Improved Formulations through Synergistic Combinations based on Alkyl Glucosides

2008 ◽  
pp. 41-41-10
Author(s):  
K Bergström ◽  
IM Johansson
Keyword(s):  
Alkyl Glucosides ◽  
Synergistic Combinations

Improved Formulations through Synergistic Combinations Based on Alkyl Glucosides

2005 ◽  
Vol 2 (7) ◽  
pp. 12160
Author(s):  
SW Dean ◽  
K Bergström ◽  
IM Johansson
Keyword(s):  
Alkyl Glucosides ◽  
Synergistic Combinations

Alkali Metal Cationization of Alkyl Glucosides under Electrospray Ionization Conditions

2005 ◽  
Vol 42 (4) ◽  
pp. 226-228 ◽  
Author(s):  
Joanna Zembrzuska ◽  
Agnieszka Zgoła-Grześkowiak ◽  
Magdalena Frańska
Keyword(s):  
Alkali Metal ◽  
Electrospray Ionization ◽  
Alkyl Glucosides

scholarly journals COMP-09. A CANCER DRUG ATLAS ENABLES PREDICTION OF PARALLEL DRUG VULNERABILITIES OF GLIOBLASTOMA

2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi62-vi63
Author(s):  
Ravi Narayan ◽  
Piet Molenaar ◽  
Fleur Cornelissen ◽  
Tom Wurdinger ◽  
Jan Koster ◽  
...  
Keyword(s):  
Drug Combination ◽  
Drug Response ◽  
Cancer Drug ◽  
Cancer Treatments ◽  
Drug Synergy ◽  
Map Data ◽  
Personalized Cancer ◽  
Synergistic Combinations ◽  
Synergistic Drug Combinations

Abstract Personalized cancer treatments using synergistic combinations of drugs is attractive but proves to be highly challenging. The combinatorial nature of such problems results in an enormous parameter space that cannot be resolved by empirical research, i.e. testing all combinations for all molecularly defined tumors. In addition, effective drug synergy is hard to predict. Here we present an approach to map data of drug-response encyclopedias and represent these as a drug atlas. This atlas consists of a framework of chemotherapeutic responses that represents a drug vulnerability landscape of cancer. Based on data from the literature we found that many synergistic drug combinations show distinct inter therapy responses and drug sensitivities. We confirmed this by performing a drug combination screen against glioblastoma where we used 270 combination experiments. From the identified dual therapies we were able to predict and validate a triple drug synergy which was validated in vivo. This new and generalizable strategy opens the door to unforeseen personalized multidrug combination approaches.

Alkyl Glucosides

Dermatitis ◽  
2017 ◽  
Vol 28 (1) ◽  
pp. 3-4 ◽  
Author(s):  
Maisa Alfalah ◽  
Camille Loranger ◽  
Denis Sasseville
Keyword(s):  
Alkyl Glucosides

scholarly journals Formulation, Stability, Pharmacokinetic, and Modeling Studies for Tests of Synergistic Combinations of Orally Available Approved Drugs Against Ebola Virus In Vivo

2021 ◽  
Author(s):  
Courtney L. Finch ◽  
Julie Dyall ◽  
Shuang Xu ◽  
Elizabeth A. Nelson ◽  
Elena Postnikova ◽  
...  
Keyword(s):  
Mouse Model ◽  
Oral Delivery ◽  
Ebola Virus ◽  
Cost Effective ◽  
High Morbidity ◽  
Strong Activity ◽  
Approved Drugs ◽  
Formulation Stability ◽  
Synergistic Combinations

Outbreaks of Ebola ebolavirus (EBOV) have been associated with high morbidity and mortality. Milestones have been reached recently in the management of EBOV disease (EVD) with licensure of an EBOV vaccine and two monoclonal antibody therapies. However, neither vaccines nor therapies are available for other disease-causing filoviruses. In preparation for such outbreaks, and for more facile and cost-effective management of EVD, we seek a cocktail containing orally available and room temperature stable drugs with strong activity against multiple filoviruses. We previously showed that (bepridil + sertraline) and (sertraline + toremifene) synergistically suppress EBOV in cell cultures. Here we describe steps towards testing these combinations in a mouse model of EVD. We identified a vehicle suitable for oral delivery of the component drugs and determined that, thus formulated the drugs are equally active against EBOV as preparations in DMSO, and they maintain activity upon storage in solution for up to seven days. Pharmacokinetic (PK) studies indicated that the drugs in the oral delivery vehicle are well tolerated in mice at the highest doses tested. Collectively the data support advancement of these combinations to tests for synergy in a mouse model of EVD. Moreover, mathematical modeling based on human oral PK projects that the combinations would be more active in humans than their component single drugs.

scholarly journals Enzymatic Synthesis of Alkyl Glucosides by β ‐Glucosidases in a 2‐in‐1 Deep Eutectic Solvent System

2021 ◽  
Author(s):  
André Delavault ◽  
Jens Grüninger ◽  
Daniel Kapp ◽  
Rebecca Hollenbach ◽  
Jens Rudat ◽  
...  
Keyword(s):  
Enzymatic Synthesis ◽  
Deep Eutectic Solvent ◽  
Solvent System ◽  
Alkyl Glucosides
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