scholarly journals Zinc oxide nanoparticles: potential novel applications in cellular physiology, pathology, neurosciences and cancer research

2019 ◽  
Vol 58 (1) ◽  
pp. 17-21 ◽  
Author(s):  
Senka Pantic ◽  
Sanja Radojevic Skodric ◽  
Zlatibor Loncar ◽  
Igor Pantic
Keyword(s):  
Cancer Research ◽  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Rapid Development ◽  
Short Review ◽  
Consumer Products ◽  
Oxide Nanoparticles ◽  
Zno Nps ◽  
Cellular Physiology ◽  
Anticancer Properties

Abstract With the rapid development of nanotechnology during the past several years, attention has been focused on metallic nanomaterials, due to their specific physical and chemical characteristics. Zinc oxide nanoparticles (ZnO NPs) have numerous potential applications in industry, as a part of various consumer products, but also in medical research. Anticancer properties of ZnO NPs have been suggested in cell cultures, however, the precise mechanism responsible for their activity in these conditions remains elusive. Cytotoxicity and genotoxicity of ZnO NPs are also unclear. Apart from cancer research, ZnO NPs are today widely researched in almost all areas of fundamental medicine. In this short review, we discuss recently published articles on ZnO NPs applications in cellular physiology, pathology, neurosciences and oncology.

Emerging investigator series: Chemical transformation of silver and zinc oxide nanoparticles in the simulated human tear fluids: Influence of biocorona

2021 ◽  
Author(s):  
Lingxiangyu Li ◽  
Ashfeen Ubaid Khan ◽  
Xiang Zhang ◽  
Xiaoting Qian ◽  
Yawei Wang
Keyword(s):  
Silver Nanoparticles ◽  
Zinc Oxide ◽  
Chemical Transformation ◽  
Zinc Oxide Nanoparticles ◽  
Biological Fluids ◽  
Rapid Development ◽  
Oxide Nanoparticles ◽  
Personal Care ◽  
Ag Nps ◽  
Zno Nps

With the rapid development of nanotechnology, personal care products with silver nanoparticles (Ag-NPs) or zinc oxide nanoparticles (ZnO-NPs) are being widely used because of their superior antibacterial efficacies. Biological fluids...

scholarly journals Genotoxicity of zinc oxide nanoparticles: anin vivoandin silicostudy

2019 ◽  
Vol 8 (2) ◽  
pp. 277-286 ◽  
Author(s):  
Tatiane R. Cardozo ◽  
Raíne F. De Carli ◽  
Allan Seeber ◽  
Wladimir H. Flores ◽  
Jordana A. N. da Rosa ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Industrial Applications ◽  
Consumer Products ◽  
Oxide Nanoparticles ◽  
Zno Nps

Zinc oxide (ZnO) NPs are being used worldwide in consumer products and industrial applications.

scholarly journals Short Review: Phytofabrication of Zinc Oxide Nanoparticles for Anticancer Applications

2021 ◽  
Vol 3 (1) ◽  
pp. 82-89
Author(s):  
Siti Nur Amalina Mohamad Sukri ◽  
Kamyar Shameli ◽  
Sin-Yeang Teow ◽  
Eleen Dayana Mohamed Isa ◽  
Mostafa Yusefi ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Short Review ◽  
Review Article ◽  
Oxide Nanoparticles ◽  
Synthesis Methods ◽  
Inhibition Activity ◽  
Zno Nps ◽  
Cancerous Cells ◽  
High Inhibition

Zinc oxide nanoparticles (ZnO NPs) are one of the most well-known materials in the field of nanotechnology. Adopting a more environmentally friendly synthesis methods of ZnO NPs have been the focus in the last few decades. Of all green synthesis methods of ZnO NPs, fabrication with the help of plant extracts has been the most popular due to its many benefits. The use of phytofabricated ZnO NPs in anticancer studies has been conducted increasingly over the last decade because of its high inhibition activity against various types of cancerous cells. This short review article will present the current update on the phytofabrication of ZnO NPs in recent years and discuss on their cytotoxicity mechanism against cancer cells.

