scholarly journals Noxious Cutaneous Thermal Stimuli Induce a Graded Release of Endogenous Substance P in the Spinal Cord: Imaging Peptide ActionIn Vivo

1997 ◽  
Vol 17 (15) ◽  
pp. 5921-5927 ◽  
Author(s):  
Brian J. Allen ◽  
Scott D. Rogers ◽  
Joseph R. Ghilardi ◽  
Patrick M. Menning ◽  
Michael A. Kuskowski ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Substance P ◽  
Endogenous Substance ◽  
Graded Release ◽  
Thermal Stimuli ◽  
Spinal Cord Imaging

scholarly journals Substance P releases GABA from neurons in the isolated spinal cord of the newborn rat

1988 ◽  
Vol 46 ◽  
pp. 60
Author(s):  
Masafumi Sakuma ◽  
Nobuyuki Kobayashi ◽  
Mitsuhiko Yanagisawa ◽  
Masanori Otsuka
Keyword(s):  
Spinal Cord ◽  
Substance P ◽  
Newborn Rat

Distribution of substance P in the spinal cord of patients with syringomyelia

1996 ◽  
Vol 84 (6) ◽  
pp. 992-998 ◽  
Author(s):  
Thomas H. Milhorat ◽  
Harrison T. M. Mu ◽  
Carole C. LaMotte ◽  
Ade T. Milhorat
Keyword(s):  
Spinal Cord ◽  
Substance P ◽  
Dorsal Horn ◽  
Ventral Horn ◽  
Immunohistochemical Method ◽  
Positive Staining ◽  
Content Type ◽  
Normal Individuals ◽  
Neurologically Normal ◽  
Intermediolateral Nucleus

✓ The distribution of substance P, a putative neurotransmitter and pain-related peptide, was studied using the peroxidase—antiperoxidase immunohistochemical method in the spinal cords obtained from autopsy of 10 patients with syringomyelia and 10 age- and sex-matched, neurologically normal individuals. Substance P immunoreactivity was present in axons and in terminal-like processes in close apposition to neurons in the first, second, and third laminae of the dorsal horn. Smaller amounts of peroxidase-positive staining were found in the fifth lamina of the dorsal horn, the intermediolateral nucleus, the intermediomedial nucleus, and the ventral horn. In nine of 10 patients with syringomyelia, there was a substantial increase in substance P immunoreactivity in the first, second, third, and fifth laminae below the level of the lesion. A marked reduction or absence of staining was present in segments of the spinal cord occupied by the syrinx. Central cavities produced bilateral abnormalities, whereas eccentric cavities produced changes that were ipsilateral to the lesion. No alterations in staining were found in the spinal cord of an asymptomatic patient with a small central syrinx. The authors conclude that syringomyelia can be associated with abnormalities in spinal cord levels of substance P, which may affect the modulation and perception of pain.

Localization and changes of substance P in spinal cord of paraplegic cats

1978 ◽  
Vol 153 (3) ◽  
pp. 507-513 ◽  
Author(s):  
N.E. Naftchi ◽  
S.J. Abrahams ◽  
H.M. St. Paul ◽  
E.W. Lowman ◽  
W. Scholosser
Keyword(s):  
Spinal Cord ◽  
Substance P
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