scholarly journals Diagnostic value of serum procalcitonin for diagnosis of bacterial infection in patients with chronic kidney disease under hemodialysis

2020 ◽  
Vol 6 (1) ◽  
pp. e08-e08
Author(s):  
Rasoul Estakhri ◽  
Nava Moghadasian Niaki ◽  
Hamid Noshad ◽  
Mohammad Asghari ◽  
Hojjat Barghi
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Bacterial Infections ◽  
Bacterial Culture ◽  
Positive Culture ◽  
Diagnostic Value ◽  
Cross Sectional ◽  
Mortality And Morbidity ◽  
Positive Bacterial Culture ◽  
Before And After

Introduction: Bacterial infections are common causes of mortality and morbidity among chronic kidney disease (CKD) patients under hemodialysis. Objectives: In this study the diagnostic value of serum procalcitonin for diagnosis of bacterial infections in patients with CKD under hemodialysis was assessed. Patients and Methods: In this cross-sectional comparative investigation, 47 patients with CKD under hemodialysis were enrolled to the study. We studied the relationship of serum procalcitonin (PTC) and C-reactive protein (CRP) levels (before and after dialysis) with "positive bacterial culture" and "systemic inflammatory response syndrome (SIRS)" results. Sensitivity and specificity were determined by ROC test. Results: Serum PTC before and after dialysis as well as the CRP before dialysis had no significant association with positive bacterial culture (P=0.492, P=0.1 and P=0.268 respectively), however after-dialysis CRP had a significant association with positive bacterial culture (P=0.032). Conclusion: According to the obtained results, it may be concluded that the diagnostic value of serum PTC for diagnosis of positive culture bacterial infections in hemodialysis patients is not satisfactory since the serum CRP level especially after dialysis is more useful.

scholarly journals MO529PREVALENCE AND DETERMINANT FACTORS OF DEPRESSION AND ANXIETY IN PEOPLE WITH CHRONIC KIDNEY DISEASE : A MOROCCAN CROSS-SECTIONAL  STUDY

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Amina Chrifi Alaoui ◽  
Mohammed Omari ◽  
Noura Qarmiche ◽  
Omar Kouiri ◽  
Basmat Amal Chouhani ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Depression Scale ◽  
Clinical Information ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Depression And Anxiety ◽  
Cross Sectional ◽  
Determinant Factors ◽  
Before And After

Abstract Background and Aims The Chronic kidney disease (CKD), like many chronic illnesses, is invariably associated with various psychiatric conditions and poorer quality of life. This study aims to assess the prevalence of depression and anxiety among CKD patient and their determinant factors. Method this is a cross sectional single center study in a Moroccan university hospital. Patients aged ≥ 18 years old and followed for more than one year were included. The data was collected using a questionnaire for sociodemographic and clinical information and the Hospital anxiety and depression scale (HADS) to assess depression and anxiety prevalence. After the description of the population’s characteristics, the statistical analysis aimed to assess the association between depression and anxiety disorders and the estimated glomerular filtration rate before and after adjustment on several confounding factors. Results 88 patients were included (63.6% of them were women, the mean age was 61.8±14.0 years), 21 were on stage 3, 46 were on stage 4, and 21 were on stage 5 of the CKD. The median of depression sub-score was 5.00[2.00; 10.0], the median of anxiety sub-score was 6.00[4.00; 9.00], and the median of the global score was 11.0[7.00; 20.0], 22.0% of included patients had depression and 22.0% had anxiety. Both depression and anxiety scores were associated to eGFR before and after adjustment (p= 0.001, p<0.001and p=0.04, p=0.03 respectively). Conclusion This study showed that depression and anxiety are strongly related to the CKD progression, which should motivate both doctors and nurses to improve their psychological care toward CKD patients.

scholarly journals Perbedaan Kadar Hemoglobin pada Penderita Gagal Ginjal Kronik Sebelum dan Setelah Melakukan Hemodialisa

2021 ◽  
Vol 8 (1) ◽  
pp. 146-151
Author(s):  
Virania Arvianti ◽  
◽  
Septian Septian ◽  
Aturut Yansen ◽  
◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Kidney Function ◽  
Secondary Data ◽  
Sampling Technique ◽  
Chronic Kidney Failure ◽  
Wilcoxon Test ◽  
Cross Sectional ◽  
Significant Difference ◽  
Before And After

