scholarly journals Collagen membrane versus platelet rich fibrin membrane in bone graft healing: An experimental study in sheep.

2020 ◽  
Vol 3 (2) ◽  
pp. 104-111
Author(s):  
Mahdi Abdullah ◽  
Ahmed Hayder
Keyword(s):  
Experimental Study ◽  
Bone Graft ◽  
Bone Healing ◽  
Bone Substitute ◽  
Low Cost ◽  
Collagen Membrane ◽  
Platelet Rich Fibrin ◽  
Membrane Bone ◽  
Significant Difference ◽  
Fibrin Membrane

Background and objectives: Guided bone regeneration is a term used to define the use of barri-er membranes to promote complete osteogenesis. The aim of study was to histologically com-pare the effect of platelet rich fibrin membrane and resorbable Collagen membrane on bone substitute healing. Methods: in this experimental study three sheep’s which their weighted between 60-70 kg were used. After intramuscular sedation and local anesthesia, eighteen defects were created about 8 mm in diameter and 5 mm in depth in the lower border of mandible. Six defects on each animal which three in right side and three in left side of the mandible. The defects were filled with Biphasic calcium phosphate bone substitute. The first defect was covered by platelet rich fibrin membrane, the second one covered by Collagen membrane, and third one was left uncovered. The animals were sacrificed at 2, 6, and 12 weeks. Results: The healing of the grafted defects was histologically studied in all groups, and there was non-significant difference between PRF membrane and collagen membrane in healing of bone substitute at 2, 6, and 12 weeks.There was significant deference between PRF membrane and collagen membrane at 6 weekregarding scaffold replacement with mature bone. Conclusion: The use of PRF membrane shows a good outcome as a low cost biological material capable of improving bone healing defects, grafted with bone substitute. Keywords: Platelet rich fibrin membrane, collagen membrane, bone graft, bone healing.

Combining platelet rich fibrin with different bone graft materials: An experimental study on the histopathological and immunohistochemical aspects of bone healing

2019 ◽  
Vol 47 (5) ◽  
pp. 815-825 ◽  
Author(s):  
Fatih Karayürek ◽  
Ela Tules Kadiroğlu ◽  
Yusuf Nergiz ◽  
Neslihan Coşkun Akçay ◽  
Selçuk Tunik ◽  
...  
Keyword(s):  
Experimental Study ◽  
Bone Graft ◽  
Bone Healing ◽  
Platelet Rich Fibrin

The effect of platelet-rich fibrin membrane on the repair of perforated tympanic membrane: an experimental study

2017 ◽  
Vol 137 (7) ◽  
pp. 695-699 ◽  
Author(s):  
Nuray Ensari ◽  
Özer Erdem Gür ◽  
Mehmet Türker Öztürk ◽  
Dinç Süren ◽  
Ömer Tarık Selçuk ◽  
...  
Keyword(s):  
Experimental Study ◽  
Tympanic Membrane ◽  
Platelet Rich Fibrin ◽  
Perforated Tympanic Membrane ◽  
Fibrin Membrane

scholarly journals Use of Platelet-Rich Fibrin Associated with Xenograft in Critical Bone Defects: Histomorphometric Study in Rabbits

Symmetry ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1293
Author(s):  
Paulo Wilson Maia ◽  
Marcelo Lucchesi Teixeira ◽  
Luís Guilherme Scavone de Macedo ◽  
Antonio Carlos Aloise ◽  
Celio Amaral Passos Junior ◽  
...  
Keyword(s):  
Bone Formation ◽  
Saline Solution ◽  
Healing Process ◽  
Test Group ◽  
The Other ◽  
Control Group ◽  
Collagen Membrane ◽  
Platelet Rich Fibrin ◽  
Histomorphometric Study ◽  
Significant Difference

