scholarly journals Photodynamic Therapy With Bengal Rose and Derivatives Against Leishmania amazonensis

2017 ◽  
Vol 8 (1) ◽  
pp. 46-50 ◽  
Author(s):  
Taisa Rocha Navasconi ◽  
Vanessa Nesi dos Reis ◽  
Camila Fabiano Freitas ◽  
Paulo Cesar de Souza Pereira ◽  
Wilker Caetano ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Leishmania Amazonensis ◽  
Bengal Rose

Cell death of Leishmania amazonensis promastigotes induced by photodynamic therapy

2015 ◽  
Vol 12 (3) ◽  
pp. 337
Author(s):  
Debora Picanço Aureliano ◽  
José Angelo Lauletta Lindoso ◽  
Sandra Regina Castro Soares ◽  
Martha Simões Ribeiro
Keyword(s):  
Cell Death ◽  
Photodynamic Therapy ◽  
Leishmania Amazonensis

scholarly journals In vitro activity of chlorophyll A and B in Photodynamic Therapy on Leishmania (Leishmania) amazonensis

2018 ◽  
Vol 73 ◽  
pp. 299
Author(s):  
L.D.S. Braga ◽  
D.S.S.L. Lera ◽  
Á. C. F.H.R. Milaré ◽  
W. Caetano ◽  
S.M.A. Aristides ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Chlorophyll A ◽  
Leishmania Amazonensis ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Chlorophyll A And B

Efficacy of photodynamic therapy using TiO2 nanoparticles doped with Zn and hypericin in the treatment of cutaneous Leishmaniasis caused by Leishmania amazonensis

2020 ◽  
Vol 30 ◽  
pp. 101676 ◽  
Author(s):  
Alex Arbey Lopera Sepúlveda ◽  
Angela Maria Arenas Velásquez ◽  
Irwin Alexander Patiño Linares ◽  
Leticia de Almeida ◽  
Carla Raquel Fontana ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cutaneous Leishmaniasis ◽  
Tio2 Nanoparticles ◽  
Leishmania Amazonensis

scholarly journals Photodynamic therapy for American cutaneous leishmaniasis: The efficacy of methylene blue in hamsters experimentally infected with Leishmania (Leishmania) amazonensis

2011 ◽  
Vol 128 (4) ◽  
pp. 353-356 ◽  
Author(s):  
Lílian Somenci Peloi ◽  
Carlos Eduardo Guerino Biondo ◽  
Elza Kimura ◽  
Mario José Politi ◽  
Maria Valdrinez Campana Lonardoni ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Photodynamic Therapy ◽  
Cutaneous Leishmaniasis ◽  
Leishmania Amazonensis ◽  
American Cutaneous Leishmaniasis

scholarly journals In vivo study of the effects of photodynamic therapy mediated by phthalocyanine hydrogels and led light on Leishmania amazonensis

2018 ◽  
Vol 73 ◽  
pp. 300-301
Author(s):  
V.N. Reis ◽  
T.R. Navasconi ◽  
J. Oyama ◽  
D.S.S.L. Lera-Nosone ◽  
T.G.V. Silveira ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Leishmania Amazonensis ◽  
In Vivo Study ◽  
Led Light

scholarly journals Effect of serial photodynamic therapy with curcumin on Leishmania braziliensis and Leishmania amazonensis promastigotes

2021 ◽  
Vol 10 (11) ◽  
pp. e219101119544
Author(s):  
Lucas Tobias Rodrigues Maciel ◽  
Luciana Maria Cortez Marcolino ◽  
Fernanda Bueno Sant’Anna Pereira Maciel ◽  
Juliana Guerra Pinto ◽  
Juliana Ferreira-Strixino
Keyword(s):  
Photodynamic Therapy ◽  
Skin Diseases ◽  
Leishmania Amazonensis ◽  
Leishmania Braziliensis ◽  
Trypan Blue Exclusion ◽  
Morphological Alterations ◽  
Viability Analysis ◽  
Trypan Blue Exclusion Test ◽  
Light Fluence

