scholarly journals Q10 supplementation effects on cardiac enzyme CK-MB and troponin in patients undergoing coronary artery bypass graft: a randomized, double-blinded, placebo-controlled clinical trial

2016 ◽  
Vol 8 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Jalal Moludi ◽  
Seyedali Keshavarz ◽  
Ali Sadeghpour Tabaee ◽  
Saeid Safiri ◽  
Reza Pakzad
Keyword(s):  
Clinical Trial ◽  
Coronary Artery ◽  
Coronary Artery Bypass Graft ◽  
Coronary Artery Bypass ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Controlled Clinical Trial ◽  
Artery Bypass Graft ◽  
Cardiac Enzyme ◽  
Double Blinded

scholarly journals Comparing the Effects of Ketorolac and Paracetamol on Postoperative Pain relief after Coronary Artery Bypass Graft surgery. A randomized clinical trial

2020 ◽  
Author(s):  
Fatemeh Javaherforoosh Zadeh ◽  
Hasan Abdalbeygi ◽  
Farahzad Janatmakan ◽  
Behnam Gholizadeh
Keyword(s):  
Clinical Trial ◽  
Coronary Artery ◽  
Pain Relief ◽  
Coronary Artery Bypass Graft ◽  
Coronary Artery Bypass ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Artery Bypass Graft ◽  
Hemodynamic Variables ◽  
Vas Scores

Abstract Introduction : Pain management after coronary artery bypass graft (CABG) surgery remains challenging. Objective This study aimed to compare the effects of Ketorolac and Paracetamol on postoperative CABG pain relief. Method: This double-blind randomized clinical trial study was conducted in Ahvaz, Iran, from September 2018- December 2019. Two consecutive groups of 60 patients undergoing elective on-pump coronary artery bypass graft surgery. Intervention The patients were divided into 0.5 mg/kg of ketorolac mg/dl and 10 mg/kg of Paracetamol after surgery for pain management . Primary outcomes were: visual analog pain scale (VAS) at the time point immediately after extubation (baseline) and at 6, 12, 24 and 48 hours and the total dose of morphine consumption. Secondary outcomes included the hemodynamic variables, weaning time, chest tube derange, in-hospital mortality and myocardial infarction. Statistical analysis: The data were analyzed using SPSS version 22(SPSS, Chicago, IL). The Mann-Whitney U-test was used to compare demographic data, VAS scores, vital signs, and side effects. Repeated measurements were tested within groups using Friedman's ANOVA and the Wilcoxon rank-sum test. Values were expressed as means ± standard deviations. Statistical significance was defined as a p-value < 0.05. Results : Compared with baseline scores, there were significant declines in VAS scores in both groups throughout the time sequence (P＜ 0.05). The statistical VAS score was slightly higher in the Paracetamol group at most time points, except for the time of 6 h. However, at 24 and 48 hours, the VAS score in group Paracetamol was significantly higher than in group Ketorolac. There were no significant differences between groups about hemodynamic variables. Conclusion: The efficacy of ketorolac is comparable to that of Paracetamol in postoperative CABG pain relief. Trial registry: IRCT20150216021098N5. Registered at 2019-09-12

Sign in / Sign up

Export Citation Format

Share Document