Structure-Toxicity Relationships of Para-Position Alkyl- and Halogen-Substituted Monoaromatic Compounds

2009 ◽  
pp. 410-410-14
Author(s):  
TW Schultz ◽  
M Cajina-Quezada ◽  
M Chang ◽  
DT Lin ◽  
R Jain
Keyword(s):  
Para Position

The Anticoagulant Activity of 3.3’-(p-Alkylthio-Benzylidene)-Bis-4-Hydroxycoumarins and Their Oxidation Products

1967 ◽  
Vol 17 (01/02) ◽  
pp. 277-286 ◽  
Author(s):  
Maria Gumińska ◽  
M Eckstein ◽  
Barbara Stachurska ◽  
J Sulko
Keyword(s):  
Biological Activity ◽  
Anticoagulant Activity ◽  
Oxidation Products ◽  
Para Position ◽  
Sulphur Atom ◽  
Group I ◽  
One Step

SummaryThe anticoagulant activity of 3.3’-(benzylidene)-bis-4-hydroxycoumarin derivatives has been estimated by one step Quick’s method. The derivatives contained the following groups in the para position of benzylidene residue: NCS- (I), CH3-S- (II), CH3-SO-(III), CH3-S02- (IV), C2H5-S- (V), C2H5-SO- (VI), C2H5-S02- (VII). All these compounds were much more active than 3.3’-(benzylidene)-bis-4-hydroxycoumarin itself.Compounds possessing the ethyl chain at the sulphur atom (V, VI, VII) were more active than methyl homologues (II, III, IV). Comparison of the activity of the series of thio-, sulphoxy-, and sulphonyl-derivatives showed that among methyl- and ethyl-derivatives those with the sulphoxy grouping (III, VI) displayed the greatest anticoagulant activity. The action of sulphonyl (IV, VII) and thio-derivatives (II, V) was weaker and shortest. The derivative with the NCS-group (I) possessed a relatively the lowest activity among the investigated compounds. 3.3’-(p-Ethylsulphoxybenzyl-idene)-bis-4-hydroxycoumarin (VI), with distinct biological activity reached about ½ of dicoumarol activity.

Impact para position on rho value and rate constant and study of liquid crystalline behavior of azo compounds

2021 ◽  
Author(s):  
Mohammed Mezher Aftan ◽  
Abdualwahid Abdualsatar Talloh ◽  
Adil Hussein Dalaf ◽  
Hanaa Kaain Salih
Keyword(s):  
Rate Constant ◽  
Liquid Crystalline ◽  
Para Position ◽  
Azo Compounds

scholarly journals Synthesis of 4-Substituted-1,2-Dihydroquinolines by Means of Gold-Catalyzed Intramolecular Hydroarylation Reaction of N-Ethoxycarbonyl-N-Propargylanilines

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3366
Author(s):  
Antonio Arcadi ◽  
Andrea Calcaterra ◽  
Giancarlo Fabrizi ◽  
Andrea Fochetti ◽  
Antonella Goggiamani ◽  
...  
Keyword(s):  
Building Blocks ◽  
Fine Tuning ◽  
Para Position ◽  
Cyclization Product ◽  
Synthetic Route ◽  
Substituted Anilines ◽  
Novel Approach ◽  
High Yields

An alternative Au(I)-catalyzed synthetic route to functionalized 1,2-dihydroquinolines is reported. This novel approach is based on the use of N-ethoxycarbonyl protected-N-propargylanilines as building blocks that rapidly undergo the IMHA reaction affording the 6-endo cyclization product in good to high yields. In the presence of N-ethoxycarbonyl-N-propargyl-meta-substituted anilines, the regiodivergent cyclization at the ortho-/para-position is achieved by the means of catalyst fine tuning.

Synthesis, characterization and third order nonlinear optical properties of trans-A2B-tpye cobalt corroles

2021 ◽  
Author(s):  
Guifen Lu ◽  
Peng Zhang ◽  
Yuanyuan Fang ◽  
Yongjie Gao ◽  
Qikang Hu
Keyword(s):  
Optical Properties ◽  
Nonlinear Optical ◽  
Nonlinear Optical Properties ◽  
Para Position ◽  
Third Order

A series of trans-A2B cobalt corroles, represented as [Cor(p-RPh)2(p-NO2Ph)]Co(PPh3) (1-5), where Cor is trianion of corrole, R is a CN, F, CH3, C(CH3)3 or PhCH2O on the para-position of the...

scholarly journals Syntheses of two deacetyl-thymosin β4analogs and their anti-inflammatory effect on carrageenin-induced edema in the mouse paw

