Resorption Profile and Biological Response of Calcium Phosphate filled PLLA and PHB7V

2008 ◽  
pp. 69-69-14 ◽  
Author(s):  
NL Jones ◽  
JJ Cooper ◽  
RD Waters ◽  
DF Williams
Keyword(s):  
Calcium Phosphate ◽  
Biological Response

Research on the In Situ Fabrication of Bioceramic Composite Coatings by Laser Cladding

2007 ◽  
Vol 330-332 ◽  
pp. 625-628
Author(s):  
Ying Chun Wang ◽  
Jian Guo Li ◽  
Yaohe Zhou
Keyword(s):  
Calcium Phosphate ◽  
Laser Cladding ◽  
Composite Coatings ◽  
Biological Response ◽  
Ceramic Coatings ◽  
Calcium Pyrophosphate ◽  
Research Field ◽  
Cladding Layer ◽  
In Situ Fabrication ◽  
Cellular Microstructure

Hydroxyapatite(HAP) has excellent osteoconductive properties. By controlling the Ca/P ratio better biphasic calcium phosphate ceramics can be produced than pure HAP ceramics. β- calcium pyrophosphate(β-Ca2P2O7) is a new biodegradable ceramic material and its biological response is quite similar to HAP. Obtaining HAP and other bioactive calcium phosphate ceramic coatings has been a popular research field in the past. In our research a new bioceramic composite coating was obtained by laser cladding with pre-depositing mixed powders of CaHPO4·2H2O and CaCO3 directly on the metal substrate. Its main constituents are HAP and β-Ca2P2O7. The microstructure of the coating consists of minute granular HAP that is distributed among the overlapped club-shaped or needle-like β-Ca2P2O7. The hardness distribution in the cladding layer is even and its value is much higher than that in the substrate. There is a bonded structure of the epitaxial planar growth between the substrate and cladding layer, and both a typical cellular microstructure in the middle and an equiaxed microstructure at the top of the cladding layer.

scholarly journals Calcium Phosphate Based Bioactive Ceramic Layers on Implant Materials Preparation, Properties, and Biological Performance

Coatings ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 823
Author(s):  
Monika Furko ◽  
Csaba Balázsi
Keyword(s):  
Calcium Phosphate ◽  
Current Density ◽  
Pulse Current ◽  
Ph Value ◽  
Biological Response ◽  
Biological Properties ◽  
Implant Materials ◽  
Foreign Materials ◽  
Biological Performance ◽  
Implant Coatings

Calcium phosphate based bioactive ceramics (CPCs) can be successfully applied as implant coatings since they are chemically similar to the inorganic constituent of hard tissues (bones, teeth). Nowadays, in orthopedic surgeries, it is still common to use metallic implants. However, the biological response of the human body to these foreign materials can be adverse, causing the failure of implant materials. This disadvantage can be avoided by bioactive coatings on the surface of implants. CPCs can be prepared by different routes that provide coatings of different quality and properties. In our paper, we compared the morphological, chemical, and biological properties of CPC coatings prepared by the pulse current electrochemical method. The size and thickness of the pulse current deposited platelets largely depended on the applied parameters such as the length of ton and the current density. The decrease in the ton/toff ratio resulted in thinner, more oriented platelets, while the increase in current density caused a significant decrease in grain size. The higher pH value and the heat treatment favored the phase transformation of CPCs from monetite to hydroxyapatite. The contact angle measurements showed increased hydrophilicity of the CPC sample as well as better biocompatibility compared to the uncoated implant material.

Processing and Characterization of a Composite of Hyaluronic Acid (HA) and Microspheres Biphasic Calcium Phosphate (BCP) for Dermal Repair

2012 ◽  
Vol 529-530 ◽  
pp. 421-425
Author(s):  
Edirlaine Soares Silva ◽  
Deny Gomes de Freitas ◽  
Sidney Nicodemos da Silva
Keyword(s):  
Hyaluronic Acid ◽  
Calcium Phosphate ◽  
Soft Tissue ◽  
Biphasic Calcium Phosphate ◽  
Soft Tissues ◽  
Biological Response ◽  
Water Soluble ◽  
Potential Candidate ◽  
Dermal Fillers

Dermal fillers are injectable implants made of biological materials (collagen, autologous fat and hyaluronic acid animal) or synthetic (PMMA microparticles of hydroxyapatite and non-animal hyaluronic acid), biodegradable or not, that include features such as ideal biocompatibility, durability, non-profile migration and ability to promote a smooth, natural-looking correction. Its main indication is intended to treat contour defects caused by aging, photo damage, disease, trauma or scarification. The fact of biodegradable fillers are absorbed within a year after application resulted in the emergence of products permanent and semi-permanent to offer patients long-lasting effects. Currently, one of the most effective strategies has been the development of scaffolds formed by combining two or more biomaterials seeking the restoration of tissue function. The bioceramic associated with water-soluble polymers have been developed as substitutes for the repair of soft tissues with optimal biological response. The objective of this study was to process and characterize a composite hydrogel in the form of hyaluronic acid (HA) microspheres and biphasic calcium phosphate (BCP) in order injectable applications for repair of soft tissue. The powders of HA and BCP were characterized by Infrared Spectroscopy Fourier Transform (FTIR) and X-ray diffraction (XRD) and Scanning Electron Microscopy (SEM). The characterization of the hydrogel injectability pure and the composite with different ratios of HA and BCP was performed. The components were characterized compatible for use as dermal fillers. The composite of hyaluronic acid (HA) and biphasic calcium phosphate (BCP) had adequate characterization and injetabilidade proving to be a potential candidate for restoration of soft tissue.

