scholarly journals Ozone therapy in chronic diseases; a narrative review of the literature

2019 ◽  
Vol 8 (3) ◽  
pp. 195-198
Author(s):  
Mohamad Ali Dayani ◽  
Ali Hasanpour Dehkordi ◽  
Maryam Miraghajani
Keyword(s):  
Vascular Diseases ◽  
Cost Effective ◽  
Complementary Therapy ◽  
Cyclic Guanosine Monophosphate ◽  
The Body ◽  
Guanosine Monophosphate ◽  
Ozone Therapy ◽  
Messenger Molecule ◽  
Physiological And Biochemical ◽  
Oxidative Effect

Nitric oxide (NO) has various physiological and biochemical effects. In many biological systems of the body, NO acts as a messenger molecule via cyclic guanosine monophosphate (cGMP), which affects the body cells. NO is synthesized in the body from the L-arginine amino acid by the NO synthases enzyme. This enzyme consists of three major isoforms including neurotransmitter, endothelial and inductive types. According to the results of numerous studies, the administration of ozone as a complementary therapy of the diseases is a less complicated and cost-effective way. Over the past forty years, the results of ozone therapy have been satisfactory and without any problems. Ozone therapy affects various diseases. For example, in treatment for vascular diseases and some degenerative diseases, it has an ameliorative impact. Regarding kidney disease, still many experimental or clinical studies are necessary to find its improvement/anti-oxidative effect.

Nitric oxide and regulation of vascular tone: pharmacological and physiological considerations

1998 ◽  
Vol 7 (2) ◽  
pp. 131-140 ◽  
Author(s):  
J McHugh ◽  
DJ Cheek
Keyword(s):  
Nitric Oxide ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Vascular System ◽  
Biological Activities ◽  
Vascular Diseases ◽  
Cyclic Guanosine Monophosphate ◽  
Guanosine Monophosphate ◽  
Physical Stimuli ◽  
Artery Disease

The endothelial cells of the vascular system are responsible for many biological activities that maintain vascular homeostasis. Responding to a variety of chemical and physical stimuli, the endothelium elaborates a host of vasoactive agents. One of these agents, endothelium-derived relaxing factor, now accepted as nitric oxide, influences both cellular constituents of the blood and vascular smooth muscle. A principal intracellular target for nitric oxide is guanylate cyclase, which, when activated, increases the intracellular concentration of cyclic guanosine monophosphate, which in turn activates protein kinase G. Acting by this pathway, nitric oxide induces relaxation of vascular smooth muscle and inhibits platelet activation and aggregation. Derangements in endothelial production of nitric oxide are implicated as both cause and consequence of vascular diseases, including hypertension, atherosclerosis, and coronary artery disease.

scholarly journals cGMP: a unique 2nd messenger molecule – recent developments in cGMP research and development

2019 ◽  
Vol 393 (2) ◽  
pp. 287-302 ◽  
Author(s):  
Andreas Friebe ◽  
Peter Sandner ◽  
Achim Schmidtko
Keyword(s):  
Guanylyl Cyclase ◽  
Soluble Guanylyl Cyclase ◽  
Cell Types ◽  
Cyclic Guanosine Monophosphate ◽  
Guanosine Monophosphate ◽  
Therapeutic Implications ◽  
Cellular Effects ◽  
Recent Developments ◽  
And Function ◽  
Messenger Molecule

AbstractCyclic guanosine monophosphate (cGMP) is a unique second messenger molecule formed in different cell types and tissues. cGMP targets a variety of downstream effector molecules and, thus, elicits a very broad variety of cellular effects. Its production is triggered by stimulation of either soluble guanylyl cyclase (sGC) or particulate guanylyl cyclase (pGC); both enzymes exist in different isoforms. cGMP-induced effects are regulated by endogenous receptor ligands such as nitric oxide (NO) and natriuretic peptides (NPs). Depending on the distribution of sGC and pGC and the formation of ligands, this pathway regulates not only the cardiovascular system but also the kidney, lung, liver, and brain function; in addition, the cGMP pathway is involved in the pathogenesis of fibrosis, inflammation, or neurodegeneration and may also play a role in infectious diseases such as malaria. Moreover, new pharmacological approaches are being developed which target sGC- and pGC-dependent pathways for the treatment of various diseases. Therefore, it is of key interest to understand this pathway from scratch, beginning with the molecular basis of cGMP generation, the structure and function of both guanylyl cyclases and cGMP downstream targets; research efforts also focus on the subsequent signaling cascades, their potential crosstalk, and also the translational and, ultimately, the clinical implications of cGMP modulation. This review tries to summarize the contributions to the “9th International cGMP Conference on cGMP Generators, Effectors and Therapeutic Implications” held in Mainz in 2019. Presented data will be discussed and extended also in light of recent landmark findings and ongoing activities in the field of preclinical and clinical cGMP research.

