scholarly journals Effects of coenzyme Q10 supplementation on C-reactive protein and homocysteine as the inflammatory markers in hemodialysis patients; a randomized clinical trial

2015 ◽  
Vol 5 (1) ◽  
pp. 38-43 ◽  
Author(s):  
Narges-Sadat Zahed ◽  
Maryam Ghassami ◽  
Hajar Nikbakht
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Coenzyme Q10 ◽  
Inflammatory Markers ◽  
Hemodialysis Patients ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Coenzyme Q10 Supplementation

Abstract P542: Coenzyme Q10 Supplementation in Orthostatic Hypotension and Multiple-system Atrophy, Report on 5 Cases

Hypertension ◽  
2017 ◽  
Vol 70 (suppl_1) ◽  
Author(s):  
Christopher Rembold
Keyword(s):  
Clinical Trial ◽  
Multiple System Atrophy ◽  
Orthostatic Hypotension ◽  
Randomized Clinical Trial ◽  
Coenzyme Q10 ◽  
Sitting Position ◽  
Neurologic Disorder ◽  
Sporadic Cases ◽  
Coenzyme Q10 Supplementation ◽  
Paired T Test

Multiple-system atrophy is a neurologic disorder characterized by orthostatic hypotension, Parkinsonian signs, and cerebellar signs. Mutations in COQ2, an enzyme involved in coenzyme Q10 (CoQ10) synthesis were recently associated with familial and sporadic cases of multiple-system atrophy. I hypothesized that people with symptoms suggesting multiple-system atrophy might benefit from CoQ10 administration. Five patients with symptomatic orthostatic hypotension were treated in an unrandomized manner with 240±40 mg CoQ10 daily for 8±3 months - two had Parkinsonian and one had cerebellar signs. Prior to starting CoQ10, systolic BP fell 30±5 mmHg upon standing from a sitting position. After treatment with CoQ10, systolic BP fell 8±5 mmHg upon standing from a sitting position (p=0.013 for change in systolic BP fall by paired t test). These data suggest that orthostatic hypotension could possibly improve with CoQ10 administration and that a randomized clinical trial to test this hypothesis should be begun.

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