Prostaglandin E[1] treatment in patent ductus arteriosus dependent congenital heart defects

2004 ◽  
Vol 32 (4) ◽  
Author(s):  
G. Tálosi ◽  
M. Katona ◽  
K. Rácz ◽  
E. Kertész ◽  
B. Onozó ◽  
...  
Keyword(s):  
Patent Ductus Arteriosus ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Ductus Arteriosus ◽  
Prostaglandin E ◽  
Patent Ductus

scholarly journals Feasibility and Safety of Percutaneous Cardiac Interventions for Congenital and Acquired Heart Defects in Infants ≤1000 g

Children ◽  
2021 ◽  
Vol 8 (9) ◽  
pp. 826
Author(s):  
Ranjit Philip ◽  
Jeffrey Towbin ◽  
Neil Tailor ◽  
Vijaya Joshi ◽  
Jason N. Johnson ◽  
...  
Keyword(s):  
Adverse Event ◽  
Patent Ductus Arteriosus ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Transcatheter Closure ◽  
Heart Defects ◽  
Ductus Arteriosus ◽  
Major Adverse Event ◽  
Procedural Success ◽  
Patent Ductus

The transcatheter closure of patent ductus arteriosus (TCPC) has been demonstrated to be feasible even in infants weighing ≤1000 g. However, other percutaneous cardiac interventions (PCI) for such small infants born with congenital heart defects (CHD) or acquired heart defects (AHD) have not been well described. The purpose of this study was to describe the feasibility and safety of PCI in infants ≤1000 g. A retrospective review was conducted between June 2015 and May 2021, looking at 148 consecutive PCIs performed on infants weighing ≤1000 g at the time of the procedure. The procedural success rate was 100%. The major adverse event (AE) rate for TCPC was 3%, while there were no major AEs for other PCI. It is feasible to perform PCIs in infants weighing ≤1000 g with CHD and AHD using currently available technologies.

scholarly journals Intravenous Indomethacin Therapy in Infants With a Patent Ductus Arteriosus Complicating Other Congenital Heart Defects

2003 ◽  
Vol 67 (9) ◽  
pp. 750-752 ◽  
Author(s):  
Ken Watanabe ◽  
Hideshi Tomita ◽  
Yasuo Ono ◽  
Osamu Yamada ◽  
Ken-ichi Kurosaki ◽  
...  
Keyword(s):  
Patent Ductus Arteriosus ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Ductus Arteriosus ◽  
Patent Ductus

scholarly journals Patent Ductus Arteriosus: An Overview

2007 ◽  
Vol 12 (3) ◽  
pp. 138-146 ◽  
Author(s):  
James E. Dice ◽  
Jatinder Bhatia
Keyword(s):  
Patent Ductus Arteriosus ◽  
Preterm Infants ◽  
Congenital Heart ◽  
Heart Defects ◽  
Ductus Arteriosus ◽  
Clinical Signs ◽  
Medical Intervention ◽  
Fluid Restriction ◽  
Term Infants ◽  
Patent Ductus

Patent ductus arteriosus (PDA) is one of the most common congenital heart defects, accounting for 5%–10% of all congenital heart disease in term infants. The occurrence of PDA is inversely related to gestational age and weight, with an even greater incidence in preterm infants. The maintenance of ductal patency is essential for the normal development of the fetus. In the neonate, however, persistent patency of the ductus arteriosus (DA) is associated with significant morbidity and mortality. Normally, at birth, the DA constricts, resulting in intraluminal ischemic hypoxia, which eventually leads to closure and remodeling of the ductus. PDA in term infants is usually associated with a functional defect, whereas in preterm infants it is associated with immaturity. Normal physiologic mechanisms contributing to closure - oxygen tension and decreased prostaglandins—are altered in prematurity. Clinical signs of ductal patency include murmur, tachycardia, bounding peripheral pulses, and congestive heart failure and associated symptoms. Symptoms are not always present; therefore, diagnostic imaging is critical if a PDA is suspected on clinical grounds. Three management strategies are currently available for PDA: fluid restriction and diuretics (as clinically appropriate), medical intervention, and surgical ligation. Pharmacologic closure can be achieved via administration of intravenous indomethacin or ibuprofen lysine. While both agents have shown similar efficacy, ibuprofen lysine has demonstrated an improved safety profile, particularly in terms of renal effects, compared to indomethacin.

