Grafts of HTR Polymer Versus Kiel Bone in Experimental Long Bone Defects in Rats

2008 ◽  
pp. 370-370-7
Author(s):  
I Binderman ◽  
M Goldstein ◽  
I Horowitz ◽  
N Fine ◽  
S Taicher ◽  
...  
Keyword(s):  
Bone Defects ◽  
Long Bone

Bone transport over an intramedullary nail for reconstruction of long bone defects in tibia

2007 ◽  
Vol 128 (8) ◽  
pp. 801-808 ◽  
Author(s):  
Chang-Wug Oh ◽  
Hae-Ryong Song ◽  
Jae-Young Roh ◽  
Jong-Keon Oh ◽  
Woo-Kie Min ◽  
...  
Keyword(s):  
Intramedullary Nail ◽  
Bone Defects ◽  
Bone Transport ◽  
Long Bone

scholarly journals Biocompatibility and Bone Formation of Flexible, Cotton Wool-like PLGA/Calcium Phosphate Nanocomposites in Sheep

2011 ◽  
Vol 5 (1) ◽  
pp. 63-71 ◽  
Author(s):  
Oliver D Schneider ◽  
Dirk Mohn ◽  
Roland Fuhrer ◽  
Karina Klein ◽  
Käthi Kämpf ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Antimicrobial Properties ◽  
Drill Hole ◽  
Bone Defects ◽  
Long Bone ◽  
Minimal Amount ◽  
Cotton Wool

Background: The purpose of this preliminary study was to assess the in vivo performance of synthetic, cotton wool-like nanocomposites consisting of a biodegradable poly(lactide-co-glycolide) fibrous matrix and containing either calcium phosphate nanoparticles (PLGA/CaP 60:40) or silver doped CaP nanoparticles (PLGA/Ag-CaP 60:40). Besides its extraordinary in vitro bioactivity the latter biomaterial (0.4 wt% total silver concentration) provides additional antimicrobial properties for treating bone defects exposed to microorganisms. Materials and Methods: Both flexible artificial bone substitutes were implanted into totally 16 epiphyseal and metaphyseal drill hole defects of long bone in sheep and followed for 8 weeks. Histological and histomorphological analyses were conducted to evaluate the biocompatibility and bone formation applying a score system. The influence of silver on the in vivo performance was further investigated. Results: Semi-quantitative evaluation of histology sections showed for both implant materials an excellent biocompatibility and bone healing with no resorption in the adjacent bone. No signs of inflammation were detectable, either macroscopically or microscopically, as was evident in 5 µm plastic sections by the minimal amount of inflammatory cells. The fibrous biomaterials enabled bone formation directly in the centre of the former defect. The area fraction of new bone formation as determined histomorphometrically after 8 weeks implantation was very similar with 20.5 ± 11.2 % and 22.5 ± 9.2 % for PLGA/CaP and PLGA/Ag-CaP, respectively. Conclusions: The cotton wool-like bone substitute material is easily applicable, biocompatible and might be beneficial in minimal invasive surgery for treating bone defects.

Long Bone Defects Treated With Demineralized Bone

1985 ◽  
Vol 78 (8) ◽  
pp. 933-934 ◽  
Author(s):  
LAURENCE E. DAHNERS ◽  
RAE R. JACOBS
Keyword(s):  
Bone Defects ◽  
Long Bone ◽  
Demineralized Bone

scholarly journals Oxidized alginate hydrogels for bone morphogenetic protein-2 delivery in long bone defects

2014 ◽  
Vol 10 (10) ◽  
pp. 4390-4399 ◽  
Author(s):  
Lauren B. Priddy ◽  
Ovijit Chaudhuri ◽  
Hazel Y. Stevens ◽  
Laxminarayanan Krishnan ◽  
Brent A. Uhrig ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Bone Defects ◽  
Bone Morphogenetic Protein 2 ◽  
Long Bone ◽  
Morphogenetic Protein ◽  
Alginate Hydrogels

Glycosylation of DMP1 promotes bone reconstruction in long bone defects

2020 ◽  
Vol 526 (4) ◽  
pp. 1125-1130
Author(s):  
Hui Xue ◽  
Pingping Niu ◽  
Yang Liu ◽  
Yao Sun
Keyword(s):  
Bone Defects ◽  
Long Bone ◽  
Bone Reconstruction

Designing microtissue bioassemblies for skeletal regeneration: Healing critical size long bone defects

Cytotherapy ◽  
2018 ◽  
Vol 20 (5) ◽  
pp. S14
Author(s):  
G. Nilsson Hall ◽  
L. Mendes ◽  
L. Geris ◽  
I. Papantoniou ◽  
F. Luyten
Keyword(s):  
Critical Size ◽  
Bone Defects ◽  
Long Bone ◽  
Skeletal Regeneration
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