scholarly journals Dimensional Traits of Schizotypy Associated With Glycine Receptor GLRA1 Polymorphism: An Exploratory Candidate-Gene Association Study

2018 ◽  
Vol 32 (3) ◽  
pp. 421-432 ◽  
Author(s):  
Anvi K. Vora ◽  
Amanda M. Fisher ◽  
Antonia S. New ◽  
Erin A. Hazlett ◽  
Margaret McNamara ◽  
...  
Keyword(s):  
Personality Disorder ◽  
Glycine Receptor ◽  
Principal Component ◽  
Single Nucleotide ◽  
Schizotypal Personality ◽  
Candidate Gene Association ◽  
Minor Alleles ◽  
The Relationship ◽  
Single Nucleotide Poly ◽  
Gene Association Study

Schizotypy captures the underlying genetic vulnerability to schizophrenia. However, the genetic underpinnings of schizotypy remain unexplored. The authors examined the relationship between single nucleotide poly-morphisms (SNPs) and schizotypy. A sample of 137 subjects (43 healthy controls, 34 subjects with schizotypal personality disorder [SPD], 32 with borderline personality disorder, and 25 with other personality disorders) completed the Schizotypal Personality Questionnaire (SPQ). Subjects were genotyped using a custom array chip. Principal component analysis was used to cluster SPQ variables. Linear regression tested for associations between dimensional schizotypy and SNPs. Logistic regression tested for associations between SNPs and SPD diagnosis. There were significant associations between the minor alleles of three SNPs within the glycine receptor alpha 1 subunit (GLRA1) and the disorganized schizotypy dimension, even after Bonferroni correction. There were no significant associations between any SNPs and the categorical SPD diagnosis. Glycine receptor pathways may have an impact on dimensional traits of psychosis.

scholarly journals Non-syndromic cleft palate: Association analysis on three gene polymorphisms of the folate pathway in Asian and Italian populations

2019 ◽  
Vol 33 ◽  
pp. 205873841985857 ◽  
Author(s):  
Francesco Carinci ◽  
Annalisa Palmieri ◽  
Luca Scapoli ◽  
Francesca Cura ◽  
Francesco Borelli ◽  
...  
Keyword(s):  
Cleft Palate ◽  
Cleft Lip ◽  
Folic Acid Supplementation ◽  
Nucleotide Polymorphisms ◽  
Orofacial Clefts ◽  
Single Nucleotide ◽  
Candidate Gene Association ◽  
Folate Pathway ◽  
Family Based ◽  
Gene Association Study

Periconceptional folic acid supplementation can reduce the risk of inborn malformations, including orofacial clefts. Polymorphisms of MTHFR, TCN2, and CBS folate-related genes seem to modulate the risk of cleft lip with or without cleft palate (CL/P) in some populations. CL/P and cleft palate only (CPO) are different malformations that share several features and possibly etiological causes. In the present investigation, we conducted a family-based, candidate gene association study of non-syndromic CPO. Three single nucleotide polymorphisms, namely, rs1801133 of MTHFR, rs1801198 of TCN2, and rs4920037 of CBS, were investigated in a sample that included 129 Italian and 65 Asian families. No evidence of association between the three genotyped polymorphisms and CPO was found in the Italian and Asian cases, indeed the transmission disequilibrium test did not detect any asymmetry of transmission of alleles. This investigation, although with some limitation, further supports that CL/P and CPO diverge in their genetic background.

PERCEIVED PARENTING STYLES AND DISORDERED PERSONALITY TRAITS IN ADOLESCENT AND ADULT STUDENTS AND IN PERSONALITY DISORDER PATIENTS

2007 ◽  
Vol 35 (5) ◽  
pp. 587-598 ◽  
Author(s):  
Rongrong Yu ◽  
Zhi Wang ◽  
Fuyong Qian ◽  
Kerry L. Jang ◽  
W. John Livesley ◽  
...  
Keyword(s):  
Personality Disorder ◽  
Adult Students ◽  
Personality Disorders ◽  
Parenting Styles ◽  
Parental Bonding ◽  
Principal Component ◽  
Perceived Parenting ◽  
Three Samples ◽  
Dimensional Assessment ◽  
The Relationship

To examine the relationship between perceptions of parenting and personality, the Parental Bonding Instrument (PBI; Parker, Tupling, & Brown, 1979) and the Dimensional Assessment of Personality Pathology – Basic Questionnaire (DAPP; Livesley & Jackson, in press) were administered to 167 adolescent and 422 adult students, as well as to 198 patients with personality disorders. Principal component analysis of the PBI yielded 3 factors in all three samples: Care, Freedom Control, and Autonomy Denial. Chinese personality disorder patients perceived less parental Care than did adolescent and adult students, more paternal Freedom Control than did adults, and more paternal Autonomy Denial than did adolescents. Most regression coefficients between PBI and DAPP scales were moderate, but consistent with previous literature. These findings are similar to those found in the non-Chinese samples, suggesting that parental bonding is important in the development of personality disorders across different nations.