scholarly journals Congenital heart defects in dogs: A retrospective study of 301 dogs

2017 ◽  
Vol 73 (10) ◽  
pp. 651-656
Author(s):  
Magdalena Garncarz ◽  
Marta Parzeniecka-Jaworska ◽  
Olga Szaluś-Jordanow
Keyword(s):  
Retrospective Study ◽  
Congenital Heart Defects ◽  
Medical Records ◽  
Congenital Heart ◽  
Septal Defect ◽  
Early Recognition ◽  
Heart Defects ◽  
Ductus Arteriosus ◽  
Subaortic Stenosis ◽  
Patent Ductus

The aim of the study was to assess the frequency of congenital heart defects in a population of dogs in Poland and to determine which breeds were affected by particular defects. A retrospective study of the medical records of cardiologically examined dogs revealed 301 cases of echocardiographically confirmed congenital heart defects. Dogs with congenital heart defects made up 2.7% of the dogs that underwent a cardiologic examination. The age at diagnosis ranged from 2 weeks to 190 months. Mixed breeds (33 dogs, 11%), Bull Terriers (31, 10%), Boxers (28, 9%), German Shepherds (17, 6%), Yorkshire Terriers (17, 6%), and French Bulldogs (16, 5%) were the most frequently affected breeds. Subaortic stenosis (120 cases, 33.9%), pulmonic stenosis (64, 18.1%), patent ductus arteriosus (59, 16.7%), mitral valve dysplasia (56, 15.8%), ventricular septal defect (24, 6.8%) and tricuspid valve dysplasia (17, 4.8%) were the most frequent congenital heart defects recognized in this study. Isolated congenital heart disease occurred in 258 dogs (86%), while multiple heart defects were noted in 43 dogs (14%). Most (60%) congenital heart defects were recognized in dogs older than 1 year. Early recognition of congenital heart defects is important for better patient care. Collecting information on the frequency of congenital heart defects in particular breeds will be useful in educating breeders and thus in improving the overall health of the breed.

scholarly journals A Framework for AI-Assisted Detection of Patent Ductus Arteriosus from Neonatal Phonocardiogram

Healthcare ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 169
Author(s):  
Sergi Gómez-Quintana ◽  
Christoph E. Schwarz ◽  
Ihor Shelevytsky ◽  
Victoriya Shelevytska ◽  
Oksana Semenova ◽  
...  
Keyword(s):  
Patent Ductus Arteriosus ◽  
Heart Defects ◽  
Ductus Arteriosus ◽  
Area Under The Curve ◽  
Clinical Decision ◽  
Heart Sounds ◽  
Decision Tree Classifier ◽  
Support Tool ◽  
Tree Classifier ◽  
Patent Ductus

The current diagnosis of Congenital Heart Disease (CHD) in neonates relies on echocardiography. Its limited availability requires alternative screening procedures to prioritise newborns awaiting ultrasound. The routine screening for CHD is performed using a multidimensional clinical examination including (but not limited to) auscultation and pulse oximetry. While auscultation might be subjective with some heart abnormalities not always audible it increases the ability to detect heart defects. This work aims at developing an objective clinical decision support tool based on machine learning (ML) to facilitate differentiation of sounds with signatures of Patent Ductus Arteriosus (PDA)/CHDs, in clinical settings. The heart sounds are pre-processed and segmented, followed by feature extraction. The features are fed into a boosted decision tree classifier to estimate the probability of PDA or CHDs. Several mechanisms to combine information from different auscultation points, as well as consecutive sound cycles, are presented. The system is evaluated on a large clinical dataset of heart sounds from 265 term and late-preterm newborns recorded within the first six days of life. The developed system reaches an area under the curve (AUC) of 78% at detecting CHD and 77% at detecting PDA. The obtained results for PDA detection compare favourably with the level of accuracy achieved by an experienced neonatologist when assessed on the same cohort.

