scholarly journals Impact of vitamin D deficiency on health with regard to kidney disease; an updated mini-review

2018 ◽  
Vol 7 (2) ◽  
pp. 55-60
Author(s):  
Nozar Dorestan ◽  
Sara Bahadoram ◽  
Mohammad Bahadoram ◽  
Mohammadreza Khosravi ◽  
Mohammad Davoodi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Kidney Disease ◽  
Vitamin D Deficiency ◽  
Heart Diseases ◽  
Daily Intake ◽  
Type I ◽  
Bowel Diseases ◽  
Progression Of Kidney Disease ◽  
Vitamin D Supplements ◽  
The Relationship

Vitamin D or cholecalciferol, as a steroidal hormone, regulates the calcium homeostasis, and bone formation with reabsorption through kidneys, parathyroid glands and bowel. There are at least 800 human genes connected with vitamin D. Previous research has confirmed the relationship between vitamin D and colorectal cancers, infections, heart diseases, multiple sclerosis (MS), bone disorders, inflammatory and autoimmune diseases, inflammatory bowel diseases, diabetes mellitus type-I and II and also progression of kidney disease. However, the relationship of vitamin D deficiency and developing of breast cancer, rheumatoid arthritis and osteoporosis is unknown. In fact, the effect of vitamin D deficiency on pathogenesis of different diseases is controversial. To cope with vitamin D deficiency, there are different recommendations such as daily intake of vitamin D supplements and more exposure to sunlight.

scholarly journals Vitamin D Deficiency in Chronic Kidney Disease: Recent Evidence and Controversies

2018 ◽  
Author(s):  
Pedro Henrique Franca Gois ◽  
Martin Wolley ◽  
Dwarakanathan Ranganathan ◽  
Antonio Carlos Seguro
Keyword(s):  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Kidney Disease ◽  
Vitamin D Deficiency ◽  
Redox Balance ◽  
Biologically Active ◽  
Public Health Care ◽  
Paracrine Signaling ◽  
Innate And Adaptive Immunity ◽  
Progression Of Kidney Disease

Vitamin D (VD) is a pro-hormone essential for life in higher animals. It is present in few types of foods and is produced endogenously in the skin by a photochemical reaction. The final step of VD activation occurs in the kidneys involving a second hydroxylation reaction to generate the biologically active metabolite 1,25(OH)2-VD. Extrarenal 1α-hydroxylation has also been described to have an important role in autocrine and paracrine signaling. Vitamin D deficiency (VDD) has been in the spotlight as a major public health-care issue with an estimated prevalence of more than a billion people worldwide. Among individuals with chronic kidney disease (CKD), VDD prevalence has been reported to be as high as 80%. Classically VD plays a pivotal role in calcium and phosphorus homeostasis. Nevertheless, there is a growing body of evidence supporting the importance of VD in many vital nonskeletal biological processes such as endothelial function, renin-angiotensin-aldosterone system modulation, redox balance and innate and adaptive immunity. In individuals with CKD, VDD has been associated with albuminuria, faster progression of kidney disease and increased all-cause mortality. Recent guidelines support VD supplementation in CKD based on extrapolation from cohorts conducted in the general population. In this review, we discuss new insights on the multifactorial pathophysiology of VDD in CKD as well as how it may negatively modulate different organs and systems. We also critically review the latest evidence and controversies of VD monitoring and supplementation in CKD patients.

The association between vitamin D levels and precocious puberty: a meta-analysis

2020 ◽  
Vol 33 (3) ◽  
pp. 427-429
Author(s):  
Shanshan Liu ◽  
Xun Zhu ◽  
Yuanxin Wang ◽  
Shoumeng Yan ◽  
Dong Li ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Precocious Puberty ◽  
Meta Analysis ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Comprehensive Search ◽  
Vitamin D Supplements ◽  
The Relationship

AbstractThe objective of this short communication was the relationship between vitamin D and precocious puberty (PP). In this study, a comprehensive search of multiple databases was performed to identify studies focused on the association between vitamin D deficiency and PP. Studies that compared serum vitamin D levels between patients with PP and controls were selected for the systematic meta-analysis. The main outcome was the mean difference in serum vitamin D levels between PP and controls. Vitamin D-deficient subjects were more likely to develop PP. Our findings suggest that PP may be linked to vitamin D deficiency. Thus, providing supplements of vitamin D to PP patients may improve their nutritional status and prevent diseases. But, the amount of vitamin D required is uncertain, so it is important to be careful when taking vitamin D supplements.

scholarly journals Vitamin D Deficiency in Chronic Kidney Disease: Recent Evidence and Controversies

2018 ◽  
Vol 15 (8) ◽  
pp. 1773 ◽  
Author(s):  
Pedro Franca Gois ◽  
Martin Wolley ◽  
Dwarakanathan Ranganathan ◽  
Antonio Seguro
Keyword(s):  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Kidney Disease ◽  
Vitamin D Deficiency ◽  
Redox Balance ◽  
Biologically Active ◽  
Public Healthcare ◽  
Paracrine Signaling ◽  
Innate And Adaptive Immunity ◽  
Progression Of Kidney Disease

