Control

Cancer Genes ◽  
1996 ◽  
pp. 177-191
Author(s):  
Jane Clifford Azizkhan ◽  
Shiaw Yih Lin ◽  
David Jensen ◽  
Dusan Kostic ◽  
Adrian R. Black
Keyword(s):  
Gene Expression ◽  
Cell Cycle ◽  
Protein Gene ◽  
Cell Cycle Control ◽  
Retinoblastoma Protein

scholarly journals The retinoblastoma protein-binding region of simian virus 40 large T antigen alters cell cycle regulation in lenses of transgenic mice.

1994 ◽  
Vol 14 (10) ◽  
pp. 6743-6754 ◽  
Author(s):  
L Fromm ◽  
W Shawlot ◽  
K Gunning ◽  
J S Butel ◽  
P A Overbeek
Keyword(s):  
Cell Cycle ◽  
Transgenic Mice ◽  
Retinoblastoma Protein ◽  
Simian Virus 40 ◽  
Cell Types ◽  
Simian Virus ◽  
T Antigen ◽  
Lens Fiber ◽  
Large T Antigen ◽  
Fiber Cells

Regulation of the cell cycle is a critical aspect of cellular proliferation, differentiation, and transformation. In many cell types, the differentiation process is accompanied by a loss of proliferative capability, so that terminally differentiated cells become postmitotic and no longer progress through the cell cycle. In the experiments described here, the ocular lens has been used as a system to examine the role of the retinoblastoma protein (pRb) family in regulation of the cell cycle during differentiation. The ocular lens is an ideal system for such studies, since it is composed of just two cell types: epithelial cells, which are capable of proliferation, and fiber cells, which are postmitotic. In order to inactivate pRb in viable mice, genes encoding either a truncated version of simian virus 40 large T antigen or the E7 protein of human papillomavirus were expressed in a lens-specific fashion in transgenic mice. Lens fiber cells in the transgenic mice were found to incorporate bromodeoxyuridine, implying inappropriate entry into the cell cycle. Surprisingly, the lens fiber cells did not proliferate as tumor cells but instead underwent programmed cell death, resulting in lens ablation and microphthalmia. Analogous lens alterations did not occur in mice expressing a modified version of the truncated T antigen that was mutated in the binding domain for the pRb family. These experimental results indicate that the retinoblastoma protein family plays a crucial role in blocking cell cycle progression and maintaining terminal differentiation in lens fiber cells. Apoptotic cell death ensues when fiber cells are induced to remain in or reenter the cell cycle.

Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

Nature ◽  
1997 ◽  
Vol 386 (6621) ◽  
pp. 177-181 ◽  
Author(s):  
Daniel S. Peeper ◽  
Todd M. Upton ◽  
Mohamed H. Ladha ◽  
Elizabeth Neuman ◽  
Juan Zalvide ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Retinoblastoma Protein ◽  
Cell Cycle Machinery ◽  
Ras Signalling

ATM is involved in cell-cycle control through the regulation of retinoblastoma protein phosphorylation

2010 ◽  
pp. n/a-n/a ◽  
Author(s):  
Javier G. Pizarro ◽  
Jaume Folch ◽  
Aurelio Vazquez de la Torre ◽  
Felix Junyent ◽  
Ester Verdaguer ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Protein Phosphorylation ◽  
Cell Cycle Control ◽  
Retinoblastoma Protein

scholarly journals Key role for p27Kip1, retinoblastoma protein Rb, and MYCN in polyamine inhibitor-induced G1 cell cycle arrest in MYCN-amplified human neuroblastoma cells

Oncogene ◽  
2005 ◽  
Vol 24 (36) ◽  
pp. 5606-5618 ◽  
Author(s):  
Christopher J Wallick ◽  
Ivonne Gamper ◽  
Mike Thorne ◽  
David J Feith ◽  
Kelsie Y Takasaki ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Neuroblastoma Cells ◽  
Retinoblastoma Protein ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma ◽  
Cycle Arrest ◽  
G1 Cell Cycle Arrest
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