Photodynamic Therapy (PDT) consists of using a light source and a photosensitive drug at an appropriate wavelength and molecular oxygen to trigger cell death through the production of reactive oxygen species. Because it is a localised therapy, PDT is shown to be ideal for skin diseases. American cutaneous Leishmaniasis (ACL) is a highly prevalent protozoan disease worldwide that presents different clinical evolutions and may result in ulcerations and disfiguring lesions on the skin and cartilage. This study was aimed at evaluating the effect in vitro of PDT applied serially using curcumin as a photosensitiser. For this, a concentration of 125 µg.mL-1 of curcumin was used on Leishmania braziliensis and Leishmania amazonensis strains, with a light fluence of 10 J.cm-2 and irradiance of 110 mW.cm-2. The tests done were viability analysis by trypan blue exclusion test, analysis of photosensitizer (PS) internalization by confocal microscopy and morphological alterations by May-Grunwald/Giemsa staining. We observed that there was internalisation of the PS before the first and second application of PDT, with L. braziliensis and L. amazonensis strains mortality of 92% and 82% respectively, after the second application, and induction of alterations in the structural conformation, such as cell size and non-evidence of nucleus and flagellum, demonstrating that PDT was effective. We conclude that serial PDT was effective in inducing the mortality of promastigotes forms of L. braziliensis and L. amazonensis in vitro, thus highlighting its potential for the treatment of leishmaniasis.

scholarly journals Photodynamic Therapy for the Treatment of American Tegumentary Leishmaniasis: Evaluation of Therapies Association in Experimentally Infected Mice With Leishmania (Leishmania) amazonensis

2018 ◽  
Vol 9 (4) ◽  
pp. 274-282
Author(s):  
Roberta Ayres Ferreira do Nascimento Volpe ◽  
Taisa Rocha Navasconi ◽  
Vanessa Nesi dos Reis ◽  
Noboru Hioka ◽  
Tânia Cristina Alexandrino Becker ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Light Emitting Diode ◽  
Leishmania Amazonensis ◽  
Control Group ◽  
Volume Data ◽  
Tegumentary Leishmaniasis ◽  
Long Term Treatment ◽  
Red Led ◽  
Significant Difference ◽  
American Tegumentary Leishmaniasis

Introduction: American tegumentary leishmaniasis (ATL) is a zoonotic disease caused by protozoan parasites of the genus Leishmania that affects the skin and mucous membrane. Currently, the available drugs for the treatment are injectable, with side effects, long-term treatment regimen and there is the possibility of drug resistance. Thus, alternative therapies have been tested, including photodynamic therapy (PDT). We evaluated the efficacy of PDT on its own and associated with the prescribed ATL treatment. Methods: BALB/c mice were infected with Leishmania (Leishmania) amazonensis and divided into 6 groups: Gluc+PDT, treated with Glucantime® and photodynamic therapy (PDT) with methylene blue (MB)/red LED (light-emitting diode); Gluc, treated with Glucantime®; PDT, treated with PDT with MB/red LED; Ampho+PDT, treated with amphotericin and PDT with MB/red LED; Ampho, treated with amphotericin; and control, which were infected but not treated. Two treatment cycles were performed. After 165 days of infection, the parasite load was determined. Results: Statistical differences were not found (P>0.05) between measures of volume and thickness of the infected footpads in the treated groups when compared with the control group. However, there was a significant reduction (P<0.05) in the parasitic load of the popliteal lymph nodes of the Gluc+PDT, Gluc, PDT and Ampho groups when compared to the control group. In the histological analysis of the infected footpads, the Gluc+PDT group presented a smaller amount of amastigote nests and lower intensity of the mononuclear infiltrate when compared to the Gluc and PDT groups. Conclusion: The results showed that although there is no significant difference in the evaluations of footpad size (thickness and volume), there is a downward measurement tendency in the Gluc+PDT group, as it can be observed by volume data and corroborated by parasite negative load.

Cell death mechanisms in Leishmania amazonensis triggered by methylene blue-mediated antiparasitic photodynamic therapy

2018 ◽  
Vol 23 ◽  
pp. 1-8 ◽  
Author(s):  
Débora P. Aureliano ◽  
José Angelo Lauletta Lindoso ◽  
Sandra Regina de Castro Soares ◽  
Cleusa Fumika Hirata Takakura ◽  
Thiago Martini Pereira ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Cell Death ◽  
Photodynamic Therapy ◽  
Leishmania Amazonensis ◽  
Cell Death Mechanisms
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