scholarly journals Anti-aging and Sunscreens: Paradigm Shift in Cosmetics

2019 ◽  
Vol 9 (3) ◽  
pp. 348-359 ◽  
Author(s):  
Shreya Shanbhag ◽  
Akshatha Nayak ◽  
Reema Narayan ◽  
Usha Yogendra Nayak
Keyword(s):  
Paradigm Shift ◽  
Skin Aging ◽  
Health Condition ◽  
Extrinsic Factors ◽  
Complex Biological Process ◽  
General Health Condition ◽  
Aging Product ◽  
Increasing Demand ◽  
Insight Into ◽  
Sunscreen Products

Skin, being one of the vital organs and a protective barrier needs to be pampered and taken care of from early childhood. It is the most visible and the widest exposed organ and by far reflects the general health condition and the aging process in humans. Both intrinsic and extrinsic factors contribute to this complex biological process of skin aging. In recent times, skin health and its beauty is perceived as an indicator of one’s health which has resulted in an increasing demand for anti-aging products. Exposure to UV radiation is considered to be one of the factors responsible for aging termed as photoaging. In this review, we have discussed the various factors which may accelerate the process of skin aging. Various approaches and strategies to delay the process of skin aging have been emphasized upon. The patents filed in the area of anti-aging and sunscreen products have also been reviewed to gain an insight into the new formulations which have been developed as an anti-aging product. There has been a tremendous rise in the cosmetic and cosmeceuticals market with products having a dual activity of anti-aging and sun protection. Research is constantly on the rise to ensure the safety of these products. Alternatives to the current topical application of sunscreen are being considered to overcome the drawback of reapplication of the sunscreen often which can be a boon to the cosmeceutical market.

scholarly journals Polyphenols as Natural Antioxidants in Skin Aging

2020 ◽  
Vol 3 (3) ◽  
Author(s):  
Satya Wydya Yenny ◽  
Yulia Eka Suryani
Keyword(s):  
Human Life ◽  
Radical Scavenging ◽  
Natural Antioxidants ◽  
Skin Aging ◽  
The Body ◽  
Extrinsic Factors ◽  
Naturally Occurring ◽  
Complex Biological Process ◽  
Scavenging Capacity ◽  
High Antioxidant Activity

Skin aging is a complex biological process influenced by a combination of intrinsic and extrinsic factors, leading to cumulative alterations of skin struture, function and appearance. Polyphenols represent a superfamily of diverse naturally occurring phytochemicals. Current research reveals that phenolic compounds in plants possess high antioxidant activity and free radical scavenging capacity and can prevent the body from oxidative damage over human life span. This review focuses on present understanding of skin aging and the effects of polyphenols in the context of anti-agieng activity.  

scholarly journals Ceramides metabolism and impaired epidermal barrier in cutaneous diseases and skin aging: focus on the role of the enzyme PNPLA1 in the synthesis of ω-O-acylceramides and its pathophysiological involvement in some forms of congenital ichthyoses

OCL ◽  
2019 ◽  
Vol 26 ◽  
pp. 17 ◽  
Author(s):  
Nathalie Jonca
Keyword(s):  
Lipid Metabolism ◽  
Stratum Corneum ◽  
Barrier Function ◽  
Skin Aging ◽  
Lipid Matrix ◽  
Animal Testing ◽  
Extrinsic Factors ◽  
Epidermal Barrier ◽  
Lipid Metabolism Disorders ◽  
Complex Biological Process

The outermost layer of the skin, the stratum corneum, is essential for the protective barrier functions of the skin. It results from the stacking of corneocytes, the dead flattened cells resulting from epidermal terminal differentiation of underlying living keratinocytes. The cornified lipid envelope, encapsulating corneocytes, and the extracellular mortar-like multilayered lipid matrix, called lamellae, are two crucial elements of the epidermal barrier. Stratum corneum extracellular lipids are mainly composed of ceramides, cholesterol and free fatty acids. Ceramides, and more specifically the epidermis specific ω-O-acylceramides, are essential for lipid-matrix organization into lamellae and formation of the corneocyte lipid envelope. Pathophysiological studies of inherited lipid metabolism disorders recently contributed to a better understanding of stratum corneum lipid metabolism. In the lab, our data from patients with Autosomal Recessive Congenital Ichthyosis and a murine knock-out model showed that the enzyme PNPLA1 is essential for the last step of synthesis of omega-O-acylceramides. Skin aging is a complex biological process caused by genetic and extrinsic factors e.g. sun exposure, smoke, and pollution. Aging skin is marked by a senescence-related decline in lipid and water content, which ultimately impairs epidermal barrier function. Thus, aged epidermis is prone to develop altered drug permeability, increased susceptibility to irritants contact dermatitis and severe xerosis. Ceramide deficiency may account, at least in part, for the dysfunction of the stratum corneum associated with ageing. Hence, treatments able to increase skin-ceramide levels could improve the epidermal barrier function in aged skin. Many animal testing and clinical trials are taken in that regard.