IntroductionAnemia is the most common occurrence in chronic kidney disease undergoing hemodialysis therapy. In the condition of chronic kidney disease, the decline in kidney function can occur slowly and chronically until the kidneys do not function at all. Hemodialysis is one of the therapies used to replaced kidney function. During hemodialysis, a decrease in hemoglobin levels often occurs, this is due to the disruption of the hormon erythropoietin. Objective:determine the differences in hemoglobin levels in patients with chronic kidney disease before and after hemodialysis at Bhayangkara TK. I Raden Said SukantoHospital. Method: The design of this research is cross sectional using secondary data and the sampling technique of this research was random sampling with a total of 133 patients. Result: The normality test was carried out first using the Kolmogorov-Smirnova test which showed the results were not normally distributed with a sig value of 0.001. the next test was the Wilcoxon test with a sig (2-tailed_ value of 0.002 with an average hemoglobin level of 8,81 g/dL before hemodialysis and 9,09 g/dL after hemodialysis. Conclusion:Based on the results of the study means that there is a significant difference in a patient with chronic kidney failure before and after hemodialysis.

scholarly journals Prescribing pattern of drugs in chronic kidney disease patients on hemodialysis at a tertiary care hospital

2017 ◽  
Vol 6 (4) ◽  
pp. 928
Author(s):  
Narayana Murthy B. V. ◽  
Satyanarayana V.
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Tertiary Care ◽  
Hypoglycemic Agents ◽  
Phosphate Binders ◽  
Care Hospital ◽  
Oral Hypoglycemic Agents ◽  
Prescribing Pattern ◽  
Cross Sectional ◽  
Mortality And Morbidity

Background: CKD (chronic kidney disease) is a general term for heterogeneous disorders affecting kidney structure and its function. It is defined as either kidney damage or a decreased glomerular filtration rate of less than 60 mL/min/1.73m2 for 3 or more months. Objective of present work is to study the drug utilization pattern in chronic kidney disease patients undergoing hemodialysis.Methods: After taking the clearance and approval from the institutional ethics committee, a cross sectional prospective observational study conducted on chronic kidney disease (CKD) patients undergoing hemodialysis, in the department of nephrology, of Rajarajeshwari Medical College and Hospital, Bangalore. The data was analyzed descriptively.Results: Study included 52 patients, among them 41 males, 11were females, with a mean age of 47.6yrs. In our study large number pt were suffering from hypertension (HTN) 88.46% (46), in them the calcium channel blocker (CCB) 08.48% (38) was most commonly prescribed anti hypertensive drug. Around 1/3 of pt suffering from diabetes mellitus (DM) 36.53% (19) most of these patients were treated with them treated with oral hypoglycemic agents (OHA), and less than half of pt treated with insulin01.56% (07). Other drugs like phosphate binders (calcium carbonate & acetate) used in 11.16% (50), aspirin in 08.70% (39), statins in 10.04% (45) pt were being most commonly prescribed drugs.  Totally 448 drugs were prescribed In 52 pts Ie about 8.61 drugs / prescription, showing poly pharmacy.Conclusions: Patients undergoing hemodialysis with CKD will be having multiple diseases associated, regular monitoring and counseling regarding these diseases and its complication may reduce the incidence of CKD and the mortality and morbidity associated. The poly pharmacy noted in the study found inevitable because of the multifactorial etiologiesinvolved and needful multi-interventional approach towards it.

scholarly journals Elevated Endothelin-1 in Intradialytic Hypertension

2019 ◽  
Vol 7 (2) ◽  
pp. 102-107
Author(s):  
Rubin Surachno Gondodiputro ◽  
Andika Wiratama ◽  
Stefanie Yuliana Usman ◽  
Erma Arnika Dewi ◽  
Evan Susandi ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Observational Study ◽  
Significant Elevation ◽  
Cross Sectional ◽  
Dialysis Unit ◽  
Endothelin 1 ◽  
Before And After ◽  
Relative Change ◽  
Hospital General

