Bioprocessing: Engineering Know-How in Greater Demand than Ever

2006 ◽  
Vol 3 (4) ◽  
Author(s):  
Christina Hirche ◽  
Charles Butcher

AbstractIntroductionSeveral studies forecast that the share of biotechnological processes in the total sales volume of chemical products will probably soar to around 15–20 % by 2010. Alone for the chemical industry, the potential value added of biotechnological production has been predicted to reach € 11–22 billion worldwide annually by then. The value added stems not only from new biotechnological products, but also from the effects of improved manufacturing processes. At ACHEMA 2006 in May 2006 in Frankfurt am Main - the world's leading event for the process industries - besides the integral general topic Biotechnological Equipment, which focuses on the equipment sector a special Industrial Biotechnology Exhibition and a Partnering Conference took place, thus paying tribute to the growing significance of industrial biotechnology and supporting international networking.

Konstruktion ◽  
2017 ◽  
Vol 69 (01-02) ◽  
pp. 18-19

Der Vertrieb hochwertiger rotativer und lineartechnischer Komponenten ist seit über dreißig Jahren das Kerngeschäft des Antriebsspezialisten Rodriguez. Inzwischen gibt es jedoch auch eigene Produktionskapazitäten, die unter anderem für die Fertigung von kundenspezifischen Lösungen genutzt werden: Basierend auf dem langjährigen Engineering-Know-how sowie den speziellen Kenntnissen und Erfahrungen in der Mechanik hat Rodriguez einen eigenen Geschäftsbereich mit großem Potenzial entwickelt, die „Value-Added Products“ (VAP). Nicht zuletzt dank kurzer Entscheidungswege und der eigenen Fertigung kann das Unternehmen weitaus flexibler agieren als seine Wettbewerber – ein Grund, warum die bedarfsgerechten Systemlösungen auf dem Markt so erfolgreich sind.


2019 ◽  
Vol 69 (1) ◽  
pp. 81-99 ◽  
Author(s):  
Pawel Folfas ◽  
Beáta Udvari

Nowadays, global production networks (GPN) and global value chains (GVC) play an important role in the world economy intensifying the trade and production networks and resulting in products having value-added in different countries. The analysis of how many intermediate products a country imports in order to produce a product and of how many products a country exports to another country in order to produce new products draws the attention to value-added trade. In the present study, we compare the Hungarian and Polish value-added trade of chemicals and chemical products. We use the OECD-WTO data of value-added trade, which is based on an input-output table. By calculating numerous indices, we reveal that the domestic value-added of chemicals and chemical products in the two countries was relatively low and should be increased by adequate economic policy.


