scholarly journals Fulminant Liver Failure Due to Amanita Phalloides Toxicity Treated with Emergent Liver Transplantation

2015 ◽  
Vol 12 (3) ◽  
Author(s):  
Funda Gok ◽  
Ahmet Topal ◽  
Gülçin Hacibeyoglu ◽  
Atilla Erol ◽  
Murat Biyik ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Failure ◽  
Amanita Phalloides ◽  
Fulminant Liver Failure

scholarly journals Acute Liver Failure Caused byAmanita phalloidesPoisoning

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Luca Santi ◽  
Caterina Maggioli ◽  
Marianna Mastroroberto ◽  
Manuel Tufoni ◽  
Lucia Napoli ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Rna Polymerase Ii ◽  
Gastrointestinal Symptoms ◽  
Amanita Phalloides ◽  
Prognostic Indicators ◽  
Mushroom Poisoning ◽  
Lag Phase ◽  
Kidney Involvement

Mushroom poisoning is a relatively rare cause of acute liver failure (ALF). The present paper analyzes the pathogenesis, clinical features, prognostic indicators, and therapeutic strategies of ALF secondary to ingestion ofAmanita phalloides, which represents the most common and deadly cause of mushroom poisoning. Liver damage fromAmanita phalloidesis related to the amanitins, powerful toxins that inhibit RNA polymerase II resulting in a deficient protein synthesis and cell necrosis. After an asymptomatic lag phase, the clinical picture is characterized by gastrointestinal symptoms, followed by the liver and kidney involvement. Amatoxin poisoning may progress into ALF and eventually death if liver transplantation is not performed. The mortality rate afterAmanita phalloidespoisoning ranges from 10 to 20%. The management of amatoxin poisoning consists of preliminary medical care, supportive measures, detoxification therapies, and orthotopic liver transplantation. The clinical efficacy of any modality of treatment is difficult to demonstrate since randomized, controlled clinical trials have not been reported. The use of extracorporeal liver assist devices as well as auxiliary liver transplantation may represent additional therapeutic options.

scholarly journals Prognosis and treatment options in cases of acute liver failure caused by mushroom poisoning due to Amanita phalloides

2020 ◽  
Vol 7 (5) ◽  
pp. 875
Author(s):  
Anant Parasher ◽  
Akshay Aggrawal
Keyword(s):  
Liver Transplantation ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Orthotopic Liver Transplantation ◽  
Renal Involvement ◽  
Clinical Manifestations ◽  
Amanita Phalloides ◽  
Penicillin G ◽  
Mushroom Poisoning ◽  
Mushroom Ingestion

Poisoning due to mushroom ingestion is a relatively rare but deadly cause of acute liver failure (ALF). Consumption of the poisonous mushroom Amanita phalloides, also known as ‘death cap’, is one of the most common causes of mushroom poisoning worldwide, being involved in the majority of human fatalities caused due to mushroom ingestion. A major portion of the liver damage due to Amanita phalloides is related to powerful toxins known as amanitins, which cause impairment in protein synthesis and subsequent cell necrosis by the inhibition of RNA polymerase II. Initially the presentation is that of an asymptomatic lag phase, followed by gastrointestinal symptoms and hepato-renal involvement. Amatoxin poisoning may progress into fulminant hepatic failure and eventually death if liver transplantation is not performed. It is based on a careful assessment of history of type and duration of mushroom ingestion, as well as the clinical manifestations. Diagnosis can be confirmed by laboratory tests measuring urinary amatoxin levels and identification of the mushroom. Although N-Acetyl Cysteine and Penicillin-G have proven to be effective therapeutic agents, Orthotopic Liver Transplantation (OLT) or Auxiliary Partial Orthotopic Liver Transplantation (APOLT) is the only treatment option for most of the cases carrying a poor prognosis.

Recurrent Fulminant Liver Failure Caused by Hepatitis B Virus After Liver Transplantation

1994 ◽  
Vol 19 (3) ◽  
pp. 238-241 ◽  
Author(s):  
Manuel de la Mata ◽  
Sebasti??n Rufi??n ◽  
Federico G??mez ◽  
Evaristo Varo ◽  
P L??pez-Cillero ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Liver Failure ◽  
Fulminant Liver Failure ◽  
B Virus

Liver Transplantation due to Fulminant Liver Failure by Heat Stroke

2018 ◽  
Vol 102 ◽  
pp. S880-S881
Author(s):  
Luis Martinez Insfran ◽  
Pedro P Cascales Campos ◽  
Pablo P Ramirez Romero ◽  
Felipe F Alconchel Gago ◽  
Beatriz B Gomez Perez ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Failure ◽  
Heat Stroke ◽  
Fulminant Liver Failure

Bacillus cereus, an unusual cause of fulminant liver failure: diagnosis may prevent liver transplantation

2012 ◽  
Vol 61 (5) ◽  
pp. 743-745 ◽  
Author(s):  
Mohamed Saleh ◽  
Malik Al Nakib ◽  
Alexandra Doloy ◽  
Sébastien Jacqmin ◽  
Sébastien Ghiglione ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Failure ◽  
Bacillus Cereus ◽  
Failure Diagnosis ◽  
Fulminant Liver Failure
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