scholarly journals Novel analytical approaches to determination of chemical warfare agents and related compounds for verification of nonproliferation of chemical weapons

2017 ◽  
Vol 89 (10) ◽  
pp. 1491-1503 ◽  
Author(s):  
Igor V. Rybalchenko ◽  
Igor A. Rodin ◽  
Timur M. Baygildiev ◽  
Andrey N. Stavrianidi ◽  
Arcady V. Braun ◽  
...  

AbstractIn this paper a summary of the author’s approaches for investigation of the mass spectral behavior of some chemical warfare agents (CWAs), their degradation products and metabolites, as well as the results of development of analytical methods for confirmation of nerve and blister agents application are presented. Hydrolysis and oxidation metabolites of nerve agents, sulfur mustard and lewisite were used as biomarkers of the exposure. Sensitive analytical methods have been developed for their detection, based mainly on tandem mass spectrometry coupled with liquid chromatography. Several techniques for fast screening of CWAs degradation products based on capillary electrophoresis were also proposed. Some of developed approaches were successfully applied in the frame of the proficiency testing system of the Organization for the Prohibition of Chemical Weapons.

2002 ◽  
Vol 74 (12) ◽  
pp. 2281-2291 ◽  
Author(s):  
H. H. Hill ◽  
S. J. Martin

Analytical methods that are currently used for the detection and identification of chemical warfare agents are reviewed and classified by the number of dimensions of information they provide. Single dimensional sensors target specific compounds or classes of compounds. Although they can be less expensive and more portable than multidimensional sensors, multidimensional sensors detect a broader threat spectrum with greater precision and accuracy. The recommendation for analytical field verification during inspections under the Chemical Weapons Convention (CWC) is to use simple two-dimensional analytical methods, such as gas chromatography (GC) or ion mobility spectrometry (IMS), for on-site screening of chemical weapons (CW) agents or to fully equip a modern, mobile analytical laboratory located in an airplane, which can be moved rapidly throughout the world to each inspection site and provide high-quality analytical data on-site.


2021 ◽  
Vol 5 (2) ◽  
pp. 173-198

Despite serious attention to the issues of war crimes and crimes against humanity, committed on an unprecedented scale in concentration camps in Nazi Germany, the problem of medical experiments on prisoners appears to be one of the least-studied in modern Russian historiography. Moreover, no special attention was paid to testing chemical weapons on humans. The aim of this work is to review the history of the development and testing of chemical warfare agents (CWA) in Germany in 1933–1945. During the First World War, Germany was one of the leading countries in the sphere of military chemistry in the world. After the Versailles treaty this potential was largely lost as a result of the restrictions. After the National Socialist German Workers' Party (NSDAP) came to power, Germany not only restored, but also increased its military power and achieved a qualitative superiority over its opponents in the field of chemical weapons. The tests of CWA, as well as the study of the effectiveness of the means and protocols for the treatment of the lesions caused by CWA, were carried out both by the military structures of the Wehrmacht and the SS, and by civilian research and academic institutions. Experiments on prisoners were carried out in the concentration camps of Dachau, Ravensbrück, Auschwitz-Birkenau, Buchenwald, Sachsenhausen, Natzweiler-Struthof, Neuengamme, etc. Basically, the damaging effects of sulfur mustard and phosgene was investigated. In Auschwitz-Birkenau «a study of the action of various chemical preparations was carried out on the orders of German firms». After the war several SS doctors, who performed involuntary experiments on humans, were convicted by military tribunals for war crimes and crimes against humanity. Seven doctors were sentenced to death and executed on June 2, 1948, at the prison for war criminals in Landsberg, Bavaria. As a result of the Nuremberg trials, the Nuremberg Code was drawn up. It was the first international document that introduced ethical standards for scientists engaged in experiments on humans. It consisted of 10 principles, including the necessity of voluntary informed consent of the patient for the participation in medical experiments after providing him with full information about the nature, duration and purpose of the experiment; on the methods of its implementation; about all the perceived inconveniences and dangers associated with the experiment, and, finally, the possible consequences for the physical or mental health of the subject, which may arise as a result of his participation in the experiment.


