Neurotoxocity, nephrotoxicity, and hepatotoxicity of copper-based nanoparticles: potential implications in molecular medicine and neurosciences

2019 ◽  
Vol 58 (1) ◽  
pp. 201-205 ◽  
Author(s):  
Senka Pantic ◽  
Sanja Radojevic Skodric ◽  
Zlatibor Loncar ◽  
Igor Pantic
Keyword(s):  
Scientific Community ◽  
Clinical Medicine ◽  
Storage Systems ◽  
Metallic Copper ◽  
Living Organism ◽  
Chemical Processes ◽  
Molecular Medicine ◽  
Essential Trace Element ◽  
Concise Review ◽  
Potential Use

Abstract Copper is an essential trace element and is an integral part of many metabolic and other chemical processes in cells and tissues. Copper-based nanoparticles (CuNPs) have wide industrial and engineering applications, as catalysts, sensing materials, part of superconductors, storage systems, and phototermal / thermoelectric materials. In recent years, their potential use in biology and medicine has also contributed to the increased interest by scientific community. Unfortunately, many aspects of CuNP interactions with cells and tissues remain unknown. It is unclear if, in a living organism, CuNPs behave the same way as conventional metallic copper. Possible impact of CuNPs on the functioning of organs such as liver, kidney and brain is of particular concern. This concise review aims to cover recent research on potential CuNP toxicity, with the emphasis on neurotoxocity, nephrotoxicity and hepatotoxicity. Also, potential implications of CuNPs toxicity in fundamental and clinical medicine are discussed.

STATUS AND POTENTIAL OF GENE THERAPY IN CLINICAL MEDICINE

2002 ◽  
Vol 18 (3) ◽  
pp. 645-674 ◽  
Author(s):  
Anita Lyngstadaas
Keyword(s):  
Gene Therapy ◽  
Clinical Research ◽  
Clinical Medicine ◽  
Severe Combined Immunodeficiency ◽  
Molecular Medicine ◽  
Phase Iii ◽  
Somatic Therapy ◽  
Health Authorities ◽  
Three Phase ◽  
Somatic Gene

Objective: Somatic gene therapy is a new method in the rapidly expanding field of molecular medicine. Due to recent encouraging results and the promising prospect for some disease groups, Norwegian health authorities wanted to assess somatic therapy with evidence-based standards for strategic use. This article presents the results of this assessment, discussed in the context of the policy-making process in Norway, including ethical and legislational considerations.Methods: Clinical gene therapy protocols, ongoing or completed with published results, where available, were identified through a systematic survey of descriptive protocols and publications. Preclinical literature was also reviewed.Results: Gene therapy is dominated by preclinical and clinical research. Most of the gene therapy protocols identified are in early phases (phases I and II) with only a few patients in each study. Of the protocols included in the assessment, only three phase III studies are represented. Except for the use of soluble antisense oligonucleotides against cytomegalovirus eye infection, gene therapy is presently not an established treatment modality. Promising results have been observed in treatment of cancer and cardiovascular diseases and, most recently, in inherited severe combined immunodeficiency and hemophilia. Several interesting principles addressing a large panel of conditions are currently being developed and tested.Conclusions: Gene therapy is developing into an important medical concept that needs to be included within the Norwegian healthcare system. It is recommended that the Norwegian Ministry of Health and Social Affairs fund a national program to boost infrastructure in selected scientific groups both in preclinical and clinical research. The national procedures regulating approval of gene therapy trials should be made more efficient while at the same time allowing for proper control and ethical considerations. It is emphasized that gene therapy trials should be carefully monitored for side effects.

