Chapter 1—Bone Grafts and Bone Graft Substitutes: A Brief History

2009 ◽  
pp. 3-3-6 ◽  
Author(s):  
CT Laurencin ◽  
CT Laurencin ◽  
Y Khan
Keyword(s):  
Bone Graft ◽  
Bone Grafts ◽  
Bone Graft Substitutes

Biofilm formation on bone grafts and bone graft substitutes: Comparison of different materials by a standard in vitro test and microcalorimetry

2010 ◽  
Vol 6 (9) ◽  
pp. 3791-3797 ◽  
Author(s):  
Martin Clauss ◽  
Andrej Trampuz ◽  
Olivier Borens ◽  
Marc Bohner ◽  
Thomas Ilchmann
Keyword(s):  
Bone Graft ◽  
Biofilm Formation ◽  
Bone Grafts ◽  
In Vitro Test ◽  
Vitro Test ◽  
Bone Graft Substitutes

Bone Grafts and Bone Graft Substitutes

2021 ◽  
pp. 197-273
Author(s):  
Jae Hyuk Yang ◽  
Juliane D. Glaeser ◽  
Linda E. A. Kanim ◽  
Carmen Y. Battles ◽  
Shrikar Bondre ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Grafts ◽  
Bone Graft Substitutes

Bone Grafts and Bone Graft Substitutes in Orthopaedic Trauma Surgery

2007 ◽  
Vol 89 (3) ◽  
pp. 649-658 ◽  
Author(s):  
William G. De Long ◽  
Thomas A. Einhorn ◽  
Kenneth Koval ◽  
Michael McKee ◽  
Wade Smith ◽  
...  
Keyword(s):  
Bone Graft ◽  
Trauma Surgery ◽  
Bone Grafts ◽  
Orthopaedic Trauma ◽  
Bone Graft Substitutes

scholarly journals Exosomes in the Repair of Bone Defects: Next-Generation Therapeutic Tools for the Treatment of Nonunion

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Jian Lu ◽  
Qi-Yang Wang ◽  
Jia-Gen Sheng
Keyword(s):  
Bone Graft ◽  
Bone Metabolism ◽  
Cell Communication ◽  
Bone Grafts ◽  
Bone Defects ◽  
Long Bone ◽  
Safety Issues ◽  
Cell Based Therapy ◽  
Bone Graft Substitutes ◽  
Autologous Bone Grafts

Nonunion with bone defects, a common complication after long bone fracture, is a major challenge for orthopaedic surgeons worldwide because of the high incidence rate and difficulties in achieving successful treatment. Bone defects are the main complications of nonunion. The conventional biological treatments for nonunion with bone defects involve the use of autologous bone grafts or bone graft substitutes and cell-based therapy. Traditional nonunion treatments have always been associated with safety issues and various other complications. Bone grafts have limited autologous cancellous bone and there is a risk of infection. Additionally, problems with bone graft substitutes, including rejection and stimulation of bone formation, have been noted, and the health of the stem cell niche is a major consideration in cell-based therapy. In recent years, researchers have found that exosomes can be used to deliver functional RNA and mediate cell-to-cell communication, suggesting that exosomes may repair bone defects by regulating cells and cytokines involved in bone metabolism. In this review, we highlight the possible relationships between risk factors for nonunion and exosomes. Additionally, we discuss the roles of exosomes in bone metabolism and bone regeneration.

scholarly journals ROLE OF BONE GRAFTS AND BONE GRAFT SUBSTITUTES IN ISOLATED SUBTALAR JOINT ARTHRODESIS

2017 ◽  
Vol 25 (5) ◽  
pp. 183-187 ◽  
Author(s):  
ASHISH SHAH ◽  
SAMEER NARANJE ◽  
IBUKUNOLUWA ARAOYE ◽  
OSAMA ELATTAR ◽  
ALEXANDRE LEME GODOY-SANTOS ◽  
...  
Keyword(s):  
Bone Graft ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Case Series ◽  
Bone Grafts ◽  
Union Rate ◽  
Level Of Evidence ◽  
Subtalar Arthrodesis ◽  
Significant Difference ◽  
Bone Graft Substitutes

ABSTRACT Objectives: The purpose of this study was to compare union rates for isolated subtalar arthrodesis with and without the use of bone grafts or bone graft substitutes. Methods: We retrospectively reviewed 135 subtalar fusions with a mean follow-up of 18 ± 14 months. The standard approach was used for all surgeries. Graft materials included b-tricalcium phosphate, demineralized bone matrix, iliac crest autograft and allograft, and allograft cancellous chips. Successful subtalar fusion was determined clinically and radiographically. Results: There was an 88% (37/42) union rate without graft use and an 83% (78/93) union rate with bone graft use. Odds ratio of union for graft versus no graft was 0.703 (95% CI, 0.237-2.08). The average time to union in the graft group was 3 ± 0.73 months and 3 ± 0.86 in the non-graft group, with no statistically significant difference detected (p = 0.56). Conclusion: Graft use did not improve union rates for subtalar arthrodesis. Level of Evidence IV, Case Series.

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