Subcutaneous Fat Necrosis and Hypercalcemia Following Therapeutic Hypothermia – a Patient Report and Review of the Literature

2010 ◽  
Vol 23 (11) ◽  
Author(s):  
Eyal Zifman ◽  
Marie Mouler ◽  
Alon Eliakim ◽  
Dan Nemet ◽  
Avishalom Pomeranz
Keyword(s):  
Therapeutic Hypothermia ◽  
Subcutaneous Fat ◽  
Fat Necrosis ◽  
Review Of The Literature ◽  
Patient Report ◽  
Subcutaneous Fat Necrosis

Subcutaneous Fat Necrosis After Moderate Therapeutic Hypothermia in Neonates

PEDIATRICS ◽  
2011 ◽  
Vol 128 (2) ◽  
pp. e450-e452 ◽  
Author(s):  
B. Strohm ◽  
A. Hobson ◽  
P. Brocklehurst ◽  
A. D. Edwards ◽  
D. Azzopardi ◽  
...  
Keyword(s):  
Therapeutic Hypothermia ◽  
Subcutaneous Fat ◽  
Fat Necrosis ◽  
Subcutaneous Fat Necrosis

Subcutaneous Fat Necrosis in a Newborn after Brief Therapeutic Hypothermia: Ultrasonographic Examination

2014 ◽  
Vol 32 (3) ◽  
pp. 427-429 ◽  
Author(s):  
Linda Tognetti ◽  
Georgios Filippou ◽  
Sara Bertrando ◽  
Valentina Picerno ◽  
Giuseppe Buonocore ◽  
...  
Keyword(s):  
Therapeutic Hypothermia ◽  
Subcutaneous Fat ◽  
Fat Necrosis ◽  
Subcutaneous Fat Necrosis ◽  
Ultrasonographic Examination

Haematoma complicating subcutaneous fat necrosis of the newborn: a rare complication following therapeutic hypothermia

2020 ◽  
Vol 13 (6) ◽  
pp. e234360
Author(s):  
Elhaytham Omar Sanad Elsayed ◽  
Kamran Yusuf ◽  
Frankie O G Fraulin ◽  
Prashanth Murthy
Keyword(s):  
Therapeutic Hypothermia ◽  
Neonatal Intensive Care ◽  
Rare Complication ◽  
Subcutaneous Fat ◽  
Meconium Aspiration Syndrome ◽  
Large For Gestational Age ◽  
Unusual Complication ◽  
Skin Defect ◽  
Fat Necrosis ◽  
Subcutaneous Fat Necrosis

A term, large for gestational age male newborn, was admitted to the neonatal intensive care unit with meconium aspiration syndrome and severe hypoxic-ischaemic encephalopathy. The baby was treated with therapeutic hypothermia using a total body cooling blanket. After 48 hours, the baby developed tender, indurated subcutaneous nodules consistent with subcutaneous fat necrosis (SCFN). The lesions started initially over the back but gradually spread to cover both shoulders, upper arms, chest area and both thighs. On day 19 of life, multiple small nodules on the back softened and coalesced to form one sizeable fluctuant swelling over the thoracolumbar area. Over a few hours, the swelling rapidly progressed to a large, tense mass with sloughing of the gangrenous overlying skin. This unusual complication of SCFN required surgical intervention for evacuation and debridement of the haematoma followed by graft repair of the skin defect.

Is Therapeutic Hypothermia Real Cause of Subcutaneous Fat Necrosis in Newborns?

2012 ◽  
Vol 80 (4) ◽  
pp. 355-356
Author(s):  
Nilay Hakan ◽  
Mustafa Aydin ◽  
Ayşegül Zenciroğlu ◽  
Sara Erol ◽  
Nurullah Okumuş
Keyword(s):  
Therapeutic Hypothermia ◽  
Subcutaneous Fat ◽  
Fat Necrosis ◽  
Subcutaneous Fat Necrosis

Occult Massive Visceral Fat Necrosis Following Therapeutic Hypothermia for Neonatal Encephalopathy

2017 ◽  
Vol 21 (5) ◽  
pp. 502-506
Author(s):  
Salwa Khedr ◽  
Anna Piskorski ◽  
Adrienne R Bingham ◽  
Justin Goldstein ◽  
Abbot R Laptook ◽  
...  
Keyword(s):  
Therapeutic Hypothermia ◽  
Visceral Fat ◽  
Subcutaneous Fat ◽  
Neurodevelopmental Outcome ◽  
Pulmonary Artery Hypertension ◽  
Whole Body ◽  
Common Side Effect ◽  
Close Monitoring ◽  
Fat Necrosis ◽  
Subcutaneous Fat Necrosis

Therapeutic hypothermia (head or whole-body cooling) improves survival and neurodevelopmental outcome in term newborns with moderate-to-severe encephalopathy. Hypothermia treatment is well tolerated; the most common side effect is thrombocytopenia. In about 1% of infants, focal subcutaneous fat necrosis has been reported. We describe a case of clinically unsuspected massive visceral fat necrosis in a term infant with Apgar score 0 at 1 min (“resuscitated apparently stillborn” infant) who was treated with therapeutic hypothermia for 72 h and expired on the 25th day of life following a neonatal course complicated by severe encephalopathy, pulmonary artery hypertension, persistent thrombocytopenia, hypoglycemia, and severe basal ganglia-thalamic abnormalities on magnetic resonance imaging. Postmortem examination revealed extensive visceral (brown) fat necrosis, involving thoracic, abdominal, and retroperitoneal adipose tissue, with distinctive sparing of the subcutaneous (white) fat. The fulminant—yet clinically occult—visceral fat necrosis seen in this case suggests that (lesser degrees of) fat necrosis may go unrecognized in hypoxic-ischemic newborns, especially in those treated with hypothermia, and underscores the importance of close monitoring of encephalopathic newborns both in the short and long terms for complications of fat necrosis (hypercalcemia and nephrocalcinosis).

Subcutaneous Fat Necrosis of the Newborn and Hypercalcemia: Case Report and Review of the Literature

1993 ◽  
Vol 10 (3) ◽  
pp. 271-276 ◽  
Author(s):  
M. John Hicks ◽  
Moise L. Levy ◽  
Joshua Alexander ◽  
Catherine M. Flaitz
Keyword(s):  
Case Report ◽  
Subcutaneous Fat ◽  
Fat Necrosis ◽  
Review Of The Literature ◽  
Subcutaneous Fat Necrosis
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