Accelerated carpal bone maturation in juvenile idiopathic arthritis: pitfall for bone age measurement

2011 ◽  
Vol 24 (7-8) ◽  
Author(s):  
Arturo Borzutzky ◽  
Alejandro Martinez-Aguayo
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Bone Age ◽  
Carpal Bone ◽  
Bone Maturation ◽  
Bone Age Measurement

Carpal Bone Segmentation Using Fully Convolutional Neural Network

2019 ◽  
Vol 15 (10) ◽  
pp. 983-989
Author(s):  
Liang Kim Meng ◽  
Azira Khalil ◽  
Muhamad Hanif Ahmad Nizar ◽  
Maryam Kamarun Nisham ◽  
Belinda Pingguan-Murphy ◽  
...  
Keyword(s):  
Neural Network ◽  
Convolutional Neural Network ◽  
Automatic Segmentation ◽  
Ground Truth ◽  
Bone Age ◽  
Image Feature ◽  
Qualitative Assessment ◽  
Carpal Bone ◽  
Radiographic Images ◽  
Accurate Quantitative Analysis

Background: Bone Age Assessment (BAA) refers to a clinical procedure that aims to identify a discrepancy between biological and chronological age of an individual by assessing the bone age growth. Currently, there are two main methods of executing BAA which are known as Greulich-Pyle and Tanner-Whitehouse techniques. Both techniques involve a manual and qualitative assessment of hand and wrist radiographs, resulting in intra and inter-operator variability accuracy and time-consuming. An automatic segmentation can be applied to the radiographs, providing the physician with more accurate delineation of the carpal bone and accurate quantitative analysis. Methods: In this study, we proposed an image feature extraction technique based on image segmentation with the fully convolutional neural network with eight stride pixel (FCN-8). A total of 290 radiographic images including both female and the male subject of age ranging from 0 to 18 were manually segmented and trained using FCN-8. Results and Conclusion: The results exhibit a high training accuracy value of 99.68% and a loss rate of 0.008619 for 50 epochs of training. The experiments compared 58 images against the gold standard ground truth images. The accuracy of our fully automated segmentation technique is 0.78 ± 0.06, 1.56 ±0.30 mm and 98.02% in terms of Dice Coefficient, Hausdorff Distance, and overall qualitative carpal recognition accuracy, respectively.

Bone Age Measurement-Based on Dental Radiography, Employing a New Model

2021 ◽  
pp. 51-61
Author(s):  
Fatemeh Sharifonnasabi ◽  
N. Z. Jhanjhi ◽  
Jacob John ◽  
Prabhakaran Nambiar
Keyword(s):  
Bone Age ◽  
Dental Radiography ◽  
New Model ◽  
Bone Age Measurement

scholarly journals Automated determination of bone age and bone mineral density in patients with juvenile idiopathic arthritis: a feasibility study

2014 ◽  
Vol 16 (4) ◽  
Author(s):  
Janneke Anink ◽  
Charlotte M Nusman ◽  
Lisette WA van Suijlekom-Smit ◽  
Rick R van Rijn ◽  
Mario Maas ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Juvenile Idiopathic Arthritis ◽  
Feasibility Study ◽  
Bone Mineral ◽  
Bone Age ◽  
Mineral Density ◽  
Automated Determination

Evaluation of Bone Age of Patients with Juvenile Idiopathic Arthritis in Puberty

2010 ◽  
Vol 10 (1) ◽  
pp. 24-28
Author(s):  
Muferret Erguven ◽  
Elif Yuksel Karatoprak ◽  
Oznur Yilmaz Hamzah
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Bone Age

Metformin for Rapidly Maturing Girls with Central Adiposity: Less Liver Fat and Slower Bone Maturation

2017 ◽  
Vol 89 (2) ◽  
pp. 136-140 ◽  
Author(s):  
Francis de Zegher ◽  
Cristina García Beltrán ◽  
Abel López-Bermejo ◽  
Lourdes Ibáñez
Keyword(s):  
Body Composition ◽  
Bone Age ◽  
Liver Fat ◽  
Metformin Treatment ◽  
X Rays ◽  
Central Adiposity ◽  
Bone Maturation ◽  
Original Cohort ◽  
Chronological Aging ◽  
Hepatic Fat