2007 ◽  
Vol 2 (4) ◽  
pp. 80 ◽  
Author(s):  
Shelagh K. Genuis

A review of: Kuhlthau, Carol C. “Inside the Search Process: Information Seeking from the User's Perspective.” Journal of the American Society for Information Science 42.5 (1991): 361-71. Objective – To extend understanding of purposeful information seeking and to present a model of the information search process (ISP) from the perspective of the user. Design – Review of theoretical foundation, summing up of qualitative and quantitative data from a series of five foundational studies, and presentation of ISP model. Setting – Summarised research was conducted primarily in high school and college environments where subjects were investigating an assigned topic. A small proportion of public libraries were used in the fifth study within the reviewed series. Subjects – The ISP model as presented in this ‘classic’ article is based on studies involving a total of 558 participants. The first study involved 26 academically advanced high school seniors, and the 2 subsequent studies involved respectively 20 and 4 of the original participants following their completion of 4 years of college. The final 2 studies involved respectively 147 high, middle and low achieving high school seniors, and 385 academic, public and school library users. Methods – This paper presents the foundation for the ISP model by reviewing the relationship between Kelly’s personal construct theory, Belkin, Brooks, and Oddy’s investigation of cognitive aspects of the constructive information seeking process, and Taylor’s work on levels of information need (“Question-negotiation”) and value-added information (“Value-added”). This is followed by a review of Kuhlthau’s five foundational studies, which investigated the common information seeking experiences of users who were seeking to expand knowledge related to a particular topic or problem. The first of these studies was a small-scale exploration in which participants were given two assignments. Questionnaires, journaling, search logs, and reflective writing were used to collect data throughout the process of assignment completion. Data collection was augmented by case studies involving in-depth interviews and construction of timelines and flowcharts with six study participants. The six-stage ISP model was developed from qualitative content analysis of participants’ perceptions and experiences (Kuhlthau, “Library Research Process”). In the second study, the same questionnaire was used to determine how students’ perceptions of the ISP had changed over time. Post-college responses were compared to responses given in high school and statistical significance was determined through t Tests (Kuhlthau, Perceptions). Four of the original 6 case study participants were interviewed in the third study, in which interview data and search process timelines were compared with high school case studies (Kuhlthau, Longitudinal). In the fourth and fifth studies, large-scale field studies were conducted to verify the ISP model. Process surveys elicited participants’ thoughts and feelings at initiation, midpoint, and closure of a search task. Data were analysed using descriptive and inferential statistics including measures of significance and analysis of variance (Kuhlthau, Information Search; Kuhlthau et al.). Following a summation of these 5 research studies, this article details and discusses the ISP model. Main results – Based on the data from the five studies, the ISP presents a constructivist approach to information seeking and incorporates affective, cognitive, and physical dimensions at each of six information searching stages: initiation, topic selection, pre-focus exploration, focus formulation, information collection, and presentation. Individuals become aware of an information need at initiation. Feelings of uncertainty and apprehension are common as wide-ranging task exploration begins. At topic selection a general topic is selected and users frequently experience initial optimism, which is commonly followed by confusion and doubt as pre-focus exploration commences and users struggle to extend personal knowledge through initial investigation of the general topic. A turning point occurs during focus formulation as constructs become clearer and uncertainty decreases. During information collection the user is able to articulate focused need and is able to interact effectively with intermediaries and systems. Relief is commonly experienced at presentation stage when findings are presented or used. Although stages are laid out sequentially, Kuhlthau notes that the ISP is an iterative process in which stages merge and overlap. Central to this model is the premise that uncertainty is not due merely to a lack of familiarity with sources and technologies, but is an integral and critical part of a process of learning that culminates in finding meaning through personal synthesis of topic or problem. Conclusion – Kuhlthau provides evidence for a view of information seeking as an evolving, iterative process and presents a model for purposeful information searching which, if understood by users, intermediaries and information system designers, provides a basis for productive interaction. While users will benefit from understanding the evolving nature of focus formulation and the affective dimensions of information seeking, intermediaries and systems are challenged to improve information provision in the early formative stages of a search. Although Kuhlthau identifies this research on the ISP as exploratory in nature, this article affords methodological insight into the use of mixed methods for exploring complex user-oriented issues, presents a model that effectively communicates an approximation of the common information-seeking process of users, and provides ongoing impetus for exploring the user’s perspective on information seeking.


2020 ◽  
Vol 86 (18) ◽  
Author(s):  
Jessica Eggers ◽  
Carl Simon Strittmatter ◽  
Kira Küsters ◽  
Emre Biller ◽  
Alexander Steinbüchel

ABSTRACT The biotin metabolism of the Gram-negative facultative chemolithoautotrophic bacterium Ralstonia eutropha (syn. Cupriavidus necator), which is used for biopolymer production in industry, was investigated. A biotin auxotroph mutant lacking bioF was generated, and biotin depletion in the cells and the minimal biotin demand of a biotin-auxotrophic R. eutropha strain were determined. Three consecutive cultivations in biotin-free medium were necessary to prevent growth of the auxotrophic mutant, and 40 ng/ml biotin was sufficient to promote cell growth. Nevertheless, 200 ng/ml biotin was necessary to ensure growth comparable to that of the wild type, which is similar to the demand of biotin-auxotrophic mutants among other prokaryotic and eukaryotic microbes. A phenotypic complementation of the R. eutropha ΔbioF mutant was only achieved by homologous expression of bioF of R. eutropha or heterologous expression of bioF of Bacillus subtilis but not by bioF of Escherichia coli. Together with the results from bioinformatic analysis of BioFs, this leads to the assumption that the intermediate of biotin synthesis in R. eutropha is pimeloyl-CoA instead of pimeloyl-acyl carrier protein (ACP) like in the Gram-positive B. subtilis. Internal biotin content was enhanced by homologous expression of accB, whereas homologous expression of accB and accC2 in combination led to decreased biotin concentrations in the cells. Although a DNA-binding domain of the regulator protein BirA is missing, biotin synthesis seemed to be influenced by the amount of acceptor protein present. IMPORTANCE Ralstonia eutropha is applied in industry for the production of biopolymers and serves as a research platform for the production of diverse fine chemicals. Due to its ability to grow on hydrogen and carbon dioxide as the sole carbon and energy source, R. eutropha is often utilized for metabolic engineering to convert inexpensive resources into value-added products. The understanding of the metabolic pathways in this bacterium is mandatory for further bioengineering of the strain and for the development of new strategies for biotechnological production.