2001 ◽  
Vol 10 (2) ◽  
pp. 89-92 ◽  
Author(s):  
T. Abiko ◽  
R. Ogawa
Keyword(s):  
Marked Reduction ◽  
Solid Phase ◽  
The Other ◽  
Para Position ◽  
Phase Method ◽  
Antiinflammatory Effect ◽  
Solid Phase Method ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Two {Met(0)6}deacetyl-thymosin β4analogs containing Phe(4F) or Tyr(Me) at position 12 were synthesized by the manual solid-phase method, and their anti-inflammatory effect on carrageenin-induced edema in the mouse paw was studied. Fluorination of the para-position of Phe12resulted in a marked antiinflammatory effect on carrageenin-induced edema in the mouse paw compared with that of our synthetic {Met(0)6}deacetyl-thymosin β4, but the other analog, {Met(0)6, Tyr(Me)12}deacetyl-thymosin β4, showed a marked reduction of the anti-inflammatory effect.

Para-position derivatives of fungal anthelmintic cyclodepsipeptides engineered with Streptomyces venezuelae antibiotic biosynthetic genes

2004 ◽  
Vol 22 (7) ◽  
pp. 848-855 ◽  
Author(s):  
Koji Yanai ◽  
Naomi Sumida ◽  
Kaoru Okakura ◽  
Tatsuki Moriya ◽  
Manabu Watanabe ◽  
...  
Keyword(s):  
Para Position ◽  
Streptomyces Venezuelae ◽  
Biosynthetic Genes ◽  
Derivatives Of

Effects of structural variations on the optical and electronic properties of eumelanin-inspired small molecules

2016 ◽  
Vol 4 (18) ◽  
pp. 3995-3999 ◽  
Author(s):  
Subhashini Selvaraju ◽  
Santosh Adhikari ◽  
RaiAnna A. Hopson ◽  
Shuo Dai ◽  
Arnold L. Rheingold ◽  
...  
Keyword(s):  
Small Molecules ◽  
Electronic Properties ◽  
Para Position ◽  
Structural Variations ◽  
Optical And Electronic Properties

In this work, five new eumelanin-inspired indole small molecules have been synthesized which differ by the substituents attached to the para position of the phenylene ring.

Chiral Pyrophosphoric Acid Catalysts for the para-Selective and Enantioselective Aza-Friedel–Crafts Reaction of Phenols

Synthesis ◽  
2018 ◽  
Vol 50 (23) ◽  
pp. 4577-4590 ◽  
Author(s):  
Akira Sakakura ◽  
Manabu Hatano ◽  
Kazuaki Ishihara ◽  
Haruka Okamoto ◽  
Kohei Toh ◽  
...  
Keyword(s):  
Antifungal Agent ◽  
Para Position ◽  
Scale Transformation ◽  
Acid Catalysts ◽  
Pyrophosphoric Acid

Chiral BINOL-derived pyrophosphoric acid catalysts were developed and used for the regio- and enantioselective aza-Friedel–Crafts reaction of phenols with aldimines. ortho/para-Directing phenols could react at the para-position selectively with moderate to good enantioselectivities. Moreover, the gram-scale transformation of a product into the key intermediate for the antifungal agent (R)-bifonazole was demonstrated.

Vicarious nucleophilic amination of nitroquinolines with 4-amino-1,2,4-triazole

2008 ◽  
Vol 86 (7) ◽  
pp. 682-685 ◽  
Author(s):  
Barbara Szpakiewicz ◽  
Maria Grzegożek
Keyword(s):  
Dimethyl Sulfoxide ◽  
Nucleophilic Substitution ◽  
Nitro Group ◽  
Para Position ◽  
Basic Medium ◽  
Ortho Position ◽  
Vicarious Nucleophilic Substitution

3-, 5-, 6-, 7- and 8-Nitroquinolines react with 4-amino-1,2,4-triazole in basic medium (potassium tert-butoxide-dimethyl sulfoxide) giving amino products of the vicarious nucleophilic substitution (VNS) of hydrogen, predominantly at ortho position to the nitro group, except 8-nitroquinoline, which reacts at para position. Additionally, furazano[3,4-f]- and furazano[3,4-h]quinoline were obtained in the case of 5- and 8- nitroquinoline, respectively. 2-Nitroquinoline was aminated to 2-quinolino(1,2,4-triazol-4-yl)amine in these conditions.Key words: nitroquinolines, vicarious nucleophilic substitution (VNS), 4-amino-1,2,4-triazole.

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