The Role of TGA-DTA in the Initial Evaluation of the Solid State Forms for Pharmaceutical New Chemical Entities, Part 1: Evaluation of Pure Forms

2009 ◽  
pp. 23-23-10
Author(s):  
Nancy L. Redman-Furey ◽  
Michael L. Dicks ◽  
Jane Godlweski ◽  
Dana C. Vaughn ◽  
Wendy J. Collins
Keyword(s):  
Solid State ◽  
Initial Evaluation ◽  
New Chemical Entities

scholarly journals Understanding solid-state processing of pharmaceutical cocrystals via milling: Role of tablet excipients

2021 ◽  
Vol 601 ◽  
pp. 120514 ◽  
Author(s):  
Rahamatullah Shaikh ◽  
Saeed Shirazian ◽  
Sarah Guerin ◽  
Eoin Sheehan ◽  
Damien Thompson ◽  
...  
Keyword(s):  
Solid State ◽  
Pharmaceutical Cocrystals ◽  
Tablet Excipients ◽  
State Processing

The Role of Microscopy in Preclinical Safety Assessment

2000 ◽  
Vol 6 (S2) ◽  
pp. 998-999
Author(s):  
Barbara J. Dovey-Hartman
Keyword(s):  
Electron Microscopy ◽  
Vital Role ◽  
Pathology Report ◽  
Clinical Phase ◽  
Transmission Electron ◽  
New Chemical Entities ◽  
Regulatory Submissions ◽  
Hematoxylin And Eosin ◽  
Preclinical Safety

Microscopy plays a vital role in assessing the safety of New Chemical Entities (NCE) in the pre-clinical phase of drug development. Light microscopy (LM), transmission electron microscopy (TEM) and scanning electron microscopy (SEM) are used at the Schering-Plough Research Institute (SPRI) for evaluation of NCE. To support regulatory submissions, NCE are routinely tested in rodents in short-term studies such as one-month toxicity studies, and in longterm studies such as oncogenicity studies that may last 24 months. At the completion of a study, the animals are necropsied and the required tissues collected and stored in fixative. The tissues for LM are processed to slides and stained with Hematoxylin and Eosin (H&E). The information derived from the examination of these tissues by LM becomes an essential part of the pathology report. The LM examination of these tissues usually yields the information needed to either progress a NCE or otherwise deter or halt development.

The Role of Protons and Formation Cu(NH3)2+ During Ammonia-Assisted Solid-State Ion Exchange of Copper(I) Oxide into Zeolites

2018 ◽  
Vol 62 (1-4) ◽  
pp. 100-107 ◽  
Author(s):  
Peter N. R. Vennestrøm ◽  
Lars F. Lundegaard ◽  
Christoffer Tyrsted ◽  
Dmitriy A. Bokarev ◽  
Alina I. Mytareva ◽  
...  
Keyword(s):  
Solid State ◽  
Ion Exchange

Role of solid-state structure in propene hydrogenation with nickel catalysts

1990 ◽  
Vol 86 (4) ◽  
pp. 739 ◽  
Author(s):  
Giovanni Carturan ◽  
Stefano Enzo ◽  
Renzo Ganzerla ◽  
Maurizio Lenarda ◽  
Roberto Zanoni
Keyword(s):  
Solid State ◽  
Nickel Catalysts ◽  
State Structure ◽  
Solid State Structure

scholarly journals Electrochemiluminescence Study of Europium (III) Complex with Coumarin3-Carboxylic Acid

2008 ◽  
Vol 2008 ◽  
pp. 1-6 ◽  
Author(s):  
Stefan Lis ◽  
Krzysztof Staninski ◽  
Tomasz Grzyb
Keyword(s):  
Aqueous Solution ◽  
Spectral Analysis ◽  
Energy Transfer ◽  
Solid State ◽  
Carboxylic Acid ◽  
Elemental Analysis ◽  
Aluminium Electrode ◽  
The Eu

The europium (III) complex of coumarin-3-carboxylic acid (C3CA) has been prepared and characterized on the basis of elemental analysis, IR, and emission (photoluminescence and electrochemiluminescence) spectroscopy. The synthesised complex having a formula Eu was photophysically characterized in solution and in the solid state. Electrochemiluminescence, ECL, of the system containing the Eu(III)/C3CA complex was studied using an oxide-covered aluminium electrode. The goal of these studies was to show the possibility of the use of electrochemical excitation of the Eu(III) ion in aqueous solution for emission generation. The generated ECL emission was very weak, and therefore its measurements and spectral analysis were carried out with the use of cut-off filters method. The studies proved a predominate role of the ligand-to-metal energy transfer (LMET) in the generated ECL.

Investigation of the role of anions in hydrotalcite for quasi-solid state dye-sensitized solar cells application

2013 ◽  
Vol 1 (13) ◽  
pp. 4345 ◽  
Author(s):  
Xiu Wang ◽  
Ran Deng ◽  
Sneha A. Kulkarni ◽  
Xiaoyan Wang ◽  
Stevin Snellius Pramana ◽  
...  
Keyword(s):  
Solar Cells ◽  
Solid State ◽  
Dye Sensitized Solar Cells ◽  
Dye Sensitized ◽  
Sensitized Solar Cells
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