Polymers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 3999
Author(s):  
Gabriela Toader ◽  
Aurel Diacon ◽  
Traian Rotariu ◽  
Mioara Alexandru ◽  
Edina Rusen ◽  
...  

In the context of imminent threats concerning biological and chemical warfare agents, the aim of this study was the development of a new method for biological and chemical decontamination, employing non-toxic, film-forming, water-based biodegradable solutions, using a nano sized reagent together with bentonite as trapping agents for the biological and chemical contaminants. Bentonite-supported nanoparticles of Cu, TiO2, and Ag were successfully synthesized and dispersed in a polyvinyl alcohol (PVA)/glycerol (GLY) aqueous solution. The decontamination effectiveness of the proposed solutions was evaluated by qualitative and quantitative analytical techniques on various micro-organisms, with sulfur mustard (HD) and dimethyl methylphosphonate (DMMP) as contaminants. The results indicate that the peelable active nanocomposite films can be successfully used on contaminated surfaces to neutralize and entrap the hazardous materials and their degradation products. Mechanical and thermal characterization of the polymeric films was also performed to validate the decontamination solution’s potential as peelable-film generating materials. The removal efficacy from the contaminated surfaces for the tested micro-organisms varied between 93% and 97%, while for the chemical agent HD, the highest decontamination factor obtained was 90.89%. DMMP was almost completely removed from the contaminated surfaces, and a decontamination factor of 99.97% was obtained.


2007 ◽  
Vol 42 (12) ◽  
pp. 1550-1561 ◽  
Author(s):  
Barbora Papoušková ◽  
Petr Bednář ◽  
Iveta Fryšová ◽  
Jakub Stýskala ◽  
Jan Hlaváč ◽  
...  

Sensor Review ◽  
2015 ◽  
Vol 35 (3) ◽  
pp. 237-243 ◽  
Author(s):  
Robert Bogue

Purpose – The purpose of this paper is to provide details of recent developments in sensors for detecting explosives and chemical warfare agents. Design/methodology/approach – Following an introduction, this paper first discusses a selection of new sensing techniques aimed at detecting explosives and explosive devices. It then considers new developments in sensors for detecting chemical warfare agents. Brief concluding comments are drawn. Findings – This paper shows that a diversity of sensor technologies is being investigated, including various advanced optical methods, nanomaterials, microelectromechanical system, electronic noses, biosensors and electrochemical techniques, several of which offer levels of sensitivity in the parts-per-trillion region. These not only have the potential to yield improved devices for detecting explosives and chemical weapons but may also play a role in health care, environmental monitoring, drug detection and industrial health and safety. Originality/value – In an era of escalating terrorism and military conflicts, this provides a timely review of new technologies for detecting explosives and chemical warfare agents.


The Analyst ◽  
2011 ◽  
Vol 136 (20) ◽  
pp. 4103 ◽  
Author(s):  
Svetlana S. Aleksenko ◽  
Pierre Gareil ◽  
Andrei R. Timerbaev

1994 ◽  
Vol 47 (11) ◽  
pp. 2065 ◽  
Author(s):  
VT Borrett ◽  
RJ Mathews ◽  
ER Mattsson

Under the provisions of the United Nations Chemical Weapons Convention (CWC), certain parts of chemical industry will be monitored to verify compliance with the Convention. This will include analysis of samples from industrial sites to check for the presence or absence of chemical warfare related compounds. One of the problems in screening the chemicals to be monitored under the CWC is that certain classes of chemical warfare agents are represented as families of chemicals, with many of the individual chemicals having no analytical data available. One example is the alkyl methylphosphonofluoridate family with an alkyl ester substituent from CH3 to C10H21. In this work, the mass spectra of 60 alkyl methylphosphonofluoridate family members have been studied to enable the development of rapid on-site screening methods for this family of chemicals.


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