Cytoprotective Polyphenols Against Chronological Skin Aging and Cutaneous Photodamage

2018 ◽  
Vol 24 (2) ◽  
pp. 99-105 ◽  
Author(s):  
Sergio Davinelli ◽  
Juan Carlos Bertoglio ◽  
Ascanio Polimeni ◽  
Giovanni Scapagnini
Keyword(s):  
Recent Progress ◽  
Biological Process ◽  
Regulatory Elements ◽  
Skin Aging ◽  
Plant Metabolites ◽  
Extrinsic Factors ◽  
Secondary Plant Metabolites ◽  
Complex Biological Process ◽  
Molecular Bases

Background: Skin aging is a complex biological process influenced by a combination of intrinsic and extrinsic factors, leading to cumulative alterations of skin structure, function and appearance. Polyphenols, which are secondary plant metabolites, represent one of the largest classes of compounds used in dermatology and nutricosmetics to combat skin aging. The main objective is to provide an overview of the existing literature linking skin aging and the ability of polyphenols as regulatory elements able to maintain skin homeostasis. Methods: In this review, we discuss recent progress in understanding the molecular bases of skin aging, with specific emphasis on some well known and extensively studied polyphenols which have significant anti-aging influences and photoprotective effects. Results: Although no relevant clinical data exist and standard delivery systems have not been established, promising results have been obtained in many in vitro and animal models. A wide variety of polyphenols may minimize mechanisms underlying the functional manifestations of photoaging and chronological skin aging. Conclusion: Polyphenols exert their influence mostly through their antioxidant and anti-inflammatory effects, thereby abrogating collagen degradation and/or increasing procollagen synthesis.

scholarly journals Stamping Monitoring by Using an Adaptive 1D Convolutional Neural Network

Sensors ◽  
2021 ◽  
Vol 21 (1) ◽  
pp. 262
Author(s):  
Chih-Yung Huang ◽  
Zaky Dzulfikri
Keyword(s):  
Neural Network ◽  
Convolutional Neural Network ◽  
Template Matching ◽  
Health Condition ◽  
Vibration Measurement ◽  
One Dimensional ◽  
Stamping Process ◽  
Metalworking Industry ◽  
Increasing Demand ◽  
Wear Condition

Stamping is one of the most widely used processes in the sheet metalworking industry. Because of the increasing demand for a faster process, ensuring that the stamping process is conducted without compromising quality is crucial. The tool used in the stamping process is crucial to the efficiency of the process; therefore, effective monitoring of the tool health condition is essential for detecting stamping defects. In this study, vibration measurement was used to monitor the stamping process and tool health. A system was developed for capturing signals in the stamping process, and each stamping cycle was selected through template matching. A one-dimensional (1D) convolutional neural network (CNN) was developed to classify the tool wear condition. The results revealed that the 1D CNN architecture a yielded a high accuracy (>99%) and fast adaptability among different models.

Rethinking bibliographic utilities for library consortia

2020 ◽  
Vol 37 (8) ◽  
pp. 7-9
Author(s):  
Israel Odede
Keyword(s):  
Literature Review ◽  
Paradigm Shift ◽  
Design Methodology ◽  
Distributed Network ◽  
Network Resources ◽  
Content Type ◽  
Library Consortia ◽  
Individual Ownership ◽  
Insight Into

Purpose The paper aims to critically examine the bibliographic utility as a roadmap to increase library consortia and provide an insight into a new library consortia strategy that integrates librarians into a system of sharing both resources and knowledge. Design/methodology/approach This study adopted a literature review approach with a focus on bibliographic utility as a necessary prerequisite for effective library consortia, which is a paradigm shift from the concept of individual ownership to a collective access of distributed network resources and knowledge. Findings The reviewed literature indicated that significant bibliographic utilities and integrated library systems are factors that shaped and developed consortia activities in libraries. Originality/value The bibliographic utility has limited literature, and a few published scholarly studies have combined bibliographic utility and library consortia as strategies to share resources and knowledge

scholarly journals A new insight into root responses to external cues: Paradigm shift in nutrient sensing

