Physiotherapeutic interventions in patients with migraines

2018 ◽  
Vol 25 (1) ◽  
pp. 21-25
Author(s):  
L. Piejko
Keyword(s):  
Clinical Practice ◽  
Migraine Attack ◽  
Preventive Care ◽  
Pharmacological Treatment ◽  
Migraine Headaches ◽  
Human Functioning ◽  
Abortive Treatment ◽  
New Strategies

Abstract Migraine headaches represent one of the most frequent chronic problems which significantly impact on the limitation of everyday human functioning. Despite pharmacological treatment, many people also need preventive care to reduce intensity of the symptoms of the disease, reduce frequency of migraine attack and to enhance the response to the abortive treatment. New strategies of combining pharmacological and non-pharmacological treatment have been demonstrated to be as effective as taking modern medicines. Unfortunately, the awareness of availability and effectiveness of non-pharmacological methods to treat migraines remains to be insufficient. Therefore, the need arises for educating medical staffs and patients and continuation of the research in this field of science. The study presents a brief characterization of the disease, discusses non-pharmacological methods to treat migraines and proposes the guidelines for physiotherapists to be used in the clinical practice.

Migraine Abortive Treatment in Children and Adolescents in Israel

2021 ◽  
Author(s):  
Jacob Genizi ◽  
Dana Lahoud ◽  
Rony Cohen
Keyword(s):  
Children And Adolescents ◽  
Migraine Attack ◽  
Migraine Headache ◽  
Pediatric Population ◽  
Improvement Rate ◽  
Pediatric Neurology ◽  
Migraine Headaches ◽  
Headache Episode ◽  
Neurology Clinic ◽  
Abortive Treatment

Abstract Migraine headaches in children may cause attacks that require abortive treatment. This study evaluated the incidence and efficacy of medications used for relieving migraine headache attacks in the pediatric population in Israel. Children 6–18 years of age who were diagnosed in our pediatric neurology clinic as having migraine headaches were enrolled into the study. Children and their parents recorded the children response to abortive treatment during three consecutive migraine attacks. Fifty children, with 116 migraine attacks, were included in the study (30 females; mean age 12; range 6–18). Forty-seven (94%) reported on abortive treatment on the first migraine attack, 43 (86%) on a second migraine attack and 26 (52%) on a third migraine attack. During the first recorded migraine attack, 41 children (87.5%) reported taking only one type of medication for each headache episode, mainly ibuprofen or acetaminophen; less than a quarter used dipyrone. The improvement rate after two hours was 65.4%±27 for ibuprofen, 59.8±35.3 for acetaminophen and 50.9±27.4 for dipyrone. In conclusion, Children with migraine in Israel mainly use a single medication for each headache episode. Ibuprofen is the most commonly used abortive treatment; however, acetaminophen was associated with a better response.

New Strategies in High Sensitivity Characterization of Proteins Separated from 1-D or 2-D Gels

1995 ◽  
pp. 15-26 ◽  
Author(s):  
Kris Gevaert ◽  
Marc Rider ◽  
Magda Puype ◽  
Jozef Van Damme ◽  
Stefaan De Boeck ◽  
...  
Keyword(s):  
High Sensitivity ◽  
New Strategies

scholarly journals Mechanisms of Atrial Fibrillation – Reentry, Rotors and Reality

2014 ◽  
Vol 3 (2) ◽  
pp. 90 ◽  
Author(s):  
Jonathan W Waks ◽  
Mark E Josephson ◽  
◽  
Keyword(s):  
Atrial Fibrillation ◽  
Clinical Practice ◽  
Catheter Ablation ◽  
20Th Century ◽  
Experimental Studies ◽  
Therapeutic Targets ◽  
Spiral Waves ◽  
Historical Understanding ◽  
New Strategies ◽  
Complex Fractionated Atrial Electrograms

Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in clinical practice, yet our understanding of the mechanisms that initiate and sustain this arrhythmia remains quite poor. Over the last 50 years, various mechanisms of AF have been proposed, yet none has been consistently observed in both experimental studies and in humans. Recently, there has been increasing interest in understanding how spiral waves or rotors – which are specific, organised forms of functional reentry – sustain human AF and how they might be therapeutic targets for catheter-based ablation. The following review describes the historical understanding of reentry and AF mechanisms from earlier in the 20th century, advances in our understanding of mechanisms that are able to sustain AF with a focus on rotors and complex fractionated atrial electrograms (CFAEs), and how the study of AF mechanisms has resulted in new strategies for treating AF with novel forms of catheter ablation.

