scholarly journals Administration of calcium and vitamin D supplementation in kidney stone formers

2018 ◽  
Vol 6 (2) ◽  
pp. 74-75
Author(s):  
Tayebeh Soleymanian
Keyword(s):  
Vitamin D ◽  
Kidney Stone ◽  
Vitamin D Supplementation ◽  
Stone Formers

scholarly journals Calcium and Vitamin D Supplementation and Their Association with Kidney Stone Disease: A Narrative Review

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4363
Author(s):  
Matteo Bargagli ◽  
Pietro Manuel Ferraro ◽  
Matteo Vittori ◽  
Gianmarco Lombardi ◽  
Giovanni Gambaro ◽  
...  
Keyword(s):  
Vitamin D ◽  
Kidney Stone ◽  
Stone Formation ◽  
Vitamin D Supplementation ◽  
Stone Disease ◽  
Normal Body Mass Index ◽  
Calcium Excretion ◽  
Kidney Stone Disease ◽  
Low Calcium Diet ◽  
Stone Formers

Kidney stone disease is a multifactorial condition influenced by both genetic predisposition and environmental factors such as lifestyle and dietary habits. Although different monogenic polymorphisms have been proposed as playing a causal role for calcium nephrolithiasis, the prevalence of these mutations in the general population and their complete pathogenetic pathway is yet to be determined. General dietary advice for kidney stone formers includes elevated fluid intake, dietary restriction of sodium and animal proteins, avoidance of a low calcium diet, maintenance of a normal body mass index, and elevated intake of vegetables and fibers. Thus, balanced calcium consumption protects against the risk for kidney stones by reducing intestinal oxalate availability and its urinary excretion. However, calcium supplementation given between meals might increase urinary calcium excretion without the beneficial effect on oxalate. In kidney stone formers, circulating active vitamin D has been found to be increased, whereas higher plasma 25-hydroxycholecalciferol seems to be present only in hypercalciuric patients. The association between nutritional vitamin D supplements and the risk for stone formation is currently not completely understood. However, taken together, available evidence might suggest that vitamin D administration worsens the risk for stone formation in patients predisposed to hypercalciuria. In this review, we analyzed and discussed available literature on the effect of calcium and vitamin D supplementation on the risk for kidney stone formation.

scholarly journals Genetic variants of calcium and vitamin D metabolism in kidney stone disease

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Sarah A. Howles ◽  
Akira Wiberg ◽  
Michelle Goldsworthy ◽  
Asha L. Bayliss ◽  
Anna K. Gluck ◽  
...  
Keyword(s):  
Vitamin D ◽  
Kidney Stone ◽  
Association Studies ◽  
Vitamin D Supplementation ◽  
Stone Disease ◽  
Calcium Excretion ◽  
Genome Wide Association Studies ◽  
Vitamin D Metabolism ◽  
Kidney Stone Disease

AbstractKidney stone disease (nephrolithiasis) is a major clinical and economic health burden with a heritability of ~45–60%. We present genome-wide association studies in British and Japanese populations and a trans-ethnic meta-analysis that include 12,123 cases and 417,378 controls, and identify 20 nephrolithiasis-associated loci, seven of which are previously unreported. A CYP24A1 locus is predicted to affect vitamin D metabolism and five loci, DGKD, DGKH, WDR72, GPIC1, and BCR, are predicted to influence calcium-sensing receptor (CaSR) signaling. In a validation cohort of only nephrolithiasis patients, the CYP24A1-associated locus correlates with serum calcium concentration and a number of nephrolithiasis episodes while the DGKD-associated locus correlates with urinary calcium excretion. In vitro, DGKD knockdown impairs CaSR-signal transduction, an effect rectified with the calcimimetic cinacalcet. Our findings indicate that studies of genotype-guided precision-medicine approaches, including withholding vitamin D supplementation and targeting vitamin D activation or CaSR-signaling pathways in patients with recurrent kidney stones, are warranted.