Platelet-rich fibrin (PRF) is an autologous material used to improve bone regeneration when associated with bone grafts. It affects tissue angiogenesis, increasing the healing process and, theoretically, presenting potential to increase bone neoformation. The aim of this study was to verify, histomorphometrically, the effects of the association of PRF to a xenograft. Twelve adult white New Zealand rabbits were randomly assigned into two groups containing six animals each. After general anesthesia of the animals, two critical defects of 12 mm were created in the rabbit calvaria, one on each side of the sagittal line. Each defect was filled with the following biomaterials: in the control group (CG), xenograft hydrated with saline solution filling one defect and xenograft hydrated with saline solution covered with collagen membrane on the other side; in the test group (TG), xenograft associated with PRF filling the defect of one side and xenograft associated with PRF covered with collagen membrane on the other side. After eight weeks the animals were euthanized and a histomorphometric analysis was performed. The results showed that in the sites that were covered with collagen membrane, there was no statistically significant difference for all the analyzed parameters. However, when comparing the groups without membrane coverage, a statistically significant difference could be observed for the vital mineralized tissue (VMT) and nonmineralized tissue (NMT) parameters, with more VMT in the test group and more NMT in the control group. Regarding the intragroup comparison, the use of the membrane coverage presented significant outcomes in both groups. Therefore, in this experimental model, PRF did not affect the levels of bone formation when a membrane coverage technique was used. However, higher levels of bone formation were observed in the test group when membrane coverage was not used.

scholarly journals Early Proliferation of Bone Marrow Mononuclear Cells on Collagen Membrane, Bone Graft and Tooth Cementum

2009 ◽  
Vol 27 (4) ◽  
Author(s):  
Débora Milagres ◽  
Carlos R Rueff-Barroso ◽  
Simone N Carvalho ◽  
Laís de Carvalho ◽  
Andréa Monte-Alto-Costa ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Graft ◽  
Mononuclear Cells ◽  
Collagen Membrane ◽  
Bone Marrow Mononuclear Cells ◽  
Membrane Bone

scholarly journals Effectiveness of Platelet-Rich Fibrin as an Adjunctive Material to Bone Graft in Maxillary Sinus Augmentation: A Meta-Analysis of Randomized Controlled Trails

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Ruimin Liu ◽  
Mingdong Yan ◽  
Sulin Chen ◽  
Wenxiu Huang ◽  
Dong Wu ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Bone Formation ◽  
Bone Graft ◽  
Bone Substitute ◽  
Meta Analysis ◽  
New Bone Formation ◽  
Sinus Augmentation ◽  
Platelet Rich Fibrin ◽  
Randomized Controlled ◽  
Tissue Area

Purpose. To date, it remains unknown whether the addition of platelet-rich fibrin (PRF) to bone grafts actually improves the effectiveness of maxillary sinus augmentation. This study aimed to perform a meta-analysis to evaluate the efficacy of PRF in sinus lift.Materials and Methods. PubMed, Embase, and the Cochrane Library were searched. Randomized controlled studies were identified. The risk of bias was evaluated using the Cochrane Collaboration tool.Results. Five RCTs were included in our meta-analysis. Clinical, radiographic, and histomorphometric outcomes were considered. No implant failure or graft failure was detected in all included studies within the follow-up period. The percentage of contact length between newly formed bone substitute and bone in the PRF group was lower but lacked statistical significance (3.90%, 95% CI, -2.91% to 10.71%). The percentages of new bone formation (-1.59%, 95% CI, -5.36% to 2.18%) and soft-tissue area (-3.73%, 95% CI, -10.11% to 2.66%) were higher in the PRF group but were not significantly different. The percentage of residual bone graft was not significant in either group (4.57%, 95% CI, 0% to 9.14%).Conclusions. Within the limitations of this review, it was concluded that there were no statistical differences in survival rate, new bone formation, contact between newly formed bone and bone substitute, percentage of residual bone graft (BSV/TV), and soft-tissue area between the non-PRF and PRF groups. Current evidence supporting the necessity of adding PRF to bone graft in sinus augmentation is limited.

scholarly journals Effects of Platelet-Rich Fibrin on Hard Tissue Healing: A Histomorphometric Crossover Trial in Sheep

Materials ◽  
2020 ◽  
Vol 13 (7) ◽  
pp. 1695
Author(s):  
Esra Ondur ◽  
Nilufer Bolukbasi Balcioglu ◽  
Merva Soluk Tekkesin ◽  
Ozlem Guzel ◽  
Selim Ersanli
Keyword(s):  
Bone Regeneration ◽  
Bone Defects ◽  
Collagen Membrane ◽  
Bovine Bone ◽  
Graft Material ◽  
Hard Tissue ◽  
Platelet Rich Fibrin ◽  
Tissue Healing ◽  
Significant Difference ◽  
Time Point

