Practice for Evaluating Material Extracts by Intracutaneous Injection in the Rabbit

10.1520/f0749 ◽  
2008 ◽  
Author(s):  
Keyword(s):  
Intracutaneous Injection

Mast cell-nerve fiber interaction: Ultrastructural studies

1990 ◽  
Vol 48 (3) ◽  
pp. 428-429
Author(s):  
E.Y. Chi ◽  
M.L. Su ◽  
Y.T. Tien ◽  
W.R. Henderson
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Substance P ◽  
Nerve Fiber ◽  
Sensory Nerves ◽  
Ultrastructural Studies ◽  
Morphological Studies ◽  
Granulocyte Infiltration ◽  
Intracutaneous Injection ◽  
Recent Attention

Recent attention has been directed to the interaction of the nerve and immune systems. The neuropeptide substance P, a tachykinnin which is a neurotransmitter in the central and peripheral nervous systems produces tissue swelling, augemntation of intersitial fibrin deposition and leukocyte infiltration after intracutaneous injection. There is a direct correlation reported between the extent of mast cell degranulation at the sites of injection and the tissue swelling or granulocyte infiltration. It has previously been demonstrated that antidromic electrical stimulation of sensory nerves induces degranulation of cutaneous mast cells, cutaneous vasodilation and augmented vascular permeability. Morphological studies have documented a close anatiomical association between mast cells and nonmyelinated nerves, that contain substance P and other neuropeptides. However, the presence of mast cells within nerve fasicles has not been previously examined ultrastructurally. In this study, we examined ultrastructurally the distribution of mast cells in the nerve fiber bundles located in the muscular connective tissue of rat tongues (n=20).

scholarly journals EXPERIMENTAL ACUTE GLOMERULITIS

1931 ◽  
Vol 53 (4) ◽  
pp. 511-526 ◽  
Author(s):  
Francis D. W. Lukens ◽  
Warfield T. Longcope
Keyword(s):  
Renal Artery ◽  
Skin Reaction ◽  
Left Renal Artery ◽  
Bismuth Oxychloride ◽  
Intracutaneous Injection

1. Both focal and diffuse glomerulitis has been produced in rabbits by the injection directly into the left renal artery of suspensions of heat killed hemolytic streptococci. 2. Similar lesions in the glomeruli could not be obtained by the injection of suspensions of bismuth oxychloride into the left renal artery of normal rabbits. 3. The acute glomerulitis occurred in only about one-half of the rabbits employed for the experiments. 4. Glomerulitis was observed much more frequently in rabbits in which an acute localized streptococcus infection had been produced by the intracutaneous injection of living hemolytic streptococci, than in normal rabbits. The occurrence of acute glomerulitis was usually associated with a well marked skin reaction to the filtrates of hemolytic streptococci.

Scarlet fever immunization by intracutaneous injection of scarlatinal streptococcus toxin

1938 ◽  
Vol 9 (2) ◽  
pp. 125-135 ◽  
Author(s):  
Richard A. Kern ◽  
Jean Crump ◽  
Rudolf L. Roddy ◽  
Sydney Borow
Keyword(s):  
Scarlet Fever ◽  
Intracutaneous Injection

In vivo pharmacokinetics of protoporphyrin IX accumulation following intracutaneous injection of 5-aminolevulinic acid

2001 ◽  
Vol 61 (1-2) ◽  
pp. 21-29 ◽  
Author(s):  
A.W. de Blois ◽  
M.R.T.M Thissen ◽  
H.S. de Bruijn ◽  
R.J.E. Grouls ◽  
R.P. Dutrieux ◽  
...  
Keyword(s):  
Aminolevulinic Acid ◽  
Protoporphyrin Ix ◽  
Intracutaneous Injection ◽  
In Vivo Pharmacokinetics

scholarly journals SPECIFIC ANTIBODY RESPONSE OF HUMAN SUBJECTS TO INTRACUTANEOUS INJECTION OF PNEUMOCOCCUS PRODUCTS

1932 ◽  
Vol 55 (6) ◽  
pp. 853-865 ◽  
Author(s):  
Maxwell Finland ◽  
W. D. Sutliff
Keyword(s):  
Human Subjects ◽  
Type I ◽  
Type Ii ◽  
Specific Antibody Response ◽  
Specific Antibodies ◽  
Virulent Strains ◽  
Before And After ◽  
Specific Polysaccharide ◽  
Protective Antibodies ◽  
Intracutaneous Injection

The blood of 63 human subjects selected because of the absence of recent infections, was studied for its content of specific antibodies against virulent strains of Types I, II, and III pneumococci before and after intracutaneous injections of minute amounts of pneumococcus products. The simultaneous injection of the specific polysaccharides of all three types of pneumococci and of proteins and autolysates derived from Types I and II pneumococci was followed by the appearance or increase of pneumococcidal power in the whole defibrinated blood and, in most instances, by the appearance of mouse-protective antibodies and agglutinins for one or more types. A single intracutaneous injection of 0.01 mg. of the protein-free type-specific polysaccharide of either Type I, Type II, or Type III pneumococci or 4 similar daily injections was followed, in most of 29 subjects, by the appearance of antibodies against the homologous, but not against the heterologous type pneumococci. Some subjects showed a simultaneous lowering of a preexisting pneumococcidal power for heterologous or homologous types. A single intracutaneous injection of O.1 mg. of pneumococcus protein in 13 individuals was not followed by the appearance of specific antibodies to any appreciable degree. Single intracutaneous injections of small amounts of autolysates derived from virulent strains of Type I, II, or III pneumococci were followed in 11 subjects by a more or less general rise in the pneumococcidal power with the appearance of homologous type agglutinins and protective antibodies in about one-third of the subjects.

Sign in / Sign up

Export Citation Format

Share Document