Increased nuchal translucency is associated with large for gestational age neonates in singleton pregnancies

2011 ◽  
Vol 39 (3) ◽  
Author(s):  
Alina Weissmann-Brenner ◽  
Boaz Weisz ◽  
Liat Lerner-Geva ◽  
Liat Gindes ◽  
Reuven Achiron
Keyword(s):  
Gestational Age ◽  
Nuchal Translucency ◽  
Large For Gestational Age ◽  
Singleton Pregnancies ◽  
Increased Nuchal Translucency

scholarly journals Uterine distention as a factor in birth timing: retrospective nationwide cohort study in Sweden

BMJ Open ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. e022929 ◽  
Author(s):  
Jonas Bacelis ◽  
Julius Juodakis ◽  
Kristina M Adams Waldorf ◽  
Verena Sengpiel ◽  
Louis J Muglia ◽  
...  
Keyword(s):  
Cohort Study ◽  
Preterm Birth ◽  
Fetal Growth ◽  
Gestational Age ◽  
Large For Gestational Age ◽  
Maternal Height ◽  
Birth Timing ◽  
Gestational Age At Birth ◽  
Age At Birth ◽  
Singleton Pregnancies

ObjectivesTo determine whether uterine distention is associated with human pregnancy duration in a non-invasive observational setting.DesignRetrospective cohort study modelling uterine distention by interaction between maternal height and uterine load.SettingThe study is based on the 1990–2013 population data from all delivery units in Sweden.ParticipantsUncomplicated first pregnancies of healthy Nordic-born mothers with spontaneous onset of labour. Pregnancies were classified as twin (n=2846) or singleton (n=527 868). Singleton pregnancies were further classified as carrying a large for gestational age fetus (LGA, n=24 286) or small for gestational age fetus (SGA, n=33 780).Outcome measuresStatistical interaction between maternal height and uterine load categories (twin vs singleton pregnancies, and LGA vs SGA singleton pregnancies), where the outcome is pregnancy duration.ResultsIn all models, statistically significant interaction was found. Mothers carrying twins had 2.9 times larger positive linear effect of maternal height on gestational age than mothers carrying singletons (interaction p=5e−14). Similarly, the effect of maternal height was strongly modulated by the fetal growth rate in singleton pregnancies: the effect size of maternal height on gestational age in LGA pregnancies was 2.1 times larger than that in SGA pregnancies (interaction p<1e−11). Preterm birth OR was 1.4 when the mother was short, and 2.8 when the fetus was extremely large for its gestational age; however, when both risk factors were present together, the OR for preterm birth was larger than expected, 10.2 (interaction p<0.0005).ConclusionsAcross all classes, maternal height was significantly associated with child’s gestational age at birth. Interestingly, in short-statured women with large uterine load (twins, LGA), spontaneous delivery occurred much earlier than expected. The interaction between maternal height, uterine load size and gestational age at birth strongly suggests the effect of uterine distention imposed by fetal growth on birth timing.

scholarly journals The Relationship Between First-Trimester Aneuploidy Markers and Birth Weight

2021 ◽  
pp. 1-6
Author(s):  
Cenk Soysal ◽  
İsmail Biyik ◽  
Özlem Erten ◽  
Onur Ince ◽  
Hatice Sari ◽  
...  
Keyword(s):  
Plasma Protein ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Protein A ◽  
First Trimester ◽  
Nuchal Translucency ◽  
Maternal Serum ◽  
Large For Gestational Age ◽  
Aneuploidy Screening ◽  
Beta Human Chorionic Gonadotropin

OBJECTIVE: We aimed to determine the relationship between the first-trimester aneuploidy screeningma and the predicted weight at birth: Small for gestational age and large for gestational age. STUDY DESIGN: 594 low-risk pregnant women with a singleton pregnancy, who underwent first-trimester aneuploidy screening by measuring nuchal translucency, maternal serum free beta-human chorionic gonadotropin, and pregnancy-associated plasma protein-A were included in the study. Those weighing above the 3rd percentile and below the 10th percentile were defined as small for gestational age, and those over the 90th percentile were defined as large for gestational age. RESULTS: A total of 594 pregnant women were enrolled. The mean maternal age of the studied group was 28.8±5.5 years. Low maternal serum pregnancy-associated plasma protein-A levels and decreased nuchal translucency measurements were associated with the small for gestational age newborn (p<0.001 and p=0.001, respectively). There is a significant correlation with large for gestational age for newborns only with an increase in maternal serum pregnancy-associated plasma protein-A levels (p=0.001). beta-human chorionic gonadotropin levels were not associated with the birth weight (p=0.735). CONCLUSION: Maternal serum pregnancy-associated plasma protein-A levels, one of the markers in first-trimester aneuploidy screening, can be used in the prediction of small for gestational age and large for gestational age However, due to its low correlation, it is not a suitable screening test for clinical practice.

