scholarly journals Estimation of serum 25-hydroxy vitamin D and zinc levels in patients with acne vulgaris and their association with disease severity

2020 ◽  
Keyword(s):  
Vitamin D ◽  
Disease Severity ◽  
Acne Vulgaris ◽  
25 Hydroxy Vitamin D ◽  
Zinc Levels

Evaluation of 25‐hydroxy vitamin D levels and disease severity in patients with acne vulgaris

2020 ◽  
Vol 33 (3) ◽  
Author(s):  
Funda Kemeriz ◽  
Sibel Çiğdem Tuncer ◽  
Emine Müge Acar ◽  
Burcu Tuğrul
Keyword(s):  
Vitamin D ◽  
Disease Severity ◽  
Acne Vulgaris ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D

25-Hydroxy vitamin D levels in chronic urticaria and its correlation with disease severity from a tertiary care centre in South India

2014 ◽  
Vol 52 (6) ◽  
Author(s):  
Laxmisha Chandrashekar ◽  
Medha Rajappa ◽  
Malathi Munisamy ◽  
Palghat Hariharan Ananthanarayanan ◽  
Devinder Mohan Thappa ◽  
...  
Keyword(s):  
Vitamin D ◽  
Disease Severity ◽  
Chronic Urticaria ◽  
South India ◽  
Tertiary Care ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D

scholarly journals Plasma 25-Hydroxy Vitamin D is not Associated with Acne Vulgaris

Nutrients ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1525 ◽  
Author(s):  
Abdullah Al-Taiar ◽  
Mona AlKhabbaz ◽  
Abdur Rahman ◽  
Reem Al-Sabah ◽  
Lemia Shaban ◽  
...  
Keyword(s):  
Vitamin D ◽  
Public Schools ◽  
Acne Vulgaris ◽  
Cross Sectional Study ◽  
Continuous Variable ◽  
Vitamin D Supplementation ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
Liquid Chromatography Tandem Mass ◽  
25 Hydroxy Vitamin D

Few studies have investigated the association between Acne vulgaris (AV) and vitamin D level. In this study we aimed to investigate the association between 25-hydroxyvitamin D (25-OH-VitD) level and AV in a country with plenty of sunshine. A cross-sectional study was conducted on 714 adolescents who were randomly selected from public schools using multistage cluster random sampling with probability proportional to size. 25-OH-VitD levels were measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The Global Acne Grading System (GAGS) was used to assess the severity of AV. Data on potential confounders were collected from the parents through a self-administered questionnaire, and from the adolescents using a face-to-face interview. Of 714 participants, 351 (41.16%) were males. The mean (standard deviation (SD)) age was 12.28 (0.81) years. AV was observed in 479 (67.1%) adolescents. There was no significant association between 25-OH-VitD level and clinically assessed AV before or after adjusting for potential confounders. This was consistent whether 25-OH-VitD was fitted as a continuous variable or categorized using acceptable cutoff points or tertiles. In this study vitamin D status was not associated with AV, therefore our data do not support vitamin D supplementation either to treat or to prevent AV.

scholarly journals 25-Hydroxyl Vitamin D Deficiency in Nasal Polyposis

2019 ◽  
Vol 24 (03) ◽  
pp. e308-e312
Author(s):  
Ankur Kumar Chandrakar ◽  
Arun Alexander ◽  
Medha R. ◽  
Kalaiselvi Rajendiran ◽  
Karthikeyan Ramasamy
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Disease Severity ◽  
Nasal Polyposis ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cross Sectional ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D ◽  
The Mean ◽  
Hs Crp

Abstract Introduction Vitamin D is known to have immunomodulatory functions and has action on chronic inflammatory processes, such as nasal polyposis. Objective The present study assessed the levels of 25-hydroxy vitamin D and high-sensitivity C-reactive protein (hs-CRP) in patients with nasal polyposis, as compared with healthy control subjects, and identified their association with disease severity in nasal polyposis. It further assessed the levels of 25-hydroxyl vitamin D and hs-CRP in patients with nasal polyposis and atopy and compared it with patients with nasal polyposis without atopy. Methods This was a cross-sectional study involving 2 groups: 80 patients with nasal polyposis and 80 healthy subjects. In patients with nasal polyposis, the disease severity is assessed by the sino-nasal outcome test (SNOT20) and by the Lund & Mackay staging system. Levels of 25-hydroxy vitamin D and hs-CRP were measured by enzyme-linked immunosorbent assay (ELISA). Result The mean 25-hydroxyl vitamin D levels (ng/ml) was 12.01 ± 7.29 for cases and 22.87 ± 14.95 for controls, with p < 0.0001. The mean hs-CRP levels (mg/L) was 5.99 ± 2.74 in cases and 2.41 ± 1.95 in controls, with p < 0.0001. The severity of polyposis correlated negatively with serum levels of 25-hydroxy vitamin D and positively with hs-CRP. Conclusion The study has thus shown significant correlation between vitamin D deficiency and inflammation in patients with nasal polyps.