scholarly journals TETRALOGI FALLOT DAN ATRESIA PULMONAL

2013 ◽  
Vol 4 (3) ◽  
Author(s):  
Alice I. Supit ◽  
Erling D. Kaunang
Keyword(s):  
Patent Ductus Arteriosus ◽  
Right Ventricle ◽  
Tetralogy Of Fallot ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Ductus Arteriosus ◽  
Ventricle Hypertrophy ◽  
The Right ◽  
Right Ventricle Hypertrophy ◽  
Patent Ductus

Abstract: Congenital heart disease is a structural defect due to the malformation of the heart, aorta, and or great blood vessels. It is the most frequent congenital malformation in newborn babies. Tetralogy of Fallot is one of the congenital heart diseases (CHD) with central cyanosis, and covers 5-10% of all CHD. We reported a boy of one year old with Tetralogy of Fallot and pulmonal atresia (ToF-PA), associated with bronchopneumonia. The diagnosis was based on anamnesis, physical examination, and other supporting examinations. The chest X-ray showed a normal sized heart (CTR 57%) with coer-en-sabot shape, and right and left parahilar infiltration, which resulted in bronchopneumonia and ToF. The electrocardiography showed a right deviation of axis and a hypertrophy of the right ventricle; the echocardiography showed a right ventricle hypertrophy, an over-riding aorta, a large malalignment of the ventricular septal defect, no visualization of pulmonar artery, and no visualization of patent ductus arteriosus (PDA). Conclusion: Based on all the tests performed, the diagnosis of this patient was Tetralogy of Fallot and pulmonal atresia (ToF-PA), associated with bronchopneumonia. The prognosis related to bronchopneumonia in this case was good due to the use of antibiotics. Keywords: tetralogy of Fallot, pulmona atresia, bronchopneumonia.  Abstrak: Penyakit jantung bawaan (PJB) ialah kelainan struktural akibat malformasi jantung, aorta dan atau pembuluh darah besar, dan merupakan kelainan kongenital tersering pada bayi baru lahir. Tetralogi Fallot merupakan salah satu PJB dengan sianosis sentral, dan mencakup 5-10% dari seluruh PJB. Kami melaporkan kasus seorang anak laki-laki berusia satu tahun dengan Tetralogi Fallot dan atresia pulmonal (ToF-PA) disertai bronkopneumonia. Diagnosis ditegakkan melalui anamnesis, pemeriksaan fisik, dan pemeriksaan penunjang. Hasil ekspertisi foto toraks AP memperlihatkan ukuran jantung normal (CTR 57%) berbentuk coer-en-sabot, dan pada paru-paru terlihat infiltrat parahilar kanan dan kiri serta corakan vaskular paru berkurang yang menunjukkan suspek bronkopneumonia dan ToF. Elektrokardiografi memperlihatkan deviasi aksis ke kanan dan hipertrofi ventrikel kanan, dan pada ekokardiografi tampak right ventricle hypertrophy, overriding aorta, VSD malalignment besar, tidak tampak visualisasi arteri pulmonal, dan tidak tampak patent ductus arteriosus (PDA) dengan hasil Tetralogi Fallot dan atresia pulmonal. Simpulan: Berdasarkan hasil pemeriksaan yang dilakukan, diagnosis pasien ini ialah Tetralogi Fallot dan atresia pulmonal (ToF-PA) disertai bronkopneumonia. Prognosis bronkopenumonia pada kasus ini baik yang dapat diatasi dengan antibiotika.Kata kunci: tetralogi Fallot, atresia pulmonal, bronkopneumonia.  