OP01.02: Enlarged nuchal translucency: more common in boys large for gestational age at birth

2008 ◽  
Vol 32 (3) ◽  
pp. 308-308
Author(s):  
E. Timmerman ◽  
E. Pajkrt ◽  
M. C. van Maarle ◽  
R. J. M. Snijders ◽  
C. M. Bilardo
Keyword(s):  
Gestational Age ◽  
Nuchal Translucency ◽  
Large For Gestational Age ◽  
Gestational Age At Birth ◽  
Age At Birth

First trimester severe ductus venosus flow abnormalities in isolation or combination with other markers of aneuploidy and fetal anomalies

2016 ◽  
Vol 44 (2) ◽  
Author(s):  
Marcin Wiechec ◽  
Agnieszka Nocun ◽  
Anna Matyszkiewicz ◽  
Ewa Wiercinska ◽  
Emilia Latała
Keyword(s):  
Screening Tool ◽  
Heart Defects ◽  
First Trimester ◽  
Nuchal Translucency ◽  
Ductus Venosus ◽  
Inclusion Criteria ◽  
Crown Rump Length ◽  
High Incidence ◽  
Singleton Pregnancies ◽  
Increased Nuchal Translucency

AbstractAltered flow in ductus venosus (DV) may be caused by the changes in preload or afterload. Its association with aneuploidy and congenital heart defects (CHDs) was widely described.The aim of this study was to examine the incidence of a reversed a-wave in DV flow (revDV) and the absence of DV (noDV), their coincidences with other markers of aneuploidy or fetal abnormalities in a mixed-risk population.The study group covered women who underwent an ultrasound scan between 11+0 and 13+6 weeks’ gestation.Singleton pregnancies with known pregnancy outcome and a crown-rump length of 45–84 mm.A total of 5811 cases, including 137 aneuploidies, met the inclusion criteria: 35 subjects of noDV, 189 of revDV and 5587 of normal DV flow. The incidence of noDV in euploidy was 0.47%, and in aneuploidy 5.8%. The incidence of revDV in euploidy was 2.46%, and in aneuploidy 35.7%. Among aneuploidy, the highest prevalence of noDV was found in monosomy 45X. revDV showed the highest prevalence in trisomy 18. Isolated noDV was only found in euploidy. Isolated revDV subjects were only observed in euploidy and trisomy 21. Any combination of revDV with additional markers showed high incidence in major trisomies. Extracardiac anatomy and abnormal cardiac findings showed a higher prevalence in noDV and revDV cases.The presence of noDV might be useful in suspicion of monosomy X among cases with increased nuchal translucency, as well as in differentiating them from other aneuploidies. The combinations of aneuploidy markers with revDV are strong indicators of aneuploidy. revDV alone is a poor screening tool for aneuploidy and euploidy with CHD.

CHROMOSOMAL DEFECTS IN INCREASED NUCHAL TRANSLUCENCY FETUS

2021 ◽  
Vol 62 (6) ◽  
Author(s):  
Nguyen Hai Long ◽  
Tran Danh Cuong ◽  
Ngo Toan Anh ◽  
Le Pham Sy Cuong ◽  
Nguyen Thi Thu Huong ◽  
...  
Keyword(s):  
Chromosomal Aberrations ◽  
Trisomy 21 ◽  
Maternal Age ◽  
Nuchal Translucency ◽  
Trisomy 13 ◽  
Crown Rump Length ◽  
Chromosomal Defects ◽  
Singleton Pregnancies ◽  
Increased Nuchal Translucency

Objectives: Determination of the prevalence of all chromosomal defects and its distribution in fetuses with increased nuchal translucency thickness. Methodology: This is a retrospective study among pregnant women indicated for amniocentesis by nuchal translucency above 2.5 mm and consent to the study. 2720 cases were included to the study during 6 years’ period from 2015 to 2020. All singleton pregnancies whose nuchal transluciency measurements were equal or over 2.5mm, were indicated for amniocentesis. Results: The study was consist of 2720 amniocentesis in which fetal nuchal transluciency was elevated. The median maternal age was 29.19 years old (range 17-46), and the median fetal crown-rump length was 66.9 mm (range 45– 84). The fetal karyotype was abnormal in 560 (20.6%) pregnancies. The popular chromosomal conditions were including trisomy 21(55%), trisomy 18 (11.2%), trisomy 13 (3.9%), 45, XO (2.7%). Chromosomal aberrations rate was 17.6% at maternal age of 30- 34, 34% and 50.0% at maternal age of 35- 39 and ≥ 40 respectively. Conclusion: In fetuses with increased nuchal translucency, more than a half of the chromosomal aberrations were trisomy 21 (55.0%). Structural rearrangements were 22.5%. Advanced maternal age (above 35) increases the risk of chromosomal aberrations.

Abstract #91: Comparison of Cord Blood Insulin in Large-for-Gestational-Age Infants and Appropriate-for-Age Filipino Infants of Nondiabetic Mothers: A Pilot Study

2004 ◽  
Vol 10 ◽  
pp. 31
Author(s):  
Florence M. Amorado-Santos ◽  
Maria Honolina S. Gomez ◽  
Maria Victoria R. Olivares ◽  
Zayda N. Gamilla
Keyword(s):  
Pilot Study ◽  
Cord Blood ◽  
Gestational Age ◽  
Large For Gestational Age ◽  
Blood Insulin
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