scholarly journals A CASE STUDY ON THE EFFECT OF LEKHAN BASTI WITH UDVARTANA IN THE MANAGEMENT OF STHAULYA WITH SPECIAL REFERENCE TO OBESITY

2020 ◽  
Vol 11 (10) ◽  
pp. 37-41
Author(s):  
Kamre Sneha S ◽  
Solanke S G ◽  
Chawre S V ◽  
Kabra P R
Keyword(s):  
Vascular Diseases ◽  
Cost Effective ◽  
Modern Medicine ◽  
Lifestyle Changes ◽  
The Body ◽  
Effective Management ◽  
Obstructive Sleep ◽  
Cardio Vascular

To study the effect of Lekhan Basti with Udavartana in the Management of Sthaulya. The study was conducted to evaluate cost effective and convenient treatment for Sthaulya in Ayurved. Obesity means accumulation of excess body fat in the body. Obesity increases various disease and complications particularly Cardio-vascular diseases, Type 2 Diabetes, Obstructive sleep apnea, Cancer, Osteoarthritis and Depression. As per Modern medicine, the management of Obesity include lifestyle changes, medications, or surgery advised but medications advised have so many side effects like heart valve problem, blood vessel problem. Also, surgery is not a cost-effective therapy. So that, to find out cost effective management in Obesity through Ayurveda following study was carried out. Charak has mentioned Sthaulya (~Obesity) as Santarpan-janya Vikar, accumulation of excessive Meda and Mansa Dhatu. Management in Ayurveda for Sthaulya consists of Langhana, Shodhan and Shaman Chikitsa. Sushruta has described Lekhan Basti in Sthaulya. In all classical texts, Udavartana is mentioned as part of Dincharya and for Sthaulya. Udvartana procedure remove the foetid odours, alleviates aggravated Kapha and Meda. A case study of 38 years old female patient with Sharirbhar Vriddhi for 10 years, Katishula and Ubhaya Janusandhi Shula since 2 years was treated with Lekhan Basti and Udvartana. Encouraging results were obtained which are presented in full paper. A case recorded and treated in our institute. Significant reduction in weight from 103kg to 93kg and BMI from 45.41 to 39.5 was seen in patient in one month without exercise.

scholarly journals Secondary Metabolites of Plants as Modulators of Endothelium Functions

2021 ◽  
Vol 22 (5) ◽  
pp. 2533
Author(s):  
Anna Bartáková ◽  
Marie Nováková
Keyword(s):  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
Cyclic Guanosine Monophosphate ◽  
The Body ◽  
Guanosine Monophosphate ◽  
Biologically Active ◽  
World Health ◽  
Intracellular Calcium Level ◽  
Health Organization ◽  
Active Substances

According to the World Health Organization, cardiovascular diseases are the main cause of death worldwide. They may be caused by various factors or combinations of factors. Frequently, endothelial dysfunction is involved in either development of the disorder or results from it. On the other hand, the endothelium may be disordered for other reasons, e.g., due to infection, such as COVID-19. The understanding of the role and significance of the endothelium in the body has changed significantly over time—from a simple physical barrier to a complex system encompassing local and systemic regulation of numerous processes in the body. Endothelium disorders may arise from impairment of one or more signaling pathways affecting dilator or constrictor activity, including nitric oxide–cyclic guanosine monophosphate activation, prostacyclin–cyclic adenosine monophosphate activation, phosphodiesterase inhibition, and potassium channel activation or intracellular calcium level inhibition. In this review, plants are summarized as sources of biologically active substances affecting the endothelium. This paper compares individual substances and mechanisms that are known to affect the endothelium, and which subsequently may cause the development of cardiovascular disorders.