Necrotizing tracheobronchitis in patent ductus arteriosus‐dependent cyanotic congenital heart disease

2001 ◽  
Vol 32 (6) ◽  
pp. 480-483 ◽  
Author(s):  
Yuji Nakata ◽  
Yoshiyuki Morikawa ◽  
Masaru Miura ◽  
Kazuki Kawasaki ◽  
Hiroshi Toyoma ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Patent Ductus Arteriosus ◽  
Congenital Heart ◽  
Ductus Arteriosus ◽  
Cyanotic Congenital Heart Disease ◽  
Necrotizing Tracheobronchitis ◽  
Patent Ductus

Double Intervention in Single Sitting in a Girl with Atrial Septal Defect and Patent Ductus Arteriosus: A Case Report

1970 ◽  
Vol 24 (1) ◽  
pp. 34-37
Author(s):  
NN Fatema ◽  
SMM Rahman ◽  
MR Karim ◽  
M Haque
Keyword(s):  
Patent Ductus Arteriosus ◽  
Atrial Septal Defect ◽  
Congenital Heart ◽  
Septal Defect ◽  
Ductus Arteriosus ◽  
Single Patient ◽  
Catheterization Laboratory ◽  
Interventional Closure ◽  
Heart Lesions ◽  
Patent Ductus

Atrial septal defect (ASD) and patent ductus arteriosus (PDA) are commonly encountered problems and constitute about 20% of all congenital heart lesions. Association of these two conditions in a single patient is not very uncommon. Both these conditions can be treated by placing intracardiac devices. Double interventional closure of Atrial Septal Defect (secundum type) and Patent Ductus Arteriosus was performed in single sitting in a 12 year-old girl in Catheterization Laboratory of CMH Dhaka. This is the first ever-reported double interventional closure of two separate diseases in a single patient in single setting, which led writing this report. (J Bangladesh Coll Phys Surg 2006; 24: 34-37)

scholarly journals High prevalence of congenital heart disease at high altitudes in Tibet

2018 ◽  
Vol 26 (7) ◽  
pp. 756-759 ◽  
Author(s):  
Hua Chun ◽  
Yan Yue ◽  
Yibin Wang ◽  
Zhaxi Dawa ◽  
Pu Zhen ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Patent Ductus Arteriosus ◽  
High Altitude ◽  
Congenital Heart ◽  
Septal Defect ◽  
Heart Diseases ◽  
Ductus Arteriosus ◽  
Congenital Heart Diseases ◽  
Patent Ductus

Background Previous small sample studies suggested that elevated altitudes might be associated with the incidence of cardiovascular diseases. However, it remains uncertain whether high altitudes (over 3000 m above sea level) are related to congenital heart disease. We therefore explored the prevalence of congenital heart disease in a large cohort of students in the world's largest prefecture-level city with the highest altitude. Methods This cross-sectional study included 84,302 student participants (boys 52.12%, girls 47.88%, with an average age of 10.62 ± 3.33 years). Data were extracted from the screening results among different altitude area schools in Nagqu from June 2016 to August 2017. Students were first screened by performing a physical examination consisting of cardiac auscultations and clinical manifestation screenings. An echocardiography was performed to confirm and identify the subtype of congenital heart disease. Results The prevalence of congenital heart disease among students in Nagqu, Tibet, was 5.21‰ (439 cases). The most common congenital heart disease type was patent ductus arteriosus, representing 66.3% of congenital heart diseases diagnosed in this study, followed by atrial septal defect and ventricular septal defect, representing 20.3% and 9.1% of congenital heart diseases, respectively. Students living in higher altitudes were significantly more prone to have congenital heart disease than students in locations with lower altitudes. The prevalence of congenital heart disease in girls was found to be higher than that of boys. Conclusions The correlation between congenital heart disease and increased altitude is noteworthy. This study's results are the first big data epidemiological investigation to confirm that high altitude is a significant environmental risk factor for congenital heart disease, especially patent ductus arteriosus. Furthermore, the results provide additional support to make a diagnostic and treatment plan to prevent congenital heart disease in high altitude areas.

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