Objective: To determine the relative change in endothelin-1 (ET-1) during hemodialysis procedure in Stage Five Dialysis-Dependent Chronic Kidney Disease (CKD-5D)patients with and without intradialytic hypertension (IDH). Methods: This was a cross-sectional, observational study involving 40 CKD-5D patients who received two hemodialysis per week for at least three months at the dialysis unit of Dr. Hasan Sadikin Hospital General Bandung, Indonesia during September 2016. Subjects were divided two groups: with IDH (n=20) and without IDH (n=20). Plasma ET-1 level was examined before and after hemodialysis. Results: There was a significant elevation of ET-1 level (mean±SD pg/mL) between pre- and post-dialysis state in patients with IDH (3.33±1.28 vs. 3.84±1.75; relative changes: 15.32%, p=0.013). No change was observed in patients without IDH (3.99±2.30 vs. 4.38±1.81; relative changes: 9.77% p=0.083). The post-dialysis absolute ET-1 level was significantly lower in CKD-5D patients with IDH (3.84±1.75 vs. 4.38±1.81; p=0.024). Conclusion: There was a significant elevation of ET-1 level in CKD-5D patients with IDH during hemodialysis procedure at the dialysis unit of Dr. Hasan Sadikin General Hospital Bandung.

scholarly journals Kultur Bakteri Positif pada Pasien dengan Perforasi Gaster di RSUD Dr. Moewardi Surakarta: Sebuah Studi Retrospektif

2021 ◽  
Vol 4 (1) ◽  
pp. 56
Author(s):  
Muhammad David Perdana Putra ◽  
Muhammad Singgih Nugraha ◽  
Agus Raharjo
Keyword(s):  
Bacterial Infections ◽  
Bacterial Culture ◽  
Gastric Perforation ◽  
Abdominal Cavity ◽  
Bacteroides Fragilis ◽  
Positive Culture ◽  
Positive Bacterial Culture ◽  
Stomach Acid ◽  
Chemical Peritonitis ◽  
Over 40 Years

<p class="AbstractNormal"><strong>Pendahuluan: </strong>Perforasi gaster mengakibatkan kebocoran asam lambung kedalam rongga perut, sehingga berkembang menjadi peritonitis kimia. Infeksi bakteri dapat menyertai peritonitis dengan mayoritas patogen penyebab infeksi adalah <em>Enterobactericeae Sp.</em>, <em>Stretococcus Sp.</em>,<em> dan</em> <em>Bacteroides Fragilis</em>.<strong> </strong>Penelitian ini bertujuan untuk mengetahui profil penderita perforasi gaster dengan kultur bakteri positif di RSUD Dr. Moewardi.</p><p class="AbstractNormal"><strong>Metode: </strong>Pasien diobservasi secara retrospektif dari rekam medis pasien yang didiagnosis perforasi gaster dalam kurun waktu 2017 - 2018.</p><p class="AbstractNormal"><strong>Hasil: </strong>Dalam 2017-2018 ditemukan 84 pasien, 13 diantaranya hasil pemeriksaan kultur positif, onset dilakukan operasi lebih dari 12 jam pada 10 pasien (77%) wanita, 3 pasien (23%) Laki-laki. Sembilan pasien (69%) diatas umur 40 th, 4 pasien (31%) dibawah 40 th. Berdasarkan letak perforasi, 1 pasien (8%) di Antrum, 10 pasien (77%) di pylorus dan 2 pasien (15%) di curvatura mayor. Jenis bakteri yang ditemukan <em>Staphilococcus Epidermidis </em>4 pasien (30%), <em>Staphilococcus Haemoliticus</em> 5 pasien (40%) dan <em>Enterobacter chloacae </em>4 pasien (30%).</p><p class="AbstractNormal"><strong>Kesimpulan: </strong>Didapatkan 13 pasien pemeriksaan kultur positif. Tidak ditemukan jenis bakteri yang dominan.</p><p class="Keywords"> </p><div class="WordSection1"><p class="AbstractNormal"><strong>Introduction: </strong>Gastric perforation results in leakage of stomach acid into the abdominal cavity, thus developing into chemical peritonitis. Bacterial infections can accompany peritonitis with the majority of pathogens causing infection are Enterobactericeae sp., Streptococcus sp., and Bacteroides fragilis. This study aims to determine the profile of patients with gastric perforation with positive bacterial culture in Dr. Moewardi Hospital Surakarta.</p><p class="AbstractNormal"><strong>Methods: </strong>Patients were observed retrospectively from the medical records of patients diagnosed with gastric perforation in the period 2017 - 2018.</p><p class="AbstractNormal"><strong>Results: </strong>In 2017-2018 84 patients were found, 13 of them were positive culture results, the onset of surgery was more than 12 hours in 10 patients (77%) female, 3 patients (23%) male. Nine patients (69%) were over 40 years old, 4 patients (31%) were under 40 years old. Based on the perforation location, 1 patient (8%) in antrum, 10 patients (77%) in pylorus and 2 patients (15%) in curvatura major. The types of bacteria found were Staphylococcus epdermidis in 4 patients (30%), Staphylococcus haemoliticus in 5 patients (40%) and Enterobacter chloacae in 4 patients (30%).</p><p class="AbstractNormal"><strong>Conclusion: </strong>There were 13 positive culture examination patients. No dominant bacterial type was found.</p><p class="Keywords"><strong>Keywords:</strong> retrospective, gastric perforation, infection, bacterial culture</p></div><p class="Keywords"><strong><br clear="all" /></strong></p>