25-hydroxy vitamin D and ischaemia-modified albumin levels in psoriasis and their association with disease severity

2015 ◽  
Vol 72 (2) ◽  
pp. 56-60 ◽  
Author(s):  
L. Chandrashekar ◽  
G. R. Krishna Kumari ◽  
M. Rajappa ◽  
G Revathy ◽  
M. Munisamy ◽  
...  
Keyword(s):  
Vitamin D ◽  
Disease Severity ◽  
25 Hydroxy Vitamin D

scholarly journals The Hidden Function of Vitamin D

2016 ◽  
Vol 4 (4) ◽  
pp. 591-595 ◽  
Author(s):  
Hiba Mohamed Riad Sibaii ◽  
Salwa Refat El-Zayat ◽  
Azza Abd El-Shaheed ◽  
Nermine N. Mahfouz ◽  
Sara F. Sallam ◽  
...  
Keyword(s):  
Vitamin D ◽  
Large Scale ◽  
Thymosin Β4 ◽  
Thymic Hormone ◽  
Positive Correlation ◽  
Significant Difference ◽  
25 Hydroxy Vitamin D ◽  
Group 2 ◽  
Zinc Levels ◽  
Group 1

AIM: There are no reports regarding the influence of vitamin D on thymosin ß4 and the cluster of differentiation CD4 levels which are important for maintaining a healthy immune system. Consequently, we aimed to explore this relationship through a study.MATERIAL AND METHODS: The study was carried out on 35 subjects, screened for 25-hydroxy vitamin D[25 (OH) D] using ELISA method and they were divided into two groups: Group 1 consists of 10 healthy subjects with sufficient vit. D level > 24.8 ng/ml. Group 2 consists of 25 subjects suffering, severely, from vitamin D deficiency at level < 11.325 ng/ml. Also, Thymosin ß4, CD4 and zinc levels were performed.RESULTS: There were significant differences between the two groups in the concentration levels of thymosin β4, as the group 1 has shown higher levels (P = 0.005). Whereas, CD4 and zinc levels didn’t show any significant difference between the two groups. At the same time, a significant positive correlation has been observed between vitamin D, thymosin β4, and CD4 at (r = 0.719; P = 0.001), and (r = 0.559, P = 0.001) respectively.CONCLUSION: We concluded that vitamin D may be an essential factor that influence or determine the level of thymosin β4. This study is the first that focused on demonstrating that sufficient level of vitamin D may have the ability to influence the thymic hormone thymosin β4 levels. Further studies on large scale of subjects are needed to explore the positive correlation we had found between vitamin D and thymosin β4 and CD4.

scholarly journals Infantile atopic dermatitis: Serum vitamin D, zinc and TARC levels and their relationship with disease phenotype and severity

2021 ◽  
Vol 49 (3) ◽  
pp. 162-168
Author(s):  
Saliha Esenboga ◽  
Pınar Gur Cetinkaya ◽  
Neriman Sahiner ◽  
Esra Birben ◽  
Ozge Soyer ◽  
...  
Keyword(s):  
Vitamin D ◽  
Atopic Dermatitis ◽  
Disease Severity ◽  
Serum Vitamin ◽  
Serum Zinc ◽  
Control Group ◽  
Healthy Controls ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Zinc Levels

Background: Several markers that influence the clinical course of atopic dermatitis (AD) have been investigated so far. Thymus and activation regulated chemokine (TARC) – a Th2-related cytokine – increase in various atopic diseases. It has been shown that vitamin D affects Treg cells and immune responses. Zinc as an essential trace element for cell–cell interactions, cellular differentiation, and proliferation. However, the effect of these markers on infantile AD and disease severity are mostly unknown.Objective: The aim of this study was to investigate the relationship between TARC, vitamin D, zinc levels, and the disease severity in infants with AD.Method: AD patients (n = 160) with age and sex that matched healthy controls (n = 79) were included in the study. The diagnosis of AD was made based on the Hanifin–Rajka criteria. The objective SCORAD index was used for the assessment of disease severity.Results: A total of 160 patients (male 71.9%) with AD were included in the study. The median age of onset of symptoms was 2 (1.0–3.5) months. The lesions initially started on face 76.9%, neck 6.9%, extremities 7.5%, and body 8.8%. Nearly 40% of the patients were found to be atopic. Food allergy was found in 39.4%. The median of objective SCORAD index was 27.5 (17.5–40) in the study group. The TARC levels of AD patients were higher than control group [1803 pg/ml (1006– 3123) vs 709 pg/ml (504–1147), p < 0.001] There was a significant correlation between objective SCORAD scores and TARC values in subjects with AD (r = 0.363, p < 0.001). As the severity of AD increased, vitamin D levels decreased (p for trend 0.015) and TARC values increased (p for trend < 0.001). Serum zinc levels did not change with the severity of the disease. The presence of atopy did not have an influence on serum TARC, zinc, and vitamin D levels.Conclusion: In infants with AD, disease severity is positively related with TARC levels; and inversely proportional to vitamin D levels. TARC levels differ between patients and healthy controls. The presence of atopy has not been shown to affect these markers.

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