FP006METABOLIC EFFECTS OF CHOLECALCIFEROL SUPPLEMENTATION IN KIDNEY STONE FORMERS WITH VITAMIN D DEFICIENCY

2019 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
Corrado Vitale ◽  
Francesca Bermond ◽  
Cristina Guiotto ◽  
Diega Marranca ◽  
Laura Fabbrini ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Kidney Stone ◽  
Stone Formers ◽  
Cholecalciferol Supplementation

scholarly journals Altered Calcium and Vitamin D Homeostasis in First-Time Calcium Kidney Stone-Formers

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0137350 ◽  
Author(s):  
Hemamalini Ketha ◽  
Ravinder J. Singh ◽  
Stefan K. Grebe ◽  
Eric J. Bergstralh ◽  
Andrew D. Rule ◽  
...  
Keyword(s):  
Vitamin D ◽  
Kidney Stone ◽  
Stone Formers ◽  
First Time

Vitamin D Repletion in Kidney Stone Formers: A Randomized Controlled Trial

2017 ◽  
Vol 197 (4) ◽  
pp. 1079-1083 ◽  
Author(s):  
Matthew C. Ferroni ◽  
Kevin J. Rycyna ◽  
Timothy D. Averch ◽  
Michelle J. Semins
Keyword(s):  
Vitamin D ◽  
Randomized Controlled Trial ◽  
Kidney Stone ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Stone Formers

The Prevalence of Vitamin D Deficiency, Its Predisposing Factors and Association with 24-hour Urine Metabolites Among Iranian Kidney Stone Formers

2021 ◽  
Vol 15 (4) ◽  
Author(s):  
Maryam Taheri ◽  
Sanaz Tavasoli ◽  
Fatemeh Taheri ◽  
Fahimeh Bagheri Amiri ◽  
Nasrin Borumandnia ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Kidney Stone ◽  
Predisposing Factors ◽  
Urine Metabolites ◽  
Stone Formers

scholarly journals Seasonal variations in urinary calcium, volume, and vitamin D in kidney stone formers

2018 ◽  
Vol 44 (5) ◽  
pp. 947-951
Author(s):  
Kyrollis Attalla ◽  
Shubha De ◽  
Carl Sarkissian ◽  
Manoj Monga
Keyword(s):  
Vitamin D ◽  
Seasonal Variations ◽  
Kidney Stone ◽  
Urinary Calcium ◽  
Stone Formers

scholarly journals Long-term incidence of urolithiasis post-bariatric surgery

2014 ◽  
Vol 8 (9-10) ◽  
pp. 688 ◽  
Author(s):  
Nicholas Haddad ◽  
Patrick Scheffler ◽  
Mohamed Aly Elkoushy ◽  
Olivier Court ◽  
Nicolas V Christou ◽  
...  
Keyword(s):  
Vitamin D ◽  
De Novo ◽  
Vitamin D Supplementation ◽  
Stone Formers ◽  
Medical Histories ◽  
Recurrent Stone ◽  
Post Bariatric Surgery ◽  
Telephone Questionnaire

Introduction: The risk of urolithiasis post-Roux-en-Y gastric bypass (RYGB) surgery is higher when compared to the general population. Calcium and vitamin D supplementation is routinely prescribed to these patients, yet compliance with these supplements is unknown. The aim of this study was to assess the incidence of symptomatic de novo urolithiasis post-RYGB and compliance with calcium and vitamin D supplementation.Methods: A standardized telephone questionnaire was administered to patients who underwent RYGB between 1996 and 2011. Personal and medical histories were obtained with emphasis on episodes of symptomatic urolithiasis and calcium and vitamin D supplementation.Results: The response rate was 48% with 478 patients completing the telephone questionnaire. After a mean follow-up of 7.0 years (range: 1-15), the incidence of post-RYGB symptomatic urolithiasis was 7.3%, while the rate of de novo symptomatic urolithiasis was 5%. The overall median time to present with symptomatic urolithiasis was 3.1 years, with 3.3 years for de novo stone-formers, and 2.0 years for recurrent stone-formers (p = 0.38). In de novo stone-formers, 33% presented with symptomatic urolithiasis 4 to 14 years postoperatively. Compliance with calcium and vitamin D supplementation was 56% and 51%, respectively.Conclusions: Despite recall bias and lack of confirmatory imaging studies, a high postoperative incidence of symptomatic urolithiasis was found in a large sample of post-RYGB patients. A third of patients with de novo stones, presented with symptomatic urolithiasis 4 to 14 years postoperatively. Compliance with postoperative calcium and vitamin D supplementation was poor and needs improvement.

scholarly journals Effect of Vitamin D Repletion on Urinary Calcium Excretion among Kidney Stone Formers

2012 ◽  
Vol 7 (5) ◽  
pp. 829-834 ◽  
Author(s):  
David E. Leaf ◽  
Ruslan Korets ◽  
Eric N. Taylor ◽  
Jie Tang ◽  
John R. Asplin ◽  
...  
Keyword(s):  
Vitamin D ◽  
Kidney Stone ◽  
Urinary Calcium ◽  
Urinary Calcium Excretion ◽  
Calcium Excretion ◽  
Stone Formers
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