Research Needs in Validating and Determining the Predictability of Laboratory Data to the Field

2008 ◽  
pp. 61-61-6 ◽  
Author(s):  
TP Boyle
Keyword(s):  
Laboratory Data ◽  
Research Needs

Antipsychotic Use and the Risk of Rhabdomyolysis

2014 ◽  
Vol 27 (5) ◽  
pp. 501-512 ◽  
Author(s):  
Kathleen Packard ◽  
Paul Price ◽  
Ashley Hanson
Keyword(s):  
United States ◽  
Adverse Effect ◽  
Risk Factor ◽  
Antipsychotic Drug ◽  
Laboratory Data ◽  
The United States ◽  
Patient Specific ◽  
Research Needs ◽  
Concomitant Medications ◽  
The Relationship

Rhabdomyolysis is not a well-understood adverse effect of antipsychotic use. Proposed mechanisms suggest involvement of serotoninergic and/or dopaminergic blockade. The purpose of this study was to describe the relationship between antipsychotic use and rhabdomyolysis. Patients admitted with rhabdomyolysis and taking an antipsychotic from January 2009 to October 2011 were included. Background demographics, laboratory data, medical and physical history, concomitant medications, and hospital course data were collected. Of the 673 cases admitted with rhabdomyolysis, 71 (10.5%) were on an antipsychotic. This is significantly greater when compared to the general US population, where only 1.3% of individuals take an antipsychotic drug ( P < .0001). Cause of rhabdomyolysis was not documented in 38% of cases, and antipsychotic use was suspected in 10% of cases. No significant correlations were found between antipsychotic type and other patient-specific parameters. Seventeen (25%) of these patients were taking 2 or more antipsychotics. The largest percentage was on quetiapine (Seroquel®; AstraZeneca, Wilmington, Delaware), the most commonly prescribed antipsychotic in the United States. Antipsychotic use is a risk factor for rhabdomyolysis and seems to be more common in those taking multiple agents. More research needs to be done to determine which antipsychotics have a higher risk and which receptors are involved. Providers should be aware of rhabdomyolysis associated with antipsychotic use.

Understanding Limited Use of Amplification in Infants and Children Who Are Hard of Hearing

2015 ◽  
Vol 25 (1) ◽  
pp. 15-23 ◽  
Author(s):  
Ryan W. McCreery ◽  
Elizabeth A. Walker ◽  
Meredith Spratford
Keyword(s):  
Hard Of Hearing ◽  
Hearing Aid ◽  
Management Strategies ◽  
Infants And Children ◽  
Future Research ◽  
Research Needs ◽  
Case Examples ◽  
Hearing Aid Use ◽  
Wide Range ◽  
In Infants And Children

The effectiveness of amplification for infants and children can be mediated by how much the child uses the device. Existing research suggests that establishing hearing aid use can be challenging. A wide range of factors can influence hearing aid use in children, including the child's age, degree of hearing loss, and socioeconomic status. Audiological interventions, including using validated prescriptive approaches and verification, performing on-going training and orientation, and communicating with caregivers about hearing aid use can also increase hearing aid use by infants and children. Case examples are used to highlight the factors that influence hearing aid use. Potential management strategies and future research needs are also discussed.

Locus of Control, Safety Attitudes and Involvement in Hazardous Events in Indian Army Aviators

2013 ◽  
Vol 3 (1) ◽  
pp. 9-18 ◽  
Author(s):  
Catherine Joseph ◽  
Suhasini Reddy ◽  
Kanwal Kashore Sharma
Keyword(s):  
Locus Of Control ◽  
Future Research ◽  
Research Needs ◽  
Negative Attitudes ◽  
Human Errors ◽  
Safety Attitudes ◽  
Positive Correlation ◽  
Self Confidence

Locus of control (LOC), safety attitudes, and involvement in hazardous events were studied in 205 Indian Army aviators using a questionnaire-based method. A positive correlation was found between external LOC and involvement in hazardous events. Higher impulsivity and anxiety, and decreased self-confidence, safety orientation, and denial were associated with a greater number of hazardous events. Higher external LOC was associated with higher impulsivity, anxiety, and weather anxiety and with lower self-confidence, safety orientation, and denial. Internal LOC was associated with increased self-confidence, safety orientation, and denial. Hazardous events and self-confidence were higher in those involved in accidents than those not involved in accidents. Future research needs to address whether training can effectively modify LOC and negative attitudes, and whether this would cause a reduction in, and better management of, human errors.

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