Bone defects lead to aesthetic and functional losses, causing dental rehabilitation to be more difficult. The objective of this work is to histologically assess the hard tissue healing of bone defects filled with platelet-rich fibrin (PRF) alone or as an adjuvant for mixing with and covering anorganic bovine bone (ABB), compared to ABB covered with a resorbable collagen membrane (CM). This study was designed as a crossover animal study. Four 5-mm tibia defects, 5 mm apart from each other, were surgically created on the tibias of 6 sheep. The defects were randomly filled with ABB + CM; PRF alone; ABB+PRF; or were left empty. The animals were euthanized on days 10, 20, and 40 post-operatively. No group showed any signs of bone necrosis. Inflammation was observed in 2 control and 3 test defects with no statistically significant difference between groups at each time point. The ABB + CM and ABB + PRF groups experienced the highest bone regeneration ratios. No differences between the empty-defect and PRF groups were observed in regard to bone regeneration. No statistical difference was observed between the ABB+PRF and ABB + CM groups in regard to bone regeneration and the amount of residual graft material at each time point. The use of PRF should be preferred due to its autogenous origin, low cost, and ease of use.

Use of Beta-tricalcium Phosphate Bone Graft with Collagen Membrane as Guided Bone Regeneration in Long Bone Fractures with Bone Loss in Dogs: A Clinical Study

2020 ◽  
Author(s):  
K. Preethi ◽  
V. Gireesh Kumar ◽  
K.B.P. Raghavender ◽  
D. Pramod Kumar ◽  
M. Lakshman
Keyword(s):  
Bone Loss ◽  
Bone Graft ◽  
Bone Regeneration ◽  
Bone Healing ◽  
Bone Fractures ◽  
Guided Bone Regeneration ◽  
Long Bone ◽  
Collagen Membrane ◽  
Beta Tricalcium Phosphate ◽  
Long Bone Fractures

Background: Fractures associated with bone loss requires stabilization with suitable fixation devices, placement of appropriate bone grafts to fill up the bone defects and barrier membranes as space maintainers for enhanced bone regeneration. The aim of this study was to evaluate the use of beta-tricalcium phosphate (β-TCP) bone graft with collagen membrane as guided bone regeneration in long bone fractures with bone loss in dogs. Method: Six dogs with long bone fractures accompanied with bone loss in Radius-ulna, Femur and Tibia were surgically treated with suitable bone plate as internal fixation with β-TCP bone graft along with collagen membrane placed at the fracture site. Conclusion: The application of β-TCP along with collagen membrane for filling the bone defect is extremely simple, convenient and less time consuming and proved to be effective in promoting early bone healing with rapid later phase bone healing and provided osteoconductive support and early resorption.

Sinus Augmentation With Platelet-Rich Fibrin in Combination With Bovine Bone Graft Versus Bovine Bone Graft in Combination With Collagen Membrane

2015 ◽  
Vol 41 (5) ◽  
pp. 586-595 ◽  
Author(s):  
Nilufer Bolukbasi ◽  
Selim Ersanlı ◽  
Nurullah Keklikoglu ◽  
Cansu Basegmez ◽  
Tayfun Ozdemir
Keyword(s):  
Bone Graft ◽  
Test Group ◽  
Control Group ◽  
Collagen Membrane ◽  
Bovine Bone ◽  
Graft Material ◽  
Sinus Augmentation ◽  
Platelet Rich Fibrin ◽  
Bone Graft Material ◽  
Sinus Floor

The purpose of this study was to compare the efficacy between the use of bovine bone graft material and platelet-rich fibrin (PRF) mixture (test group) and bovine bone graft material and collagen membrane combination (control group) in 2-stage maxillary sinus augmentation. According to specific inclusion/exclusion criteria, patients treated between 2008 and 2012 were selected. Panoramic radiographs were used for radiologic assessments. To evaluate the relationship between sinus-graft height and each implant, the bone level (BL) was divided by implant length (IL). To evaluate the change in the height of grafted sinus, the grafted sinus floor above the lowest part of the original sinus height (GSH) was divided by the original sinus height (OSH). Samples taken during implant surgery were used for histologic and histomorphometric analyses. Twenty-five patients, 32 augmentation surgeries, and 66 one-stage implants were included in the study. No implant loss or complication was observed in either group. There were no statistical differences according to new bone formation (P = .61) and biomaterial remnant (P = .87). During the evaluation period, the test group showed statistically less change in the BL/IL ratio (P = .022). The difference of GSH/OSH ratio was found to be insignificant between groups (P = .093). It was observed that the grafted sinus covering the implant apex and sinus floor was above the original sinus height in both groups. It may be concluded from this study that both combinations can be successfully used for sinus augmentation. Further studies evaluating different graft materials and PRF combinations in the early phases of healing would be beneficial.

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