Evaluation of the Effect of Nanoparticles Zinc Oxide/Camellia sinensis Complex on the Kidney of Rats Treated with Monosodium Glutamate: Antioxidant and Histological Approaches

2019 ◽  
Vol 20 (7) ◽  
pp. 542-550 ◽  
Author(s):  
Nahla S. El-Shenawy ◽  
Reham Z. Hamza ◽  
Fawziah A. Al-Salmi ◽  
Rasha A. Al-Eisa
Keyword(s):  
Zinc Oxide ◽  
Camellia Sinensis ◽  
Zinc Oxide Nanoparticles ◽  
Morphological Changes ◽  
Monosodium Glutamate ◽  
Oxide Nanoparticles ◽  
High Dose ◽  
Enzymatic Antioxidants ◽  
Zno Nps ◽  
Tea Extract

Background: Zinc oxide nanoparticles (ZnO NPs) are robustly used biomedicine. Moreover, no study has been conducted to explore the consequence of green synthesis of ZnO NPs with Camellia sinensis (green tea extract, GTE) on kidneys of rats treated with monosodium glutamate (MSG). Methods: Therefore, the objective of the research was designed to explore the possible defensive effect of GTE/ZnO NPs against MSG-induced renal stress investigated at redox and histopathological points. Results: The levels of urea and creatinine increased as the effect of a high dose of MSG, in addition, the myeloperoxidase and xanthine oxidase activates were elevated significantly with the high dose of MSG. The levels of non-enzymatic antioxidants (uric acid, glutathione, and thiol) were decreased sharply in MSG-treated rats as compared to the normal group. Conclusion: The data displayed that GTE/ZnO NPs reduced the effects of MSG significantly by reduction of the level peroxidation and enhancement intracellular antioxidant. These biochemical findings were supported by histopathology evaluation, which showed minor morphological changes in the kidneys of rats.

Zinc oxide nanoparticles help to enhance plant growth and alleviate abiotic stress: A review

2020 ◽  
Vol 21 ◽  
Author(s):  
Mohammad Faizan ◽  
Fangyuan Yu ◽  
Chen Chen ◽  
Ahmad Faraz ◽  
Shamsul Hayat
Keyword(s):  
Zinc Oxide ◽  
Plant Growth ◽  
Abiotic Stresses ◽  
Zinc Oxide Nanoparticles ◽  
Growth And Yield ◽  
Oxide Nanoparticles ◽  
Main Concern ◽  
Negative Effects ◽  
Zno Nps ◽  
Agricultural Yield

: Abiotic stresses arising from atmosphere change belie plant growth and yield, leading to food reduction. The cultivation of a large number of crops in the contaminated environment is a main concern of environmentalists in the present time. To get food safety, a highly developed nanotechnology is a useful tool for promoting food production and assuring sustainability. Nanotechnology helps to better production in agriculture by promoting the efficiency of inputs and reducing relevant losses. This review examines the research performed in the past to show how zinc oxide nanoparticles (ZnO-NPs) are influencing the negative effects of abiotic stresses. Application of ZnO-NPs is one of the most effectual options for considerable enhancement of agricultural yield globally under stressful conditions. ZnO-NPs can transform the agricultural and food industry with the help of several innovative tools in reversing oxidative stress symptoms induced by abiotic stresses. In addition, the effect of ZnO-NPs on physiological, biochemical, and antioxidative activities in various plants have also been examined properly. This review summarizes the current understanding and the future possibilities of plant-ZnO-NPs research.

Thermodynamic and anticancer properties of inorganic zinc oxide nanoparticles synthesized through co-precipitation method

2021 ◽  
Vol 330 ◽  
pp. 115602
Author(s):  
Seyyed Vahid Mousazad Goorabjavari ◽  
Fateme Golmohamadi ◽  
Saba Haririmonfared ◽  
Hosein Ahmadi ◽  
Soheil Golisani ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Precipitation Method ◽  
Oxide Nanoparticles ◽  
Anticancer Properties ◽  
Co Precipitation

scholarly journals Wound Healing Composite Materials of Bacterial Cellulose and Zinc Oxide Nanoparticles with Immobilized Betulin Diphosphate

Nanomaterials ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 713
Author(s):  
Nina Melnikova ◽  
Alexander Knyazev ◽  
Viktor Nikolskiy ◽  
Peter Peretyagin ◽  
Kseniia Belyaeva ◽  
...  
Keyword(s):  
Wound Healing ◽  
Zinc Oxide ◽  
Bacterial Cellulose ◽  
Zinc Oxide Nanoparticles ◽  
Wound Dressings ◽  
Oxide Nanoparticles ◽  
Burn Wound ◽  
Zno Nps ◽  
Wound Model ◽  
And Oxidative Stress

