Practice for Determination of Odor and Taste Thresholds By a Forced-Choice Ascending Concentration Series Method of Limits

2019 ◽  
Author(s):  
Keyword(s):  
Forced Choice ◽  
Series Method ◽  
Taste Thresholds ◽  
Concentration Series

Novel Determination of Anti-Hypertensive Combination; Benidipine Hydrochloride and Nebivolol Hydrochloride by High Performance Chromatographic Method

2021 ◽  
pp. 5433-5438
Author(s):  
V.L.N. Balaji Gupta Tiruveedhi ◽  
Venkateswara Rao Battula ◽  
Kishore Babu Bonige ◽  
Tejeswarudu B.
Keyword(s):  
High Performance ◽  
Degradation Products ◽  
Research Work ◽  
Hplc Method ◽  
Assay Method ◽  
Injection Quantity ◽  
Relative Standard ◽  
Nebivolol Hydrochloride ◽  
Concentration Series

This research work was designed to establish and validate a novel stability indicating RP-HPLC method for the combined determination of Benidipine hydrochloride (BHE) and Nebivolol hydrochloride (NHE) in bulk and tablets, dependent on ICH guidelines.The assay method to analyse BHE and NHE was optimized with isocratic elution using acetonitrile: 0.1M acetate buffer (45:55, pH 5.1), Lichrospher ODS RP-18 column and flow pace of 1 ml/min. Total time for single run was 14 min. The injection quantity was 20μl, and was detected at 249nm. The method was verified on a concentration series of 1.25-10μg/ml (NHE) and 1.0-10μg/ml (BHE) for precision, accuracy and linearity. The LOD values were 0.059µg/ml and 0.028µg/ml for NHE and BHE, respectively. The LOQ values were 0.196µg/ml for NHE and 0.094µg/ml for BHE. The recovery percentages were 98.60-100.11% (BHE) and 98.94-101.50% (NHE) with relative standard deviation 0.250-0.694% (BHE) and 0.183-0.400% (NHE). The method was also observed to be efficient, and was sufficiently specific to measure BHE and NHE in the presence of stress-produced degradation products.

Determination of Criminal Responsibility

1993 ◽  
Vol 20 (4) ◽  
pp. 391-405 ◽  
Author(s):  
CHERYL K. HISCOCK ◽  
PAMELA J. RUSTEMIER ◽  
MERRILL HISCOCK
Keyword(s):  
Criminal Responsibility ◽  
Forced Choice ◽  
Future Research ◽  
Control Group ◽  
General Knowledge ◽  
Prison Inmates ◽  
Choice Tests ◽  
Cutoff Scores ◽  
Analog Study

The two-alternative forced-choice principle, which has been used to detect malingering and “hysterical” symptoms, was applied to the assessment of criminal responsibility in an analog study. Prison inmates and university students completed forced-choice tests of general knowledge and moral reasoning on which below-chance scores indicate dishonest performance. Subjects were assigned randomly to one of three groups: control, naive faking, and coached faking. Significantly greater proportions of subjects in the naive and coached faking groups than in the control group scored significantly below chance on each test. Cutoff scores to maximize accuracy of classification were established for both tests. Implications of the findings for detecting individuals who fake a lack of criminal responsibility are considered, as well as directions for future research with other populations.

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