Status of the utilization of jack pine (Pinusbanksiana) in the pulp and paper industry

1994 ◽  
Vol 24 (10) ◽  
pp. 2078-2084 ◽  
Author(s):  
Kwei-Nam Law ◽  
Jacques L. Valade
Keyword(s):  
Paper Industry ◽  
Chemical Properties ◽  
Pulp And Paper Industry ◽  
Jack Pine ◽  
Chemical Processes ◽  
Future Research ◽  
Physical And Chemical Properties ◽  
Physical And Chemical ◽  
Potential Use ◽  
And Chemical Properties

Although jack pine (Pinusbanksiana Lamb.), which represents 20% of the total softwood volume, is one of the most abundant commercial softwood species in Canada, its rate of utilization in pulping is surprisingly low. This paper reviews the literature concerning the physical and chemical properties as well as the pulping characteristics of this species by mechanical, thermomechanical, chemithermomechanical, chemimechanical, and chemical processes to better understand its potential use in papermaking. The objective is to identify the problems related to the use of jack pine so that solutions might be sought to promote its usage. Some recommendations are put forth concerning future research.

scholarly journals REVIEW OF PROPERTIES, COMPOSITION AND DEFECTS OF DIFFERENT GLASSES WITH POTENTIAL USE FOR GAS HYDROGEN STORAGE SYSTEMS

2021 ◽  
Vol 6 (3) ◽  
pp. 142-147
Author(s):  
Andrei RĂȚOI ◽  
Corneliu MUNTEANU ◽  
Bogdan ISTRATE ◽  
Dan ELIEZER
Keyword(s):  
Mechanical Properties ◽  
High Pressure ◽  
Tensile Strength ◽  
Hydrogen Storage ◽  
Storage Systems ◽  
Different Types ◽  
Research Findings ◽  
The Impact ◽  
Potential Use

The article reviews the research findings available on different types of glasses that presents potential use for high pressure gas hydrogen storage systems. An overview of the mechanical properties of different glasses, the influence of main constituents and the impact of defects to the strength of glass was presented. As part of this research, it can be concluded that the glass gets a significant improvement of tensile strength by reducing its dimensions to fibre sizes or capillaries due to reduced probability of defects presence.

scholarly journals Isolation and identification of proteolytic, amylolytic, lipolytic, and chitinolytic bacteria from shrimp waste

2021 ◽  
Vol 28 (1) ◽  
pp. e18353
Author(s):  
Susana Sirvas Cornejo ◽  
Vanesa Buleje ◽  
Licia Salvatierra ◽  
Michael L. Jaramillo
Keyword(s):  
Waste Treatment ◽  
Industrial Applications ◽  
Chemical Processes ◽  
Shrimp Waste ◽  
Bacterial Strains ◽  
Isolation And Identification ◽  
Microbial Enzymes ◽  
Chitinolytic Bacteria ◽  
By Products ◽  
Potential Use

Bacteria and microbial enzymes are biocatalysts and can be used as an alternative to industrial chemical processes. The present study focused on isolating and identifying bacterial strains from shrimp waste, that produce amylases, lipases, proteases and chitinases with potential use on shrimp waste treatment. Thirty-two bacterial strains were isolated, phenotypically characterized, and identified by the API system and the molecular analysis of the 16S rDNA. It was found that 28.13% of the isolated bacterial strains had amylolytic capacity, 87.50% lipolytic, 96.88% proteolytic and 28.13% chitinolytic capacity on agar plates with specific substrates. The genera Bacillus, Burkholderia, Ochrobactrum, Vibrio, Pseudomonas and Shewanella were identified. Bacteria with enzymatic capacities isolated in the present study, could be used to obtain by-products from shrimp waste as well as other industrial applications.

Role of MXenes/Polyaniline Nanocomposites in Fabricating Innovative Supercapacitor Technology

2021 ◽  
pp. 30-53
Author(s):  
Dipanwita Majumdar
Keyword(s):  
Energy Storage ◽  
Charge Transport ◽  
Special Reference ◽  
Structural Properties ◽  
Scientific Community ◽  
High Performance ◽  
Storage Systems ◽  
Electronic Charge ◽  
Wearable Electronics

Versatile and exclusive electronic, optical, physicochemical, electrochemical and mechanical features of both conducting polymers and MXenes have stimulated global scientists to take serious impetuses in designing innovative high-performance energy storage systems with these materials, for resolving the growing needs for auto-powering mechanically flexible and wearable electronics for all essential technological fields. However, both the materials have experienced some serious practical limitations, which have driven the scientific community to look for necessary modifications in the form of MXenes/PANI nanocomposites with suitable compositions that would essentially restore their representative characteristics but successfully suppress their functional drawbacks concurrently and considerably. Accordingly, in the present overview, the different strategies of fabrication of MXenes/PANI nanocomposites for advanced supercapacitors with special reference to the necessary morphological modifications brought about by synthetic improvisations that resulted in superior capacitive, electronic charge transport as well as structural properties have also been recognized and compared. Such analysis would purposefully assist in adjusting the integral mechanical and electrochemical responses for scheming smarter and highly flexible microelectronics soon.

