scholarly journals Retraction Note: Inhibition of hTERT Gene Expression by Silibinin-Loaded PLGA-PEG-Fe₃O₄ in T47D Breast Cancer Cell Line

Bioimpacts ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 321-321 ◽  
Author(s):  
Zohreh Ebrahimnezhad ◽  
Nosratollah Zarghami ◽  
Manoutchehr Keyhani ◽  
Soumaye Amirsaadat ◽  
Abolfazl Akbarzadeh ◽  
...  
Keyword(s):  
Experimental Error ◽  
Cancer Cell Line ◽  
Editorial Team ◽  
Publication Ethics ◽  
Htert Gene ◽  
Ethical Misconduct ◽  
T47d Breast Cancer Cell ◽  
Data Fabrication ◽  
Redundant Publication ◽  
Published Paper

This paper was published in BioImpacts in 2013 (doi: 10.5681/bi.2013.005).1 Based on an email received from a researcher recently, we were informed that this published paper presented some data (i.e., Fig. 3a and 3b) as same as data presented in three other published papers (i.e., doi: 10.1111/Cbdd.12318; doi: 10.1111/Cbdd.12318; and doi: 10.1186/1477-3155-10-46),2-4 which are considered as the ethical misconduct. This issue was brought up with and comprehensively investigated by the editorial team of BioImpacts through comparison of the papers and the within-data. As a result, in accordance with the Committee on Publication Ethics (COPE), the editors decided to retract this paper. The authors were informed and advised on this serious ethical breach. Based on the COPE guidelines on the retraction, BioImpacts considers retracting a publication if: - It has clear evidence that the findings are unreliable, either as a result of misconduct (e.g., data fabrication and/or falsification) or honest error (e.g. miscalculation or experimental error). - The findings have previously been published elsewhere without proper crossreferencing, permission or justification (i.e. cases of redundant publication). As a peer-review multidisciplinary international "Publish Free" and "Access Free" journal, BioImpacts strongly adheres to the "Publication Ethics", and its foremost goal is to preserve the integrity of the scientific reports in the highest standards, therefore, the journal takes all issues of publication misconduct seriously.

scholarly journals Korean court cases regarding research and publication ethics from 2009 to 2020

2021 ◽  
Vol 8 (1) ◽  
pp. 98-103
Author(s):  
Ju Yoen Lee
Keyword(s):  
Supreme Court ◽  
Copyright Law ◽  
Publication Ethics ◽  
Court Cases ◽  
Criminal Cases ◽  
Legal Cases ◽  
Ethical Misconduct ◽  
The Supreme Court ◽  
Data Fabrication ◽  
Ethical Norms

Research and publication misconduct may occur in various forms, including author misrepresentation, plagiarism, and data fabrication. Research and publication ethics are essentially not legal duties, but ethical obligations. In reality, however, legal disputes arise over whether research and publication ethics have been violated. Thus, in many cases, misconduct in research and publication is determined in the courts. This article presents noteworthy legal cases in Korea regarding research and publication ethics to help editors and authors prevent ethical misconduct. Legal cases from 2009 to 2020 were collected from the database of the Supreme Court of Korea in December 2020. These court cases represent three case types: 1) civil cases, such as affirmation of nullity of dismissal and damages; 2) criminal cases, such as fraud, interference with business, and violations of copyright law; and 3) administrative cases related to disciplinary measures against professors affiliated with a university. These cases show that although research and publication ethics are ethical norms that are autonomously established by the relevant academic societies, they become a criterion for case resolution in legal disputes where research and publication misconduct is at issue.