Platelet Function Disorders

2017 ◽  
pp. 117-137
Author(s):  
Zubair A. Karim ◽  
Fadi T. Khasawneh
Keyword(s):  
Clinical Practice ◽  
Molecular Characterization ◽  
Platelet Function ◽  
Clinical Manifestations ◽  
Functional Responses ◽  
Platelet Function Disorders ◽  
Coagulant Activity ◽  
Common Causes ◽  
Adp Receptor

Platelets play an important role in thrombosis and hemostasis. Moreover, platelet dysfunction due to congenital and acquired etiologies is also one of the most common causes of bleeding encountered in clinical practice. Mostly, platelet function disorders are deficiencies of glycoprotein mediators of adhesion and aggregation, whereas defects of primary receptors for stimuli include those of the P2Y12 ADP receptor. Studies on inherited defects of (1) secretion for storage organelles (dense and alpha-granules), (2) the platelet cytoskeleton, and (3) the generation of pro-coagulant activity have allowed for the identification of genes directly and/or indirectly controlling specific functional responses. This chapter will review recent advances in the molecular characterization of platelet function defects, the spectrum of clinical manifestations of these disorders and their management.

Adrenal incidentaloma

2011 ◽  
pp. 781-788
Author(s):  
Massimo Terzolo
Keyword(s):  
Clinical Practice ◽  
Medical Practice ◽  
Adrenal Mass ◽  
Adrenal Incidentaloma ◽  
Specific Diagnosis ◽  
Incidental Discovery ◽  
Definition Of ◽  
Adrenal Disease ◽  
Ct And Mri

Adrenal incidentaloma is an adrenal mass that is discovered serendipitously with a radiological examination performed for indications unrelated to adrenal disease (1). The incidental discovery of an adrenal mass has become an increasingly common problem, because of the widespread use of ultrasonography, CT, and MRI in clinical practice (2, 3). These techniques have greatly improved their power of resolution over recent years, thereby increasing the possibility of detection of tiny adrenal lumps. Several factors hinder a clear characterization of the phenomenon ‘adrenal incidentaloma’, which may be considered as a byproduct of technology applied to medical practice. Adrenal incidentaloma is not a single pathological entity and the likelihood of any specific diagnosis depends both on the circumstances of discovery and the applied definition of incidentaloma. Unfortunately, published reports are inconsistent in applying inclusion and exclusion criteria for these various factors, making the results difficult to interpret. A further issue is the lack of specific clinical features of the patients carrying an adrenal incidentaloma.

MicroRNAs as Therapeutic Agents: The Future of the Battle Against Cancer

2019 ◽  
Vol 18 (30) ◽  
pp. 2544-2554 ◽  
Author(s):  
Sumit Biswas
Keyword(s):  
Drug Resistance ◽  
Cancer Biology ◽  
Therapeutic Agents ◽  
Nucleotide Level ◽  
Target Mrnas ◽  
Sequencing Technologies ◽  
Tumour Suppressors ◽  
The Future ◽  
New Strategies

Since their discovery in the 1990’s, the study of a class of non-coding, single-stranded RNAs, christened the microRNAs has opened up new vistas in the field of cancer biology. MicroRNAs bind to their target mRNAs to act as either oncogenes or tumour suppressors. With the near-complete elucidation of the biogenesis pathway, and the advent of rapid sequencing technologies, microRNAs have slowly cemented their place as essential biomarkers for delineating the progression, metastasis, relapse or drug resistance of cancer. Being crucial players in the cancer pathway, there has been considerable urgency in designing molecules - both at the nucleotide and non-nucleotide level to counter the effects of their binding. A number of different approaches have yielded quite a body of compounds which have been found to be effective in the treatment of various tumours across many different organs. In this study, the focus is on the review of the timeline of discovery and characterization of microRNAs, underlining their importance in different cancers, shedding light on the discovery of anti-microRNA compounds and illustrating their uses in deriving new strategies to combat cancer.

scholarly journals Characterization of Degraded Proteins in Paintings Using Bottom-Up Proteomic Approaches: New Strategies for Protein Digestion and Analysis of Data

2018 ◽  
Vol 90 (11) ◽  
pp. 6403-6408 ◽  
Author(s):  
Sibilla Orsini ◽  
Avinash Yadav ◽  
Marialaura Dilillo ◽  
Liam A. McDonnell ◽  
Ilaria Bonaduce
Keyword(s):  
Protein Digestion ◽  
Bottom Up ◽  
New Strategies

scholarly journals SpatialDB: a database for spatially resolved transcriptomes

2019 ◽  
Author(s):  
Zhen Fan ◽  
Runsheng Chen ◽  
Xiaowei Chen
Keyword(s):  
Spatial Organization ◽  
Expression Patterns ◽  
Functional Enrichment ◽  
Web Interface ◽  
Current Version ◽  
Transcriptomic Data ◽  
Spatially Resolved ◽  
User Friendly ◽  
New Strategies