2020 ◽  
Vol 8 (10) ◽  
pp. 789 ◽  
Author(s):  
Samuel Jannel ◽  
Yanis Caro ◽  
Marc Bermudes ◽  
Thomas Petit

Astaxanthin shows many biological activities. It has acquired a high economic potential and its current market is dominated by its synthetic form. However, due to the increase of the health and environmental concerns from consumers, natural forms are now preferred for human consumption. Haematococcus pluvialis is artificially cultured at an industrial scale to produce astaxanthin used as a dietary supplement. However, due to the high cost of its cultivation and its relatively low biomass and pigment productivities, the astaxanthin extracted from this microalga remains expensive and this has probably the consequence of slowing down its economic development in the lower added-value market such as food ingredient. In this review, we first aim to provide an overview of the chemical and biochemical properties of astaxanthin, as well as of its natural sources. We discuss its bioavailability, metabolism, and biological activities. We present a state-of-the-art of the biology and physiology of H. pluvialis, and highlight novel insights into the biotechnological processes which allow optimizing the biomass and astaxanthin productivities. We are trying to identify some lines of research that would improve the industrial sustainability and economic viability of this bio-production and to broaden the commercial potential of astaxanthin produced from H. pluvialis.


2011 ◽  
Vol 21 (5) ◽  
pp. 628-638 ◽  
Author(s):  
Alan W. Hodges ◽  
Charles R. Hall ◽  
Marco A. Palma

Economic contributions of the green industry in each state of the United States were estimated for 2007–08 using regional economic multipliers, together with information on horticulture product sales, employment, and payroll reported by the U.S. Economic Census and a nursery industry survey. Total sales revenues for all sectors were $176.11 billion, direct output was $117.40 billion, and total output impacts, including indirect and induced regional economic multiplier effects of nonlocal output, were $175.26 billion. The total value added impact was $107.16 billion, including employee compensation, proprietor (business owner) income, other property income, and indirect business taxes paid to state/local and federal governments. The industry had direct employment of 1.20 million full-time and part-time jobs and total employment impacts of 1.95 million jobs in the broader economy. The largest individual industry sectors in terms of employment and value added impacts were Landscaping services (1,075,343 jobs, $50.3 billion), Nursery and greenhouse production (436,462 jobs, $27.1 billion), and Building materials and garden equipment and supplies stores (190,839 jobs, $9.7 billion). The top 10 individual states in terms of employment contributions were California (257,885 jobs), Florida (188,437 jobs), Texas (82,113 jobs), North Carolina (81,113 jobs), Ohio (79,707 jobs), Pennsylvania (75,604 jobs), New Jersey (67,993 jobs), Illinois (67,382 jobs), Georgia (66,042 jobs), and Virginia (58,677 jobs). The total value added of the U.S. green industry represented 0.76% of U.S. Gross Domestic Product (GDP) in 2007, and up to 1.60% of GDP in individual states. On the basis of a similar previous study for 2002 (Hall et al., 2006), total sales of horticultural products and services in 2007–08 increased by 3.5%, and total output impacts increased by 29.2%, or an average annual rate of 5.8% in inflation-adjusted terms.