Background/Aims: Girls with low-birth weight (LBW) and postnatal weight catch-up tend to develop visceral and hepatic fat excess, which may be accompanied by an upregulated adrenarche with precocious pubarche (PP) and by a rapidly progressive puberty with early menarche and shorter stature. A pilot study suggested that metformin treatment for 4 years reduces central adiposity in LBW-PP girls and normalizes puberty and adult height. In this cohort, we studied the relationship between metformin treatment, bone maturation, and body composition. Methods: Longitudinal hand X-rays (0–4 years, analyzed by BoneXpert) were available from 34 LBW-PP girls (89% of the original cohort; n = 17 untreated, n = 17 metformin-treated; age at the start of treatment 8 years) along with body composition (0–4 years, by DXA), hepatic fat, and abdominally subcutaneous and visceral fat (posttreatment, by MRI). Results: The tempo of bone aging was accelerated in untreated girls (≈16% faster vs. chronological aging) and normal in metformin-treated girls (≈20% slower vs. untreated girls). Metformin-treated girls gained more height per bone-age year and had less visceral and hepatic fat. The tempo of bone maturation was associated (R = 0.55; p < 0.001) with hepatic fat. Conclusion: Metformin treatment in rapidly maturing girls with central adiposity normalized bone maturation. This normalization was accompanied by less central fat and was related closely to hepatic fat.

Growth curves for congenital adrenal hyperplasia from a national retrospective cohort

2016 ◽  
Vol 29 (12) ◽  
Author(s):  
Patricia Bretones ◽  
Benjamin Riche ◽  
Emmanuel Pichot ◽  
Michel David ◽  
Pascal Roy ◽  
...  
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Adult Height ◽  
Bone Age ◽  
Strong Impact ◽  
Adrenal Hyperplasia ◽  
Hydroxylase Deficiency ◽  
Bone Maturation ◽  
The Mean ◽  
Puberty Onset ◽  
21 Hydroxylase Deficiency

Abstract Background: In congenital adrenal hyperplasia (CAH), adjusting hydrocortisone dose during childhood avoids reduced adult height. However, there are currently no CAH-specific charts to monitor growth during treatment. Our objective was to elaborate growth reference charts and bone maturation data for CAH patients. Methods: We conducted a retrospective observational cohort study, in 34 French CAH centers. Patients were 496 children born 1970–1991 with genetically proven 21-hydroxylase deficiency. Their growth and bone maturation data were collected until age 18 together with adult height, puberty onset, parental height, and treatment. The mean (SD) heights were modeled from birth to adulthood. The median±1 SD and ±2 SDs model-generated curves were compared with the French references. A linear model for bone maturation and a logistic regression model for the probability of short adult height were built. Results: Growth charts were built by sex for salt wasting (SW) and simple virilizing (SV) children treated before 1 year of age. In girls and boys, growth was close to that of the general French population up to puberty onset. There was almost no pubertal spurt and the mean adult height was shorter than that of the general population in girls (−1.2 SD, 156.7 cm) and boys (−1.0 SD, 168.8 cm). Advanced bone age at 8 years had a strong impact on the risk of short adult height (OR: 4.5 per year advance). Conclusions: The 8-year bone age is a strong predictor of adult height. It will help monitoring the growth of CAH-affected children.

An Automatic System for Skeletal Bone Age Measurement by Robust Processing of Carpal and Epiphysial/Metaphysial Bones

2010 ◽  
Vol 59 (10) ◽  
pp. 2539-2553 ◽  
Author(s):  
Daniela Giordano ◽  
Concetto Spampinato ◽  
Giacomo Scarciofalo ◽  
Rosalia Leonardi
Keyword(s):  
Automatic System ◽  
Bone Age ◽  
Robust Processing ◽  
Skeletal Bone ◽  
Bone Age Measurement
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