scholarly journals Borderline Personality Traits and Substance Use: Genetic Factors Underlie the Association With Smoking and Ever Use of Cannabis, but Not With High Alcohol Consumption

2012 ◽  
Vol 26 (6) ◽  
pp. 867-879 ◽  
Author(s):  
Marijn A. Distel ◽  
Tim J. Trull ◽  
Marleen M. H. de Moor ◽  
Jacqueline M. Vink ◽  
Lot M. Geels ◽  
...  
Keyword(s):  
Substance Use ◽  
Alcohol Consumption ◽  
Personality Traits ◽  
Genetic Factors ◽  
Borderline Personality ◽  
High Alcohol ◽  
High Alcohol Consumption ◽  
Borderline Personality Traits

scholarly journals Potential influence of socioeconomic status on genetic correlations between alcohol consumption measures and mental health

2019 ◽  
Vol 50 (3) ◽  
pp. 484-498 ◽  
Author(s):  
Andries T. Marees ◽  
Dirk J. A. Smit ◽  
Jue-Sheng Ong ◽  
Stuart MacGregor ◽  
Jiyuan An ◽  
...  
Keyword(s):  
Mental Health ◽  
Substance Use ◽  
Alcohol Consumption ◽  
Genetic Correlations ◽  
High Alcohol ◽  
Genetic Associations ◽  
Potential Influence ◽  
High Alcohol Consumption ◽  
Genome Wide ◽  
Consumption Frequency

AbstractBackground. Frequency and quantity of alcohol consumption are metrics commonly used to measure alcohol consumption behaviors. Epidemiological studies indicate that these alcohol consumption measures are differentially associated with (mental) health outcomes and socioeconomic status (SES). The current study aims to elucidate to what extent genetic risk factors are shared between frequency and quantity of alcohol consumption, and how these alcohol consumption measures are genetically associated with four broad phenotypic categories: (i) SES; (ii) substance use disorders; (iii) other psychiatric disorders; and (iv) psychological/personality traits.Methods. Genome-Wide Association analyses were conducted to test genetic associations with alcohol consumption frequency (N = 438 308) and alcohol consumption quantity (N = 307 098 regular alcohol drinkers) within UK Biobank. For the other phenotypes, we used genome-wide association studies summary statistics. Genetic correlations (rg) between the alcohol measures and other phenotypes were estimated using LD score regression.Results. We found a substantial genetic correlation between the frequency and quantity of alcohol consumption (rg = 0.52). Nevertheless, both measures consistently showed opposite genetic correlations with SES traits, and many substance use, psychiatric, and psychological/personality traits. High alcohol consumption frequency was genetically associated with high SES and low risk of substance use disorders and other psychiatric disorders, whereas the opposite applies for high alcohol consumption quantity.Conclusions. Although the frequency and quantity of alcohol consumption show substantial genetic overlap, they consistently show opposite patterns of genetic associations with SES-related phenotypes. Future studies should carefully consider the potential influence of SES on the shared genetic etiology between alcohol and adverse (mental) health outcomes.

Innate gut microbiota predisposes to high alcohol consumption

2021 ◽  
Author(s):  
Fernando Ezquer ◽  
Maria Elena Quintanilla ◽  
Francisco Moya‐Flores ◽  
Paola Morales ◽  
José Manuel Munita ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Gut Microbiota ◽  
High Alcohol ◽  
High Alcohol Consumption

scholarly journals Association between alcohol consumption status and obesity-related comorbidities in men: data from the 2016 Korean community health survey

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Bo-Yeon Kim ◽  
Hyewon Nam ◽  
Jeong-Ju Yoo ◽  
Yoon-Young Cho ◽  
Dug-Hyun Choi ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Binge Drinking ◽  
Community Health ◽  
Health Survey ◽  
High Alcohol ◽  
High Alcohol Consumption ◽  
Community Health Survey ◽  
Alcoholic Drinks ◽  
Binge Drinkers ◽  
Obesity Hypertension