scholarly journals Hemoglobin, Hematocrit, Leukocyte, and Platelet Changes Due To Ultrafiltrationhemodialysis in Chronic Kidney Disease Patients

2020 ◽  
Vol 26 (3) ◽  
Author(s):  
Nathalya Dwi Kartikasari ◽  
Paulus Budiono Notopuro ◽  
Widodo Widodo ◽  
Yetti Hernaningsih
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Blood Count ◽  
Complete Blood Count ◽  
Proper Time ◽  
Cross Sectional Study ◽  
Blood Sampling ◽  
Sectional Study ◽  
Cross Sectional ◽  
Before And After

Managing anemia in Chronic Kidney Disease (CKD) patients with hemodialysis (HD) is a challenge to physicians. The present consensus does not address the proper time of blood sampling in HD patients, but higher ultrafiltration (UF) volume (a process of removing fluid excess during HD) may alter hematologic parameters. The objective of this study was to compare some parameters of the Complete Blood Count (CBC); hemoglobin (Hb), hematocrit (Hct), leukocyte (WBC), and platelet counts (Plt) before and after HD. This method was a cross-sectional study performed in the HD Unit, Dr.Soetomo Hospital, including 51 CKD patients selected consecutively, divided into two groups based on the UF volume (2 L and >2 L). Complete blood count pre- and post-HD were measured using Sysmex XN 1000. The results were 25 males and 26 females in this study, age ranged from 20 to 74-year-old, and 36 patients with UF volume >2 L. Only HD with UF >2 L showed significant increases for Hb (9.35g/dL to 10.00 g/dL), Hct (29.80% to 31.15 %), and Plt (209.00x103/µL to 213.00x103/µL) but WBC did not change significantly. These changes were believed to be caused by ultrafiltration. The conclusion was Hb, Hct, and Plt increased significantly with UF ≥2 L in HD CKD patients.

scholarly journals Pengaruh Hemodialisis Terhadap Kadar Glutation Tereduksi (GSH) Plasma Pasien Hemodialisis RSUD Arifin Ahmad

2017 ◽  
Vol 5 (1) ◽  
pp. 13
Author(s):  
Hannan Khairu Anami ◽  
W. Ristua Butar-Butar ◽  
Enikarmila Asni
Keyword(s):  
Chronic Kidney Disease ◽  
Free Radicals ◽  
Kidney Disease ◽  
General Population ◽  
Blood Plasma ◽  
Hemodialysis Patient ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Before And After

Chronic kidney disease patients who received hemodialysis therapy have higher risks to get atherosclerosis, inflammation,and cancer than general population at the same age. Imbalance of free radicals level and antioxidants defense whichdefined as oxidative stres may cause these complications. This study investigated the influence of hemodialysis onreduced glutathione (GSH) level, one of antioxidant, in blood plasma of hemodialysis patient at RSUD Arifin Ahmad.This was a cross sectional study that compare plasma GSH level before and after hemodialysis process. Population ofthis study was 72 patient in RSUD Arifin Ahmad but only 17 patient fulfilled all the inclusion and exclusion criteria.Plasma GSH level was measured by using Ellman method. The result showed that there were no significant differenceof plasma GSH level in patient before and after hemodialysis process (p=0,426).