A design of new nanocomposites of bacterial cellulose (BC) and betulin diphosphate (BDP) pre-impregnated into the surface of zinc oxide nanoparticles (ZnO NPs) for the production of wound dressings is proposed. The sizes of crystalline BC and ZnO NPs (5–25%) corresponded to 5–6 nm and 10–18 nm, respectively (powder X-ray diffractometry (PXRD), Fourier-infrared (FTIR), ultraviolet (UV), atomic absorption (AAS) and photoluminescence (PL) spectroscopies). The biological activity of the wound dressings “BC-ZnO NPs-BDP” was investigated in rats using a burn wound model. Morpho-histological studies have shown that more intensive healing was observed during treatment with hydrophilic nanocomposites than the oleophilic standard (ZnO NPs-BDP oleogel; p < 0.001). Treatment by both hydrophilic and lipophilic agents led to increases in antioxidant enzyme activity (superoxide dismutase (SOD), catalase) in erythrocytes and decreases in the malondialdehyde (MDA) concentration by 7, 10 and 21 days (p < 0.001). The microcirculation index was restored on the 3rd day after burn under treatment with BC-ZnO NPs-BDP wound dressings. The results of effective wound healing with BC-ZnO NPs-BDP nanocomposites can be explained by the synergistic effect of all nanocomposite components, which regulate oxygenation and microcirculation, reducing hypoxia and oxidative stress in a burn wound.

scholarly journals Biosynthesis of Zinc Oxide Nanoparticles from Acacia nilotica (L.) Extract to Overcome Carbapenem-Resistant Klebsiella Pneumoniae

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 1919
Author(s):  
Elsayim Rasha ◽  
AlOthman Monerah ◽  
Alkhulaifi Manal ◽  
Ali Rehab ◽  
Doud Mohammed ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Zinc Oxide ◽  
Klebsiella Pneumoniae ◽  
Zinc Oxide Nanoparticles ◽  
Acacia Nilotica ◽  
Oxide Nanoparticles ◽  
Zno Nps ◽  
X Ray ◽  
Carbapenem Resistant

Recently, concerns have been raised globally about antimicrobial resistance, the prevalence of which has increased significantly. Carbapenem-resistant Klebsiella pneumoniae (KPC) is considered one of the most common resistant bacteria, which has spread to ICUs in Saudi Arabia. This study was established to investigate the antibacterial activity of biosynthesized zinc oxide nanoparticles (ZnO-NPs) against KPC in vitro and in vivo. In this study, we used the aqueous extract of Acacia nilotica (L.) fruits to mediate the synthesis of ZnO-NPs. The nanoparticles produced were characterized by UV-vis spectroscopy, zetasizer and zeta potential analyses, X-ray diffraction (XRD) spectroscopy, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), and transmission electron microscopy (TEM). The antimicrobial activity of ZnO-NPs against KPC was determined via the well diffusion method, and determining minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC), the results showed low MIC and MBC when compared with the MIC and MBC of Imipenem and Meropenem antibiotics. The results of in vitro analysis were supported by the results upon applying ZnO-NP ointment to promote wound closure of rats, which showed better wound healing than the results with imipenem ointment. The biosynthesized ZnO-NPs showed good potential for use against bacteria due to their small size, applicability, and low toxicity to human cells.

scholarly journals Scolicidal activity of biosynthesized zinc oxide nanoparticles by Mentha longifolia L. leaves against Echinococcus granulosus protoscolices

2021 ◽  
Author(s):  
Bushra H. Shnawa ◽  
Samir M. Hamad ◽  
Azeez A. Barzinjy ◽  
Payman A. Kareem ◽  
Mukhtar H. Ahmed
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Public Health Problem ◽  
Analytical Techniques ◽  
Oxide Nanoparticles ◽  
Zno Nps ◽  
Leaf Extracts ◽  
X Ray ◽  
Morphological Alterations ◽  
Mentha Longifolia

AbstractCystic echinococcosis is a public health problem in developing countries that practice sheep breeding extensively. In the current study, the protoscolicidal activity of biosynthesized zinc oxide nanoparticles (ZnO NPs) derived from Mentha longifolia L. leaf extracts was investigated. The resultant ZnO NPs were characterized by means of various analytical techniques, such as ultraviolet–visible (UV–Vis) spectrometry, Fourier transform infrared (FT-IR) spectrophotometry, X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX) analysis. The results showed that the ZnO NP had the highest scolicidal activity at 400 ppm concentration after 150 min of exposure time, showing 100% mortality rate. The treated protoscolices exhibited loss of viability with several morphological alterations. Hence, an easy and effective green synthesis of ZnO NPs, with efficient scolicidal potential, is reported in this study.

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