Biocompatibility and an Enhanced Acute Inflammatory Phase Model

2008 ◽  
pp. 251-251-16 ◽  
Author(s):  
RE Marchant ◽  
T Sugie ◽  
A Hiltner ◽  
JM Anderson
Keyword(s):  
Phase Model ◽  
Inflammatory Phase

Leadership and member voice in action teams: Test of a dynamic phase model.

2018 ◽  
Vol 103 (1) ◽  
pp. 97-110 ◽  
Author(s):  
Crystal I. C. Farh ◽  
Gilad Chen
Keyword(s):  
Phase Model ◽  
Dynamic Phase

Two-phase model for human classical conditioning.

1968 ◽  
Vol 78 (3, Pt.1) ◽  
pp. 359-368 ◽  
Author(s):  
William F. Prokasy ◽  
Martha A. Harsanyi
Keyword(s):  
Classical Conditioning ◽  
Phase Model ◽  
Two Phase

Phase Model of Market Economy

2005 ◽  
pp. 41-47 ◽  
Author(s):  
N. Yegorenkov ◽  
E. Kazakova ◽  
M. Starodubtseva
Keyword(s):  
Market Economy ◽  
Consumer Goods ◽  
Imperfect Competition ◽  
Phase Model ◽  
Status Change ◽  
Means Of Production

The phase model of market economy is suggested in the article. It is formalized in the cubical equation The equation takes into account the imperfections of competition and the fact that consumer goods are produced with the help of means of production. Transitions from the imperfect competition to the perfect one and visa versa yield qualitative status change of market economy.

PHENOTYPIC HETEROGENEITY OF CARDIAC MACROPHAGES DURING WOUND HEALING FOLLOWING MYOCARDIAL INFARCTION: PERSPECTIVES IN CLINICAL RESEARCH

2018 ◽  
Vol 33 (2) ◽  
pp. 70-76 ◽  
Author(s):  
A. E. Gombozhapova ◽  
Yu. V. Rogovskaya ◽  
M. S. Rebenkova ◽  
J. G. Kzhyshkowska ◽  
V. V. Ryabov
Keyword(s):  
Myocardial Infarction ◽  
Wound Healing ◽  
Cardiac Remodeling ◽  
Phenotypic Heterogeneity ◽  
Macrophage Infiltration ◽  
Myocardial Regeneration ◽  
Control Group ◽  
M2 Macrophage ◽  
Inflammatory Phase ◽  
Regenerative Phase

Purpose. Myocardial regeneration is one of the most ambitious goals in prevention of adverse cardiac remodeling. Macrophages play a key role in transition from inflammatory to regenerative phase during wound healing following myocardial infarction (MI). We have accumulated data on macrophage properties ex vivo and in cell culture. However, there is no clear information about phenotypic heterogeneity of cardiac macrophages in patients with MI. The purpose of the project was to assess cardiac macrophage infiltration during wound healing following myocardial infarction in clinical settings taking into consideration experimental knowledge.Material and Methods. The study included 41 patients with fatal MI type 1. In addition to routine analysis, macrophages infiltration was assessed by immunohistochemistry. We used CD68 as a marker for the cells of the macrophage lineage, while CD163, CD206, and stabilin-1 were considered as M2 macrophage biomarkers. Nine patients who died from noncardiovascular causes comprised the control group.Results. The intensity of cardiac macrophage infiltration was higher during the regenerative phase than during the inflammatory phase. Results of immunohistochemical analysis demonstrated the presence of phenotypic heterogeneity of cardiac macrophages in patients with MI. We noticed that numbers of CD68+, CD163+, CD206+, and stabilin-1+ macrophages depended on MI phase.Conclusion. Our study supports prospects for implementation of macrophage phenotyping in clinic practice. Improved understanding of phenotypic heterogeneity might become the basis of a method to predict adverse cardiac remodeling and the first step in developing myocardial regeneration target therapy.