2015 ◽  
Vol 10 (12) ◽  
pp. e1049791 ◽  
Author(s):  
Deepak Bhardwaj ◽  
Anna Medici ◽  
Alain Gojon ◽  
Benoît Lacombe ◽  
Narendra Tuteja
Keyword(s):  
Paradigm Shift ◽  
Nutrient Sensing ◽  
External Cues ◽  
Root Responses ◽  
Insight Into

scholarly journals Current perspective on production and applications of microbial cellulases: a review

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Nisha Bhardwaj ◽  
Bikash Kumar ◽  
Komal Agrawal ◽  
Pradeep Verma
Keyword(s):  
Critical Factor ◽  
Industrial Sector ◽  
Industrial Applications ◽  
Cellulolytic Enzymes ◽  
Promising Tool ◽  
The Status ◽  
Key Enzyme ◽  
Increasing Demand ◽  
Immobilization Techniques ◽  
Insight Into

AbstractThe potential of cellulolytic enzymes has been widely studied and explored for bioconversion processes and plays a key role in various industrial applications. Cellulase, a key enzyme for cellulose-rich waste feedstock-based biorefinery, has increasing demand in various industries, e.g., paper and pulp, juice clarification, etc. Also, there has been constant progress in developing new strategies to enhance its production, such as the application of waste feedstock as the substrate for the production of individual or enzyme cocktails, process parameters control, and genetic manipulations for enzyme production with enhanced yield, efficiency, and specificity. Further, an insight into immobilization techniques has also been presented for improved reusability of cellulase, a critical factor that controls the cost of the enzyme at an industrial scale. In addition, the review also gives an insight into the status of the significant application of cellulase in the industrial sector, with its techno-economic analysis for future applications. The present review gives a complete overview of current perspectives on the production of microbial cellulases as a promising tool to develop a sustainable and greener concept for industrial applications.

scholarly journals Lobular panniculitis: A manifestation of pancreatic tumor with fatal outcome

2005 ◽  
Vol 13 (3-4) ◽  
pp. 153-155 ◽  
Author(s):  
Marina Jovanovic ◽  
Zoran Golusin ◽  
Aleksandra Petrovic ◽  
Nada Vuckovic ◽  
Silvija Brkic ◽  
...  
Keyword(s):  
Fatal Outcome ◽  
Subcutaneous Fat ◽  
Pancreatic Head ◽  
Skin Lesions ◽  
Skin Condition ◽  
Pancreatic Disease ◽  
Health Condition ◽  
Subcutaneous Fat Necrosis ◽  
General Health Condition ◽  
Lobular Panniculitis

Lobular panniculitis is a skin condition that may be the first sign of underlying pancreatic disease. Though rare, the condition has been sufficiently well defined and pathognomonic, thus making differentiation from idiopathic lobular panniculitis quite possible. A 77-year-old woman was in apparently good general health condition when developed skin lesions in a form of erythematous painful fluctuant nodules localized predominantly on the breast, but also present on the arms, thighs, and trunk. Her serum and urinary amylase levels were respectively 3 and 8 fold higher than normal. On histology, skin biopsy showed acute lobular panniculitis with large foci of adipocyte necrosis. Examination of the breast excluded any specific process other than nodular subcutaneous inflammation, but revealed a tumor of the pancreatic head. The nodules spontaneously ulcerated exuding an oily thick brownish material. Her condition deteriorated, and she became progressively debilitated. The patient died before operation, within the next 3 weeks. Subcutaneous fat necrosis was the first manifestation of an otherwise occult pancreatic disease with fatal outcome.

Ultradeformable vesicles: concepts and applications relating to the delivery of skin cosmetics

2021 ◽  
Author(s):  
Andang Miatmoko ◽  
Qurrota Ayunin ◽  
Widji Soeratri
Keyword(s):  
Skin Aging ◽  
Water Soluble ◽  
In Vivo Studies ◽  
Active Ingredients ◽  
Self Confidence ◽  
Skin Delivery ◽  
Cosmetic Ingredients ◽  
Insight Into

Skin aging is a phenomenon resulting in reduced self-confidence, thus becoming a major factor in social determinants of health. The use of active cosmetic ingredients can help prevent skin aging. Transfersomes are well known to be capable of deeply penetrating the dermis. This scoping review provides an insight into transfersomes and their prospective use in anti-aging cosmetics. Numerous reports exist highlighting the successful skin delivery of therapeutic agents such as high-molecular-weight, poorly water soluble and poorly permeable active ingredients by means of transfersomes. Moreover, in vitro and in vivo studies have indicated that transfersomes increase the deposition, penetration and efficacy of active ingredients. However, the use of transfersomes in the delivery of active cosmetic ingredients is limited. Considering their similar physicochemical properties, transfersomes should possess considerable potential as a delivery system for anti-aging cosmetics.

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