METHYL PYRUVATE

1944 ◽  
Vol 24 ◽  
pp. 72
Keyword(s):  
Methyl Pyruvate

Studies with GIP/Ins cells indicate secretion by gut K cells is KATPchannel independent

2003 ◽  
Vol 284 (5) ◽  
pp. E988-E1000 ◽  
Author(s):  
Song Yan Wang ◽  
Maggie M.-Y. Chi ◽  
Lin Li ◽  
Kelle H. Moley ◽  
Burton M. Wice
Keyword(s):  
Tricarboxylic Acid Cycle ◽  
Calcium Mobilization ◽  
Enteroendocrine Cells ◽  
Glycolytic Flux ◽  
K Cells ◽  
Antibody Staining ◽  
Methyl Pyruvate ◽  
Fructose 1,6 Bisphosphate ◽  
Insulinoma Cells

K cells are a subpopulation of enteroendocrine cells that secrete glucose-dependent insulinotropic polypeptide (GIP), a hormone that promotes glucose homeostasis and obesity. Therefore, it is important to understand how GIP secretion is regulated. GIP-producing (GIP/Ins) cell lines secreted hormones in response to many GIP secretagogues except glucose. In contrast, glyceraldehyde and methyl pyruvate stimulated hormone release. Measurements of intracellular glucose 6-phosphate, fructose 1,6-bisphosphate, and pyruvate levels, as well as glycolytic flux, in glucose-stimulated GIP/Ins cells indicated that glycolysis was not impaired. Analogous results were obtained using glucose-responsive MIN6 insulinoma cells. Citrate levels increased similarly in glucose-treated MIN6 and GIP/Ins cells. Thus pyruvate entered the tricarboxylic acid cycle. Glucose and methyl pyruvate stimulated 1.4- and 1.6-fold increases, respectively, in the ATP-to-ADP ratio in GIP/Ins cells. Glyceraldehyde profoundly reduced, rather than increased, ATP/ADP. Thus nutrient-regulated secretion is independent of the ATP-dependent potassium (KATP) channel. Antibody staining of mouse intestine demonstrated that enteroendocrine cells producing GIP, glucagon-like peptide-1, CCK, or somatostatin do not express detectable levels of inwardly rectifying potassium (Kir) 6.1 or Kir 6.2, indicating that release of these hormones in vivo may also be KATPchannel independent. Conversely, nearly all cells expressing chromogranin A or substance P and ∼50% of the cells expressing secretin or serotonin exhibited Kir 6.2 staining. Compounds that activate calcium mobilization were potent secretagogues for GIP/Ins cells. Secretion was only partially inhibited by verapamil, suggesting that calcium mobilization from intracellular and extracellular sources, independent from KATPchannels, regulates secretion from some, but not all, subpopulations of enteroendocrine cells.

Fundamental aspects of enantioselective heterogeneous catalysis: a NEXAFS study of methyl pyruvate and (S)-(−)-1-(1-naphthyl) ethylamine on Pt{1 1 1}

2001 ◽  
Vol 482-485 ◽  
pp. 207-214 ◽  
Author(s):  
J.M Bonello ◽  
E.C.H Sykes ◽  
R Lindsay ◽  
F.J Williams ◽  
A.K Santra ◽  
...  
Keyword(s):  
Heterogeneous Catalysis ◽  
Methyl Pyruvate

Singlet quenching of methyl pyruvate

1981 ◽  
Vol 15 (3) ◽  
pp. 177-183 ◽  
Author(s):  
M.V. Encina ◽  
E.A. Lissi
Keyword(s):  
Methyl Pyruvate

Electroanalysis of Infection with Methyl Pyruvate

ACS Sensors ◽  
2020 ◽  
Vol 5 (2) ◽  
pp. 535-540 ◽  
Author(s):  
Michael Bekhit ◽  
Waldemar Gorski
Keyword(s):  
Methyl Pyruvate

Structure and Reaction Pathways of Methyl Pyruvate on Pd(111)

2009 ◽  
Vol 113 (34) ◽  
pp. 15298-15306 ◽  
Author(s):  
Luke Burkholder ◽  
Wilfred. T. Tysoe
Keyword(s):  
Reaction Pathways ◽  
Methyl Pyruvate

Orientation and Conformation of Methyl Pyruvate on Ni(111)

2000 ◽  
Vol 122 (3) ◽  
pp. 518-524 ◽  
Author(s):  
M. Castonguay ◽  
J. -R. Roy ◽  
A. Rochefort ◽  
P. H. McBreen
Keyword(s):  
Methyl Pyruvate

The interaction between amines and methyl pyruvate involving protonated species

2005 ◽  
Vol 107-108 ◽  
pp. 31-39 ◽  
Author(s):  
José Walkimar de M. Carneiro ◽  
Ceciliana da S.B. de Oliveira ◽  
Fabio B. Passos ◽  
Donato A.G. Aranda ◽  
Paulo Rogério N. de Souza ◽  
...  
Keyword(s):  
Methyl Pyruvate ◽  
Protonated Species

Keto-Enol Driven Assembly of Methyl Pyruvate on Pt(111)

2007 ◽  
Vol 129 (38) ◽  
pp. 11668-11669 ◽  
Author(s):  
Stéphane Lavoie ◽  
Marc-André Laliberté, ◽  
Gautier Mahieu ◽  
Vincent Demers-Carpentier ◽  
Peter McBreen
Keyword(s):  
Methyl Pyruvate
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