Influence of Fresh and Thermoxidized Carotino Oil on Cyclic Guanosine Monophosphate (cGMP) in Erythrocytes from Sprague Dawley Rats

2012 ◽  
Vol 9 (1) ◽  
pp. 63
Author(s):  
Mohd Fakharul Zaman Raja Yahya ◽  
Athifah Najwani Shahidan
Keyword(s):  
Gene Expression ◽  
Beta Carotene ◽  
Cyclic Guanosine Monophosphate ◽  
Guanosine Monophosphate ◽  
Control Group ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Wide Range ◽  
Messenger Molecule ◽  
Metabolism Gene

Cyclic guanosine monophosphate (cGMP) is a second messenger molecule involved in the intracellular signalling mechanism which is important in a wide range of cellular process including metabolism, gene expression, cell proliferation and cell death. This study was conducted to determine the effect of fresh carotino oil (FCO) and thermoxidized carotino oil (TCO) on erythrocyte cGMP levels .fi·om Sprague Dawley rats. A total of 30 Sprague dawley rats were randomly segregated into three groups: the first o.f which was placed on a Fresh Carotino Oil (FCO) diet, the second on a Thermoxidized Carotino Oil (TCO) diet and the control group on commercial rat chow on(v for a period of 6 and 9 weeks. The two oil diets comprised o.f 20% (w:w) of each oil mixed with commercial rat.feed. The enzyme immunoassays, performed in week 6, revealed that the erythrocytes cG MP levels for the FCO and TCO groups were 66.198±3.193 pmol/ml and 61.990±6.318 pmol/ml respectively, and were significant (p<0.05) lower than the value .for the control group, 77.978±10.479 pmol/ml. The assays performed in week 9 revealed the erythrocytes cG MP levels for the FCO and TCO groups to be 66.522±8.194 pmol/ml and 56.842±8.546 pmol/ml respectively which were also significantly (p<0.05) lower than that for the control group, 82.817±6.677 pmol/mL. The results indicate that the presence o.l antioxidants, such as beta-carotene and tocols in carotino oil may modulate cG MP levels in rats.

Influence of Fresh and Thermoxidized Carotino Oil on Cyclic Guanosine Monophosphate (cGMP) in Erythrocytes from Sprague Dawley Rats

2012 ◽  
Vol 9 (1) ◽  
pp. 63
Author(s):  
Mohd Fakharul Zaman Raja Yahya ◽  
Athifah Najwani Shahidan
Keyword(s):  
Gene Expression ◽  
Beta Carotene ◽  
Cyclic Guanosine Monophosphate ◽  
Guanosine Monophosphate ◽  
Control Group ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Wide Range ◽  
Messenger Molecule ◽  
Metabolism Gene

Cyclic guanosine monophosphate (cGMP) is a second messenger molecule involved in the intracellular signalling mechanism which is important in a wide range of cellular process including metabolism, gene expression, cell proliferation and cell death. This study was conducted to determine the effect of fresh (FCO) and thermoxidized carotino oil (TCO) on erythrocyte cGMP levels from Sprague dawley rats. A total of 30 Sprague dawley rats were randomly segregated into three groups: the first of which was placed on a Fresh Carotino Oil (FCO) diet, the second on a Thermoxidized Carotino Oil (TCO) diet and the control group on commercial rat chow only for a period of 6 and 9 weeks. The two oil diets comprised of 20% (w:w) of each oil mixed with commercial rat feed. The enzyme immunoassays, performed in week 6, revealed that the erythrocytes cGMP levels for the FCO and TCO groups were 66.198±3.193 pmol/mL and 61.990±6.318 pmol/mL respectively, and were significantly (p<0.05) lower than the value for the control group, 77.978±10.479 pmol/mL. The assays performed in week 9 revealed the erythrocytes cGMP levels for the FCO and TCO groups to be 66.522±8.194 pmol/mL and 56.842±8.546 pmol/mL respectively which were also significantly (p<0.05) lower than that for the control group, 82.817±6.677 pmol/mL. The results indicate that the presence of antioxidants, such as beta-carotene andtocols in carotino oil may modulate cGMP levels in rats.

The Toxicity of Castor Beans and its Treatment with Doxycycline in Local Rabbits

2018 ◽  
Vol 9 (2) ◽  
Author(s):  
Nael Mohammed Sarheed ◽  
Osamah Faisal Kokas ◽  
Doaa Abd Alabas Muhammed Ridh
Keyword(s):  
Castor Bean ◽  
The Body ◽  
Control Group ◽  
High Concentration ◽  
Biochemical Tests ◽  
Doxycycline Treatment ◽  
High Concentrations ◽  
Physiological Tests ◽  
Animal House ◽  
Physiological And Biochemical