Book Review: Industrial green chemistry, Editors: Serge Kaliaguine and Jean-Luc Dubois

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Hugo I. de Lasa
Keyword(s):  
Green Chemistry ◽  
Scientific Community ◽  
Chemical Processes

Abstract The book Industrial Green Chemistry, recently published by De Gruyter and co-edited by Serge Kaliaguine and Jean-Luc Dubois, provides several valuable examples of sustainable green chemical processes being developed today. The ten-chapter multi-author book, led by these two reputable researchers, opens a stimulating debate for the scientific community, bringing into focus new perspectives on green chemistry, by describing opportunities for sustainable chemical processes.

Tuning the Structural Skeletal of a Phenanthroline-based Covalent Organic Framework for better Electrochemical Performance as Cathode Material for Zn-Ion Batteries: A Theoretical Exploration

2021 ◽  
Author(s):  
Biswajit Ball ◽  
Pranab Sarkar
Keyword(s):  
Energy Storage ◽  
Electrochemical Performance ◽  
Cathode Material ◽  
Lithium Ion Batteries ◽  
Scientific Community ◽  
Large Scale ◽  
Storage Systems ◽  
Lithium Ion ◽  
Zinc Ion ◽  
Significant Attention

Rechargeable zinc ion batteries (ZIBs) have attained significant attention to the scientific community as an alternative to lithium ion batteries (LIBs) for large-scale energy storage systems owing to their high...

Prospects Of Non-Coding Elements In Genomic Dna Based Gene Therapy

2021 ◽  
Vol 21 ◽  
Author(s):  
Simna SP ◽  
Zongchao Han
Keyword(s):  
Gene Therapy ◽  
Genomic Dna ◽  
Insertional Mutagenesis ◽  
Molecular Medicine ◽  
Significant Development ◽  
Complementary Dna ◽  
A Genome ◽  
Next Generation Sequencing Ngs ◽  
Potential Use ◽  
Generation Sequencing

: Gene therapy has made significant development since the commencement of the first clinical trials a few decades ago and has remained a dynamic area of research regardless of obstacles such as immune response and insertional mutagenesis. Progression in various technologies like next-generation sequencing (NGS) and nanotechnology has established the importance of non-coding segments of a genome, thereby taking gene therapy to the next level. In this review, we have summarized the importance of non-coding elements, highlighting the advantages of using full-length genomic DNA loci (gDNA) compared to complementary DNA (cDNA) or minigene, currently used in gene therapy. The focus of this review is to provide an overview of the advances and the future of potential use of gDNA loci in gene therapy, expanding the therapeutic repertoire in molecular medicine.

scholarly journals Recent Advances in Catalyzed Sequential Reactions and the Potential Use of Tetrapyrrolic Macrocycles as Catalysts

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2796 ◽  
Author(s):  
Everton Santos ◽  
Charles Carvalho ◽  
Carolina Terzi ◽  
Shirley Nakagaki
Keyword(s):  
Chemical Processes ◽  
One Pot ◽  
Solid Catalysts ◽  
Recent Advances ◽  
Multifunctional Catalysts ◽  
Ability To Act ◽  
Heterogeneous Processes ◽  
Potential Use ◽  
Sequential Reactions

Complexes of porphyrins and of other similar tetrapyrrolic macrocycles are extensively explored as catalysts for different chemical processes, and the development of solid catalysts for heterogeneous processes using molecules with the ability to act as multifunctional catalysts in one-pot reactions is increasing and can lead to the wider use of this class of molecules as catalysts. This mini review focuses on the application of this class of complexes as catalysts in a variety of sequential one-pot reactions.

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