High-Porosity Poly(ε-Caprolactone)/Mesoporous Silicon Scaffolds: Calcium Phosphate Deposition and Biological Response to Bone Precursor Cells

2008 ◽  
Vol 14 (1) ◽  
pp. 195-206 ◽  
Author(s):  
Melanie A. Whitehead ◽  
Dongmei Fan ◽  
Priyabrata Mukherjee ◽  
Giridhar R. Akkaraju ◽  
Leigh T. Canham ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Biological Response ◽  
Precursor Cells ◽  
High Porosity ◽  
Mesoporous Silicon

Fabrication of Nanostructured Hierarchical Coatings Composed of Calcium Phosphate/Titanate on Titanium Substrate

2013 ◽  
Vol 575-576 ◽  
pp. 253-258
Author(s):  
Cheng Dong Zhang ◽  
Dong Qin Xiao ◽  
Ya Kang Fu ◽  
Ke Duan ◽  
Xiong Lu ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Hydrothermal Process ◽  
Titanium Substrate ◽  
Biological Response ◽  
Hydrothermal Conditions ◽  
Implant Surface ◽  
Bone Implant ◽  
Two Temperatures ◽  
Dental Applications ◽  
Phosphate Solutions

Titanium (Ti) and its alloys have been widely used in orthopedic and dental applications. The bonding between Ti implants and tissues is significantly important in the clinical applications, which is highly relative to the characteristics of implant surface with surface improvement by various coatings such as hydroxyapatite (HA). Meanwhile, the characteristics of modified implants surface can induce special biological response of osteogenic cells to improve the bone-implant bonding. In this paper, in order to improve Ti bioactivity and enhance its osteointegration, calcium phosphate (CaP)/titanate coatings were prepared on Ti with nanoscale surface topographies by a two-step hydrothermal process. Firstly, titanium meshes were treated in sodium hydroxide solutions at two temperatures (200 °C or 240 °C). Then, the treated meshes were immersed in calcium phosphate solutions containing various concentrations of cyclohexane-hexacarboxylic acid (H6L) under hydrothermal conditions. After this two-step process, calcium phosphate deposits, confirmed to be apatite/titanate by energy dispersive X-ray spectroscopy, were successfully formed on the treated Ti mesh surface. These results suggested that this two-step hydrothermal method can be successfully applied to fabricate robust and hierarchical nanostructured coatings of CaP/titanate on Ti implants.

Effect of Calcination Conditions on Phase Formation of Calcium Phosphates Ceramics Synthesized by Homogeneous Precipitation

2006 ◽  
Vol 530-531 ◽  
pp. 612-617 ◽  
Author(s):  
Dolores Ribeiro Ricci Lazar ◽  
Sandra Maria Cunha ◽  
Valter Ussui ◽  
E. Fancio ◽  
Nelson Batista de Lima ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Calcium Phosphates ◽  
Biological Response ◽  
Phase Evolution ◽  
Atomic Ratio ◽  
Biochemical Properties ◽  
X Ray Diffraction ◽  
Calcium Phosphate Ceramic ◽  
Ammonium Hydrogen ◽  
Ammonium Hydrogen Phosphate

Phase composition of calcium phosphate ceramics is a characteristic directly related to the biological response of implants due to the differences in mechanical and biochemical properties of these compounds. In this sense, it was evaluated in this work the crystalline phase evolution of calcium phosphates samples synthesized by wet precipitation route. Fixing Ca/P atomic ratio as 1.67, precipitation was carried out from heated aqueous solutions of calcium chloride and ammonium hydrogen phosphate, in ammonium medium (pH = 10). After washing and drying steps, calcination was performed at 600 to 1100 oC for 1 and 3 hours. Milled and pressed powders were sintered at 1250 oC for 1 hour. Samples were characterized by X-ray diffraction, chemical analysis, scanning electron microscopy, gaseous adsorption, laser diffraction and apparent density measurements. Results indicate the formation of a biphasic calcium phosphate ceramic containing hydroxyapatite as a major phase and β - tricalcium phosphate, the later obtained by heat treatment above 600 oC.

High-Porosity Poly(ε-Caprolactone)/Mesoporous Silicon Scaffolds: Calcium Phosphate Deposition and Biological Response to Bone Precursor Cells

2008 ◽  
Vol 14 (1) ◽  
pp. 195-206 ◽  
Author(s):  
Melanie A. Whitehead ◽  
Dongmei Fan ◽  
Priyabrata Mukherjee ◽  
Giridhar R. Akkaraju ◽  
Leigh T. Canham ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Biological Response ◽  
Precursor Cells ◽  
High Porosity ◽  
Mesoporous Silicon
Sign in / Sign up

Export Citation Format

Share Document