Author(s):  
A.B. Zhursinali ◽  
A.A. Kurmanbaev

The filamentous fungus Aspergillus niger is frequently used for industrial production of fermentative products such as enzymes, proteins and biochemicals. In contrast to what most people might think, citric acid is not or not anymore isolated from citrus fruits, but is industrially produced by the filamentous fungus Aspergillus niger. In 1917, a food chemist named James Currie made a promising discovery: any strain of the filamentous fungus Aspergillus niger would produce high concentrations of citric acid when grown in sugar medium. This tricarboxylic acid, which we now know is an intermediate of the Krebs cycle, had previously been extracted from citrus fruits for applications in food and beverage production. Two years after Currie’s discovery, industrial-level production using Aspergillus niger began, the biochemical fermentation industry started to flourish, and industrial biotechnology was born. Aspergillus niger additionally producing a diverse range of proteins, enzymes and secondary metabolites. In this review, we presented materials on more than 100 years of use of Aspergillus niger in biotechnological production of biologically active substances and environmental protection.


2022 ◽  
Vol 2022 ◽  
pp. 1-10
Author(s):  
Yaw Gyau Akyereko ◽  
Faustina Dufie Wireko-Manu ◽  
Francis Alemawor ◽  
Mary Adzanyo

Cashew (Anacardium occidentale), a crop projecting Ghana internationally beside cocoa, is usually cultivated for its nut, for both local and international markets. The cashew apple is underutilized in many African countries. This study is aimed at determining the knowledge, perception, and utilization of cashew apples in Ghana among stakeholders in the cashew value chain. Results from the study showed that the cashew industry consisted of farmers (89.1%), nut buyers (6.8%), extension officers (3.5%), and processors (0.6%) with uneven distribution of males (66.2%) and females (33.8%). Cashew apple utilization was low (<10%), though 84.37% had in-depth knowledge on the health benefits and value-added products made from the apples. Cashew apple is mainly utilized as fresh fruits or juice, with minor uses as an ingredient in food preparation, animal feed formulation, and production of mushroom, weedicide, ethanol, and manure. The cashew apple processors identified high cost of processing equipment, perishability of apples, lack of capital, market, technical know-how, and government support as challenges. Based on these findings, education of the stakeholders on value addition or processing of the apples at household and industrial levels and provision of stimulus packages to private processors are recommended to maximize cashew apple utilization in Ghana.


Author(s):  
Yeni Marlina ◽  
Putri Suci Asriani ◽  
Bambang Sumantri

The aims of the research are to 1) determine factors that affect the production of ubi jalar ungu, 2) to know how much costs and revenues the ubi jalar ungu farming, 3) to determine the efficiency of the ubi jalar ungu farming, 4) to calculate how much added value from ubi jalar ungu processing into fried macaroni. This study sites was intentionally set in the village of Teladan. The data is obtained from the primary data and the secondary data, the respondents of ubi jalar ungu farmers was taken by census method. While the processor is home industry ZAHRA. The result shows that significant factos are seeds, Phonska fertilizers, manures and labors. While, land factor is not significant. The total cost for the ubi jalar ungu farming is Rp 2.900.054,13/Ut/Mt or Rp 8.209.106,83/Ha/Mt, and a revenue is Rp 3.241.570,87/Ut/Mt, or Rp 9.190.226,51/Ut/Ha. Result of the R/C ratio is 2,12, and the value is greater than one. It means that the farming is efficient. The added value of ZAHRA home industry is Rp 41.072,-/kg, with a profit of Rp 37.472,-/kg, and the rate of profit reaches 91.23 %. This benefit is a net plus, because it has been reduced by the share of the labor.Key words: Ubi jalar ungu, production, revenue, efficiency and value-added


2016 ◽  
Vol 10 (1) ◽  
pp. 335-341 ◽  
Author(s):  
Aishwarya Ramkumar ◽  
Nallusamy Sivakumar ◽  
Reginald Victor

Industrial biotechnology processes have recently been exploited for an economic utilization of wastes to produce value added products. Of which, fish waste is one of the rich sources of proteins that can be utilized as low cost substrates for microbial enzyme production. Fish heads, tails, fins, viscera and the chitinous materials make up the wastes from fish industries. Processing these wastes for the production of commercial value added products could result in a decrease in the cost of production. In addition, we can eliminate the pollution of the environment and health issues due to the improper disposal of these fish wastes. This review highlights the potential use of fish waste as a cheaper substrate for the production of economically important protease enzyme.


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