Abstract Spatially resolved transcriptomic techniques allow the characterization of spatial organization of cells in tissues, which revolutionize the studies of tissue function and disease pathology. New strategies for detecting spatial gene expression patterns are emerging, and spatially resolved transcriptomic data are accumulating rapidly. However, it is not convenient for biologists to exploit these data due to the diversity of strategies and complexity in data analysis. Here, we present SpatialDB, the first manually curated database for spatially resolved transcriptomic techniques and datasets. The current version of SpatialDB contains 24 datasets (305 sub-datasets) from 5 species generated by 8 spatially resolved transcriptomic techniques. SpatialDB provides a user-friendly web interface for visualization and comparison of spatially resolved transcriptomic data. To further explore these data, SpatialDB also provides spatially variable genes and their functional enrichment annotation. SpatialDB offers a repository for research community to investigate the spatial cellular structure of tissues, and may bring new insights into understanding the cellular microenvironment in disease. SpatialDB is freely available at https://www.spatialomics.org/SpatialDB.

scholarly journals Structural and Functional Characterization of the Human Thymidylate Synthase (hTS) Interface Variant R175C, New Perspectives for the Development of hTS Inhibitors

Molecules ◽  
2019 ◽  
Vol 24 (7) ◽  
pp. 1362
Author(s):  
Cecilia Pozzi ◽  
Stefania Ferrari ◽  
Rosaria Luciani ◽  
Maria Costi ◽  
Stefano Mangani
Keyword(s):  
Thymidylate Synthase ◽  
Active Site ◽  
Functional Characterization ◽  
Binding Mode ◽  
Anticancer Chemotherapy ◽  
Innovative Strategies ◽  
X Ray Crystallography ◽  
Site Targeting ◽  
New Strategies

Human thymidylate synthase (hTS) is pivotal for cell survival and proliferation, indeed it provides the only synthetic source of dTMP, required for DNA biosynthesis. hTS represents a validated target for anticancer chemotherapy. However, active site-targeting drugs towards hTS have limitations connected to the onset of resistance. Thus, new strategies have to be applied to effectively target hTS without inducing resistance in cancer cells. Here, we report the generation and the functional and structural characterization of a new hTS interface variant in which Arg175 is replaced by a cysteine. Arg175 is located at the interface of the hTS obligate homodimer and protrudes inside the active site of the partner subunit, in which it provides a fundamental contribution for substrate binding. Indeed, the R175C variant results catalytically inactive. The introduction of a cysteine at the dimer interface is functional for development of new hTS inhibitors through innovative strategies, such as the tethering approach. Structural analysis, performed through X-ray crystallography, has revealed that a cofactor derivative is entrapped inside the catalytic cavity of the hTS R175C variant. The peculiar binding mode of the cofactor analogue suggests new clues exploitable for the design of new hTS inhibitors.

Can the International Classification of Functioning, Disability and Health (ICF) be used in a prosthetics and orthotics outpatient clinic?

2011 ◽  
Vol 35 (3) ◽  
pp. 302-309 ◽  
Author(s):  
Helena Burger
Keyword(s):  
Clinical Practice ◽  
International Classification ◽  
International Classification Of Functioning ◽  
Prospective Clinical Study ◽  
Disability And Health ◽  
Medical Problems ◽  
Additional Information ◽  
Human Functioning ◽  
The Impact

Background: The International Classification of Functioning, Disability and Health (ICF) covers all aspects and levels of human functioning. Objectives: The aim of the study was to find out whether the ICF can be used in everyday prosthetics and orthotics (P&O) clinical practice for description of human functioning, and whether it can demonstrate the influence of a prosthesis or an orthosis on a person's functioning. Study Design: Prospective clinical study. Methods: A short list of ICF codes was compiled from Annex 9 and used for one month for all patients seen at the author's P&O outpatient clinics. Results: One hundred patients (59 men, average age 58 years) with different medical problems were included in the study. From 6 to 27 (14 on average) ICF categories from all four components of ICF were used in these patients. The most frequently used category for body functions was mobility of joint functions, for body structures it was structure of the skin and for activities and participation it was walking. Public and private buildings were the only barriers identified. Conclusions: It can be concluded that the ICF can be used in everyday P&O clinical practice. An ICF list of categories provides quick additional information. To be able to demonstrate the influence of P&O devices on person's functioning, at least for activities and participation, one has to use qualifiers. Clinical relevance For clinicians it is important to know that it is possible to use the ICF in clinical practice and that it can demonstrate the impact of P&O devices on a person's functioning.

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