Schizotypal personality disorder in clinical obsessive–compulsive disorder samples: a brief overview

CNS Spectrums ◽  
2020 ◽  
pp. 1-13
Author(s):  
Luigi Attademo ◽  
Francesco Bernardini
Keyword(s):  
Personality Disorder ◽  
Obsessive Compulsive Disorder ◽  
Schizotypal Personality Disorder ◽  
Obsessive Compulsive ◽  
Schizotypal Personality ◽  
Compulsive Disorder ◽  
Schizophrenia Spectrum ◽  
Categorical Diagnosis ◽  
Psychotic Features ◽  
The Relationship

Abstract Obsessive–compulsive disorder (OCD) is a chronic and disabling mental disorder characterized by the presence of obsessions and/or compulsions that cause major distress and impair important areas of functioning. About 9 out of 10 patients with OCD have comorbid psychiatric diagnoses. A high proportion of clinically diagnosed OCD patients fulfill diagnostic criteria of a schizophrenia spectrum disorder, to the point that significant evidence in the literature supports the existence and the clinical relevance of a schizo-obsessive spectrum of disorders, including schizotypal personality disorder (SPD) with OCD (schizotypal OCD). In this paper, we provide a brief but comprehensive analysis of the literature on the clinical coexistence between OCD and SPD. The clinical validity of the so-called schizotypal OCD is analyzed through a comprehensive investigation of the relationship between SPD features and obsessive–compulsive phenomena in clinical OCD samples. This review describes the potential connections between OCD and SPD on the epidemiological, sociodemographic, psychopathological, and clinical levels. SPD is commonly observed in OCD patients: about 10% of OCD patients have a full categorical diagnosis of SPD. Early clinical identification of SPD features—and, more generally, of psychotic features and personality disorders—in OCD patients is strongly recommended. In fact, a proper and early diagnosis with early treatment may have benefits for prognosis. However, although schizotypal OCD seems to have clinical and predictive validity, further neurobiological and genetic studies on etiological specificity are warranted.

What Does Human Development Index Rating Mean in Terms of Individualism/Collectivism?

2003 ◽  
Vol 8 (2) ◽  
pp. 97-100 ◽  
Author(s):  
Maria José Sotelo ◽  
Luis Gimeno
Keyword(s):  
Human Development ◽  
Human Development Index ◽  
Principal Component ◽  
General Idea ◽  
Development Index ◽  
Low Levels ◽  
The Relationship

The authors explore an alternative way of analyzing the relationship between human development and individualism. The method is based on the first principal component of Hofstede's individualism index in the Human Development Index rating domain. Results suggest that the general idea that greater wealth brings more individualism is only true for countries with high levels of development, while for middle or low levels of development the inverse is true.

HUBUNGAN KEPADATAN BIVALVIA DENGAN PARAMETER LINGKUNGAN DI PESISIR TANJUNG PURA KABUPATEN BANGKA TENGAH

2020 ◽  
Vol 13 (2) ◽  
pp. 112-121
Author(s):  
Sudiyar . ◽  
Okto Supratman ◽  
Indra Ambalika Syari
Keyword(s):  
Negative Impact ◽  
Principal Component ◽  
Environmental Parameters ◽  
Data Retrieval ◽  
Distribution Patterns ◽  
Random System ◽  
System Method ◽  
Relationship Of ◽  
The Relationship ◽  
Anadara Granosa

The destructive fishing feared will give a negative impact on the survival of this organism. This study aims to analyze the density of bivalves, distribution patterns, and to analyze the relationship of bivalves with environmental parameters in Tanjung Pura village. This research was conducted in March 2019. The systematic random system method was used for collecting data of bivalves. The collecting Data retrieval divided into five research stasions. The results obtained 6 types of bivalves from 3 families and the total is 115 individuals. The highest bivalve density is 4.56 ind / m², and the lowest bivalves are located at station 2,1.56 ind / m²,  The pattern of bivalve distribution in the Coastal of Tanjung Pura Village is grouping. The results of principal component analysis (PCA) showed that Anadara granosa species was positively correlated with TSS r = 0.890, Dosinia contusa, Anomalocardia squamosa, Mererix meretrix, Placamen isabellina, and Tellinella spengleri were positively correlated with currents r = 0.933.

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