The plant of castor is widely spread in the Iraqi land, and characterized with containing ricin toxin, which has a very serious effects, and because the seeds of this plant scattered in the agricultural soil and rivers water, which increases the exposure of humans and animals to these beans. Objective: This experiment was designed to study the effect of high concentration of castor bean powder in some physiological and biochemical parameters and changes in some tissues of the body, as well as trying to use doxycycline to reduce the effects of ingestion of these seeds. Materials and Methods: In the experiment, 24 local rabbits were raised and fed in the Animal House of the Faculty of Medicine / Al-Muthanna University, then divided into four groups and treated for three weeks (21 days), Control group: treated with normal saline solution (0.9) orally throughout the experiment, G1: was treated orally with a concentration of 25 mg / kg of castor bean powder daily during the experiment, G2 : orally treated 25 mg / kg of castor bean and 25 mg / kg of doxycycline, G3: orally treated 25 mg / kg of castor powder with 50 mg / kg of doxycycline daily throughout the trial period. Results: The results of the experiment showed significant changes (P less than 0.05) in all physiological and biochemical blood tests when compared with control group. There was a significant decrease in PCV, Hb, RBC, T.protein and body weights, while demonstrated a significant increase in WBC, Urea, Creatinine, ALT, AST and ALP, with distortions in liver and kidney of animals that treated with Castor beans. In contrast, the treatment with doxycycline and caster beans showed significant improvement reflected by a normal proportion in physiological tests and biochemical tests with improvement in the tissues when compared to control group. Conclusions: It can be concluded from this study that castor bean has high toxic and pathogenic effects that may be dangerous to the life of the organism. Therefore, it is advisable to be cautious of these pills and avoid exposure to them, also recommended to take high concentrations of doxycycline treatment when infected with castor bean poisoning.

Role of Rasayana in Prevention of COVID-19 - A Review

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 716-722
Author(s):  
Sneha Dhakite ◽  
Sadhana Misar Wajpeyi
Keyword(s):  
Immune System ◽  
Respiratory System ◽  
Viral Infections ◽  
Cost Effective ◽  
The Body ◽  
Healthy Life ◽  
Vital Functions ◽  
Healthy Life Style ◽  
And Control

The “Coronavirus disease 19 (COVID-19)” is caused by “Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)”, a newly discovered member of the Coronaviridae family of viruses which is a highly communicable. There is no effective medical treatment till date for Coronavirus disease hence prevention is the best way to keep disease away. Rasayana proved to be highly efficacious and cost effective for the Prevention and Control of viral infections when vaccines and standard therapies are lacking. Rasayana Chikitsa is one of the eight branches of Ashtanga Ayurveda which helps to maintain healthy life style. Rasayana improves immunity and performs many vital functions of human body. Vyadhikshamatva that is immune mechanism of the body is involved in Prevention of the occurrence of a new disease and it also decreases the virulence and progression of an existing disease. In COVID-19 the Respiratory system mainly get affected which is evident from its symptoms like cold, cough and breathlessness. Here the drugs help in enhancing immune system and strengthening functions of Respiratory system can be useful. For this purpose, the Rasayana like Chyavanprasha, Agastya Haritaki, Pippali Rasayana, Guduchi, Yashtimadhu, Haridra, Ashwagandha, Tulsi are used. Rasayana working on Respiratory system are best for Prevention of Coronavirus and boosting immune system. Rasayana Chikitsa can be effective in the Prevention as well as reducing symptoms of COVID-19.

Correction of cytochemical changes in patients with occupational allergodermatosis

2020 ◽  
pp. 661-661
Author(s):  
E. K. Krasavina ◽  
I. V. Yatsyna
Keyword(s):  
Recovery Period ◽  
The Body ◽  
Ozone Therapy

Professional allergodermatoses are accompanied by cytochemical and immunochemical changes in the body of patients. The use of ozone therapy techniques in this category of patients can accelerate the recovery period and normalize the above indicators.

Mechanisms and practical use of the bactericidal effects of ozone and ozonated oils

2020 ◽  
pp. 45-52
Author(s):  
S. Schetinin
Keyword(s):  
Inflammatory Diseases ◽  
Aerobic Metabolism ◽  
Active Oxygen ◽  
The Body ◽  
Bactericidal Action ◽  
Ozone Therapy ◽  
Energy Substrates ◽  
Bactericidal Effects ◽  
Viral Nature

The analysis of the clinical and immunological effectiveness of ozone therapy is carried out. The mechanism of the bactericidal action of ozone in the treatment of infectious and inflammatory diseases of a bacterial and viral nature is analyzed. Ozonation of oils leads to the formation of a complex and heterogeneous cascade of components. Ozonides provide the body with some prolonged supply of active oxygen to maintain aerobic metabolism and the required level of energy substrates.

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