The relation between 25-hydroxyvitamin D with peak bone mineral density and body composition in healthy young adults

2011 ◽  
Vol 24 (5-6) ◽  
Author(s):  
Annemieke M. Boot ◽  
Eric P. Krenning ◽  
Sabine M.P.F. de Muinck Keizer-Schrama
Keyword(s):  
Bone Mineral Density ◽  
Young Adults ◽  
Body Composition ◽  
Bone Mineral ◽  
Mineral Density ◽  
Peak Bone Mineral Density ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

scholarly journals Association of Pioglitazone Treatment with Decreased Bone Mineral Density in Obese Premenopausal Patients with Polycystic Ovary Syndrome: A Randomized, Placebo-Controlled Trial

2008 ◽  
Vol 93 (5) ◽  
pp. 1696-1701 ◽  
Author(s):  
Dorte Glintborg ◽  
Marianne Andersen ◽  
Claus Hagen ◽  
Lene Heickendorff ◽  
Anne Pernille Hermann
Keyword(s):  
Bone Mineral Density ◽  
Body Composition ◽  
Bone Mineral ◽  
Polycystic Ovary ◽  
Mineral Density ◽  
Ovary Syndrome ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Premenopausal Patients ◽  
Pioglitazone Treatment

Abstract Objective: Our objective was to investigate the effect of pioglitazone on bone mineral density (BMD) and bone turnover markers in polycystic ovary syndrome (PCOS). Design and Setting: We conducted a randomized, placebo-controlled study at an outpatient clinic at a university hospital. Patients: Thirty premenopausal patients with PCOS and 14 age- and weight-matched healthy females participated. Interventions: Pioglitazone (30 mg/d) or placebo was given for 16 wk. Main Outcome Measures: Measurements of BMD [hip (neck and total) and lumbar spine (L2–L4)], bone metabolic parameters [alkaline phosphatase (ALP), 25-hydroxyvitamin D, C-telopeptide of type I collagen (ICTP), osteocalcin, and PTH], endocrine profiles (testosterone, estradiol, and insulin), and body composition (waist to hip ratio, body mass index, and whole-body dual-energy x-ray absorptiometry scans) were performed. Results: Patients with PCOS had significantly higher levels of ICTP, fasting insulin, and testosterone than controls, whereas no differences were measured in ALP, PTH, body composition, or BMD. Pioglitazone treatment was followed by reduced BMD [geometric means (−2 to +2 sd)]: lumbar spine 1.140 (0.964–1.348) vs. 1.127 (0.948–1.341) g/cm2 (average decline 1.1%) and femoral neck 0.966 (0.767–1.217) vs. 0.952 (0.760–1.192) g/cm2 (average decline 1.4%), both P < 0.05. Both ALP and PTH decreased significantly during pioglitazone treatment, whereas no significant changes were measured in 25-hydroxyvitamin D, ICTP, osteocalcin, sex hormones, and body composition. Conclusion: Pioglitazone treatment was followed by decreased lumbar and hip BMD and decreased measures of bone turnover in a premenopausal study population relatively protected from bone mineral loss.

scholarly journals Body Composition and Bone Mineral Density in Children with Premature Adrenarche and the Association of LRP5 Gene Polymorphisms with Bone Mineral Density

2009 ◽  
Vol 94 (11) ◽  
pp. 4144-4151 ◽  
Author(s):  
Pauliina Utriainen ◽  
Jarmo Jääskeläinen ◽  
Anne Saarinen ◽  
Esko Vanninen ◽  
Outi Mäkitie ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Body Composition ◽  
Bone Mineral ◽  
Mineral Density ◽  
Single Nucleotide ◽  
Prepubertal Children ◽  
Hydroxyvitamin D ◽  
Premature Adrenarche ◽  
Minor Variant ◽  
25 Hydroxyvitamin D

Context: Precocious increase in adrenal androgen production is the hallmark of premature adrenarche (PA). Adrenal androgens have anabolic properties. Objective: The objective of the study was to test whether body composition and bone mineral density (BMD) are altered in PA and study whether genetic variation in low-density lipoprotein receptor-related protein 5 (LRP5) affects BMD in PA. Design: This was a cross-sectional study. Setting: The study was conducted at a university hospital. Subjects and Measures: The study included 126 prepubertal children (64 with PA, 10 boys; 62 non-PA controls, 10 boys). Femoral neck and lumbar spine areal and calculated volumetric BMD (dual energy X-ray absorptiometry), body composition (bioimpedance), serum 25-hydroxyvitamin D, and markers of bone turnover and calcium homeostasis were compared between the PA and control groups. Single-nucleotide polymorphisms of LRP5 were determined and associated with BMD. Results: Children with PA had higher femoral neck and lumbar spine BMDareal than the controls (Z-score 0.56 vs. −0.09, P < 0.001, and 0.20 vs. −0.31, P = 0.009, respectively). However, the mean BMDs did not differ significantly between the groups when adjusted for height or bone size. BMDareal correlated strongly with height sd score in both groups. Among the PA children, LRP5 single-nucleotide polymorphism E644E minor variant was associated with lower and F549F minor variant with higher BMD. Total body fat mass, fat percent, serum PTH, and alkaline phosphatase concentrations were higher and 25-hydroxyvitamin D lower in the PA group. Conclusions: Prepubertal children with PA had higher BMDareal compared with healthy controls. This was mainly explained by their increased height. LRP5 polymorphisms may contribute to bone mass accrual in prepubertal PA children. Children with premature adrenarche have increased areal bone mineral density determined by their enhanced growth in height.

An Association between Bioavailable 25-Hydroxyvitamin D and Bone Mineral Density in a Diverse Cohort of Collegiate Athletes

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Michelle S. Rockwell ◽  
Samantha B. Kostelnik ◽  
Ryan P. McMillan ◽  
Melanie Lancaster ◽  
D. Enette Larson-Meyer ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Collegiate Athletes ◽  
Mineral Density ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

scholarly journals Serum 25-hydroxyvitamin D and bone mineral density among children and adolescents in a Northwest Chinese city

Bone ◽  
2018 ◽  
Vol 116 ◽  
pp. 28-34 ◽  
Author(s):  
Jing Li ◽  
Wenqing Ding ◽  
Juan Cao ◽  
Lijiao Sun ◽  
Shanghong Liu ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Children And Adolescents ◽  
Bone Mineral ◽  
Mineral Density ◽  
Chinese City ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D
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