The comparison of Zn(II) arginine dithiocarbamate cytotoxicity in T47D breast cancer and fibroblast cells

2021 ◽  
pp. 1-7
Author(s):  
Prihantono Prihantono ◽  
Rizal Irfandi ◽  
Indah Raya
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Breast Cancer Cell Line ◽  
Cancer Cell Line ◽  
Fibroblast Cell ◽  
Fibroblast Cells ◽  
X Ray ◽  
Dithiocarbamate Complex ◽  
T47d Breast Cancer Cell ◽  
Fibroblast Cell Lines

BACKGROUND: With essential metals being studied and developed as anticancer agents, this study aims to explore the anticancer activity of Zn(II) arginine dithiocarbamate in the T47D and fibroblast cell lines. METHOD: The Zn(II) arginine dithiocarbamate complex was prepared by the in situ method and characterized using infra-red spectroscopy, melting point, X-ray fluorescence, and X-ray diffraction instruments. The complex compound was tested for its cytotoxicity to the T47D breast cancer and fibroblast cell lines. RESULTS: The cytotoxicity of the Zn(II) arginine dithiocarbamate complex to the T47D breast cancer cell line obtained IC50 = 3.16 μg/mL, while cisplatin obtained IC50 = 28.18 μg/mL. The cytotoxicity of the Zn(II) arginine dithiocarbamate complex to fibroblast cells obtained IC50 = 8709.63 μg/mL. CONCLUSION: The Zn(II) arginine dithiocarbamate complex has increased active cytotoxicity compared to cisplatin in inducing morphological changes in the T47D breast cancer cell line and is relatively non-toxic to fibroblast cells.

Fenugreek extract diosgenin and pure diosgenin inhibit the hTERT gene expression in A549 lung cancer cell line

2014 ◽  
Vol 41 (9) ◽  
pp. 6247-6252 ◽  
Author(s):  
Mohammad Rahmati-Yamchi ◽  
Somayyeh Ghareghomi ◽  
Gholamreza Haddadchi ◽  
Morteza Milani ◽  
Mohammad Aghazadeh ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Lung Cancer Cell Line ◽  
Lung Cancer Cell ◽  
Htert Gene ◽  
A549 Lung Cancer Cell ◽  
A549 Lung

Synergistic Effect of Free and Nano-encapsulated Chrysin-Curcumin on Inhibition of hTERT Gene Expression in SW480 Colorectal Cancer Cell Line

Drug Research ◽  
2018 ◽  
Vol 68 (06) ◽  
pp. 335-343 ◽  
Author(s):  
Raana Bagheri ◽  
Zohreh Sanaat ◽  
Nosratollah Zarghami
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Synergistic Effect ◽  
Cancer Cells ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Colorectal Cancer Cell Line ◽  
Htert Gene ◽  
Sw480 Cells

Abstract Background Telomerase is known as a global therapeutic target in cancer cells due to its main role in tumorigenesis. Nowadays, it is proposed new treatment methods based on molecular target therapy by bioactive substances such as curcumin and chrysin with fewer side effects than other chemical drugs. But due to their low aqueous solubility and high clearance in the bloodstream it can be used of nanoparticles to increase their half-life and biocompatibility of them. Therefore, the goal of this study was to evaluate the effect of Chrysin-Curcumin on the expression of telomerase gene in SW480 colorectal cancer cell line. Material and method PLGA-PEG nanoparticles synthesized and were confirmed using by the scanning electron microscope (SEM) and FTIR Spectroscopy. After treatment of SW480 cells by curcumin and chrysin loaded nanoparticles, their toxicity to cancer cells, was evaluated by MTT. Then, the inhibition of hTERT gene expression was measured using qRT-PCR method. Result The results of MTT test showed nanocapsulated curcumin and chrysin compared with free forms of these compounds have high synergistic effect on sw480 cells. Also, real time-PCR showed significant decrease in hTERT gene expression in SW480 cells that treated with nano-curcumin and nano-chrysin compare to untreated cells. Conclusion Nano-encapsulation of curcumin and chrysin enhanced delivery of these compounds to SW480 colorectal cancer cells and therefore it can be conclude that PLGA-PEG nanoparticles promote anticancer effects of curcumin-chrysin by increasing bioavailability and the solubility of these drugs.