HUBUNGAN EFIKASI DIRI DENGAN KUALITAS HIDUP PASIEN GAGAL GINJAL KRONIK YANG MENJALANI HEMODIALISIS

2018 ◽  
Vol 5 (2) ◽  
pp. 56-63
Author(s):  
Abdul Wakhid ◽  
Estri Linda Wijayanti ◽  
Liyanovitasari Liyanovitasari
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Self Efficacy ◽  
Healing Process ◽  
Sampling Technique ◽  
P Value ◽  
Cross Sectional ◽  
Kolmogorov Smirnov

Background: Self efficacy can optimize the quality of life of clients who undergo the healing process due to chronic diseases. Individuals with higher self-efficacy move their personal and social resources proactively to maintain and improve the quality and length of their lives so that they experience a better quality of life. Objectives: the purpose of this study was to find the correlation between self efficacy and quality of life of patients with chronic kidney disease who undergo hemodialysis at RSUD Semarang Regency. Metode: This type of research was descriptive correlation with cross sectional approach. The samples in this study more 76 people with total sampling technique. The data collection tool for self efficacy was measured by General Self-Efficacy scale, for quality of life with WHOQoL-BREF. Statistical test used Kolmogorov-smirnov. Result: The result showed that self efficacy in patients with chronic kidney disease was mostly in moderate category (53,9%), quality of life in patients with chronic kidney disease was mostly in good category (68,4%). There was a correlation between self efficacy and quality of life of patients with chronic kidney disease who undergo hemodialysis at RSUD Semarang Regency, the result obtained p-value of 0.000 <α (0,05). Suggestion: Patients with chronic kidney disease can maintain good quality of life by helping to generate positive self-esteem and high self efficacy.

scholarly journals Elevated alanine aminotransferase and low aspartate aminotransferase/alanine aminotransferase ratio are associated with chronic kidney disease among middle-aged women: a cross-sectional study

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Hirotaka Ochiai ◽  
Takako Shirasawa ◽  
Takahiko Yoshimoto ◽  
Satsue Nagahama ◽  
Akihiro Watanabe ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Venous Blood ◽  
Cross Sectional Study ◽  
Middle Aged ◽  
Cross Sectional ◽  
Alcoholic Fatty Liver ◽  
Relationship Of

Abstract Background Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) to ALT ratio (AST/ALT ratio) have been shown to be related to non-alcoholic fatty liver disease or insulin resistance, which was associated with chronic kidney disease (CKD). However, it is unclear whether ALT and AST/ALT ratio are associated with CKD. In this study, we examined the relationship of ALT and AST/ALT ratio to CKD among middle-aged females in Japan. Methods The present study included 29,133 women aged 40 to 64 years who had an annual health checkup in Japan during April 2013 to March 2014. Venous blood samples were collected to measure ALT, AST, gamma-glutamyltransferase (GGT), and creatinine levels. In accordance with previous studies, ALT > 40 U/L and GGT > 50 U/L were determined as elevated, AST/ALT ratio < 1 was regarded as low, and CKD was defined as estimated glomerular filtration rate < 60 mL/min/1.73 m2 and/or proteinuria. Logistic regression model was used to calculate the odds ratio (OR) and 95% confidence interval (CI) for CKD. Results “Elevated ALT and elevated GGT” and “elevated ALT and non-elevated GGT” significantly increased the OR for CKD when compared with “non-elevated ALT and non-elevated GGT” (OR: 2.56, 95% CI: 2.10–3.12 and OR: 2.24, 95% CI: 1.81–2.77). Compared with “AST/ALT ratio ≥ 1 and non-elevated GGT”, “AST/ALT ratio < 1 and elevated GGT” and “AST/ALT ratio < 1 and non-elevated GGT” significantly increased the OR for CKD (OR: 2.73, 95% CI: 2.36–3.15 and OR: 1.68, 95% CI: 1.52–1.87). These findings still remained after adjustment for confounders. Conclusions Elevated ALT was associated with CKD regardless of GGT elevation. Moreover, low AST/ALT ratio was also associated with CKD independent of GGT elevation.

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