Vitamin D (VD) is a pro-hormone essential for life in higher animals. It is present in few types of foods and is produced endogenously in the skin by a photochemical reaction. The final step of VD activation occurs in the kidneys involving a second hydroxylation reaction to generate the biologically active metabolite 1,25(OH)2-VD. Extrarenal 1α-hydroxylation has also been described to have an important role in autocrine and paracrine signaling. Vitamin D deficiency (VDD) has been in the spotlight as a major public healthcare issue with an estimated prevalence of more than a billion people worldwide. Among individuals with chronic kidney disease (CKD), VDD prevalence has been reported to be as high as 80%. Classically, VD plays a pivotal role in calcium and phosphorus homeostasis. Nevertheless, there is a growing body of evidence supporting the importance of VD in many vital non-skeletal biological processes such as endothelial function, renin-angiotensin-aldosterone system modulation, redox balance and innate and adaptive immunity. In individuals with CKD, VDD has been associated with albuminuria, faster progression of kidney disease and increased all-cause mortality. Recent guidelines support VD supplementation in CKD based on extrapolation from cohorts conducted in the general population. In this review, we discuss new insights on the multifactorial pathophysiology of VDD in CKD as well as how it may negatively modulate different organs and systems. We also critically review the latest evidence and controversies of VD monitoring and supplementation in CKD patients.

scholarly journals The Relationship between Vitamin D Deficiency and Pulmonary Artery Atherosclerosis in Chronic Thromboembolic Patients

2017 ◽  
Vol 06 (02) ◽  
Author(s):  
Tarik Kivrak ◽  
Hasan Ata Bolayir ◽  
Batur Gonenc Kanar ◽  
Dursun Akaslan ◽  
Hakan Gunes ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pulmonary Artery ◽  
Vitamin D Deficiency ◽  
The Relationship

scholarly journals Vitamin D deficiency and depression in adults: systematic review and meta-analysis

2013 ◽  
Vol 202 (2) ◽  
pp. 100-107 ◽  
Author(s):  
Rebecca E. S. Anglin ◽  
Zainab Samaan ◽  
Stephen D. Walter ◽  
Sarah D. McDonald
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Randomised Controlled Trials ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Cross Sectional ◽  
Cross Sectional Studies ◽  
Randomised Controlled ◽  
The Relationship

BackgroundThere is conflicting evidence about the relationship between vitamin D deficiency and depression, and a systematic assessment of the literature has not been available.AimsTo determine the relationship, if any, between vitamin D deficiency and depression.MethodA systematic review and meta-analysis of observational studies and randomised controlled trials was conducted.ResultsOne case-control study, ten cross-sectional studies and three cohort studies with a total of 31 424 participants were analysed. Lower vitamin D levels were found in people with depression compared with controls (SMD = 0.60,95% Cl 0.23–0.97) and there was an increased odds ratio of depression for the lowest v. highest vitamin D categories in the cross-sectional studies (OR = 1.31, 95% CI 1.0–1.71). The cohort studies showed a significantly increased hazard ratio of depression for the lowest v. highest vitamin D categories (HR=2.21, 95% CI 1.40–3.49).ConclusionsOur analyses are consistent with the hypothesis that low vitamin D concentration is associated with depression, and highlight the need for randomised controlled trials of vitamin D for the prevention and treatment of depression to determine whether this association is causal.

scholarly journals THE RELATIONSHIP BETWEEN THE COTININE LEVEL IN URINE AND VITAMIN D IN THE UNIVERSITY STUDENTS

2020 ◽  
Vol 6 (6) ◽  
pp. 214-219
Author(s):  
Ayse Berivan Bakan ◽  
Naim Uzun ◽  
Senay Karadag Arli ◽  
Metin Yıldız
Keyword(s):  
Vitamin D ◽  
University Students ◽  
Vitamin D Deficiency ◽  
Age Groups ◽  
Cotinine Level ◽  
Screening Design ◽  
Significant Relationships ◽  
Blood And Urine Samples ◽  
The University ◽  
The Relationship

Background: Vitamin D deficiency is today acknowledged as a pandemic. Vitamin D deficiency and insufficiency are associated with many chronic diseases, including common cancers, cardiovascular diseases, metabolic syndrome, and infectious and autoimmune diseases.Objective: This study aims to investigate the relationship between the cotinine level in urine and Vitamin D.Methods: This study employed a descriptive and relational screening design.  It was conducted with 74 smoking university students between January 2019 and March 2020. Data were collected through socio-demographic form and Fagerstrom test for nicotine dependence. Besides, the participating students’ blood and urine samples were taken in a suitable environment.Results: The average age of the participating students was 21.50±2.09. Of all the students, 71.6% were males, 62.2% were exposed to the sun between 12 p.m. and 2 p.m., and the average number of cigarettes smoked daily was 13.52±8.22. The average Vitamin D level in blood was 32.4±15.3 (ng/mL), and the average cotinine level in urine was 1.60 ± .32 (ng/L). No statistically significant relationships were found between the Vitamin D level and the cotinine level (p<0.05).Conclusion: Smoking causes diseases and death in many people, and it is a changeable risk factor.  Nursing practices on the struggle against smoking are effective. No significant relationships were found between the Vitamin D level in blood and cotinine level in urine. Similar studies are recommended to be conducted with larger groups and participants from different age groups.

scholarly journals Clinicians should be more prone to examine children with chronic kidney disease in terms of vitamin D deficiency

2013 ◽  
Vol 33 (2) ◽  
pp. 201-201
Author(s):  
Sevket Balta ◽  
Mustafa Cakar ◽  
Seref Demirbas ◽  
Sait Demirkol
Keyword(s):  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Kidney Disease ◽  
Vitamin D Deficiency
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