scholarly journals Rejection rate and reasons for rejection after peer review: a case study of a Russian economics journal

2021 ◽  
Vol 47 ◽  
Author(s):  
Evgueniya A Balyakina ◽  
Ludmila A Kriventsova
Keyword(s):  
Peer Review ◽  
Peer Review Process ◽  
Scientific Journal ◽  
Rejection Rate ◽  
Research Area ◽  
Editorial Team ◽  
Publication Ethics ◽  
Double Blind ◽  
Blind Review ◽  
Review Reports

 Background:  Peer review remains the only way of filtering and improving research. However, there are few studies of peer review based on the contents of review reports, because access to these reports is limited. Objectives: To measure the rejection rate and to investigate the reasons for rejection after peer-review in a specialized scientific journal.  Methods:  We considered the manuscripts submitted to a Russian journal, namely ‘Economy of Region’ (Rus Экономика региона), from 2016 to 2018, and analysed the double-blind review reports related to rejected submissions in qualitative and quantitative terms including descriptive statistics. Results: Of the 1653 submissions from 2016 to 2018, 324 (20%) were published, giving an average rejection rate of 80%. Content analysis of reviewer reports showed five categories of shortcomings in the manuscripts: breaches of publication ethics, mismatch with the journal’s research area, weak research reporting (a major group, which accounted for 66%of the total); lack of novelty, and design errors. We identified two major problems in the peer-review process that require editorial correction: in 36% of the cases, the authors did not send the revised version of the manuscript to the journal after receiving editorial comments and in 30% of the cases, the reviewers made contradictory recommendations. Conclusions: To obtain a more balanced evaluation from experts and to avoid paper losses the editorial team should revise the journal’s instructions to authors, its guide to reviewers, and the form of the reviewer’s report by indicating the weightings assigned to the different criteria and by describing in detail the criteria for a good paper.

scholarly journals Design and development of nanostructured co delivery of artemisinin and chrysin for targeting hTERT gene expression in breast cancer cell line: possible clinical application in cancer treatment

2021 ◽  
Author(s):  
Leila Khoshravan Azar ◽  
Mehdi Dadashpour ◽  
Akram Firouzi-Amandi ◽  
Nosratollah Zarghami
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Cancer Treatment ◽  
Cancer Cells ◽  
Cell Line ◽  
Cancer Cell Line ◽  
Inhibitory Effect ◽  
Plga Nanoparticles ◽  
Preventive Strategy ◽  
Htert Gene

Abstract Background: Breast cancer is one of the most significant causes of female cancer death worldwide. To explore the possibility of a novel chemo-preventive strategy for improving breast cancer treatment, the anticancer effects of a combination two natural compounds, Artemisinin (Art) and Chrysin (Chr), against T47D breast cancer cells were investigated.Methods: For this purpose, Art and Chr were co-encapsulated in PEGylated PLGA nanoparticles (NPs) and evaluated for their therapeutic efficacy. The morphology and dynamic light scattering (DLS) analyses were carried out to optimize the Nano formulations. Drug release study was performed using the dialysis method and then the cytotoxic and inhibitory effect of individual and combined drugs on the expression level of hTERT in the T47D breast cell line was evaluated using MTT assay and qPCR, respectively. Results: The results showed that pure drugs and formulations exhibited dose-dependent cytotoxicity against T47D cells and especially, Art/Chr–PLGA/PEG NPs had a more synergistic anti-proliferative effect and significantly arrested the growth of cancer cells than the other groups. Real-time PCR results revealed that Art, Chr and combination of Art–Chr in pure and encapsulated forms inhibited hTERT gene expression. Conclusions: It was found that Art–Chr–PLGA/PEG NPs relative to pure combination could further decline hTERT expression in all concentrations. Our study demonstrated that Art–Chr–PLGA/PEG NPs based combinational therapy holds promising potential for the treatment of breast cancer.

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