Abstract Background This study was performed to investigate the association between the amount of alcohol consumption or binge drinking and obesity-related comorbidities in Korean men. Methods A total of 103,048 men aged 19 years or older were investigated in the 2016 Korean Community Health Survey. The participants were divided into five groups according to the standard number of alcoholic drinks consumed per week. Results Of the total participants, 20.7% were in the high alcohol consumption group, consuming more than 28 drinks per week. After adjustment for clinical factors, high alcohol consumption was significantly associated with higher odds ratios (ORs) of obesity (OR, 1.449; 95% confidence interval [CI], 1.412 to 1.591; P < 0.0001), hypertension (OR, 1.76; 95% CI, 1.636 to 1.894; P < 0.0001), and dyslipidemia (OR, 1.356; 95% CI, 1.247 to 1.474; P < 0.0001). In contrast, mild to moderate alcohol consumption was associated with a lower risk of diabetes (OR, 0.799; 95% CI, 0.726 to 0.88; P = 0.0015) and high alcohol consumption was not associated with a higher risk of diabetes (OR, 0.945; 95% CI, 0.86 to 1.039; P = 0.0662). Among drinkers, except for social drinkers, binge drinking was significantly associated with higher risks of obesity, hypertension, diabetes, and dyslipidemia. Conclusions High alcohol consumption was associated with higher risks of obesity, hypertension, and dyslipidemia in Korean men. In contrast, high consumption was not associated with a higher risk of diabetes. In particular, binge drinkers were associated with higher risks of obesity, hypertension, diabetes, and dyslipidemia compared to non-binge drinkers.

scholarly journals Cancers due to smoking and high alcohol consumption

2018 ◽  
Author(s):  
Ute Mons ◽  
Thomas Gredner ◽  
Gundula Behrens ◽  
Christian Stock ◽  
Hermann Brenner
Keyword(s):  
Alcohol Consumption ◽  
High Alcohol ◽  
High Alcohol Consumption

Screening for depression with the Edinburgh Postnatal Depression Scale and finding borderline personality disorder

2018 ◽  
Vol 53 (5) ◽  
pp. 424-432 ◽  
Author(s):  
Fiona Judd ◽  
Stephanie Lorimer ◽  
Richard H Thomson ◽  
Angela Hay
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Personality Traits ◽  
Pregnant Women ◽  
Postnatal Depression ◽  
Edinburgh Postnatal Depression Scale ◽  
Past History ◽  
Depression Scale ◽  
Borderline Personality ◽  
Borderline Personality Traits

Objective: The aim of the study was to explore the range of psychiatric diagnoses seen in pregnant women who score above the ‘cut-off’ on the Edinburgh Postnatal Depression Scale when this is used as a routine screening instrument in the antenatal period. Method: Subjects were all pregnant women referred to and seen by the Perinatal Consultation-Liaison Psychiatry Team of a tertiary public hospital over a 14-month period. Edinburgh Postnatal Depression Scale score at maternity ‘booking-in’ visit, demographic and clinical data were recorded and diagnoses were made according to Diagnostic and Statistical Manual of Mental Disorders (5th ed.) criteria following clinical interview(s) and review of documented past history. Data were analysed using descriptive statistics. Results: A total of 200 patients who had completed the Edinburgh Postnatal Depression Scale were seen for assessment; 86 (43%) scored ⩾13 on Edinburgh Postnatal Depression Scale. Of those scoring 13 or more on Edinburgh Postnatal Depression Scale, 22 (25.6%) had a depressive disorder. In total, 12 patients (14%) had an anxiety disorder, 14 (16.3%) had borderline personality disorder and 13 (15.1%) had a substance use disorder. An additional 23 women (26.7%) had two or more borderline personality traits. Conclusion: Psychiatric assessment of women who scored 13 or more on the Edinburgh Postnatal Depression Scale at routine antenatal screening identified a significant number with borderline personality disorder or borderline personality traits rather than depressive or anxiety disorders. Clinical Practice Guidelines note the importance of further assessment for all women who score 13 or more on the Edinburgh Postnatal Depression Scale. The findings here suggest that this assessment should be made by a clinician able to identify personality pathology and organise appropriate and timely interventions.

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