Direct determination of guanine in Aciclovir Dispersible Tablets solution by acylpyrazolone modified glassy carbon electrode

2011 ◽  
Vol 30 (1) ◽  
Author(s):  
Xueli Li ◽  
Jinzhou Li
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Direct Determination ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Dispersible Tablets

scholarly journals Electrooxidation of Indomethacin at Multiwalled Carbon Nanotubes-Modified GCE and Its Determination in Pharmaceutical Dosage Form and Human Biological Fluids

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Sanjeevaraddi R. Sataraddi ◽  
Shreekant M. Patil ◽  
Atmanand M. Bagoji ◽  
Vijay P. Pattar ◽  
Sharanappa T. Nandibewoor
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Direct Determination ◽  
Reduction Peak ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Multiwalled Carbon ◽  
Pharmaceutical Dosage Form ◽  
Detection Scheme

A simple, rapid, selective, and sensitive electrochemical method for the direct determination of indomethacin was developed. The electrochemical behavior of indomethacin was carried at multiwalled carbon nanotube- (MWCNTs-) modified glassy carbon electrode (GCE). The cyclic voltammetric results indicated that MWCNT-modified glassy carbon electrode remarkably enhanced electrocatalytic activity towards the oxidation of indomethacin in slightly acidic solutions. It led to a considerable improvement of the anodic peak current for indomethacin and could effectively accumulate at this electrode and produce two anodic peaks at 0.720 V and 0.991 V, respectively, and one reduction peak at 0.183 V. The electrocatalytic behavior was further exploited as a sensitive detection scheme for the determination of indomethacin by differential-pulse voltammetry (DPV). Under optimized conditions, the concentration range and detection limit were 0.2 to 6.0 μM and 13.2 nM, respectively. The proposed method was successfully applied to determination of Indomethacine in pharmaceutical samples. The analytical performance of this sensor has been evaluated for detection of analyte in human serum and urine as real samples.

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