Transport of organochlorine pesticides in soil columns enhanced by dissolved organic carbon

1997 ◽  
Vol 35 (7) ◽  
pp. 139-145 ◽  
Author(s):  
Jiann-Yuan Ding ◽  
Shian-Chee Wu
Keyword(s):  
Organic Carbon ◽  
Dissolved Organic Carbon ◽  
Organochlorine Pesticides ◽  
Transport Model ◽  
Phase Model ◽  
Soil Columns ◽  
Two Phase ◽  
Three Phase ◽  
Phase Transport ◽  
Remediation Of Soil

The objective of this study is to quantify the effects of humic acid solution infiltration on the transport of organochlorine pesticides (OCPs) in soil columns using a three-phase transport model. From experimental results, it is found that the dissolved organic carbon enhances the transport of OCPs in the soil columns. In the OCPs-only column, the concentration profiles of OCPs can be simulated well using a two-phase transport model with numerical method or analytical solution. In the OCPs-DOC column, the migrations of aldrin, DDT and its daughter compounds are faster than those in the OCPs-only column. The simulation with the three-phase model is more accurate than that with the two-phase model. In addition, significant decrease of the fluid pore velocities of the OCPs-DOC column was found. When DOC leachate is applied for remediation of soil or groundwater pollution, the decrease of mean pore velocities will be a crucial affecting factor.

Investigation of two-dimensional nonstationary processes of outflow a gas-saturated liquid from axisymmetric vessels

2012 ◽  
Vol 9 (1) ◽  
pp. 47-52
Author(s):  
R.Kh. Bolotnova ◽  
V.A. Buzina
Keyword(s):  
Comparative Analysis ◽  
Numerical Model ◽  
Liquid Mixture ◽  
Phase Model ◽  
Test Problems ◽  
Two Dimensional ◽  
Nonstationary Processes ◽  
Saturated Liquid ◽  
Two Phase ◽  
One Dimensional

The two-dimensional and two-phase model of the gas-liquid mixture is constructed. The validity of numerical model realization is justified by using a comparative analysis of test problems solution with one-dimensional calculations. The regularities of gas-saturated liquid outflow from axisymmetric vessels for different geometries are established.

Rubble Fire Multi-Phase Model Development.

2017 ◽  
Author(s):  
Heeseok Koo ◽  
Alexander Brown ◽  
Tyler Voskuilen ◽  
Flint Pierce
Keyword(s):  
Model Development ◽  
Phase Model ◽  
Multi Phase

Treatment Strategies Against Diabetic Foot Ulcer: Success so far and Road Ahead

2020 ◽  
Vol 16 ◽  
Author(s):  
Ankit Awasthi ◽  
Sachin Kumar Singh ◽  
Bimlesh Kumar ◽  
Monica Gulati ◽  
Rajesh Kumar ◽  
...  
Keyword(s):  
Lower Limb ◽  
Diabetic Foot ◽  
Treatment Strategies ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Arterial Disease ◽  
Current Status ◽  
Limb Amputation ◽  
Bibliographic Databases ◽  
Inflammatory Phase

Background: Diabetic foot ulcer (DFU) is one of the leading complications of type-2 diabetes mellitus. It isassociated with neuropathy and peripheral arterial disease of the lower limb in patients with diabetes. Basically, there are four stages of wound healing namely hemostasis phase, inflammatory phase, proliferative phase and maturation phase. In case of DFU, all these stages are disturbed which lead to delay in healing and consequently to lower limb amputation. Traditionally the dosage forms like tablets, creams, ointments, gels and capsules have been used for the treatment of diabetic foot ulcer from many years. Introduction: In this review the global prevalence as well as etiopathogenesis related to diabetic foot ulcer has been discussed. Potential role of various synthetic and herbal drugs as well as their conventional dosage form for the effective management of diabetes foot ulcer has been highlighted. Methods: Structured search of bibliographic databases for previously published peer-reviewed research papers was explored and data was culminated in terms of various approaches that are used for the treatment of diabetic foot ulcer. Results: About 142 papers including both, research and review articles, were included in this review in order to produce a comprehensive as well as readily understandable article. A series of herbal and synthetic drugs have been discussed along with their current status of treatment in terms of dose and mechanism of action. Conclusion: DFU has become one of the most common complications in patients having more than ten years of diabetes. Hence, understanding the root cause and its successful treatment is a big challenge because it depends upon multiple factors such as judicious selection of drug as well as proper control of blood sugar level. Most of the drugs that have been used so far either belong to the category of antibiotics, antihyperglycaemics or, they have been repositioned. Moreover, in clinical practice, much focus has been given towards dressings that have been used to cover the ulcer. The complete treatment of DFU is still a farfetched dream to be achieved and it is expected that a combination therapy of herbal and synthetic drug with multiple treatment pathway could be able to overcome the disease.

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